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Posted: Fri Sep 15th, 2006 17:55 |
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Do I need to get my 25-D down before I start the MP?
1.25-D is necessary for proper functioning of nearly every body system. 1,25-D and its receptor, the Vitamin D nuclear Receptor (VDR), are expressed in over 30 target tissues. 1,25-D is the only metabolite that turns the VDR on and that is good. But in Th1 inflammatory diseases too much 1,25-D is produced due to stimulation by intracellular bacteria in the affected tissues. This results in overexcitation of the VDR which reduces VDR nuclear receptor competence. This incompetence prevents the VDRnuclear receptor from doing its job as the primary activator of innate immunity and it is innate immunity that protects against intraphagocytic pathogens.
A Brief Overview of Innate and Adaptive Immunity in Relation to the Marshall Protocol
25-D binds into the Vitamin D Receptor and displaces either 1,25-D or Benicar from the VDR thus turning off the VDR or modifying its capabilities. If the level of serum 25-D is above 20ng/ml, immune system function will be hampered to some degree.
Benicar, however, displaces 25-D (and 1,25-D) from the VDR, based on relative concentrations. Thus, the Benicar blockade will, even with a high level of 25-D, help the Vitamin D nuclear Receptor to do its job as the primary activator of innate immunity.
There is no advantage to waiting to start the Marshall Protocol until the level of 25-D has been reduced by Vitamin D deprivation. This could take many months in some cases and during that time, Benicar and antibiotic/s will enable the innate immune system to begin killing the CWD bacteria. Be very careful of the increasing immunopathology as your 25-D falls.
Vitamin D deprivation will bring the level of serum 25-D down to further enhance immune system function. This is often evidenced by stronger Herxheimer reactions.
Can my Vitamin 25-D go too low?
For more details, please see:
VDR Nuclear Receptor Competence is the Key to Recovery from Chronic Inflammatory and Autoimmune Disease
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To deplete Vitamin D:
Are you diligently avoiding all foods that contain Vitamin D and using the FOOD TIPS? Check your diet carefully for Vitamin D and any supplements that may contain VitaminD. (Vitamin D may be listed or unlisted)
The VITAMIN D TUTORIAL contains the following information about 25-D:
Naturally occurring dietary sources of Vitamin D2 and D3 (especially fish, fish oils, liver, eggs), foods supplemented with Vitamin D (dairy products, cereals, processed foods) and vitamin supplements are the body's main source of calciferol (25-D). A small amount may be generated by exposure to sunlight.
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Production of Vitamin D when exposed to sunlight
"The keratinocytes of the skin can make 1,25-D directly from 7-dehydro-cholesterol, and they do this when exposed to sunlight. Because the final stage of this reaction is also catalyzed by any Interferon-gamma from any inflammation paracrine to the keratinocytes, any and all 25-D which is made from sunlight is energetically converted to 1,25-D (OK, well, NEARLY all  ." ..Trevor..
Thus, sunlight is not usually a significant contributor to the 25-D levels of Th1 patients.
Folks who are experimenting with sun exposure may be getting only a small amount of 25-D through production in the kerotinocytes. But now that we know the importance of keeping this level very low, even a small amount may be too much for some people.
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Have you had your 25-D retested to see if it has come down?
How often should I test D levels? What are the target numbers?
The alleged sources of D2 and D3 (both are forms of 25-D) do not seem to correlate with the measurements of serum D2 and D3 we have seen so far. Therefore, the measurement of these values seems to have no practical application. All forms of Vitamin D should be considered when trying to achieve the desired goal of maintaining total 25-D at 12ng/ml or lower.
We continue to uncover other factors reported in the literature that apparently influence D levels, causing anomalous results. And there are probably other unknown factors. We recommend to proceed with the MP.
Many supplements are adulterated with unlabeled vitamin D, so stopping the supplements is recommended.
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You won't start killing the bacteria in earnest until your 25D drops to below 20ng/ml. So be aware that immune response may creep up on you, as your fat storage of 25-D is gradually depleted.
Dr Marshall advises that "25-D over about 15ng/ml will reduce immune response; above 25, the antibiotics will have very little effect. At least that is what I am seeing right now. The 25-D seems to be the most critical factor as to whether the immune system is able to start working. The bacterial kill needs to be even, across many species. Killing just a few species will cause an immune response, but may not effect an eventual recovery. I think that is the wildcard that the high 25-D plays."
So, although a high 25-D may mean you may have less immune response, many with high 25-D have responded and made progress on the MP. Although you have the potential to respond on a higher level when your 25-D is lower, by then you will have killed a lot of bacteria already. Should I avoid sun exposure and Vitamin D while I'm waiting to start the MP?
Dr Marshall said: The Benicar doses that are used on the MP are high enough that the Benicar displaces enough of the 25-D that the VDR is at least partially activated (the FDA presentation has the technical background for it based on the molecular modelling). Our Presentation at the FDA CDER
25-D is stored in fatty tissue. Weight loss causes fat cells to break down and release what is in them. Since rapid weight loss may increase inflammation by making more 25-D available, it is advised to lose weight slowly. Please keep this in mind if you decide to diet and exercise.
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Member experiences with high 25-D:
25-D Coming Down at Last ...thought it would never happen!
Unable to get 25D down
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