 |
| Author | Post |
|---|
Foundation Staff
.
| Joined: | Sat Jul 10th, 2004 |
| Location: | |
| Posts: | 17283 |
| Status: |
Offline
|
|
Posted: Tue Jan 4th, 2005 00:00 |
|
My 25-D is low. Should I be concerned about osteoporosis?
It is sometimes helpful, before the MP is begun, to evaluate the level of Vitamin 25-D (the inert percursor) in reference to the level of Hormone 1,25-D (the active metabolite).
High levels of 1,25-D inhibit the conversion of vitamin D into 25-D resulting in a low level of 25-D.
Because 25-D is immunosuppressive, you need to avoid ALL sources of Vitamin D to get it down to a therapeutic level of 12ng/ml or less. Please see Foods To Avoid and The importance of avoiding vitamin D.
If you have enough 1,25-D, then you do not need any 25-D.
Persons with Th1 inflammation produce excess 1,25-D directly within the kerotinocytes in the skin and the renin-angiotensin system of the eyes when exposed to sun/lights. No 25-D is necessary for this production, as the 1,25-D is formed directly from 7-dehydrocholesterol.
Abnormally high 1,25-D (above 42 pg/ml) causes bone resorption (the gradual loss of bone) and, therefore, osteoporosis. This phenomenon is explained by Dr. Marshall in his paper A Review-Vitamin D and Calcium in Sarcoidosis.
"1,25D is osteoclastic..it breaks down bones. Not only is Vit D not needed to build bones, it is actually detrimental to bones."
..Trevor..
Vitamin D Tutorial Calciferol and Calcitriol
Reducing your Th1 inflammation and, thus, your 1,25-D, with the Marshall Protocol is the best thing you can do for your bones.
My 1,25-D is high
From P.Bear, RN:
"The high levels of 1,25D in persons with uncontrolled TH1 inflammation stimulate osteoclasts that break down our bones. On the MP we do not experience any "deprivation in vit D" as our inflammed tissues produce enough hormonal Vit D to make up for our dietary changes to reduce 25-D. A reduction from the too high levels of 1,25-D will help our bones as there will be a better balance between bone formation and bone breaking down. The normal person will "turn over" their total skeleton in about 10 years, with structuraly weak bone being broken down and replaced with stronger new bone. Bone density can be complicated because the very stucture is as important as density. In some cultures/ phenotypes there is decreased bone density but a near absence of fractures. The MP is the best thing we can do to help our bones. A lack of dietary D does not cause osteoporosis; whereas a high level of 1,25-D does."
See also:
Don’t I need to take a calcium supplement?
Medications touted to prevent osteoporosis
The biphosphanates (Fosamax, Actonel, etc.), commonly prescribed for osteoporosis, are on our list of medications to avoid because they affect the immune system or the endocrine system. These drugs can also cause calcium deposition into the soft tissues and reduced organ function.
Evista (raloxifene) is a new medication sometimes ordered to treat osteoporososis. It is neither an estrogen nor a hormone. It is a Selective Estrogen Receptor Modulator, or SERM which mimics estrogen's effects in some tissue while blocking estrogen's effects in other tissues. It helps build bone without negatively affecting the breast or uterus.
Doctors prescribing Evista are cautioned that it may interfere with thyroid hormones like levothyroxine. They are also warned to use it with caution in women who have a high level of blood triglycerides, liver disease or Vitamin D deficiency which are all common among patients with Th1 inflammation.
This indicates that it will introduce an unknown and potentially detrimental variable into the MP equation and, thus, should be avoided.
Bone remodeling
Bone remodeling is a continuously ongoing process. The bone cells that resorb bone are osteoclasts. The ones that lay down new bone are osteoblasts. If the two processes are in balance, then things are normal. But 1,25-D is a cytokine that induces increased production of osteoclasts from stem cells. In addition, 1,25-D increases osteoclastic activity. When osteoclasts outnumber osteoblasts (bone builders) and when they are working faster than osteoblasts, then existing bone is resorbed faster than new bone can be laid down and bone loss results. That's what happens when 1,25-D is unregulated and elevated.
Bone resorption can be stimulated by oral 1,25-D in healthy men taking a dose as small as .75 micrograms every 6 hours. See URL http://tinyurl.com/dktzm
1,25-D plays a crucial role in bone reformation by stimulating bone osteclast formation and activity. See the final two paragraphs of the paper at URL http://edrv.endojournals.org/cgi/content/full/23/6/763 Note that much of the previous research of 1,25-D has been done "in vitro" (in labs) rather than "in vivo" - in life. That's a big part of the reason why there has been such misconception about how 1,25-D functions.
Much of the misconception about D goes back decades, back before 1,25-D was identified and understood - when 25-D was thought to be the active hormone. That's where the notion that "more D is better" originated (when the only D known was 25-D).
Belinda Fenter
|
Foundation Staff.
.
| Joined: | Sun Jul 11th, 2004 |
| Location: | |
| Posts: | 1178 |
| Status: |
Offline
|
|
Posted: Mon Jan 30th, 2006 07:11 |
|
(filelink)
Related information is located in the topic Osteoporosis and Th1 illness.
Belinda
|
Foundation Staff
.
| Joined: | Sat Jul 10th, 2004 |
| Location: | |
| Posts: | 17283 |
| Status: |
Offline
|
|
Posted: Tue Jan 31st, 2006 03:40 |
|
Recommended nutritional supplements for a dietary deficiency recsuppslink
Folks whose diet is deficient in nutrients because of food intolerances or who have difficulty absorbing nutrients due to GI inflammation, may need to supplement the nutrients necessary for bone formation.
=======================================
"I had a bone density scan recently (after about a year on the MP) and it came out with normal bone density (I am 46 years old).
I had been a little worried, since I had a number of risk factors (like being mostly bedridden for quite a few years, with poor absorption and diarrhea, and several years of amenorrhea, and a younger sister with low bone density, and mother who broke her hip).
I think it is important to get adequate calcium (no more than the RDA with food and supplements) when on the MP and I think that some people get so worried about their vitamin D that they neglect that.
Just in case anyone is interested, I will share the supplements I have been taking that may have contributed to my maintaining bone density. I know diet is the preferred source, but if you don't have the dietary sources (or can't get them from diet for some reason), here is what helped me.
I will include the brand names because some people are concerned that certain brands have hidden added vitamin D. Since my D levels have come down quite nicely, I don't think it likely that these products of these brands have any hidden D sources.
1000-1200 Solgar Chelated calcium
400-800 mg KAL magnesium glycinate (Note: Solgar Chelated Magnesium may be more hypoallergenic)
200 mcg Solgar vitamin K (if you get leafy greens, you likely don't need this)
3 mg Solgar Multi- Chelated Boron.
I order them from NEEDS (http://www.needs.com 800-634-1380) and other online sources but you may find them at health food stores.
Others may have different needs and requirements and I'm not making recommendations, but just thought I would share what has worked for me. These are all supplements that my reading indicates help in bone formation or maintenance.
And of course, as we all know, it is essential to lower one's 1,25D.
But, it is interesting, that it seems I must have had some protection from my supplements in years past despite the high 1,25D that I had prior to the beginning the MP (above 60 pg/ml), or my current bone density would have been lower."
Joyce Waterhouse, Ph.D.
P.S. If you develop diarrhea from the magnesium, decrease the dose. Magnesium glycinate and other magnesium chelates are much better absorbed than some of the older types, like magnesium hydoxide or magnesium oxide.
==================================================
Supplementing a diet lacking in nutrition is sometimes necessary but supplementation should not used simply to forgo nutritious foods. Natural sources of nutrients are always preferable.
Boron is found in leafy vegetables, nuts, grains, apples, raisins, and grapes.
Intestinal bacteria produce some of the Vitamin K you need. The best food sources include green leafy vegetables such as kale, parsley, spinach and broccoli. Smaller amounts are found in milk and other dairy products, meat, eggs, cereal, fruits and other vegetables.
For food souces high in magnesium eat nuts, soybeans. Legumes, and dark green vegetables.
Food souces of calcium are listed in:
Don’t I need to take a calcium supplement?
Meg Mangin, R.N.Last edited on Sat Mar 10th, 2007 02:49 by Foundation Staff
|
Current time is 16:32 | |
|
|
|
|
