I think the way the Th1 inflammation initially overpowers the immune system, is that the level of infection gets to a critical value, and then an incident occurs (eg, sun-holiday, pregnancy, acute infection) which causes extra 1,25-D production, leading to a breakdown of the negative-feedback mechanisms which normally control the 1,25-D production in the phagocytes. From that point onwards those control mechanisms are not able to reliably maintain control. The patient enters a "relapsing-remitting" phase of the disease process.
Additionally, the TACO membrane protein, through which Mycobacteria infect the phagocyte (and possibly L-forms too), is down-regulated by VDR. So the actual entry of the bacteria into the phagocyte may be facilitated by excess ingested 25-D or Vitamin D causing the VDR to shut down. http://tinyurl.com/nkb7x
Continued stress will also interfere with the restoration of health even on the MP. If one has endeavoured to manage stress better but one's condition continues to deteriorate than something else is going on. If other medical problems have been ruled out, then, a chronic infection is very likely.
Remember, most of the symptoms experienced (immunopathology) are a reflection of the body's reaction to the increased toxic load and amped up detoxification and elimination process and not a deterioration.
I would suggest that the patient insure they avoid any toxic exposure such as cleaning products, chemicalized foods, unnecessary meds supplements etc. plus adjust lifestyle to support the process, ie rest, fresh foods, water.
Early on distress can and does exacerbate symptoms. Patients with better coping skills and support do better. As one improves, one experiences less or no distress in response to stressors.
* We can help you understand chronic disease, but only your physician is licensed to give you medical care * Always consult your physician before commencing or changing any treatment he/she has prescribed for you
