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Dr Trevor Marshall
Foundation Staff
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Posted: Sat Aug 15th, 2009 02:26 |
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The HD video of the presentation I gave last weekend at the '4th China Medicinal Biotech Forum' in Dalian, China, is now online:
http://vimeo.com/6110400
The presentation was more formally titled: "The VDR Nuclear Receptor is a Novel Proxy for MTSS1 and MTUS1 in Breast , Bladder and Colorectal Cancers." and a copy of the abstract is online at
http://autoimmunityresearch.org/transcripts/Marshall_CMBF-2009.pdf
Janet has produced another of her nice PDF transcripts, which you can download and print for Doc. There is a copy of it at:
http://autoimmunityresearch.org/transcripts/CMBF_2009_Dalian_Transcript.pdf
I tried to give a 15 minute overview of the pathogenesis, followed by a 5 minute explanation of how the VDR and inflammation are critical to carcinoma metastasis. It is tough to fit everything into a small timeslot  I figured that my usual 50 minute bloat needed to be trimmed
Last edited on Mon Aug 17th, 2009 08:40 by Dr Trevor Marshall
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Joyful
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| Joined: | Sat Jun 9th, 2007 |
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Posted: Sat Aug 15th, 2009 05:50 |
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Nicely done, Dr. Marshall.
On my wireless network connection (low quality) the video did stutter about every 30-50 seconds. But the slides were great with all the vivid colors. 
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Dr Trevor Marshall
Foundation Staff
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Posted: Sat Aug 15th, 2009 14:04 |
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Joyful, even on my Core-2 Duo computer the Vimeo video player is taking up a lot of bandwidth, and occasionally pausing when background tasks run (as you note).
With my Lenovo S-10 netbook, with a slow Atom CPU (XP), playback was ok (without pauses) once the file finished downloading. While the video is spooling to disk it pauses occasionally.
The HD video will clearly be difficult for many to play. If so, they should turn HD off with the 'button' near the middle right of the display image.
I will be putting up the MP4 file into the Internet Archive in a few days, and then you will be able to download it. The file does play smoothly on VLC, even on the Netbook.
This video is worth persevering to see (IMO). There are a number of key new concepts in it (incl EBV).
Did you notice I didn't mention Vitamin D even once?
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Cynthia Schnitz
Member in Phase 3
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Posted: Sat Aug 15th, 2009 17:31 |
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| I have had great success by hitting play, then pause, to let the shadow bar, behind the current play position bar, indicating the data is being down loaded, fill out. While this is happening I usually minimize the window and coming back to it a little later, after a few games of solitaire . At this point, with the info finished down loading, the software now only has to deal with playing the downloaded file. Pressing the play arrow at this point has always given me uninterrupted viewing.
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Ph1 10/08, Ph2 12/08, Ph3 6/09, 125/25D 47/43 preMP, 25D14 12/09, Estradiol .75mg, Calcium anomaly(gone?), Spondylitis, early Diverticulosis, early Macular Degeneration(AMD), Type II Diabetes (unconfirmed,PreDiabetes?), returning sense smell
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Joyful
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Posted: Sat Aug 15th, 2009 17:41 |
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Thanks Dr. Marshall & Cynthia.
I guess my swiss cheese brain missed remembering that technique. 
I guess it's time for someone to transcribe this lecture too.
But forget trying to catch the words from the question at the end.
Unintelligible. 
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paulalbert
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| Joined: | Fri Jul 16th, 2004 |
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Posted: Sun Aug 16th, 2009 22:14 |
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If anyone is interested in putting together a transcript, here's the place to do it:
http://mpkb.mp-dev.com/doku.php/home:publications:marshall_cancer_2009
Paul
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Diag CFS 6.03 / sympt since 9.02 / exercise, food intol, sleep prob / 1,25D: 16, 4.06; 1,25D:27, 25D:26 7.04; 1,25D:43, 25D:6 6.05; 1,25D:17, 25D:8 8.05; / MP: 7.04 / Ph. 3 / Bacteriality
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Joyful
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Posted: Sun Aug 16th, 2009 22:53 |
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I've inserted a slightly formatted version of the transcript Janet produced yesterday.
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Dr Trevor Marshall
Foundation Staff
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Posted: Mon Aug 17th, 2009 08:03 |
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Thanks Joyful
Janet has produced another of her nice PDF transcripts, which you can download and print for Doc. There is a copy of it at:
http://autoimmunityresearch.org/transcripts/CMBF_2009_Dalian_Transcript.pdf
..Trevor..
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wrotek
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Posted: Wed Aug 19th, 2009 19:09 |
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For core 2 duo computers perhaps it would be better to use browser like Chrome or Internet Explorer. I've read somewhere that Firefox uses only one processor, dunno whether it has been repaired.
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Joyful
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Posted: Wed Aug 19th, 2009 23:40 |
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I'm not sure the issue with Firefox and dual core is current. Most of the posts I found when searching just now were over a year old.
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Bane
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Posted: Fri Dec 25th, 2009 20:15 |
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Serum 25-hydroxyvitamin D at pregnancy and risk of breast cancer in a prospective study.
http://www.ncbi.nlm.nih.gov/pubmed/20022237
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Oral Lichen Planus(mild)/Clubbed Finger (digital clubbing)Last 25D 5.6ng/ml, phase3
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Bane
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Posted: Mon Mar 1st, 2010 11:16 |
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Hereditary/familial versus sporadic prostate cancer: few indisputable genetic differences and many similar clinicopathological features.
http://www.europeanreview.org/articolo.php?id=696
"Also VDR gene, that is a component of ligand (steroid)-dependent nuclear transcription factor superfamily, shows various polymorphisms which appear to be associated with PC risk. Except an earlier age of onset, no anatomo-clinical and tumor progression peculiarities between hereditary and sporadic PC have been generally identified. Indeed, tumor progression and metastasis, both in hereditary and sporadic PC, are mainly influenced by a variety of biochemical and immune-mediated tumor microenvironmental conditions rather than by the hereditary genetic factors, thus gene expression associated with invasive ability representing a newly acquired genetic variant rather than a selection of pre-existent gene abnormalities in PC cells. It’s questionable whether genetic testing of unaffected men of hereditary PC families might be actually useful."
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Oral Lichen Planus(mild)/Clubbed Finger (digital clubbing)Last 25D 5.6ng/ml, phase3
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titta
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| Joined: | Wed Jul 4th, 2007 |
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Posted: Tue Mar 2nd, 2010 03:14 |
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I am doing an online course at the University of Edinburgh in Translational Medicine. The theme now is drug targeting, biologics, 'the small molecule approach'.
Thus I have found a very well written work: 'Targeting the mechanisms of tumoral immune tolerance with small molecule inhibitors' . It is worth to be read.
I would have been enthusiastic if I did not know about the MP. At least they have started to recognize that there is a 'pathophysiology of cancer associated immune tolerance' and thus they are looking for molecules to inhibit this phenomenon.
But (have I overlooked it??) they just stop there. I imagine children in the kindergarten (alike Dr. Marshall) would have asked: Why is there an immune tolerance?
Here the link: http://www.nature.com/nrc/journal/v6/n8/full/nrc1929.html
Take care,
Titta
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sarcoidosis,Olmes 120/mino100 48h/clindy 48h/zith ev 10 d
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