 |
| Author | Post |
|---|
Freddie Ash
Member in Phase 3
|
Posted: Sun Oct 14th, 2007 23:43 |
|
HI DR MARSHALL & JOYCE
This is Fred in WV. Thank you so much, both of you for all the info. I just wanted to get this matter cleared up so now I will not worry any more about the calcifiation.
Joyce, I could not get that link up. It wanted me to log in and I did try to log in but it would not let me. But I am not very good at computer things, so it is most likely me not doing something right. Thanks again Dr Marshall & Joyce for all the time you spent on me and my problems.
Remember, we are all in this together and I am pulling for us.
Your friend in sarcoidosis
Freddie
____________________
Freddie: dx-sarc 2/82 lymph; skin, eyes, joints, esophagus, intestines, spleen, heart,lungs-meds digitek, L-thyroxine, nexium, furosemide, nattokinase36mg,eat cinnamon w/meals,25D-7; 125-D43
|
Dr Trevor Marshall
Research Team
|
Posted: Tue Oct 16th, 2007 03:52 |
|
Reuters is reporting that the FDA and EPA are sticking to their guidelines about lmiting the amount of fish pregnant women eat, despite pressure (apparently funded by the industry) to increase it.
see reuters link
|
jcwat101
Research Professional
|
Posted: Wed Oct 24th, 2007 17:23 |
|
Just as a continuation of the Vitamin K links, this is a newer study that showed some modest benefit from 200 mcg Vitamin K1:
Two-year randomized controlled trial of vitamin K1 2007]
It seemed to have worked through its effect on gamma-carboxylation of osteocalcin to help with bone density. Since osteoporosis and vascular calcification go hand in hand often times, it may have affected the calcification, but they did not examine that.
Joyce Waterhouse
PS 200 mcg Vitamin K1 was the amount I have taken the last few years -- Solgar brand is safest to take, IMO. I was unable to obtain it from my diet -- see above posts for information on dietary sources. I don't think it affects my immunopathology, but will double check and post again if it has any effect.
____________________
20 yrs with CFS/FM/Lyme/IBS, food sensitivities; 1,25D/25D 8/04:64/11 1/05:22/6 9/05:1,25D=12 10/06:22/8, 4/07:25/<4 chewed Ben. 40mg q8h; Mod. P2: 2/23/05, P2: 4/06; P3: 1/1/07
|
eClaire
Member in Phase 2
| Joined: | Mon Sep 25th, 2006 |
| Location: | Virginia USA |
| Posts: | 520 |
| Status: |
Offline
|
|
Posted: Wed Oct 31st, 2007 01:44 |
|
Finally a note of caution about Vit D in the news: Vitamin D may not reduce cancer deaths ( article quotes Litchfield as saying, "Overall, most research "seems to be pointing in the direction that there is a role of vitamin D," which sounds suspicously like certain leaders who have lead us down not so rosy lanes. I'm hoping that he was misquoted.
Clarie
____________________
CFS FMS MCS COPD hypermobility IBS/GERD osteoporosis 125D48 25D8 Ph1Dec06 ModPh2Jun07 NoIRs limited outings covered up low lux home abx brk 3/2/08 to 5/25/08
|
jcwat101
Research Professional
|
Posted: Tue Nov 6th, 2007 04:49 |
|
There are new links to articles that go more into the brain lesion study and vitamin D and calcification mentioned earlier.
See this thread:
Gerald Domingue: Pioneer of Atypical Bacteria - Dr Marshall's Perspective - DR
Joyce Waterhouse
____________________
20 yrs with CFS/FM/Lyme/IBS, food sensitivities; 1,25D/25D 8/04:64/11 1/05:22/6 9/05:1,25D=12 10/06:22/8, 4/07:25/<4 chewed Ben. 40mg q8h; Mod. P2: 2/23/05, P2: 4/06; P3: 1/1/07
|
jcwat101
Research Professional
|
Posted: Tue Nov 6th, 2007 19:06 |
|
The article at the link below is one I wrote that deals with a lot of the basis for vitamin D claims, particularly relating to secondary hyperparathyroidism. It describes the many flaws in the research that tries to use elevated parathyroid hormone to determine the optimal level of vitamin D. It also relates that research to studies of vascular calcification and to the new study that I mentioned earlier that has found a higher volume of brain lesions by MRI with higher vitamin D intake.
http://www.members.aol.com/SynergyHN/shpt
Amy's article at http://bacteriality.com/category/vitamin-d covers the brain lesion study more for a lay audience and her article on the myths surrounding vitamin D at the same link covers a lot of the studies, including on cancer and bone density and explains more of the latest about vitamin D dysregulation.
Joyce Waterhouse
____________________
20 yrs with CFS/FM/Lyme/IBS, food sensitivities; 1,25D/25D 8/04:64/11 1/05:22/6 9/05:1,25D=12 10/06:22/8, 4/07:25/<4 chewed Ben. 40mg q8h; Mod. P2: 2/23/05, P2: 4/06; P3: 1/1/07
|
stoneyhill
Member in Phase 2
|
Posted: Mon Jan 21st, 2008 20:42 |
|
The managed media seems to get curiouser and curiouser.
from http://www.lewrockwell.com/sardi/sardi79.html
It could be said that the enemy of my enemy is my friend but I think this article proves the error of that statement.
Do statin drugs mimic a vitamin?
In 2006 Dr. Davis S. Grimes of the Blackburn Royal Infirmary in Great Britain, ruffled a lot of feathers in the medical world when he revealed that statin drugs appear to be synthetic versions (called analogs) of vitamin D. [Lancet 2006 Jul 1; 368(9529):83–6] All the alleged health benefits of statin drugs, prevention of osteoporosis, cancer prevention, promotion of arterial health, parallel those of vitamin D. The pharmaceutical world was quick to deny the allegation.
One more reason for me to get off the Zocor.
____________________
Sarcoidosis/lungs, HTN, CAD, arthritis, NIDDM, cataract, 125D48, 25D31, MP 4-25-08 | Aspirin therapy, lisinopril, metaprolol, omeprazole, NoIRs, lite exp r/t to work, cover up, 1-08 25D33, 5-08 25D16 | "I don't think I'm in the control group."
|
Dr Trevor Marshall
Research Team
|
Posted: Mon Jan 21st, 2008 21:09 |
|
LANCET published my letter in response to Grimes' ridiculous suggestion:
Marshall TG: Are statins analogs of vitamin D?. Correspondence to Grimes, DS. The Lancet 2006; 368:1234 doi:10.1016/S0140-6736(06)69509-3
Copy available from URL http://www.thelancet.com/journals/lancet/article/PIIS0140673606695093/fulltext
...............................................................................
If you are interested in the conflicts of interest swirling around the Vit D advocates, then you will enjoy reading this article from the Canadian Broadcasting Commission:
"The Vitamin D Debate"
http://www.cbc.ca/news/viewpoint/vp_strauss/20080213.html
|
stoneyhill
Member in Phase 2
|
Posted: Fri Mar 28th, 2008 16:37 |
|
I was reading an article today, Mar 28, 2008 on http://lewrockwell.com/ about coronary calcium being a predictor of heart disease. The author (Bill Sardi, who has written numerous articles bragging up socalled Vit. D) requested that his piece not be posted on other sites, so I won't.
I googled 'calcium coronary New England Journal of Medicine' and came up with a bunch of hits, with;
http://content.nejm.org/cgi/content/short/358/13/1336 being the horses mouth.
Coronary Calcium as a Predictor of Coronary Events
I found it interesting that nothing in the abstract (they wouldn't let me read the whole article) mentioned testing the D metabolites as a way of determining whether calcium could be resorbed from the bones and teeth and deposited in the soft tissues like I keep reading here on the MP.
The picture is starting to take shape for me anyway, 1965 I get diagnosed with Pulmonary Sarcoidosis with "elevated calcium levels in blood and urine" and 35 years later come down with a MI and CAD.
This is perhaps the most important reason for me to be on the MP.
Thanks Dr. Marshall
Last edited on Fri Mar 28th, 2008 16:40 by stoneyhill
____________________
Sarcoidosis/lungs, HTN, CAD, arthritis, NIDDM, cataract, 125D48, 25D31, MP 4-25-08 | Aspirin therapy, lisinopril, metaprolol, omeprazole, NoIRs, lite exp r/t to work, cover up, 1-08 25D33, 5-08 25D16 | "I don't think I'm in the control group."
|
Santa Monica
Member in Phase 2
|
Posted: Fri May 16th, 2008 06:00 |
|
Not sure what to make of this...
Vitamin D deficiency linked to breast cancer, study finds
Patients with deficient levels at the time of diagnosis are more likely to have their cancer metastasize and turn deadly, researchers say. But experts caution against treating cancer with supplements.
By Thomas H. Maugh II, Los Angeles Times Staff Writer
____________________
Sarcoidosis/lungs CFS Hashimoto's 125D43 25D24 Armour Lunesta Ph1Mar08 25D32(Apr08) Ph2May08 abx brk r/t UTI restart Ph2Jun08 NoIRs low lux home lite exp r/t work
|
Meg Mangin R.N.
Research Team
|
Posted: Fri May 16th, 2008 06:21 |
|
See Cancer and Th1 inflammation
|
jcwat101
Research Professional
|
Posted: Fri May 16th, 2008 22:14 |
|
I think this reply to Grant (a big vitamin D proponent) that I found just recently, by Dr. Lucas, from the WHO replies very nicely to the overwrought claims regarding cancer and vitamin D made by some people.
This brief summary shows the latitudinal and sun exposure data is full of holes and mentions the two studies showing higher cancer rates when 25D was over 30 ng/ml:
https://www.who.int/bulletin/volumes/85/5/06-039446/en/
Might be a good link to send to friends and colleauges who think that vitamin D is proven to prevent cancer
Joyce Waterhouse
____________________
20 yrs with CFS/FM/Lyme/IBS, food sensitivities; 1,25D/25D 8/04:64/11 1/05:22/6 9/05:1,25D=12 10/06:22/8, 4/07:25/<4 chewed Ben. 40mg q8h; Mod. P2: 2/23/05, P2: 4/06; P3: 1/1/07
|
jrfoutin
Member Advocate
| Joined: | Tue Aug 9th, 2005 |
| Location: | Oregon USA |
| Posts: | 3845 |
| Status: |
Offline
|
|
Posted: Fri May 16th, 2008 22:52 |
|
I always like Meg's cancer link. It helped me to quit fearing it as an insurmountable and looming potential health possibility. Having watched family members and friends suffer from this disease without knowing or being able to understand D issues, I appreciated both Meg and Joyce's posts.
I also appreciate Dr Marshall's comments about his Bioessays paper this year, and rebuttal to comments:
I put out my position clearly in my BioEssays response, just published this month:
http://www.ncbi.nlm.nih.gov/pubmed/18404718
http://AutoimmunityResearch.org/Bioessays_reply_may08_preprint.pdf
in answer to the letters:
http://AutoimmunityResearch.org/BioEssays_May08_letters.pdf
"Dr Boucher has highlighted many of the difficulties confronting clinical medicine as it expands its knowledge-base from the level of tissues, as seen under the microscope, to that of individual genes and proteins, interacting at the sub-microscopic scale of the molecule. Even though there are decades of clinical studies attempting to delineate the association between health, disease, and the Vitamin D metabolites, any study conducted without reference to genes, or transcription, must necessarily lead to an incomplete characterization."
..Trevor..
Most popular press articles about D are written by people who do not understand the D metabolism and the VDR, and they often fail to describe any tests for 1,25D. Sadly, health writer's editors seem to be equally uninformed so the popular press continues to churn out marketing misinformation.
The harm comes when those exploring the MP (or early in MP notice it isn't a cake walk), their family members, uninformed doctors and of course, the general public believes the sheer volume of D misinformation. Individuals are discredited who know that low 25D is not a call for supplementation, and people continue to push and buy supplemental D.
Thank you Dr Marshall, Meg, and for the response by Dr. Lucas (WHO), Joyce.
Best to all--Janet
____________________
Sarcoidosis 125D61, MP10/05 ModP2 12/05 Ph2 6/06 Ph3 10/06, NoIRs limited outings covered, 2/08 25D6.2
|
stoneyhill
Member in Phase 2
|
Posted: Fri May 16th, 2008 23:31 |
|
Bill Sardi wrote a piece on LewRockwell.com yesterday about molecular genomics and how science will eventually figure it all out. Mr. Sardi is a hardcore Vitamin D advocate so I thought it was interesting if not hard for me to understand. Perhaps some of you smart ones could tell me what he said.
This statement seems to be at odds with the MP and I wonder if his observation of the lack of Vitiman D is really a lack of 25D because all of it is being converted to 1,25D which to the medical profession is not much worth measuring (in my experience).
A lack of vitamin D is linked with many diseases ranging from rickets, osteoporosis, autoimmune disease (rheumatoid arthritis, lupus, multiple sclerosis, Crohn’s disease, Hashimoto’s thyroiditis), obesity, mental depression, heart failure, diabetes, to lack of muscle tone.
http://www.lewrockwell.com/sardi/sardi83.html
edited for speeling
Last edited on Fri May 16th, 2008 23:32 by stoneyhill
____________________
Sarcoidosis/lungs, HTN, CAD, arthritis, NIDDM, cataract, 125D48, 25D31, MP 4-25-08 | Aspirin therapy, lisinopril, metaprolol, omeprazole, NoIRs, lite exp r/t to work, cover up, 1-08 25D33, 5-08 25D16 | "I don't think I'm in the control group."
|
Meg Mangin R.N.
Research Team
|
Posted: Fri May 16th, 2008 23:47 |
|
| Stoney, if you read the discussion in this thread you will see that most studies of vitamin D are invalid because they only measure 25-D.
|
jrfoutin
Member Advocate
| Joined: | Tue Aug 9th, 2005 |
| Location: | Oregon USA |
| Posts: | 3845 |
| Status: |
Offline
|
|
Posted: Sat May 17th, 2008 22:42 |
|
Stoney,
I also like to look at all the low 25D lists from the pro-D folks as a substantial indicator of all the things that really go wrong in Th1... they are doing a great job of finding all the "half of the story" places where low 25D is found, and where the MP will eventually be readily accepted later on as the only reasonable solution once the full story is understood  .
The other shoe to drop is the 1,25D values, just like Meg said, and of course, a full pathogenesis that comprehends the biofilm L-form bacterial communities in Th1 disease.
Once people understand they are building the ideal environment for pathogens by pumping more D, then the rest of the story will come together and more people can get well.
You might want to look at Meg Mangin's 2008DMM Karolinska poster handout to see how the cycle of disease starts and keeps going. For easy viewing, use the little magnifying glass tool in your acrobat browser window to enlarge the cycle diagram in the lower left corner of page 1.
Best to you Stoney--Janet
____________________
Sarcoidosis 125D61, MP10/05 ModP2 12/05 Ph2 6/06 Ph3 10/06, NoIRs limited outings covered, 2/08 25D6.2
|
Dogster
Member
| Joined: | Mon Jan 24th, 2005 |
| Location: | Kansas USA |
| Posts: | 277 |
| Status: |
Offline
|
|
Posted: Tue May 20th, 2008 16:44 |
|
Stoney and all,
the summary put out by AP wire service (but not in the other wires) had an interesting sentence, which shows dubious interpretation of their own data (not to mention they only measure one form of D), and i quote: " Red flag. The few women with the very highest levels of D had the lowest survival rates."
You can check for yourself, but that's what they said. One researcher in there was quoted as saying something like, well maybe the level should be somewhere in the middle somewhere. Of course, they dont have a clue of the whole infectious/immune process, but this is an example of poor research, methodology, and understanding by the researchers and of limits of the press. Too bad this kind of thing keeps being recycled . . . .
Regards, Dogster
____________________
CFS lyme RSD: pain migraine| tylenol fioricet flexeril tramadol temazepam| acidoph guaif/cold| Q| Cut D/exp Feb05| NoIR Mar05| June05 Comm Beni Q8H| July05 mino| Jan06 PH2| Aug06 1,25D=29 25D=17|
|
jcwat101
Research Professional
|
Posted: Wed May 21st, 2008 03:11 |
|
Dogster,
That's interesting. The U-shaped curve that you describe (more problems at lowest and highest 25-D) is like Tuohimaa found in prostate cancer and I discussed it in the talk I gave that is on the LAX conference DVD. I discuss it near the end --see online at: http://autoimmunityresearch.org/transcripts/waterhouse_lax2006.pdf.
Joyce Waterhouse
Last edited on Wed May 21st, 2008 03:19 by jcwat101
____________________
20 yrs with CFS/FM/Lyme/IBS, food sensitivities; 1,25D/25D 8/04:64/11 1/05:22/6 9/05:1,25D=12 10/06:22/8, 4/07:25/<4 chewed Ben. 40mg q8h; Mod. P2: 2/23/05, P2: 4/06; P3: 1/1/07
|
stoneyhill
Member in Phase 2
|
Posted: Mon Jun 9th, 2008 19:23 |
|
I am of the opinion that the author of this piece is a one trick pony. He pushes Vitamin D supplementation like I used to push my old Ford.
The study compared men with vitamin D levels at or below 15 nanograms of vitamin D per milliliter of blood (37.4 nanomoles per liter) to men with vitamin D levels above 30 nanograms per milliliter (74.8 nanomoles per liter). Men with a low (less than 15 nanograms/milliliter) level of vitamin D would need about 3000 international units (IU) of supplemental vitamin D3 per day to reach a 30 nanogram blood concentration, say study researchers. Most multivitamins provide a paltry 400 IU of vitamin D.
Men in the study group averaged 200–205 total cholesterol, which is considered a healthy range. Most of the decreased risk for a heart attack among men who had higher vitamin D levels was attributed to vitamin D’s ability to prevent arterial calcification, not cholesterol plaque.
http://www.lewrockwell.com/sardi/sardi85.html
He refers to a piece that I googled but couldn't find but I did find an article, the abstract of which said that 100 IU of D3 daily would add 1 pg/ml to the 25(OH)D count.
Serum 25(OH)D can be expected to rise by about 1 ng/mL (2.5 nmol/L) for every 100 IU of additional vitamin D each day.
http://cjasn.asnjournals.org/cgi/content/abstract/CJN.01160308v1
By my math that means that a guy with a 25D of 15 would need 1500 IU, not 3000.
Whatever. I have been dressed like Ted Kozinski (see my avatar) for the last 6 months and have avoided any and all dietary D that I could to get my 25D down from 31 to 16.
I gotta ask again. When are they going to look at 'the analogs' namely 1,25D?
____________________
Sarcoidosis/lungs, HTN, CAD, arthritis, NIDDM, cataract, 125D48, 25D31, MP 4-25-08 | Aspirin therapy, lisinopril, metaprolol, omeprazole, NoIRs, lite exp r/t to work, cover up, 1-08 25D33, 5-08 25D16 | "I don't think I'm in the control group."
|
Anthony D
Member in Phase 2
| Joined: | Thu Nov 29th, 2007 |
| Location: | New York USA |
| Posts: | 43 |
| Status: |
Offline
|
|
Posted: Tue Jun 24th, 2008 14:15 |
|
Saw on the news today ( Good Morning America) a study that say's people with low levels of vitamin d are two times more likely to die in the next eight years than those with higher levels of vitamin d. Curious about study? or what spin is attached to that it.
Last edited on Tue Jun 24th, 2008 14:16 by Anthony D
____________________
Sarcoidosis/lungs MP 1/08 Ph2 2/08, last 25D-6, 1.25d-32 albuterol/,Noirs covered up
|
Current time is 06:33 | Page:   1 2 3 4 5   |
|
|
|
|
