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Bane
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| Joined: | Sun Jan 27th, 2008 |
| Location: | Norway |
| Posts: | 35 |
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Posted: Thu Jan 8th, 2009 23:47 |
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Dr Trevor Marshall wrote: What is with the folks from Australia anyway? Is it the relentless sun?
All of the above  Barry and I both graduated (he MD, I, PhD) in the early 80s from University of Western Australia. There was no concept that Science would not conquer every barrier. Remember that my early studies ended up curing male and female Infertility and curing Cryptorchidism, both with pulsatile hormonal injections. These achievements have vanished into the mists of time because of the inability of Australian Science to understand marketing.
Barry spent many years visiting/studying in the USA, he had a lab here, and I have been here since 1982. When you take the science, and add the marketing know-how you get a killer combination (I hope )
Here is another of those silly senseless pictures which I create with my mathematics. This one was inspired by the paper "A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine."
http://www.ncbi.nlm.nih.gov/pubmed/18505790
CYP3A4 breaks down 1,25-D and you can see it at the bottom of my Bioessay's Fig.1
Here you see Olmesartan docked in the PXR superimposed on a PXR agonist, SR12813. It sure looks like Olmesartan is a likely PXR agonist... Which would help to explain why the 1,25-D levels drops so quickly after Olmesartan is commenced...
I also 'took a picture' of Minocycline docked into the PXR, just like these authors noted, but I was unable to get a satisfactory dock with Clindamycin. I assume that it hits a different receptor (which their wet-biology experiment could not differentiate).
Minocycline acting as a PXR agonist is likely responsible for the palliation achieved with frequently-dosed mino. It is also likely a major component of the initial effectiveness of Mc Pherson Brown's RoadBack protocol...
How common is the use of computers in medicine today when it comes to predicting ligands effect on receptors? From the look of it Trevor doesn't seem to be alone?
Hybrid Scoring and Classification Approaches to Predict Human Pregnane X Receptor Activators.
http://www.ncbi.nlm.nih.gov/pubmed/19115096
Machine learning methods and docking for predicting human pregnane X receptor activation.
http://www.ncbi.nlm.nih.gov/pubmed/18547065
Last edited on Thu Jan 8th, 2009 23:50 by Bane
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Oral Lichen Planus(mild)/Clubbed Finger (digital clubbing)|125D44|18th Feb. 25D14 in phase 2
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Jermack
Member in Phase 3
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Posted: Mon Apr 27th, 2009 23:14 |
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I didn't know where to post this, but I thought you all might find this interesting. It was in the Denver Post April 24th:
University of Colorado Denver School of Medicine professor Charles A. Dinarello has received the country's largest award in medicine or science.
Dinarello won the $500,000 prize for leading the cloning effort of the body's molecule that causes fever and inflammation associated with cancer and rheumatoid arthritis.
The Albany Medical Center Prize in Medicine and Biomedical Research was presented Friday in New York. It's the second major research award for Dinarello in recent months.
Dinarello isolated the molecule in the 1970s and cloned it in the 1980s. His work led to a new discipline, cytokine biology. The Denver Post
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dx sarcoids biop lymph/pulmonary/ tinnitus/ Paresthesia/fatigue/brain fog/leg pain/1,25-D 54/D25 17/Mar08 ph1Jun08/D25 11 Jul08/ ph2Aug08/Ph3Oct08
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Dr Trevor Marshall
Research Team
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Posted: Sat May 9th, 2009 15:50 |
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A new retrospective study showing Vitamin D ingestion has, if anything, a tendency to slightly increase melanoma (a skin cancer). It certainly is not protective.
The conference report is summarized at:
http://www.medpagetoday.com/MeetingCoverage/SID/14109
Of course, a Vit D proponent has commented that if a higher dose had been used (8000 IU) then the results would have been different. Sure...
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furch
Member in Phase 2
| Joined: | Sun Mar 22nd, 2009 |
| Location: | Bergen, Norway |
| Posts: | 31 |
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Posted: Sun May 10th, 2009 15:25 |
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This was pretty interesting:
"Too Much Sunshine Spurs Suicides in Arctic, Study Says The dreaded blues of dark winter months have long been blamed for seasonal depression, but too much sunshine may have an even more dire effect.
In northern Greenland more than 80 percent of suicides occur in summer, during which the sun barely dips below the horizon."
http://news.nationalgeographic.com/news/2009/05/090508-sunlight-suicide.html
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MS(dx2006), transverse myelitis (dx2006), Cluster headache(dx1999), weight loss, Ph1Dec08, modPh2apr09, 25D: 46(nov08) 15,2(mar09) 10,8(may09) benicar 40mgQ6h, NOIRs
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DNStog
Moderator
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Posted: Wed May 13th, 2009 01:19 |
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See MedPage article at link:
SteadyIncreaseInMelanomaCasesInUS
Hmmm...I'm pondering....since the number of Melanoma cases in the US is increasing and women get it more often, does that mean the sunscreen they have been using on their bikinied bodies, which has lowered their vitamin D levels (per Vit D industry), has given them Melanoma?
Wonder if the Vitamin D industry is ready to start sweating yet with this oxymoran?
Last edited on Wed May 13th, 2009 01:20 by DNStog
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Sarcoidosis/skin, joints, lungs, nerves, Raynauld's, uveitis, hypothyroid, sinus, wt. gain, Peradontal disease, GERD-hiatal hernia, breast ca 11/06, 25D7, Synthroid, Lexapro, eye vits, Milk Thistle, Quercetin, Rx glacier, cover up, 05/09 25D5, 125D11
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Sunset
Health Professional
| Joined: | Tue Oct 16th, 2007 |
| Location: | USA |
| Posts: | 111 |
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Posted: Wed May 13th, 2009 03:45 |
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Here's the latest article and commentary posted by Mercola at Mercola.com
"Shocking Update -- Sunshine Can Actually Decrease Your Vitamin D Levels"
http://articles.mercola.com/sites/articles/archive/2009/05/12/Shocking-Update-Sunshine-Can-Actually-Decrease-Your-Vitamin-D-Levels.aspx
I've read many articles written by Mercola, but this one takes the cake! The tangle of pseudo-science babble in this video commentary that he tries to assemble as facts is simply laughable!
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FM, CFS, migr HA, low adrenal, RBC coinfection 11/07 1,25D70, 25D48, 7/08 25-D 21;11/08 25-D 22; 2/09 25-D 15.6; 7/09 25-D 11; 10/09 25-D 5ng/mL. olmesart 40mg+20mg SL, T4 37.5mcg QAM, T3 10-15mcg/d. NoIRs/limit lite exp
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Knochen
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| Joined: | Thu Feb 23rd, 2006 |
| Location: | USA |
| Posts: | 349 |
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Posted: Wed May 13th, 2009 14:41 |
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Sometimes I just have to laugh at the way my mind works. As soon as I saw that article, the first thing that popped into my head was "It's that man again!". It's a historically based response, to be sure.
http://en.wikipedia.org/wiki/It%27s_That_Man_Again
Those of you wishing the full treatment, may visit
http://www.archive.org/details/OldTimeRadio-1940s
for actual episodes of the radio program.
If nothing else, I hope this post will give you a coping mechanism for the onslaught of Dr Mercola's periodic eruptions in our midst. It's either laugh or scream, and I've chosen to laugh.
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Reiter's Syndrome 25+ yrs, fatigue, joints, muscles, migraine, brainfog| 25D <4 ng/ml |Benicar May06|Ph1 June06|Ph 2 Sept06|Ph 3 Jan 07|NoIRs K-Cream Zinc Oxide cream - Always covered!
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Carricol
Member in Phase 3
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Posted: Wed May 13th, 2009 23:58 |
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| Did anyone ever think of coming up with a new term to refer to Vitamin d that more accurately describes its function. maybe if we all started putting a new label on it it would get people to quit thinking of it as a vitamin. Who knowes? It could catch on.
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Sarcoidosis 1-25D 16, 21 Oct 08; Ph1 Nov07, Synthroid, 5-HTP, tyrosine, digestive enzymes, NOIRs lite exp r/t commute cover up, Ph2 Jan 08, Ph 3, 6 May 09, 25D 5, Jul 09
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tgritton
Member in Phase 3
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Posted: Thu May 14th, 2009 01:14 |
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Perhaps
calciol for vitamin D3
calcidiol for 25 vitamin D
calcitriol for 1,25 vitamin D
http://www.chem.qmul.ac.uk/iupac/misc/D.html
Removing the "V" word would certainly be a step forward
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Lyme arrhythmia 125D76 25D39 Benicar Nov05 ModPh1May06 ModPh2Oct06 Ph2Jun07 Ph3Dec07 25D<4(Aug08) 0Meds 0Supps Lite90%<30lx otherwise NoIRs 2layer clothes gloves hat +-ZnO
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Carricol
Member in Phase 3
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Posted: Thu May 14th, 2009 01:34 |
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| I was thinking of something more descriptive and less benign.
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Sarcoidosis 1-25D 16, 21 Oct 08; Ph1 Nov07, Synthroid, 5-HTP, tyrosine, digestive enzymes, NOIRs lite exp r/t commute cover up, Ph2 Jan 08, Ph 3, 6 May 09, 25D 5, Jul 09
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Caitiegirl
Member in Phase 2
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Posted: Thu May 14th, 2009 01:51 |
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How about rat poison?
Mindy
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Caitlin(18) lyme, seizures, myoclonus, dystonia, digestive, chronic headache, mental fog: 10/23/07 25D 36 1,25D 58, 1/12/09/5.7, 1/18/08 25D 9.9 Cut sun/D 9/26/07 Benicar 10/25/07, NoIRs 10/29/07
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Rico
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| Joined: | Wed May 31st, 2006 |
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Posted: Thu May 14th, 2009 01:52 |
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Steroid D
Last edited on Thu May 14th, 2009 01:52 by Rico
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No diagnosis/some symptoms; wife with Sarc on MP; Olm 40mg q6h| avoid D| 1,25D=63 25D=32 (May 2006) 1,25D=44; 25D=10(Dec 2006)PhaseI(May06) PhaseII(Aug06) PhaseIII(Aug07)
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Kas
Member in Phase 2
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Posted: Thu May 14th, 2009 15:49 |
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According to today's Toronto Star, we should all be on huge doses of steroid D to ward off a whole slew of ailments " in our pursuit for health and longevity" The Canadian Cancer Society is now recommending 1,000 IU's a day for people aged 50 or older. They state that the older you get, the more you need to ward off diseases such as colon cancer, breast cancer, prostate cancer, diabetes, cardiovascular disease and even MS, and of course osteoporosis and ricketts. It goes on to say that the heavier you are the more you need!
The best is this claim - "Vitamin D overload is rare, and the most likely health problem it might entail is increased risk of developing kidney stones".
A Boston University D researcher ends of the article recommending that babies and kids should get 1,000IU's daily and adults 2,000 IU's
With articles such as this appearing virtually every week in the press, it is no wonder that we have such trouble convincing doctors in this country that we who are deficient in D by choice are not going to become one of their statistic claims and that we are actually getting healthier because of not pumping our bodies full of Vitamin D.
Just a stupid question here - do healthy individuals ( those without any TH1 illnesses) really need all this D supplementation, or would they manage just as well as those of us who are 'deprived' on the MP? I just wondered, as I watch my husband swallow his D pills daily to ward off osteo ( he has osteopenia) etc etc.
Last edited on Thu May 14th, 2009 15:50 by Kas
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Sarc Dx by splenectomy 03- Lungs, lymph nodes, liver. Non MP meds: natural progesterone cream three weeks a month; cal/mag; probiotics; milk thistle daily; cranberry caps prn; quercetin prn.Noirs outdoors and under flourescent work lights, Spectra 3 cream
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Knochen
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| Joined: | Thu Feb 23rd, 2006 |
| Location: | USA |
| Posts: | 349 |
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Posted: Thu May 14th, 2009 15:55 |
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I was thinking of something more descriptive and less benign.
"The Sunshine Seco-Steroid"! 
A few headlines like "Legislature forces mandatory steroid use on diary industry - consumers voice concerns" might go a long way toward getting the word out. It may be dirty pool, but sometimes you have to go for a bit of hyperbole to get the conversation started.
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Reiter's Syndrome 25+ yrs, fatigue, joints, muscles, migraine, brainfog| 25D <4 ng/ml |Benicar May06|Ph1 June06|Ph 2 Sept06|Ph 3 Jan 07|NoIRs K-Cream Zinc Oxide cream - Always covered!
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Dr Trevor Marshall
Research Team
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Posted: Thu May 14th, 2009 16:52 |
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Just a stupid question here - do healthy individuals ( those without any TH1 illnesses) really need all this D supplementation, or would they manage just as well as those of us who are 'deprived' on the MP? I just wondered, as I watch my husband swallow his D pills daily to ward off osteo ( he has osteopenia) etc etc.
As the exact VDR metabolism has become clearer, it is apparent (to me) that the human body can make all the Vitamin D it needs (it makes it from 7-dehydrocholesterol within the cytoplasm of nucleated cells). Neither healthy folk, nor ill folk, need any exogenous Vitamin D. As the level of ingested Vitamin D rises it becomes immunosuppressive. Indeed, there has recently been shown an increased clinical incidence of several cancers, including melanoma, at higher levels of Vitamin D.
Steroids are addictive. The idiots who promote Vitamin D as a magic bullet (and who usually take large quantities of the drug themselves) have long since lost their ability to reason objectively, and are in total denial of the real effects of the drug.
Thankfully, Vitamin D is not an issue in China, and so our focus shifts away from this Western lunacy as we start to transition the MP into mainstream medicine at West China Hospital
Don't forget to have another read of Paul's paper:
http://AutoimmunityResearch.org/transcripts/AR-Albert-VitD.pdf
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Sunset
Health Professional
| Joined: | Tue Oct 16th, 2007 |
| Location: | USA |
| Posts: | 111 |
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Posted: Thu May 14th, 2009 17:35 |
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I have to say that the current medical industry’s recommendations and government support of “vitamin D” supplementation to “maintain” or “improve one’s health” despite scientific evidence that shows contrary evidence, that in fact use of this hormone can easily lead to hypervitaminosis D in individuals with Th1 illnesses, is nothing less than criminal!
IMO, at least in the US, what we are now seeing is the replacement of the Military Industrial Complex with the Medical Industrial Complex to support big business and cut government costs. Dead people don’t collect social security benefit money but sick people sure do use a whole lot of medical services & costly meds and supplements as a result of chronic illness with a huge payout to big business. I can envision US President Eisenhower, who warned Americans of the harmful effects of a military industrial complex, rolling over in his grave at the thought of a Medical Industrial complex impact on the people of this nation!
I know I’m expressing a rather jaded viewpoint, but I am quite sick and tired of living through the effects of “Vitamin D” overdose and now I am watching my family and friends suffer from the impact of excess “vitamin D” use. Some people may think that the only way to deal with such a tragic state of affairs in our medical system is to laugh… I can no longer laugh at this I can only cry.
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FM, CFS, migr HA, low adrenal, RBC coinfection 11/07 1,25D70, 25D48, 7/08 25-D 21;11/08 25-D 22; 2/09 25-D 15.6; 7/09 25-D 11; 10/09 25-D 5ng/mL. olmesart 40mg+20mg SL, T4 37.5mcg QAM, T3 10-15mcg/d. NoIRs/limit lite exp
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stuckpac
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| Joined: | Sun Sep 28th, 2008 |
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Posted: Thu May 14th, 2009 17:44 |
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| Just call it what it is: "Secosteroid D"
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Markt9452
Member in Phase 3
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Posted: Thu May 14th, 2009 22:03 |
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I have to say that the current medical industry’s recommendations and government support of “vitamin D” supplementation to “maintain” or “improve one’s health” despite scientific evidence that shows contrary evidence, that in fact use of this hormone can easily lead to hypervitaminosis D in individuals with Th1 illnesses, is nothing less than criminal!
Yes it is criminal negligence. It is also "Human Sacrifice" rooted in the religious doctrine of "evolution" and "survival of the fittest". Unfortunately those who are adverslely affected by vitamin D supplementation are the ones being sacrificed by those who wish to enforce their "ends justifies the means" and "sacrifice the few for the good of the many" philosophy.
I believe that eugenics is a good word for it.
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Th1 Lyme Symptoms 125D20 D2510 Ph1Feb08 Ph2Apr08 Ph3Oct08 daily med.exp covered up NoIRs| MyStory|
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TikBitten
Member in Phase 3
| Joined: | Thu Mar 13th, 2008 |
| Location: | USA |
| Posts: | 61 |
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Posted: Thu May 14th, 2009 22:26 |
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A "Class Action Law Suit" gets peoples attention and can achieve much.
Litigiously yours,
TB
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Neurborreliosis 8/05|25SecD=46 1,25SecD=62 10/07|Avoid Sun & 25SecD since 10/07|Started NoIRs 3/08|25SecD=18 3/08|Ph1 3/08|25SecD=17 6/08|ModPh2 6/08|Ph2 9/08|Stopped NoIRs Fall 08|Ph3 1/09|25SecD=13 3/09|25SecD=10 5/09|25SecD=11 7/09|25SecD=15 9/09
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Aunt Diana
Moderator
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Posted: Sat May 16th, 2009 04:58 |
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| I really like your analogy, Sunset. I don't think you're being jaded at all. You are simply putting two and two together. It's sad that so many people have lost that abiliity.
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Lyme 1987, neuro cardio fatigue achiness brain fog depression, anxiety. Pacemaker, D.1,25 32; D <5; 12/07 <6, hydrocodone, lorazapam, benedryl, zantac, colase, Noirs, cover-up or avoid sun, house <30lux. Feb 08 Phase 3. 6/08 D <4, D1,25
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