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Dr Trevor Marshall
Research Team
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Posted: Mon Jan 21st, 2008 11:09 |
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Belinda has disseminated a Press release today, about our BioEssays paper. Please make sure the health editor for your local newspaper understands the importance of this work, as the Vitamin D lobby has been putting out its own PR, IMO intended to point out how much more qualified their experts are (LOL).
Our release is at:
http://www.prweb.com/releases/2008/1/prweb639651.htm
The PDF of the Press Release is at URL:
http://AutoimmunityResearch.org/presskits/Bioessays_Feb08_Marshall_release.pdf
Sample PR from the Vitamin D lobby is at
http://www.contracostatimes.com/ci_8026837?source=rss
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New Research Challenges Concept of Vitamin D Deficiency
Media Contact: Belinda Fenter, 1-817-732-7336
January 21, 2008 Thousand Oaks, CA
Low blood levels of vitamin D have long been associated with disease, and the assumption has been made that vitamin D supplements may protect against disease. In the light of new knowledge that hundreds of genes are dependent on vitamin D, this assumption needs to be reconsidered.
In a report published in the current issue of the journal BioEssays(1), Trevor Marshall, Ph.D., professor at Australia’s Murdoch University School of Biological Medicine and Biotechnology, explains how increased vitamin D intake affects much more than just nutrition or bone health. The paper explains how the Vitamin D Nuclear Receptor (VDR) acts in the repression or transcription of hundreds of genes, including genes associated with diseases ranging from cancers to multiple sclerosis.
"The VDR is at the heart of innate immunity, being responsible for expression of most of the antimicrobial peptides, which are the body’s ultimate response to infection," Marshall said. "Molecular biology is now forcing us to re-think the idea that a low measured value of vitamin D means we simply must add more to our diet. Supplemental vitamin D has been used for decades, and yet the epidemics of chronic disease, such as heart disease and obesity, are just getting worse."
"Our disease model has shown us why low levels of vitamin D are observed in association with major and chronic illness," Marshall added. "Vitamin D is a secosteroid hormone, and the body regulates the production of all it needs. In fact, the use of supplements can be harmful, because they suppress the immune system so that the body cannot fight disease and infection effectively."
Marshall's research has demonstrated how ingested vitamin D can actually block VDR activation, the opposite effect to that of Sunshine. Instead of a positive effect on gene expression, Marshall reported that his own work, as well as the work of others, shows that quite nominal doses of ingested vitamin D can suppress the proper operation of the immune system. It is a different metabolite, a secosteroid hormone called 1,25-dihydroxyvitamin D, which activates the VDR to regulate the expression of the genes. Under conditions that exist in infection or inflammation, the body automatically regulates its production of all the vitamin D metabolites, including 25-hydroxyvitamin D, the metabolite which is usually measured to indicate vitamin D status.
Vitamin D deficiency, long interpreted as a cause of disease, is more likely the result of the disease process, and increasing intake of vitamin D often makes the disease worse. "Dysregulation of vitamin D has been observed in many chronic diseases, including many thought to be autoimmune," said J.C. Waterhouse, Ph.D., lead author of a book chapter on vitamin D and chronic disease (2). "We have found that vitamin D supplementation, even at levels many consider desirable, interferes with recovery in these patients."
"We need to discard the notion that vitamin D affects a disease state in a simple way," Marshall said. "Vitamin D affects the expression of over 1,000 genes, so we should not expect a simplistic cause and effect between vitamin D supplementation and disease. The comprehensive studies are just not showing that supplementary vitamin D makes people healthier."
Trevor Marshall is currently executive director of Autoimmunity Research, Inc., a 501(c)(3) non-profit organization chartered in California. Its mission is to conduct scientific research into the cause and cure of disease, and to educate physicians and the public on science related to disease. More information can be obtained from http://AutoimmunityResearch.org
Citations:
1. Marshall TG. Vitamin D discovery outpaces FDA decision making. Bioessays. 2008 Jan 15;30(2):173-182 [Epub ahead of print] Online ISSN: 1521-1878 Print ISSN: 0265-9247 PMID: 18200565
Available from publisher's website at URL
http://www3.interscience.wiley.com/cgi-bin/abstract/117885976/ABSTRACT
Available from PubMed at URL
http://www.ncbi.nlm.nih.gov/pubmed/18200565
2. Waterhouse JC, Marshall TG, Fenter B, Mangin M, Blaney G, Vitamin D Metabolism in Chronic Disease. In Vitamin D: New Research, Nova Science Publishers, NY, 2006. ISBN: 1-60021-000-7
Additional Resources for Journalists:
1. A pre-print full-text of Prof. Marshall's paper is available from the author's website at URL
http://TrevorMarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf
2. American Academy of Dermatology fact sheet: “Myths and Realities of Vitamin D and Sun Exposure,” at URL http://www.aad.org/media/background/news/skincancer_2004_05_03_myths.html
3. "Rickets .. is not due to vitamin D deficiency but is caused by not having enough calcium in the diet." U.S. Dept of Agriculture, Agricultural Research Service, Available from URL http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=169216
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jcwat101
Research Professional
| Joined: | Tue Jul 20th, 2004 |
| Location: | Pasadena, USA |
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Posted: Mon Jan 21st, 2008 19:12 |
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It should be very interesting to see the response!!
Joyce Waterhouse
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20 yrs with CFS/FM/Lyme/IBS, food sensitivities; 1,25D/25D 8/04:64/11 http://SynergyHN.com
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tickbite
Member in Phase 2/3
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Posted: Mon Jan 21st, 2008 21:09 |
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I sent it to the Tulsa World.........
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"Lyme","CFS", Meningitis
Phase3 8-2-07, MP on hold 11/2007
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GeorgeinRollaMO
Member in Phase 3
| Joined: | Tue Aug 10th, 2004 |
| Location: | Rolla, Missouri USA |
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Posted: Tue Jan 22nd, 2008 00:29 |
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I sent it to the local newspaper, and to Dr. Peter H. Gott, M.D., the retired doc that is now a syndicated medical writer.
His Vicks VaporRub cure for toenail fungus worked for me. I figured if he can spread that treatment, he should be able to understand the MP. 
He graduated from Tulane Un School of Medicine in my hometown, New Orleans.
Wishing all wellness!!! 
Dark Vader...aka, George
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Borreliosis:7/14/04--125D=57,25D=61. Ben 9/1/04. Mino 10/5/04. 4/13/05--125D=58,25D=43. 8/17/05--125D=52,25D=36. April 06=125D=38,25D=29. 8/29/06--125D=37,25D=29. June 07 25D=23. Oct31'07,25D=19.
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sujay
Health Professional
| Joined: | Sun Jul 18th, 2004 |
| Location: | Washington USA |
| Posts: | 68 |
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Posted: Tue Jan 22nd, 2008 16:55 |
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I see I've dropped my small musings into the pond when the water is already roiling. Congratulations to Trevor and the team! I continue to be amazed by the patience, persistence and dedication that characterizes this effort to spread the word about Th1 illness and the effective treatment program that has been developed to address it.
Thank you, too, Trevor, for the good health so many of us now enjoy because of your efforts! We never dreamed life could be this good!
Sujay
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Dr Trevor Marshall
Research Team
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Posted: Wed Jan 23rd, 2008 00:38 |
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Thank you for your kind words, Sujay, and for all your help
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terrylmcc
Member in Phase 3
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Posted: Wed Jan 23rd, 2008 05:41 |
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Iv'e sent the link to FOX News, WDIV, and WXYX Detrot market.
Will see if any of them air it. And will update here if I see it aired.
Good work Dr Marshall, and Joyce. Fondly -Terry
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Sarcoidosis/lung &cutanious biopsy. uveitis Ph1,Jan07 ModPh2,Apr07 Ph2, Dec07 Ph3,Feb08 NoIRs avoid lite exposure, 25 D 6/08 = 5, 25D 3-09 4.
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Dr Trevor Marshall
Research Team
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Posted: Wed Jan 23rd, 2008 16:06 |
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Thanks, Terry.
This is the best way to make sure that Journals and Newspapers take our releases seriously - they need to get the news value pointed out to them.
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Jimbbb
Member
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Posted: Wed Jan 23rd, 2008 21:59 |
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I just Googled "New Research Challenges Concept of Vitamin D Deficiency"
(be sure to click the link, which uses quotes to be accurate about the pages returned)
and got 61 unique hits for the Press Release from various newswires, blogs and other pages (kind of mind-boggling that there are that many such websites -- but none of those (yet) were the well know ones or popular newspaper sites either -- might take a day or two for google to scan thru everything).
One amusing aspect is how your article can be nestled next to Advertisements touting:
Finally 5,000 IU and 50,000 IU caps Sunshine vitamin at reduced prices
But to be fair a lot of webpage ads are dynamically displayed based on keyword content of the articles. Members should visit some of these sites -- especially ones that allow you to leave comments or ratings. I saw one comment that, although slightly incoherent, was definitely on The More D The Better camp.
That one should be countered with some good arguments.
Congrats Trevor and the whole AutoImmunity Gang!
Last edited on Wed Jan 23rd, 2008 22:02 by Dr Trevor Marshall
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Interested (healthy) bystander with distant cousin who has Chronic Lyme.
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Reenie
inactive member
| Joined: | Wed Jul 21st, 2004 |
| Location: | Phoenix, Arizona USA |
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Posted: Thu Jan 24th, 2008 00:29 |
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I just contacted our local newspaper, The Arizona Republic and faxed them the press release (their instructions for contact) and followed up with an email for tips on a story. 
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Markt9452
Member in Phase 3
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Posted: Thu Jan 24th, 2008 04:26 |
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Micheal Claydon, Andrew Johnson, Sandra Kleinfeld, Cathie James and Diane Rotteau from the Canadian Broadcasting Corporation have been informed about this through the contact information on the Canadian Independant Producers Website at
http://www.cbc.ca/independentproducers/
Last edited on Thu Jan 24th, 2008 04:27 by Markt9452
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Th1 Lyme Symptoms 125D20 D2510 Ph1Feb08 Ph2Apr08 Ph3Oct08 daily med.exp covered up NoIRs| MyStory|
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Dr Trevor Marshall
Research Team
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Posted: Fri Jan 25th, 2008 20:39 |
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Belinda has just posted an updated version of our release, for the European market, on AlphaGalileo. You can see the release at
http://www.alphagalileo.org/index.cfm?fuseaction=readrelease&releaseid=526621
If you live in Europe, please help your local news journalists to notice this item
..Trevor..
ps: Thanks also to Amy
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Dr Trevor Marshall
Research Team
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Posted: Sat Jan 26th, 2008 10:57 |
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ScienceDaily has picked up the AlphaGalileo version of the news release
"Vitamin D Deficiency May Be Symptom Of Disease: Supplements May Make It Worse"
http://www.sciencedaily.com/releases/2008/01/080125223302.htm
..Trevor..
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Joyful
Board Staff
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Posted: Sat Jan 26th, 2008 11:28 |
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Hoorah!
Now the truth has hit the mainstream.
Good going to the whole team!
____________________
Lyme?1980 Lyme/Babs/Bart?05 CFS?06 | Start 125D(50) 25D(32) Jun07 | Ph1Jul07 ModPh2Sep07 Ph2Feb08 Ph3Aug08 | Latest 25D(9) Apr09 | ABC of MP
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schesche
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Posted: Sat Jan 26th, 2008 16:57 |
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hi--
good news--but if i may say ..it doesn´t come across easily understandable that the others are wrong and Dr Marshall is right--people reading papers need headlines all the way through the article..
you need to raise the volume-or people won´t hear you
good luck Chris
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CFS, Lyme/neuro,joint pain,brain fog, insomnia,rage 125D56, MP 10/07, Triazep, zolpid, bvi, NoIRs, low lux home, lite exp. r/t work, covered up, 25D16
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tickbite
Member in Phase 2/3
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Posted: Sun Jan 27th, 2008 20:13 |
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Dr Trevor Marshall wrote: ScienceDaily has picked up the AlphaGalileo version of the news release
"Vitamin D Deficiency May Be Symptom Of Disease: Supplements May Make It Worse"
http://www.sciencedaily.com/releases/2008/01/080125223302.htm
..Trevor..
Nice. Good one. That should slap a few faces (figuratively
____________________
"Lyme","CFS", Meningitis
Phase3 8-2-07, MP on hold 11/2007
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Jeannine
Board Staff
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Posted: Mon Jan 28th, 2008 10:43 |
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I sent the PR to the Shreveport Times to the reporter that did the story on antibiotics and MS. Shreveport Times Article I mentioned the article in the email to hopefully get her attention.
JeannineLast edited on Mon Jan 28th, 2008 10:44 by Jeannine
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CFS FM Lyme Morgellon's Depression/Anxiety 125D49 Ph1Aug06 25D <4(april 08)Prozac Valium Aleve ModPh2May07 Ph2Apr08 NoIRs limited outings covered lo lux home
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jillian
Member in Phase 2
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Posted: Mon Jan 28th, 2008 11:11 |
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Trevor,
Does it also make any sense to do a grass roots campaign and mail copies to docs in general (other than the ones we've all targeted that we know)? If yes, might there be reprints available to buy in bulk?
Looking forward to see the ripple rise to a tidal wave. Hope it happens sooner than later! Feels like it's been a long time coming.
Jillian
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PrimryDX-PulmoSarc79,FMS,CFIDS,etc,disabled93. AvoidD/Noirs Aug02. Oct02: 1,25D=42 NTfrzen; Apr05:25D=10. P1 Oct05-Feb06; ModP2C Feb-Nov06; P2 Nov14-Dec06; ModP2BSS Jan-Mar07; ModP2CBSS Mar07-. Noirs & total light control in house.
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Dr Trevor Marshall
Research Team
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Posted: Mon Jan 28th, 2008 12:02 |
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I think that individual Docs generally don't have any interest in material which doesn't come to them via drug companies, or their patients. I doubt that any 'grass roots' campaign would be worthwhile.
However, there are a number of non-profits whose work is impacted by what we have done, and it would be good if 'grass roots' could start calling the attention of those organizations to the press release and the paper.
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Phil Schoner
Member
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Posted: Tue Jan 29th, 2008 18:25 |
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I wrote a comment to the contra coastal times which Trevor offered as an example of the D lobby's activities to push D. I simply asked why all the research focused on 25 D and largly ignored the active hormone 1,25 D.
I have also been trying to contact Edge, a cutting edge publication of leading thinkers and scientists to recommend Trevor as a contributor to their website. Hopefully I will hear from them soon so this important vitamin D message can be disseminated here.
Phil
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Phil Schoner, MP Support Spouse, no symptoms, 125D74 5/08, ph1 11/08, ph2 12/08, 25D 16 12/08, 16 7/09, some sun avoidance
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