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Foundation Staff
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Posted: Mon Jul 11th, 2005 03:52 |
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Will the MP treat paresthesia and neuropathy?
Abnormal sensations such as prickling, tingling, itching, burning or cold, skin crawling or impaired sensations--are all called parasthesia. These symptoms usually arise from nerve damage (neuropathy). Continued nerve damage can lead to numbness (lost of sensation) or paralysis (loss of movement and sensation).
Paresthesia is one of the symptoms of Hypervitaminosis-D.
Most people have experienced temporary paresthesia -- a feeling of "pins and needles" -- at some time in their lives when they have sat with legs crossed for too long or fallen asleep with an arm crooked under their head. It happens when sustained pressure is placed on a nerve. The feeling quickly goes away once the pressure is relieved.
Paresthesia is often felt in the hands, arms, legs, or feet, but can also occur in other parts of the body such as mouth or chest. It may be constant or intermittent.
Paresthesia can be caused by disorders affecting the central nervous system (encephalitis, MS, stroke) or any of the peripheral nerves (carpel tunnel syndrome, atherosclerosis). Peripheral neuropathy is a general term indicating disturbances in the peripheral nerves. It can affect one side of the body (unilateral) or both (bilateral). The peripheral nervous system includes nerves in your face, arms, legs, torso, and some cranial nerves. All of your nerves not located in your central nervous system — which includes the brain and the spinal cord — are peripheral nerves.
Neuropathies may affect just one nerve (mononeuropathy) or several nerves (polyneuropathy). Your nerves provide communication between your brain and your muscles, skin, internal organs and blood vessels. When damaged, your nerves can't communicate properly, and that miscommunication causes symptoms such as pain or numbness.
Neuropathy can result in muscle weakness if it causes reduced nervous stimulation to the muscles. This can occur in any muscle including chest muscles (making breathing difficult) or in the lower extremities (resulting in atrophy and difficulty walking).
There are many causes of peripheral neuropathy. It is a fairly common symptom of Th1 diseases (autoimmune diseases such as lupus and sarcoidosis) and indicates inflammation of the nervous system. Irritation to the nerve can also come from inflammation to the surrounding tissue (such as Rheumatoid Arthritis).
Impaired function and symptoms depend on the type of nerves -- motor, sensory, or autonomic -- that are damaged. Some people may experience temporary numbness, tingling, and pricking sensations, sensitivity to touch, or muscle weakness. Others may suffer more extreme symptoms, including burning pain (especially at night), muscle wasting, paralysis, or organ or gland dysfunction.
Resolving neuropathy and paresthesia involves identifying and eliminating the underlying cause. The Marshall Protcol is designed to treat the underlying cause of Th1 inflammation and thus relieve many of its symptoms. Many MPers report resolution of their paresthesia. Some neuropathy that has persisted for a long time may have caused permanent damage to the nerve cells (neurons) but peripheral nerves have a remarkable ability to regenerate themselves. Only time will tell if the MP will resolve all neuropathy but the evidence so far indicates that it will resolve many paresthesia symptoms and has the potential to effect significant improvement in neuropathies.
Numbnes or pin/needles sensation in extremities during sleep
Pins/needles or numbness in extremities suffered during sleep is thought to be due to lymphatic system inflammation and reduced lymph circulation when in a prone position leading to interference with nerve function. Moving the extremity resolves the sensation quickly.
Safety
'Clumsiness' is related to neurological symptoms and these may come and go. Try to be aware of any loss of sensation (or abnormal function) in your hands, feet or ankles. Take precautions. If you are prone to dropping things, avoid cooking or any activities that may be unsafe that day. If your brain can't tell if you are picking up your feet when you walk, steer clear of rugs and obstacles and stay away from stairs.
Restless legs
Restless legs may be due to nerve inflammation which can be slow to resolve.
You could try magnesium which occasionally helps relieve muscle tension. See Is it okay to take magnesium? or Valium. See When and why should I use Valium?
-Some of us have gained great relief from RLS by reducing our intake of salicylates. ~Julia
-if I wake up enough to recognise that it's happening I've found a method that usually fixes it. I get up and walk on the spot with exaggerated arm and leg motions until my muscles are almost burning with fatigue. then I lie down, my limbs feel nice and heavy and no longer restless, and usually I can get to sleep. I even used to do this as a pre-emptive measure.
as the MP has progressed I'm finding I get restless limbs less often  It even went away for a couple of months and now comes back sometimes, but less frequently. ~RichardM
Some doctors prescribe Mirapex (pramipexole) for restless leg syndrome.
Brain lesions
-It seems you are still trying to understand if the lesions indicated on your brain MRI could have been from sarcoidosis. This article cited a couple of sources in stating, "MRI findings of CNS [central nervous system] sarcoidosis including white matter, periventricular, periacuaductal or leptomengial lesions, have often been reported."
Keep in mind that while inflammation is central to numerous diseases, it is also an important part of the body's repair processes. This report says inflammation is pivitol for repair of peripheral nerve damage, for instance. So signs of inflammation can be related to disease as well as to healing and repair.
Sarcoidosis can result in brain involvement even in pediatric patients, so you are not too young. This abstract says, "Among inflammatory conditions, granulomatous diseases such as sarcoidosis have predilection for involvement of the suprasellar regions and can spread along perivascular spaces deep within the parenchyma."
As for your concerns about use of olmesartan resulting in negative effects on the brain, please see this about the effect of olmesartan on neurons and this on the effect of olmesartan in experimental acute ischemia. There is also this on emerging evidence related to atherosclerosis. ~Belinda
Members' experiences
-Paresthesia of my left foot and leg has slowly diminished. It's been a painful process but I am hopeful for 100% resolution of Th1 inflammatory nerve damage. ~Meg
-I was placed on Neurontin long before my Sarcoidosis diagnosis, because of pain from a back injury. I developed the neuropathy while on the Neurontin. It went from annoying to terrible to unbearable at times. My doctor and I tried increasing the dosage of Neurontin at one point, and it didn't seem to change anything
I am now off of Neurontin and am no worse for not having it. My doctor mentioned that I seemed more alert after I got off of it.
The neuropathy symptoms have been varied since I started the MP. Presently, my fingers are less numb, and the feeling seems to be returning to my feet. An area on my right thigh that was numb for years now has some feeling in it. I sometimes use anti-anxiety medication when it has been "overwhelming", and that has helped me. ~Lottie
See also:
What is a neuro immunopathology?
Neuropathy and the MP
When and why should I use Valium?
MCS success
Multiple Chemical Sensitivities
Neurological manifestations of Lyme disease
Last edited on Mon Aug 25th, 2008 05:21 by Foundation Staff
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Posted: Fri Mar 17th, 2006 20:55 |
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[filelink]
Neuro symptoms
I guess the simple reply to the "science" behind these symptoms is that our brains, cranial nerves, spinal cord and nerves emerging from our cord; as well as peripheral nerves(the whole dang system) are infected with CWD organisms. I suspect there are a number of errant feedback loops and "short circuits" in our brains as well as primary nerve involvement. There is a neurologic syndrome caller Barre-Lieou that involves pinched or inflamed nerves in the cervical spine having effec! ts on the rest of the system.
http://www.medhelp.org/forums/neuro/archive/325.html
Some people have reported improvement with skilled osteopathic manipulation or prolotherapy if it is just a post whiplash type injury effecting the neck; but I feel the root of our problem is CWD infection. An MRI can not show cwd infection and can not cure you, but if expense is affordable it does rule out some possibilities like bulging disk and spinal stenosis (for peace of mind) But I feel the little beasties are most likely the problem.
P.Bear, R.N.
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