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"Vitamin D Toxicity is a non-issue" ???
 Moderated by: Prof Trevor Marshall
 

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Paisleykilt
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 Posted: Mon Jan 30th, 2012 22:08

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-Just when it seemed the article might be going in an interesting direction...

http://lymemd.blogspot.com/2009/07/lyme-bartonella-b12-folic-acid-and.html

If only the cure and conclusions were that simple!



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Prof Trevor Marshall
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 Posted: Mon Jan 30th, 2012 22:23

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I sign my name to my posts and papers. You would think this blogger would have the guts to do that too :) :)
  

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 Posted: Tue Jan 31st, 2012 02:55

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One of the comments posted below the article:

"I've had really low vitamin d for quite some time, but whenever I'm placed on supplements symptoms seem to worsen."

And a comment from the MD blogger himself:


"I have never pulsed. I cannot comment too much about it. Patients seem to relapse quickly when antibiotics are stopped so I avoid this approach."

Last edited on Tue Jan 31st, 2012 04:02 by Russ



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Ron
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 Posted: Tue Jan 31st, 2012 04:12

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Vitamin D toxicity is a non-issue. The only potential issue is hypercalcemia--excessively high levels of calcium in the blood. This is highly unlikely and can be monitored. Forget the whole Marshall distraction.
Amelogenesis Imperfecta can hardly be called a non-issue, but rather a mutilation for life.

http://ndt.oxfordjournals.org/content/21/10/2959.full.pdf

AI sometimes occurs following environmental causes, including vitamin D deficiency or intoxication
:X

Joyful
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 Posted: Tue Jan 31st, 2012 20:10

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Ron, isn't Amelogenesis Imperfecta a genetic condition?



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Ron
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 Posted: Tue Jan 31st, 2012 22:25

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Joyful,

Yes, "genetic"...

http://www.sciencedirect.com/science/article/pii/S0888754397946437

"Ameloblastin gene (AMBN) maps within the critical region for autosomal dominant amelogenesis imperfecta at chromosome 4q21"

AMBN can be found in the vitamin D response elements table of Wang et Al's "Identification of Direct 1,25-Dihydroxyvitamin D3 Target Genes" paper:

http://mend.endojournals.org/content/19/11/2685.full#SEC1

I wonder what could happen if VDR transcription were to be disrupted in a young, developing child.

Prof Trevor Marshall
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 Posted: Tue Jan 31st, 2012 22:51

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Agreed, Ron :)
 


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