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marysue
Moderator
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Posted: Sun Jan 17th, 2010 21:15 |
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Thanks Trevor. Of course, thanks to your research, we also know that as the "intraphagocytic microbiota" are killed off and health is restored, the human cells are able to restore their proper gene expression. Based on that, we can repair the damage done even by previous generations, whether the damage was epigenetic or otherwise.
I had previously thought that anything passed on by previous generations was caused by the "pea soup" or whatever bacteria was passed on by our parents via the sperm/egg. So now I imagine that it's caused by both the bacteria passed on and whatever epigenetic changes have already been made to the DNA before all the cell division starts at conception.
Marysue
"only mildly brain fogged these days....striving to become less molecular biology challenged."
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Thanks Dr. Marshall and staff for all the support!
CFS/FM '95; infert/endomet '02; hypotension; cardiac IP; start light restrict. Oct08; 125D=70 25D=30 (Feb09); Benicar26Apr09; NoIRs, low light, no sun; 25D=10 (Jun09); 25D=5 (Nov09)
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leroybrown
Member in Phase 2
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Posted: Sun Jan 17th, 2010 22:13 |
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Hi guys,
Are we talking about the kinds of genetic changes seen in chromosome abnormalities like this:
Chromosome 5q deletion syndrome (chromosome 5q monosomy, 5q- syndrome) is a rare disorder caused by loss of part of the long arm (q arm, band 5q31.1) of human chromosome 5.
(from http://en.wikipedia.org/wiki/Chromosome_5q_deletion_syndrome)
Or something different? This genetic stuff is really confusing. I had genealogical DNA testing done - can the intraphagocytic microbiome cause changes in that too?
Thanks in advance for any enlightenment!
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Autoimmune Pure Red Cell Aplasia, Jan 2009, Agranulocytosis 1991
Jan 14: hgb: 84, wbc 1.1
25D = 25 1,25D = 58 Aug 18/09
Phase 1: Sept 29/09 benicar 40mg q8hrs * Nov 26/09 40mg q6hrs
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Dr Trevor Marshall
Foundation Staff
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Posted: Sun Jan 17th, 2010 22:21 |
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I had genealogical DNA testing done - can the intraphagocytic microbiome cause changes in that too?
We cover this in the new chapter we have just written, but can't put the text online yet  The short answer is "yes" -- both from errors in testing caused by genomes that the test lab wasn't expecting to find, and from epigenetic interactions between the microbiota and the human cells (and back the other way, too).
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leroybrown
Member in Phase 2
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Posted: Sun Jan 17th, 2010 22:39 |
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Interesting. I did testing for the genographic project at National Geographic, which is supposed to give results 100's of generations back, tracing the migration of human beings. Other companies are using it to prove family relationships, not anything close like paternal testing, but in the distant past.
Will have to keep an eye on what happens in that field.
Does that mean stuff like Down's Syndrome could potentially be reversed?
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Autoimmune Pure Red Cell Aplasia, Jan 2009, Agranulocytosis 1991
Jan 14: hgb: 84, wbc 1.1
25D = 25 1,25D = 58 Aug 18/09
Phase 1: Sept 29/09 benicar 40mg q8hrs * Nov 26/09 40mg q6hrs
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titta
Health Professional
| Joined: | Wed Jul 4th, 2007 |
| Location: | United Kingdom |
| Posts: | 12 |
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Offline
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Posted: Sat Feb 13th, 2010 13:49 |
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I hope I have not missed that someone else has already posted about the below mentioned video
Bonnie Bassler talking about 'Quorum sensing'.
I have enjoyed it very much!
http://www.youtube.com/watch?v=TVfmUfr8VPA
Take care,
Titta
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sarcoidosis,Olmes 120/mino100 48h/clindy 48h/zith ev 10 d
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scooker48
Member in Phase 3
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Posted: Sat Feb 13th, 2010 19:13 |
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Wow. Thank you for putting this link up!
Sherry
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Necrotizing granulomas biopsy 10/88; Dx 12/04 Sarcoid liver spleen. 2/2/05: VitD 25/VitD125 62. 11/7/09 D25 at 6, Liver function normal 4/08; Wear NoIRs outside. No K creme used. 5/09 Liver and kidneys normal. ACE still high at 113 on 11/7/09.
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JohnMcC
Member in Phase 2
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Posted: Sat Feb 13th, 2010 23:21 |
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Good video and interesting there is a glimmer that mainstream are starting to accept that Koch was wrong, biofilms have been around longer than we have and we need to be innovative in fighting disease.
I still think that antimicrobial peptides are natures way of doing the right thing and the idea of man creating more mass spectrum antimicrobial drugs is a scary prospect.....
I saw "I am Legend".....
Thanks for posting a very enjoyable presentation.
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Diagnosed Sarc by biopsy Jan93
25/04/05(25D-41 1,25D-94 ACE 35)
25/09/08(25D-30 1,25D-63 ACE 35) Phase1 28/09/08
3/12/08 (25D 10.8 1.25D 27.5) Mod Phase 2 22/01/09
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scooker48
Member in Phase 3
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Posted: Tue Feb 16th, 2010 00:55 |
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After viewing the video, which was so informative and full of much science which gives me excitement for the MP, I now ask a question.
Where does the VDR receptor reside? On the cell wall? Or is this molecule floating around inside the cell?
Sorry about these basic questions.
Sherry
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Necrotizing granulomas biopsy 10/88; Dx 12/04 Sarcoid liver spleen. 2/2/05: VitD 25/VitD125 62. 11/7/09 D25 at 6, Liver function normal 4/08; Wear NoIRs outside. No K creme used. 5/09 Liver and kidneys normal. ACE still high at 113 on 11/7/09.
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Dr Trevor Marshall
Foundation Staff
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Posted: Tue Feb 16th, 2010 04:03 |
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Sherry,
The VDR transits between the cytoplasm and the nucleus. It gets its ligand in the cytoplasm, and then translocates to the nucleus (where the DNA is located) in order to transcribe the genes.
At least, that is what is currently believed 
..Trevor..
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marysue
Moderator
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Posted: Thu Feb 18th, 2010 04:55 |
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Thanks Trevor. And what types of cells is the VDR in? Also, are the cells that the VDR is in located everywhere in the body?
Thanks for asking Sherry--that was on my list too. No question is too basic. When I started reading about the VDR, I thought it was some singly located thing in the brain like the pineal gland or something!!! How crazy is that? We all have to start where we're at and learn from there.
Marysue
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Thanks Dr. Marshall and staff for all the support!
CFS/FM '95; infert/endomet '02; hypotension; cardiac IP; start light restrict. Oct08; 125D=70 25D=30 (Feb09); Benicar26Apr09; NoIRs, low light, no sun; 25D=10 (Jun09); 25D=5 (Nov09)
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Dr Trevor Marshall
Foundation Staff
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Posted: Thu Feb 18th, 2010 05:42 |
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Marysue,
If you ask a specialist in mouse biology you will get a totally different answer for "what type of cells is the VDR in?" That is why there is confusion on this topic. Mice VDR are very different from Human VDR (remember my video of Olmesartan in each).
All nucleated cells have VDR in them. It is believed that activation of the estrogen beta receptor, along with other cofactors, causes expression of the VDR. In turn, the VDR expresses Estrogen receptors. So there is a careful ying-yang relationship which has to be maintained.
The cells which interest us most are the phagocytic cells - the monocytes, macrophages and lymphocytes, as it is in these cells that the innate immune system is suppressed by the microbiota.
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NickBowler
Member in Phase 3
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Posted: Tue Mar 2nd, 2010 08:39 |
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http://www.ncbi.nlm.nih.gov/pubmed?term=%22PloS+one%22[Jour]+AND+Gut+Microbiota+in+Human+Adults+with+Type+2+Diabetes+Differs+from+Non-Diabetic+Adults&TransSchema=title
a clear link between diabetes and the gut microbiota shown here!
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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
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Aunt Diana
Moderator
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Posted: Tue Mar 2nd, 2010 17:31 |
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closer and closer. step by step.....
Thanks for these links, Bane
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Lyme 1987, neuro cardio fatigue achiness brain fog depression, anxiety. Pacemaker, D.1,25 32; D <5; 12/07 <6, hydrocodone, lorazapam, benedryl, zantac, colase, Noirs, cover-up or avoid sun, house <30lux. Feb 08 Phase 3. 6/08 D <4, D1,25
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NickBowler
Member in Phase 3
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Posted: Thu Mar 4th, 2010 11:49 |
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http://scienceblogs.com/notrocketscience/2010/03/cataloguing_the_genetic_zoo_in_your_bowel.php
and closer still!
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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
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Alejandro
Member in Phase 2
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Posted: Thu Mar 4th, 2010 17:17 |
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Here more of our "friends"
A human gut microbial gene catalogue established by metagenomic sequencing
http://www.nature.com/nature/journal/v464/n7285/full/nature08821.html
Alex
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Skin Sarcoidosis treated with Corticoid creme 1,25 D3 : 41 pg/ml (was 63 pg/ml) 25 D :10 ng/ml (was 22 ng/ml)
MP since Dec 2009. Benicar q8h 50mg Mino
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cali
Member in Phase 2
| Joined: | Fri Nov 27th, 2009 |
| Location: | Utah USA |
| Posts: | 25 |
| Status: |
Offline
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Posted: Thu Mar 4th, 2010 17:32 |
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Just wanted you to know that I really appreciate your research! It is something that I probably wouldn't know where to find on my own and I get to benefit from your efforts. Thank you  Thats one of the many things I love about this sight the wealth of knowledge that is shared so generously with each other!Last edited on Thu Mar 4th, 2010 17:49 by cali
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ME?/CFS/FM D25/26 D125/74 8/09 PH1 9/15 D25/25 125D/52 Ph2 12/10/09
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Daniel
Member in Phase 2
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Posted: Fri Mar 5th, 2010 17:06 |
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Just today on Yahoo:
http://news.yahoo.com/s/time/20100305/hl_time/08599196980700
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Sarcoidosis (disputed) lung nodules, Fatigue, Joint pains, GI symptoms/ Phase 1 - Sep 26th, 2008/ Phase 2 - December2 2008 ; ACE 74 [04/07/2008]; (1,25 D) - H 74; (25 D) 16 [9/22/2009] ; NOIRS, Generally no Sun exposure
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k
Member in Phase 3
| Joined: | Fri Aug 10th, 2007 |
| Location: | Australia |
| Posts: | 310 |
| Status: |
Offline
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Posted: Sun Mar 7th, 2010 05:46 |
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Yes, also reported here:
http://blogs.discovermagazine.com/loom/2010/03/04/i-for-one-welcome-our-microbial-overlords/
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CFS menorrhagia & dysmenorrhoea anxiety depression paxil 600mg calcium daily Ph1Oct07 Ph2Feb08 Ph3Sept08 25D:Jul07=50 Oct07=23 Jan08=13.2 Oct08=12.8 Sept09:10 NoIRs cover-up low lux home lite exp r/t to work
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Alejandro
Member in Phase 2
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Posted: Wed Mar 17th, 2010 08:18 |
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The problem of bacterial induced suppression of Innate Immunity seems to be an old problem in Life. According to a publication of 2006, plants face similar problems:
A Bacterial Virulence Protein Suppresses Host Innate Immunity to Cause Plant Disease
http://www.sciencemag.org/cgi/content/abstract/313/5784/220
An MP Pathology model...for Plants ?
Cheers
AlexLast edited on Wed Mar 17th, 2010 08:22 by Alejandro
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Skin Sarcoidosis treated with Corticoid creme 1,25 D3 : 41 pg/ml (was 63 pg/ml) 25 D :10 ng/ml (was 22 ng/ml)
MP since Dec 2009. Benicar q8h 50mg Mino
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titta
Health Professional
| Joined: | Wed Jul 4th, 2007 |
| Location: | United Kingdom |
| Posts: | 12 |
| Status: |
Offline
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Posted: Wed Mar 17th, 2010 12:59 |
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Hello Alex,
thank you for sharing this article. Another 'reason' to keep on talking to the plants around me.
Going from there I have found another one article:
http://rstb.royalsocietypublishing.org/content/364/1513/85.full
It gives a fine overview of recent knowledge.
Now I feel as a kind of Neandertal scientist studying Translational Medicine thinking
what and how they stick to their human DNA-protein in the body thesis and wonder about obstacles why this 'reality' does not reward them with blockbuster drugs....
Take care,
Titta
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sarcoidosis,Olmes 120/mino100 48h/clindy 48h/zith ev 10 d
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