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paulalbert
Advocate
| Joined: | Fri Jul 16th, 2004 |
| Location: | USA |
| Posts: | 618 |
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Posted: Mon Nov 6th, 2006 00:12 |
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Jeannine,
It would appear that, under current law, your answer is 2022 or so.
Olmesartan was approved by the FDA in 2002. The FDA grants a 20-year patent from the time of a drug's approval for submission. So, it would appear that the current date Benicar goes generic in 2022.
Then again, Congress could extend patent laws for drugs given the scarcity of new drugs in the pipeline.
It's also a possibility that as we learn more about some of these mystery nuclear receptors, new ARBs will be created to target or not target those as the case may be.
PaulLast edited on Mon Nov 6th, 2006 00:13 by paulalbert
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Diag CFS 6.03 / sympt since 9.02 / exercise, food intol, sleep prob / 1,25D: 16, 4.06; 1,25D:27, 25D:26 7.04; 1,25D:43, 25D:6 6.05; 1,25D:17, 25D:8 8.05; / MP: 7.04 / Ph. 3 / MP Gallery
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Dr Trevor Marshall
Research Team
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Posted: Mon Nov 6th, 2006 01:17 |
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A generic manufacturer has applied to the FDA, filing an ANDA for generic approval of their own Olmesartan, which is apparently made through a method which they claim does not infringe Sankyo's patent. Sankyo has sued them for patent infringemnt, and the battle is on. So we might see a generic in just a year or two...
http://tinyurl.com/y4oa45
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James Willis
Member in Phase 3
| Joined: | Sat Apr 2nd, 2005 |
| Location: | Australia |
| Posts: | 66 |
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Posted: Wed Dec 20th, 2006 03:26 |
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If a Benicar blockade were incomplete over a length of time (i.e. not just a day or two) say for reasons of faulty digestion or other would the die-off reactions feel more intense as a result? If the blockade was then put into place properly how would that be experienced in terms of immunopath reactions? Would the symptoms lessen, or increase? And would one become more sensitive to the abx (and need to decrease the levels, as symptoms intensified) or more tolerant and be able to increase the abx doses? Or something else?
Thanks,
James
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CFS. 10Mar05: 1,25D=50, 25D=22. 15/4:Beni q6h. 10mg noct. Endep. Rivotril, Zolpiclone noct as req. 24/4: Ph1. 2Jun:1,25D=42,25D=19. Ph2:30/9/5. 6Mar06:25D=8; Ph3:26/7; 25D=7.6.
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jrfoutin
Member Advocate
| Joined: | Tue Aug 9th, 2005 |
| Location: | Oregon USA |
| Posts: | 3846 |
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Posted: Wed Dec 20th, 2006 13:38 |
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James,
I kind of got the feeling your post was rather hypothetical. Rather like this statement:
If wishes were fishes we'd all easily catch too much D while wish-fishing.
But as I think you are fishing around for a different kind of answer, I will say from my own personal experience, without really trying to be an example of the negative, and well before I was able to set up a decent Benicar blocade as per Phase 1 guidelines, I had lowered my D intake enough for my immune system to get functional prior to starting the MP while trying to find a good MP doctor. When I introduced enough Benicar to enable my immune system but not enough to protect (20mg q8h for a day or so), I got a whammy event (neuro/brain+emotional).
Fortunately, Lottie and Dr Marshall sorted through the problem immediately the next day and encouraged me to halt low dose Benicar and wait to try the MP until I found a doctor that would prescribe Benicar at the dose clearly described in the phase 1 documentation.
Inflammatory events that are not protected or controlled do occur outside the MP. I'm sure I would not recommend that to anyone, however.
Choose well, get well--Janet
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Sarcoidosis 125D61, MP10/05 ModP2 12/05 Ph2 6/06 Ph3 10/06, NoIRs limited outings covered, 2/08 25D6.2
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James Willis
Member in Phase 3
| Joined: | Sat Apr 2nd, 2005 |
| Location: | Australia |
| Posts: | 66 |
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Posted: Wed Dec 20th, 2006 20:19 |
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Thanks Janet.
No wishfishing I'm afraid. All very practical. Thanks for your reply though.
Cheers, James
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CFS. 10Mar05: 1,25D=50, 25D=22. 15/4:Beni q6h. 10mg noct. Endep. Rivotril, Zolpiclone noct as req. 24/4: Ph1. 2Jun:1,25D=42,25D=19. Ph2:30/9/5. 6Mar06:25D=8; Ph3:26/7; 25D=7.6.
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jrfoutin
Member Advocate
| Joined: | Tue Aug 9th, 2005 |
| Location: | Oregon USA |
| Posts: | 3846 |
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Posted: Wed Dec 20th, 2006 23:47 |
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James,
Please pardon me for thinking your question is more hypothetical as opposed to knowing the real intent of your question..
Best wishes--Janet
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Sarcoidosis 125D61, MP10/05 ModP2 12/05 Ph2 6/06 Ph3 10/06, NoIRs limited outings covered, 2/08 25D6.2
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P.Bear R.N.
Research Team
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Posted: Thu Dec 21st, 2006 02:11 |
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| James, I suspect the answer to your questions would be that people can be highly variable in their reactions based upon their specific physiologic status. People who have a suppressed immune system may have little reaction to even high doses of antibiotics, and as you realize what happens is a complex interplay of several variables. Generally speaking I believe that a good Benicar blockade will help control a runaway herx, but at the same time the Benicar radically potentiates the actions of antibiotics to create a microbial die-off. What works for one person does not alway work for another, people may vary as they progress, and that is why the staff developed a few strategies for controlling an immunopathologic response. I do feel almost always the adequate Benicar blockade is the way to go, but whether to take more antibiotic or less to control herx is more variable and needs to be individualized. In many ways your questions can not be answered except to say"It all depends", and I know that is a problematic answer. Best, P.B.
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MCS, neuroborreliosis, fatigue, tinnitus, neck/facial/shoulder/lumbar pain, Bells palsy, Prostatitis, blurry vision, dizziness, 1,25D=48, MP2/05 MP3, cytomel, D25<5
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Lantern
Member in Phase 3
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Posted: Sat Dec 23rd, 2006 07:22 |
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| Not sure if this might be helpful or not. I have impaired digestion (tested positive for leaky gut syndrome and malabsorption), and for the first 6 months or so on the MP I had to take Benicar 6-hourly, as taking it 8-hourly would leave me feeling worse for the last 30-60 minutes before the next dose. Since starting to crunch my Benicar before swallowing it, it has been much more effective. I have not only felt better protected but I have also been able to drop the dosage to 8-hourly. I am still having herxes that are just as strong, but the better absorption of benicar seems to soften the blow a bit. I was trying to think of a suitable metaphor, but all I could think of was comparing the herxes to being hit with a bat, and the better benicar protection being like wearing a foam suit or something. Same strength hits, but just being able to cope with it a bit better. Hope that made sense!
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CFS IBS malabsorption hypothyroid rickettsia 125D31 Ph1Apr06 ModPh2Oct06 Ph2Feb07 Endep T3/T4 Panadol 25D14 (Aug06) NoIRs homebound in low lux
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James Willis
Member in Phase 3
| Joined: | Sat Apr 2nd, 2005 |
| Location: | Australia |
| Posts: | 66 |
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Posted: Sat Dec 23rd, 2006 12:01 |
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PBear and Shadowzone,
Thanks for your replies. After starting to dissolve the Votum tabs under my tongue I can't really tell yet what impact it has had - my ups and downs are so large. Either way, I think its the way to go by eliminating one possible variable (i.e. malabsorption) and it certainly cant hurt.
Thanks,
James
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CFS. 10Mar05: 1,25D=50, 25D=22. 15/4:Beni q6h. 10mg noct. Endep. Rivotril, Zolpiclone noct as req. 24/4: Ph1. 2Jun:1,25D=42,25D=19. Ph2:30/9/5. 6Mar06:25D=8; Ph3:26/7; 25D=7.6.
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Meg Mangin R.N.
Research Team
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Posted: Sat Dec 23rd, 2006 21:30 |
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The FDA has not approved sublingual use of Benicar and we do not know what effect its routine use would have on local soft tissues and tooth enamel. Therefore, we recommend the use of Benicar sublingually only as a bolus when an increase in the blockade is needed.
See Sublingual Benicar
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bigred
inactive member
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Posted: Wed Jan 24th, 2007 16:13 |
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I just spoke with someone at a pharmaceutical mail order company in Canada who claims that there is a generic form of Benicar on the market. They said that there are 3 countries that are able to produce a generic form of Benicar; New Zealand, Fiji and India. Is it safe to order that Benicar? The name brand version of the Benicar that they sell is manufactured in Italy. The cost difference is Generic $104.16 Qty:100 40mg and Name Brand $125 Qty:84 40mg.
Should I be leary about ordering the generic form of Benicar or is it safe? Has anyone else ordered the generic from PharmaWebGlobal.com?
Aileen
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MP Phase1;Sarc 10/05;cough,shortness breath,chest pain,headaches;prednisone 11/05-3/06;elevated prolactin 5/05 Cabergoline.25mg 2x/week stopped 9/06;ACE 83U/L 8/14/06;D,25=32 D,1,25=38 10/06;D,25=15 D,1,25=26 11/06;Beni 1/1/07;Mino 1/8/07
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Dr Trevor Marshall
Research Team
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Posted: Wed Jan 24th, 2007 16:26 |
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Aileen,
I cannot give you any info about that mail-order company, you will have to check it out with the Canadian regulators.
Olmesartan Medoxomil is available from manufacturers other than Sankyo. Indeed, one of them has filed an ANDA with the US FDA for approval as a generic, and has subsequently been sued by Sankyo USA for patent infringement. I believe that there is a manufacturer in China and one in India, but cannot be sure of that.
IMO, the key thing is to work with a reputable registered and licensed pharmacy in the country of your residence.
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bigred
inactive member
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Posted: Wed Jan 24th, 2007 18:24 |
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| I have tried pharmacies in my area but the cost of the Benicar is just TOO high! My insurance company has denied the request to authorize payment for the Benicar. I was able to start the treatment with the samples that my doctor had available in her office but that supply has run out. I have improved tremendously in the three short weeks that I have been on the treatment. I do not want to have to stop treatment but I just can't afford to pay for the Benicar. I have tried every prescription assistance program that I can find but I do not qualify for any help because I do have medical insurance. I do not know what to do now?!?!
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MP Phase1;Sarc 10/05;cough,shortness breath,chest pain,headaches;prednisone 11/05-3/06;elevated prolactin 5/05 Cabergoline.25mg 2x/week stopped 9/06;ACE 83U/L 8/14/06;D,25=32 D,1,25=38 10/06;D,25=15 D,1,25=26 11/06;Beni 1/1/07;Mino 1/8/07
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Meg Mangin R.N.
Research Team
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Posted: Wed Jan 24th, 2007 19:35 |
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| If you cannot afford Benicar, please see the info regarding Sankyo's Open Care program in BENICAR: Where to purchase Benicar for self-pay members
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bigred
inactive member
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Posted: Wed Jan 24th, 2007 20:49 |
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| Thank you for the reference to Sankyo's program. I already tried that. They told me that because I have health insurance I do not qualify for any assistance. It doesn't matter that my health insurance has denied payment for the medication it only matters that I have insurance. I am in the process of appealing the denial with my insurance company but my doctor has been very slow about helping me with the appeal. I used the letter that I found in the section about how to get your insurance company to cover the Benicar and faxed it to my doctor for her signature so that it could be sent to my insurance company. She didn't like one of the lines in the letter and wants to change it but has not done it yet. Sankyo told me that they might be able to send some samples to my doctors office while I wait for the answer to my appeal but I don't know if the doctor's office has called to request the samples yet. I only have enough Benicar for 1 more day and the insurance company has 15 days to review my appeal before they have to give me an answer. I explained that to my doctor's office but they don't seem to have any sense of urgency in regards to this situation.
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MP Phase1;Sarc 10/05;cough,shortness breath,chest pain,headaches;prednisone 11/05-3/06;elevated prolactin 5/05 Cabergoline.25mg 2x/week stopped 9/06;ACE 83U/L 8/14/06;D,25=32 D,1,25=38 10/06;D,25=15 D,1,25=26 11/06;Beni 1/1/07;Mino 1/8/07
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Dogster
Member
| Joined: | Mon Jan 24th, 2005 |
| Location: | Kansas USA |
| Posts: | 277 |
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Posted: Wed Jan 24th, 2007 21:05 |
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Aileen,
you can get the Benicar for a little over a dollar a pill from the German source listed in Meg's link. About the same as you listed for the generic, but can be assured of the quality. They are polite and efficient and speak English. Of course, it takes some time for it to come via the shipping.
Regards, Dogster
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CFS lyme RSD: pain migraine| tylenol fioricet flexeril tramadol temazepam| acidoph guaif/cold| Q| Cut D/exp Feb05| NoIR Mar05| June05 Comm Beni Q8H| July05 mino| Jan06 PH2| Aug06 1,25D=29 25D=17|
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eClaire
Member in Phase 2
| Joined: | Mon Sep 25th, 2006 |
| Location: | Virginia USA |
| Posts: | 520 |
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Posted: Tue Apr 24th, 2007 15:39 |
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Hey all,
I am thinking of purchasing generic Benicar from PharmaWebGlobal.com (http://www.pharmawebglobal.com/catalog_veritySearch.html?keywords=Benicar).
I'm wondering if anyone has experience with this company and with the generic Benicar.
If so, what was your experience? Were you satisfied with the company service? Were you satisfied with the generic Benicar?
Thanks, Claire
Last edited on Tue Apr 24th, 2007 15:40 by eClaire
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CFS FMS MCS COPD hypermobility IBS/GERD osteoporosis 125D48 25D8 Ph1Dec06 ModPh2Jun07 NoIRs limited outings covered up low lux home abx brk 3/2/08 to 5/25/08
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Meg Mangin R.N.
Research Team
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Posted: Tue Apr 24th, 2007 23:26 |
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This company appears to be selling Benicar, not generic olmesartan. Benicar is still patented and not yet available in the generic form.
Make sure of The right kind of Benicar
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eClaire
Member in Phase 2
| Joined: | Mon Sep 25th, 2006 |
| Location: | Virginia USA |
| Posts: | 520 |
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Posted: Thu Apr 26th, 2007 12:44 |
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I called the Canadian company with the above link today (4/26) and was told there is no generic Benicar available in the US, but that indeed the generic listed on the website (international generic) is olmesartan, and although it is listed as 40mg, what you receive is two 20mg tabs for each 40mg tab that you are ordering. Their brand is forumulated in Italy and the generic at one of four labs around the world. You have to call when purchasing generic to learn that the generic can be purchased only through certified check, money order, or bank transfer.
Claire
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CFS FMS MCS COPD hypermobility IBS/GERD osteoporosis 125D48 25D8 Ph1Dec06 ModPh2Jun07 NoIRs limited outings covered up low lux home abx brk 3/2/08 to 5/25/08
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LH1953
Member in Phase 3
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Posted: Wed May 2nd, 2007 17:45 |
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The right kind of Benicar
Please READ this. As you know, I help on the MP by phone. One member of the MP was given SAMPLES of Benicar by their doctors office staff. Not knowing there was a different Benicar, they just took what the office gave them. They did notice a difference in the color of the tablet, but assumed the office was giving them the proper meds.
I know that it is hard enough to do the MP, but when not given the proper meds, things can get out of control.
PLEASE try and be VERY PROACTIVE in your health care. Check ALL meds before you leave the pharmacy as well. Always ask questions.
Take care all, Lori
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Lyme, MCS, IC, asthma, reflux, UC, osteopenia, hypothy, EBV, 1,25D48, MP 8/05, alupent inhaler, PBX, diazepam, fioricet, Ph3 7/06, NoIRs, limited outings covered up, low lux home, 25D4, 1,25D24
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