All Th1 inflammatory diseases are characterized by dysregulated Vitamin D metabolism caused by an abnormal immune system response to intracellular bacteria. This results in an elevated level of the active metabolite 1,25-Dihydroxyvitamin-D. This is known as hypervitaminosis-D.
Hypervitaminosis-D is characterized by:
Fatigue
Asthenia (loss of strength and energy)
Insomnia (difficulty falling asleep or staying asleep)
Somnolence (sleepiness)
Paresthesia (numbness, tingling, burning, prickling)
Facial palsy (paralysis; usually unilateral)
Metallic taste
Irritability
Mood or mental changes
Memory loss
Inability to concentrate
Dysphonia (difficulty speaking)
Dryness of mouth
Arthralgia (pain where there should be no pain)
Podagra (pain in the great toe)
Muscle, bone and joint pain (ankles especially)
Muscle cramps
Tightening of throat muscles, difficulty swallowing
Muscle paralysis
Muscle problems leading to difficulty breathing (dyspnea)
Stiffness
Loss of muscle control
Loss of balance
Uncoordinated movement
Dysphagia (difficulty swallowing)
Vertigo (a feeling of spinning)
Dizziness, lightheadedness
Feeling of intoxication
Irregular heartbeat
Loss of sex drive
Tinnitus (ringing in ears)
Hearing loss
Nasal/sinus congestion
Photosensitivity (intolerance of light)
Irritated eyes
Redness of eyelid or lining of eyelid
Conjunctivitis (redness or discharge of eye)
Cloudy-looking eyes
Runny nose
Frequent, Excruciating Migraines
Headaches (continuing)
Hyperthermia (feeling too warm)
Night sweats
Cough
Pruritus (itching skin)
Hypercalcemia (excessive calcium in blood) causing weight loss and anemia
Bone demineralization (osteoporosis)
Calcium deposits in soft tissues of lungs, heart, blood vessels, renal tubules
Kidney stones
Impaired renal function causing:
polyuria (excessive urination)
nocturia (excessive urination at night)
polydipsia (excessive thirst)
calciuria (calcium in urine)
azotemia (nitrogen in urine)
proteinuria (protein in urine)
Irreversible renal insufficiency
Late symptoms of severe overdose: high blood pressure, high fever, severe stomach pain
The effects of administered Vitamin D can persist for two or more months after cessation of treatment.
