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TikBitten
Member in Phase 3
| Joined: | Thu Mar 13th, 2008 |
| Location: | USA |
| Posts: | 42 |
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Posted: Thu May 29th, 2008 03:07 |
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Frans wrote:the problem then gets bigger and bigger as the bacterial load gets higher and higher, this will competitively displace 1,25D from the VDR, disabling it more and more, leading to lower AMPs etc.
the higher levels of 1,25D are there, but are just not high enough to get capnine, 25D and other antagonists out of the way and activate the VDR
the bacteria win the competition...
Hope this helps, Frans
If the scenario above, as presented by Frans, is correct what is the general consensus to the following thoughts:
Item 1
Isn't capnine (like 1,25D and 25D) a key marker of Th1 chronic inflammation? And if so, is there a Quest or Labcorp test to check capnine tissue levels?
Item 2
Could the "floaters" that appear so commonly in the eyes of Th1 patients actually be biofilm elements? And if so, simple visual evidence of the condition?
Item 3
Is capnine the greater antagonistic culprit and, if so, does that shift the therapeutic level of 25,D of <= 12 ng/mL upwards? And the degree, of course, of emphasis on dietary intake of VitD and sunlight avoidance?
TikBitten
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Dx: Borreliosis/Neurborreliosis 8/05|25D=46 125D=62 10/07|VitD and sun avoidance since 10/07|Using NoIRs since 3/08|25D=18 3/08|Ph1 3/08|25D=17 6/08|ModPh2 6/08|Ph2 9/08|Ph3 1/09
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ChrisW
Member in Phase 3
| Joined: | Wed Jul 18th, 2007 |
| Location: | Chile |
| Posts: | 39 |
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Posted: Fri May 30th, 2008 11:51 |
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Thanks for your feedback Frans, Wrotek & Trevor,
1.) After reading up on Interferon gamma and "Vitamin D Discovery outpaces FDA decision making" I’ve reached the conclusion that... the rise in 1,25D is the body’s response to infection.
As far as we know the microbiota are NOT directly attempting to stimulate 1,25D as this would reduce their chances of survival. Please correct me if I’m wrong.
2.) However, as 1,25D reaches very high concentrations it blocks other receptors thereby reducing production of other AMP’s.
Is there any evidence that 1,25D is of benefit to the invaders at the lower concentrations?
Thanks again,
Chris 
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CFS osteoporosis 125D60 25D16.4 Ph1Oct07 Ph2Dec07 calcium magnesium NoIRs, low lux home, limited outings, covered up.
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Dr Trevor Marshall
Research Team
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Posted: Fri May 30th, 2008 13:26 |
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Chris said:the rise in 1,25D is the body’s response to infection
Indeed. If you look at Figure 1 in "Vit D discovery..." you will see Interferon-gamma as input to the upregulation of transcription of CYP27B1. In a healthy individual this would upregulate 1,25-D; upregulate VDR transcription, and enhance innate immune response. The metagenome has evolved to thwart that action by blocking VDR.
That is the reason that I talk about "Th1" disease - Interferon-gamma is the common thread in all these symptomatic variations, and IFg implies Th1 (by definition).
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