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NickBowler
Member in Phase 3
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Posted: Sat Oct 27th, 2007 20:59 |
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Ah yes, doublespeak. We invented it of course. Used with particular relish on all health issues it seems. For my part, I am starting MP on Nov 1 and am hoping to gain weight. I've always been as thin as a rake even though I eat like a horse (make that 2). I guess I have a lot og hungry bugs to kill!
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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
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NickBowler
Member in Phase 3
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Posted: Mon Nov 5th, 2007 17:25 |
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http://www.nutraingredients.com/news/ng.asp?n=81096&m=1NIEN05&c=mkljauldriplthi
Folic acid article here - feeding pathogens and increasing cancer risk!
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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
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NickBowler
Member in Phase 3
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Posted: Fri Nov 9th, 2007 19:16 |
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http://www.nutraingredients.com/news/ng.asp?n=81242&m=1NIEN09&c=mkljauldriplthi
And some bacteria make you age! This one is entitled 'live longer with vitamin D' - of course only 25VitD was measured, and although it was reported that telomeres on chromosomes (aging marker) were shortened due to inflammation, they didn't consider the possibility that Vitamin D supplementation might increase inflammation in some individuals instead of reducing it!
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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
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Dr Trevor Marshall
Research Team
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Posted: Fri Nov 9th, 2007 20:03 |
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Yes indeed, Nick.
The key thing here is whether the Th1 bacteria infect stem cells. Emil Wirostko was convinced that they did, but he died before he could publish his results (I was told about it by his colleagues).
You see, we know that stem cells themselves are present in the body until death, but that they lose their ability to repair, and heal, tissue as the body ages. So the question is - do they lose the healing ability more quickly because of the increasing load of Th1 pathogens that everybody accumulates during life?
At the recent conference on Aging at UCSD I heard a presentation by a German group who had been studying the use of a patient's own stem cells to repair heart tissue after a heart attack. They found that people who had suffered a myocardial infarction (which I believe is related to Th1 infection) possessed stem cells which were only about half as good at repairing the heart tissue as stem cells transplanted from healthy 20 year-old males. Not a surprise to me. A big surprise for the researchers...
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eClaire
Member in Phase 2
| Joined: | Mon Sep 25th, 2006 |
| Location: | Virginia USA |
| Posts: | 773 |
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Posted: Fri Nov 9th, 2007 20:25 |
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I have been continually impressed by how the theory/science behind the MP explains so much of the research outcomes reported--outcomes that leave the researchers scratching their heads.
And reading magazine articles are becoming a matter of scary science fiction.
In one woman's magazine I was reading a review of my dermatologists can do now to help people suffering with skin conditions and learned that some are using low dosed antibiotics for roscea (sp) and that gave me a fright, given the potential for cardiac issues. On the next page the article mentioned using steroids for psoraisis (an old treatment). So on the one hand, they are potentially reducing the bacterial load and the other they are increasing it. What do they do for folk who have both roscea and psoraisis?
Then, there's the recent article in Newsweek about food allergies. Apparently, we're too clean; not allowing our bodies to fight enough bacteria, enough viruses. I couldn't even read the article; it scared me.
Claire
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34mo on MP; CFS FMS MCS COPD hypermob. IBS/GERD osteopor.; 125D48 25D<4;
NoIRs during most daylight outings & covered up; home w/o NoIRs
Ph1.Dec06 * ModPh2.Jun07 * AbxBrk.Mar-May08 * Ph2.Oct-Nov08 * Ph1.Jan2009
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scooker48
Member in Phase 3
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Posted: Fri Nov 9th, 2007 20:33 |
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I continue to be amazed at what I read on this study site. It has allowed me to make sense of the world far more than any college degrees or other research in which I have participated.
Someday the truth of this site will come to the surface; truth always has a way of coming through.
Press on...
Sherry
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Necrotizing granulomas biopsy 10/88; Dx 12/04 Sarcoid liver spleen. 2/2/05: VitD 25/VitD125 62. 5/9/09 D25, D3 6; D25 D2 <4, Liver function normal 4/08; Wear NoIRs outside. No K creme used. 5/09 Liver and kidneys normal.
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NickBowler
Member in Phase 3
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Posted: Sun Nov 11th, 2007 15:52 |
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Infected stem cells! - that puts the cat among the pigeons with all the work going on around the world with them just now!! Do you think the MP targets them too, and so ultimately improves overall healing ability?
I take it you are familiar with the trophoblastic theory of cancer?
http://www.medscape.com/viewarticle/510222
Basically the theory assumes deranged localised steroid signaling due to various insults, followed by stem cells (germ cells) moving in to repair the damage. It implies that it is the invasive properties of the stem cells themselves that then lead to cancer, but if the stem cells are already infected with CWD bacteria, then maybe that is where the impetus to cancer formation comes from? I see a lot of synergy with your work here!
http://tinyurl.com/2zs4mf
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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
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Dr Trevor Marshall
Research Team
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Posted: Sun Nov 11th, 2007 17:29 |
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Nick,
I suspect that the real answer is much simpler than the theories of the past have suggested. We know that when the Th1 bacteria knock out the VDR they knock out transcription of the Metastasis Suppression Protein MTSS1. That has got to be somewhat important  There are many other genes (between 1000-27000 of them) for whose expression the VDR is responsible.
Yesterday I noticed a paper where researchers had sussed out a mechanism whereby the human genome was capable of making an enzyme which altered the body's own DNA. This must also be a pathway for enzymes produced by pathogens to mutate the human DNA as well. Take a look at
http://www.sflorg.com/comm_center/unv_science/p161_31.html
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NickBowler
Member in Phase 3
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Posted: Mon Nov 12th, 2007 14:29 |
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Yes that certainly opens up a whole new epigenetic can of worms beyond the well known methylation and histone acetylation! I guess that a really important question now is why some people with heavily compromised VDR’s (like the MP cohort) are obviously relatively cancer resistant, whereas others develop cancer without any prior overt TH1 disease being observed. BTW any chance from structural analysis that hCG could bind to the VDR and affect it directly?
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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
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Dr Trevor Marshall
Research Team
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Posted: Mon Nov 12th, 2007 21:04 |
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Nick, Th1 disease is rampant in the population. Everybody has the pathogens to a greater or lesser extent, but many only start to suffer damage from them as the grow older. You can see this in a chart of population 25-D levels vs age, which starts to drop at age 40 and continues to do so. The first diagnosable incident for many males is a heart attack, others a stroke.
It is generally accepted now that cancers start from inflammation, but only we are able to point the finger at Th1 inflammation, I think. Remember that excess cancer mortality has been reported (at least) in Sarcoidosis and Rheumatoid Arthritis. I think the relatively low incidence in our cohort, and the total lack of aggressive metastasis, indicates that the VDR is key, and activating it with Benicar makes all the difference... After all, the Th1 pathogens largely shut it down, even in asymptomatic individuals.
As Stella pointed out yesterday, the neolithic Iceman, which was found embedded in ice in the Alps about a decade ago, is though to have suffered from Ateriosclerosis, a stroke and Arthritis. The Th1 pathogens are not new to the human experience, what is new are the lifestyle changes we made in the 20th century...
Last edited on Mon Nov 12th, 2007 21:25 by Dr Trevor Marshall
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Frans
Member in Phase 2
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Posted: Tue Nov 20th, 2007 18:18 |
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Trevor, I was wondering.
Don't stem cells have their own protection system? Receptors and the like?
That would lead me to think that perhaps this system is also compromized by a non-functional VDR/innate immune system, which, in turn, would lead to a cleaning up of infected stem cells by restoring innate immunity/VDR function with the MP? Leaving only non-infected stem cells alive after doing MP?
Sincerely, Frans
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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
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benk
Member in Phase 3
| Joined: | Fri Dec 22nd, 2006 |
| Location: | San Clemente, USA |
| Posts: | 76 |
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Posted: Tue Nov 20th, 2007 20:24 |
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Pehaps not relevant to the MP but worthy of note is a report about "the cascade of cellular events behind some potentially dangerous autoinflammatory diseases" ..."co-workers describe how two proteins called PSTPIP1 and pyrin interact to cause autoinflammatory diseases" of allegedly genetic origin
http://www.sciencedaily.com/releases/2007/11/071112172122.htm
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Lyme 125D77 Ph1Dec06 Avodart Cr picolinate vit B12 NoIRs low lux home fully covered if outdoors Ph3Feb07 25D8Mar08
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Dr Trevor Marshall
Research Team
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Posted: Tue Nov 20th, 2007 22:16 |
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Benk,
I will be chairing the special session on "VDR, Vit D, and Immune Disease" that the Foundation is sponsoring at the 2008 International Congress on Autoimmunity in Portugal. Dr Greg Blaney will also be speaking. I expect we will shatter the myths and misconceptions about autoimmune disease pathogenesis which are bandied about so prolifically by researchers who don't even know enough about their subject to comprehend the depth of their own lack of understanding
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tickbite
Member in Phase 2/3
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Posted: Thu Nov 22nd, 2007 17:54 |
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http://www.nigms.nih.gov/News/Results/102507.htm
Scientists Unveil Structure of Molecular Target of Many Drugs (GPCR)
And i'll be darned, first article i've ever seen talking about CWD (they say intracellular). This one is a good read.
Rogue Bacteria Involved In Both Heart Disease And Infertility
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"Lyme","CFS", Meningitis
Phase3 8-2-07, MP on hold 11/2007
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NickBowler
Member in Phase 3
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Posted: Thu Nov 22nd, 2007 18:23 |
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Very cool article. So 'trophoblasts behave very much like macrophages'. The plot thickens. The link to TH1 and cancer initiation is strengthening.
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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
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Lilly
Member in Phase 2/3
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Posted: Sat Dec 29th, 2007 01:18 |
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This link reports a study whereby subjects, obese and normal, ate fast food meals laden with fat and sugar. Obese showed oxicative stress and inflammation much longer after the meal than normals.
It infers that fast food meals are bad for the obese but not so bad for normals . But it has too many different foods to show exactly what is the culprit. I suspect the sugar in the coke and pie.
Anyway, maybe some research is getting closer to acknowledging the inflammation factor in illness, especially obesity. And this supports the lo-carb eating recommendations of the MP.
http://news.yahoo.com/s/nm/20071228/hl_nm/meals_obese_dc_1
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ME/CFIDS Prozac Wellbutrin Trazadone NADH.Noirs avoiding D,sun from07/04;25D=36;Ph2 restart Sep06. Ph3 03/07
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Foundation Staff
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Posted: Sat Dec 29th, 2007 01:42 |
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| Lilly, your post has been moved to this thread and given a 'priority bump' to move it to the top of the list so interested members will see it.
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vwitcher
Member in Phase 2/3
| Joined: | Thu Jan 18th, 2007 |
| Location: | Arkansas USA |
| Posts: | 47 |
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Posted: Tue Jan 1st, 2008 04:16 |
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While looking at Lilly's link about fast food-induced inflammation, I happened upon this one about germ "gangs" and resistant bacteria. Very interesting stuff...it was just posted today. I can't figure out how to insert the link, but it is at the bottom of the "fast food story" link under "health news": Doctors Target Germs' Ability to Cluster". Would love to see Moderators' take on their findings.
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5 yrs. very high BP,fatigue,headache,hrt palp, IBS,joint/muscle pain,muscle wasting,neuro sx,deaf one ear.Start D/light avoid 1/21/07.Start MP 2/23/07; Re-started 4/18/07. Mod Ph2 6/27/07; Ph3 7/25/07 q24h.NoIr's when outside.
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Dr Trevor Marshall
Research Team
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Posted: Tue Jan 1st, 2008 07:27 |
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vwitcher,
The error in the way these folk are looking at the microbiotia causing chronic illness can be summed up in this one sentence from that article http://tinyurl.com/yp6jy9Hence the quest to disarm germs. Scientists are trying to disable "virulence factors," molecules that help germs worm their way into the body,
But the germs are already inside the body. They are part of the human existence. The only thing that changes is the balance between species. This is a terrible mistake that Medicine is making...
Take a look at the new paper on Lysobacter and Cystic Fibrosis in a thread on Cystic Fibrosis: http://www.marshallprotocol.com/forum39/10971.html
Last edited on Tue Jan 1st, 2008 08:14 by Dr Trevor Marshall
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shandym
Member
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Posted: Wed Jan 2nd, 2008 19:12 |
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I know I'm not too good at the "scientific" stuff, but I watch the biggest loser ad these people are very obese. If it was bacteria that causes them to be fat, than why when changing thier diet and excersing they are healthy again and all the High BP gone, High Choleterol Gone, Diabetes gone, thyroid problems gone..and all te other "TH1" syndromes just by diet and execrcise.
So is bacteria really at the root of ALL disease? Thats just too easy isn't it...or is my TH1 brain just not working properly, I suppose that is what I'll be told
Shandy
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FM like Pain, disequalibrium,vertigo, constant dizziness, palpitations, tachycardia, visual disturbances,headpressure/headpain 125D29, 25D7, MP 11/07, TUMS, Valium, NoIRs, limited outings covered up
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