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Frans
Member in Phase 2
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Posted: Wed Jan 2nd, 2008 19:29 |
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Hi all,
Trevor has posted some interesting genes definitely and probably transcribed by the VDR, eg some genes regarding Down syndrome, all to be found in the supplemental tables 1 and 4 of Wang, et al (http://tinyurl.com/2v28tl)
There are so many genes in there that give me a sense of: 'this can't be', that I thought it might be interesting to give Wang et al's lists a thread of ther own.
To give two examples other than Down syndrome:
- cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7), which is the gene whose mutations lead to Cystic fibrosis
and another one:
- poliovirus receptor
Furthermore I have searched the tables with the word Syndrome, which also turns up genes that boggle the mind.
It would be interesting to see which of the genes in table 4 will be confirmed by Wang in the future.
Just some thoughts,
Frans
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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
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Dr Trevor Marshall
Foundation Staff
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Posted: Wed Jan 2nd, 2008 20:06 |
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MTSS1 - Metastasis Suppressing protein #1
MTUS1 - Mitochondrial Tumor Suppressor #1
Last edited on Fri May 30th, 2008 17:05 by Dr Trevor Marshall
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Frans
Member in Phase 2
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Posted: Thu Jan 3rd, 2008 21:54 |
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Trevor,
something is puzzling me. I wanted to assess how influential the VDR is by finding out how many human genes there are in the genome and holding that number against that of the 23000+ transcribed by the VDR to get an idea about its influence.
The problem is that the best estimate I get about the human genome ranges from 120.000 to 30.000 genes. 40.000 is mentioned several times.
Now if that is true, it would mean that the VDR actually transcribes about half of the genome ?? That can't be right, can it ??
I must be missing something here.. to say the least...
Sincerely, a puzzled Frans 
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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
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Dr Trevor Marshall
Foundation Staff
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Posted: Thu Jan 3rd, 2008 22:06 |
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Frans,
If you look at the Brahmachary paper (citation 71 in my new Vit D paper) you will find that indeed the Nuclear receptors are key to the transcription of a significant proportion of the genome. That paper looks at some of the other transcription factors, and is a good place for you to start expanding your knowledge, I think 
http://www.biomedcentral.com/1471-2105/7/S5/S8
You might also review the fulltext of this excellent paper, which explores the multiplicity of different factors involved in gene transcription. The VDR (for example) could well be involved in expressing these cofactors, or their folding agents, even if it is not directly involved in the transcription at a specific promoter sequence: http://tinyurl.com/yurngs
Last edited on Fri May 30th, 2008 17:05 by Dr Trevor Marshall
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Frans
Member in Phase 2
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Posted: Fri Jan 25th, 2008 21:28 |
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Trevor, another basic question
Let's say the VDR transcribes 5 copies of a gene for a certain receptor. Would that also lead to 5 of those receptors?
Sincerely, Frans
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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
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Dr Trevor Marshall
Foundation Staff
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Posted: Sat Jan 26th, 2008 07:09 |
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Hopefully they will all be the same, Frans.
The RNA are translated by a ribosome into proteins, and then the proteins are folded by self-forces and eznymes (etc)
..Trevor..
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Frans
Member in Phase 2
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Posted: Mon Jun 1st, 2009 11:07 |
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Trevor,
I have something that might help us expand Wang's table 1.
I searched pubmed for confirmed VDRE's.
The first paper I found was PMID: 18602086
They found the VDR regulates transcription of:
- p-glycoprotein, also called
- ABCB1 or
- ATP-binding cassette sub-family B member 1
This in itself is quite interesting, since yet another name for it is MDR1, Multidrug Resistance 1 Gene.
This might be one reason why chronically ill people react differently to drugs than 'healthy' people do. (BTW is medicines a better word?)
More info on the gene:
- http://tinyurl.com/n9rktx
However, I looked in table 4 and found this gene.
The corresponding VDRE is GGTCCAGGGGGGTCA
Now, if I search table 4 with this VDRE, it results in another 16 VDR-transcribed genes.
I guess my question is if this reasoning is correct ?
Best, Frans
Last edited on Mon Jun 1st, 2009 11:15 by Frans
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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
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Frans
Member in Phase 2
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Posted: Sat Jun 6th, 2009 14:58 |
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| bump
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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
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Joyful
Foundation Staff
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Posted: Sun Jun 7th, 2009 10:52 |
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Hey Frans.
You seem to be the person who finds research on genes to be interesting.
Here's a review of studies on genes "related to" CFS...
http://www.aboutmecfs.org/Rsrch/PharmaIVMutations.aspx
Maybe there's a gem or two in there.
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Frans
Member in Phase 2
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Posted: Fri Jun 12th, 2009 19:32 |
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Hi all,
I have noticed that sleeping is a very big problem for lots of people on the MP.
Sleeping lots of hours, yet not feeling refreshed is something I have read numerous times here.
Again, Wang et al's table 1, gives us something to think about that might explain some of it.
In the past, I have already posted about the role of Histamine in our circadian rythm. The VDR transcribes 3 of the 4 histamine receptors, possibly explaning part of our sleeping problems.
This week I found another gene (transcribed by the VDR) related to sleep.
It is called: delta sleep inducing peptide, immunoreactor; DSIPI.
As the name of the gene suggests, it induces Delta Sleep, also known as Slow Wave sleep (SWS), which is part of the non-REM sleep cycle.
Two instances of DSIPI are mentioned in Wang´s table 1. DSIPI is depressed with a factor of 2.6 and 2.7, respectively. (Trevor, does this mean the VDR acts via 2 seperate VDRE's ?)
This means that th1-VDR compromised people have much higher levels of DSIPI, leading to more Slow wave sleep (SWS). People who are woken from SWS are more groggy, less cognitively active, etc.
Sound familiar ?
Another thing I read somewhere is that people who have very long SWS tend to SleepWalk or SleepTalk.
Sleeptalking has always been one of the reasons why my friends avoided sleeping in my room during vacations  Now I understand why...
Seems to explain a lot IMO ?
Perhaps West china hospital can measure this in their patients? See if it changes over time while these persons do the MP ?
PS
Joyful wrote:
You seem to be the person who finds research on genes to be interesting.
Well, the genes found to be regulated by the VDR that is
The link you gave is very interesting, I might get back to you on that, thanks for that Joyful !
Best to all, Frans
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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
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Dr Trevor Marshall
Foundation Staff
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Posted: Fri Jun 12th, 2009 21:19 |
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Two instances of DSIPI are mentioned in Wang´s table 1. DSIPI is depressed with a factor of 2.6 and 2.7, respectively. (Trevor, does this mean the VDR acts via 2 separate VDRE's ?)
It is the same gene, but they had two different targets on their micro-array, as two commercial sources of a marker were available. In this case the results from both manufacturer's 'reagents' correlated.
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kbanshee
Member in Phase 2
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Posted: Sat Jul 11th, 2009 08:07 |
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This is very interesting to me. I have a huge amount of complex issues around sleep. Mostly too much sleep w/o feeling I've slept (even w/ CPAP for Sleep Apnea) & then sleeping again most of the afternoon -- having no control of staying awake. When my brain is a bit more awake, I'll read more of the articles so I can jump in on the conversation w/ more informed back story...
Kriss
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Mult neuro gastro endo pulm genetic skeletal+see http://killerbanshee.com/mp/ |1,25D37 25D2<4 25D3-21|Ph1 7Jul09|25D39-6/09|25D19-10/09|Ph2 23Oct09|Kadian Nexium Cytomel Synthroid Humatrope Provigil Cymbalta+|NoIRs LowExp CoverUp LowLux
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Ron
Member in Phase 2
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Posted: Wed Jul 22nd, 2009 22:26 |
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July 21st, 2009:
Mutation causing one type of male infertility found
The mutation lies in one specific protein present in sperm called PLC zeta.
PLC zeta1 appears to be listed in table 4 of Wang et al...
So could this type of male infertility maybe be reversed by the MP?
Ron
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Dad with RA, MP 01/08| 25D-16.8| Apr08 7.1 Sep08 11.6 Mar09 7.6 Jul09 17 Dec09 10.4| oxycodon, NoIRs, limited outings covered up
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Dr Trevor Marshall
Foundation Staff
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Posted: Wed Jul 22nd, 2009 22:47 |
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Ron,
Table 4 is not VDR-specific. It contains VDRE which are a little unusual, and which may be targeted by other receptors. PXR and CAR are two receptors which may be involved in expressing the genes in Table 4, and there are probably others yet to be discovered. Table 1 is the table which has the confirmed VDR gene expression ratios.
Although even then there may be errors, as there may be other receptors which are activated by 1,25-D and not just the VDR. Science is a moving target...
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Ron
Member in Phase 2
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Posted: Thu Jul 23rd, 2009 15:24 |
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Thanks for that clarification!
Nevertheless, if genetic defects are due to the Th1 pathogens in general, wouldn't then restoring the VDR functionality be the key to recovery?
Also, shouldn't such a mutation be seen as a sign of inflammation and a risk of transferring pathogens to the newborn?
Instead, Big M Medicine is ready to force the conception and repair the symptom by "injecting a correct version of the gene for PLC zeta rather than relying on the sperm cell".
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Dad with RA, MP 01/08| 25D-16.8| Apr08 7.1 Sep08 11.6 Mar09 7.6 Jul09 17 Dec09 10.4| oxycodon, NoIRs, limited outings covered up
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Frans
Member in Phase 2
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Posted: Thu Jan 28th, 2010 16:35 |
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Hi all,
I just found a gem I think, regarding eyesight, myopia and hyperopia (nearsightedness and farsightedness).
I cannot remember why (my brain is playing tricks on me), but I was looking into a molecular explanation of eyesight. I sometimes háve to check something out ...
I found this paper ( http://tinyurl.com/yf8cun8 ) on eyesight. It mentioned several genes that are involved in the development of the eyes.
One gene: MSX2 (see pubmed, OMIM) is involved in myopia and hyperopia and Lo and Behold, it is in table 1, upregulated by a factor 2 ...
So:
-1: dysregulation of VDR impacts eyesight (also think of light sensitivity, the VDR is most definitely there, as is 1,25D)
-2: I had to start wearing glasses at age 10 or so. The critters might already have been doing there harmful job ...
Best to all, Frans
____________________
Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
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Dr Trevor Marshall
Foundation Staff
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Posted: Thu Jan 28th, 2010 16:53 |
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Frans,
Indeed. An excellent paper! I have just gone through the exercise of figuring out what glasses are best for my eyes at the moment. I have worn glasses since High School, yet my prescription from 1998 did not change all that much as I entered my '60s this past decade (recovering with the MP).
My eyes are definitely focusing better now, so I decided to see if I could replace my old (trusty) Zeiss progressives, and exercise my eye-muscles at the same time.
I ended up ordering a number of glasses from Zennioptical.com
I use a 3 diopter pair (with a slight astigmatism correction) for computer work, a 1.75 diopter pair for watching TV, and a set of progressives for general (travel) use. The costs from China (Zennioptical) were $15, $15 and $45 respectively)
This is the first time in my life I am really happy with with my sight. That nasty microbiota has been messing so many things up...
..Trevor..
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Ron
Member in Phase 2
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Posted: Thu Jan 28th, 2010 20:05 |
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Great find, Frans!
This adds to the confidence that the MP will improve eyesight.
Ron
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Dad with RA, MP 01/08| 25D-16.8| Apr08 7.1 Sep08 11.6 Mar09 7.6 Jul09 17 Dec09 10.4| oxycodon, NoIRs, limited outings covered up
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Leo
Guests visiting Phase 1/2/3
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Posted: Fri Jan 29th, 2010 04:08 |
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Very helpful guide for getting glasses online (Zennioptical also listed):
http://www.eyeglassretailerreviews.com/
Zennioptical charges extra for strong-ish lenses.
Glassesshop.com might be a better place to go for the "more blind" 
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Linda J
Member in Phase 3
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Posted: Fri Feb 5th, 2010 05:54 |
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I know I'm coming into this discussion late, but I broke my glasses this past week, and had to go in for an eye appointment since it's been so long since they've been checked. And the eye doctor said that my eyesight has considerably improved since the last time my eyes were checked, which surprised him, since most people my age have eyesight that gets worse with age, not better.
I've been wearing glasses since I was 4 years old. I started wearing bifocals when I was 9 years old. And my eyesight got so bad by the time I turned 40 that it was on the very edge of where it could be corrected through glasses. Definately an improvement since I started the MP.
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