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Meg Mangin R.N.
Former Team Member
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Posted: Sun Jan 23rd, 2005 03:22 |
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Is pulsed minocycline alone effective?
"Pulsed Minocycline alone, without Benicar is capable of working down the bacterial load quite a bit. But the patient does not get the palliative aspects of Benicar, nor do they get protection of their organs from damage due to the cytokines released while the bacteria are dying, and they will need a greater dose of minocycline than would be needed on the MP to kill those same bacteria.
Additionally, the antibiotic alone seems not capable of taking the patient to the endpoint of "recovery." I have been talking with "Road-Back Physicians" (who do not yet use Benicar) one of whom could not believe that one could induce 'Herx' in patients beyond the first few months, and who readily admitted that his patients experienced quick early gains, which then plateau'ed; and maintaining the quality of life at the plateau had been the major challenge of his practice.
We see no similar effect with the MP. Immunopathology just keeps coming and coming. Thankfully it is under the control of the patient, and, once you get out 9-12 months into therapy, is no longer debilitating. At about 24 months it is hardly even an annoyance, but if you forget to take your 6-8 hour Benicar you get a reminder the 'herx' is still there."
..Trevor..
Antibiotics Protocols
AP/Roadback and similar protocols or studies rely on antibiotics only to do the job. Self-replicating plasmids cannot be killed by any ABx, only the immune system can do that.
The NIMH (ASD study) don't have a model, in any normal sense of the word. They don't have a clue what they are doing. They are just trying this drug or that drug with this or that supposed healing property.
On the other hand we have a molecular-biology-based model for chronic inflammatory disease which is well developed and well tested. The only variable is whether (a disease) is a chronic inflammatory disease described by the model. When a patient responds according to the model's predictions then we can be pretty certain that the progress of that patient will be along the same trajectory as others who have gone before.
So as long as patients follows the expected symptomatic and healing trajectory then we can have confidence in the outcome. There is no black-magic, no experimental drugs, just a model based on how the body actually works
This is a paradigm shift in medicine, but it is not our vision alone. The Commissioner of the FDA himself recently stated to congress:
This new science combines an understanding of disease and its origins at the molecular level (including adverse events resulting from treatment) with new methods of signal detection, data mining, and analysis. This enables researchers to generate hypotheses about, and confirm the existence and cause of safety problems, as well as explore the unique genetic and biologic features of individuals that will determine how he or she responds to treatment. This science of safety encompasses the entire life cycle of a product, from pre-market animal and human safety testing to widespread clinical use beyond original indications.
http://www.fda.gov/ola/2007/overview050107.html
"Minocycline alone is inadequate to induce recovery from the Th1 inflammatory diseases. You need to make the VDR do its job properly by using the agonist 'Benicar.'
We have extensive data from the other diseases which clearly show that any one antibiotic is inadequate to induce recovery, and that multiple antibiotics alone don't induce recovery either.
So the current studies using antibiotics in these diseases are only nibbling at the heels of what we have already achieved. More details can be found in our peer-reviewed publications. For example, look at
"VDR Nuclear Receptor Competence is the Key to Recovery from Chronic Inflammatory and Autoimmune Disease"
..Trevor.. (May 07)
With the MP, you aren't working around your immune system, you are working with it.
Dropping vitamin D from one's diet and adding Benicar enables the immune system to work with pulsed ABx."
Anything else published anywhere else other than this site should be measured against accurate content from this site.
For best reference, please review 2006 AAEM and Bio21 videos from this site or order "The Science" DVD set to get the full details.
Should I take minocycline alone first?
We do not recommend that people pulse minocycline in order to give them a headstart with the Marshall Protocol. In fact, monotherapy with minocycline runs the risk of allowing previously cleared tissues of being repopulated by bacteria that are resistant to mincocyline alone. This is why we like to see people move from phase one to phase two within several months.
Also, diligently avoiding Vitamin D and light exposure while pulsing minocycline without Benicar can cause intolerable immunopathology and increased inflammation without the protection of the inflammatory blockade.
If you are on minocycline alone and wish to start the Benicar blockade, discontinue minocycline 48 hours before your first dose of Benicar.
A physician's advice
"The cause of elevated 1,25 OH Vit D is due to intracellular bacteria especially in macrophages. These bacteria are very adept at avoiding immune surveillance. Anyone with a Th1 disorder requires antibiotic therapy, IMO. However, the balming effect of the Benicar induced reduced inflammation and its enhancement of antibiotic effectiveness is superior to antibiotic therapy alone.
From a personal point of view and as a medical practitioner, I have found it amazing where Herx symptoms arise from, such as skin, GI tract, prostate etc where previously the person either has had no complaints or if so, either in the past or at a very low level.
I, personally believe, that treating these intracellular and/or L form bacterial infections, should be done as early as possible, to prevent future problems. If mild or early, and with a low 1,25 OH D level, one can use just antibiotics as the inflammation may not be so high as to interfer with the medication. But remember, labs do make errors. I have had a number of patients, who despite low blood levels of 1,25 OH D, have had significant Herx with antibiotics alone and when put on Benicar had better results." ~Greg Blaney, MD
Cardiac Immunopathology
The Benicar blockade is a critical component for persons with cardiac inflammation who are taking minocycline. Cardiac inflammmation is often subclinical and only evident when an effective antibiotic provokes immunopathology. If the use of pulsed minocycline alone causes immune system reactions that are cardiac in nature, you are at risk for a sudden cardiac event. It is imperative that you speak with your doctor about establishing a Benicar blockade if you are to continue taking pulsed minocycline. The Need for a Benicar Blockade
Patients do not improve with antibiotics alone
I can speculate about the D phenom but let us just say that it has been my experience that after treatment with only antibiotics, the 1,25 D level goes up but with Benicar, it goes down.
It may be that the antibiotics reduce opportunistic co-infections which contribute to the exhaustion of the immune response and afterwards the impact of the underlying macrophage dwelling pathogens become more apparent. Patients treated with this higher antibiotic dose and frequency, though they don't Herx as strongly, also do not improve that dramatically and if continue with just antibiotics tend to plateau or relapse. ~Greg Blaney, M.D.
Follow the Phase One guideline
You need to have the healing and protective and palliative actions of both the Benicar and the mino combined with the essential aspects as outlined in the Phase One doc for the treatment to be safe and effective.
When you start the meds, they can and should be adjusted as necessary to keep the herx to tolerable. By delaying any of the essential aspects you may be suffering longer than is necessary.
Delaying any aspects of the MP or using some aspects and not others is unsafe and ineffective. See safety warning.
Member experiences
I too was on mino before the MP. Once you start the Beni, as I tell everyone, it is a whole new ball game. Whatever you did in the past, your reaction on the MP will be quite different. Just remember to listen to your body and don't rush. ~Lori
For more information, please read:
Phase One Guideline
I cannot afford Benicar. Is there an acceptable substitute?
Benicar: Where to purchase Benicar for self-pay members Includes information about countries where Benicar not sold and "Open Care" Program for low income patients
What is a therapeutic probe?
Why do we take minocycline only every other day? Why do I feel worse on the second day? is the secret of MP
Can I delay MP while avoiding Light and D?
Cell Wall Deficient Bacteria and the Marshall Protocol
The Marshall Protocol -- simple explanations
Safety Warning
Last edited on Sun Aug 24th, 2008 21:36 by Meg Mangin R.N.
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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