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The Marshall Protocol Study Site > MEMBER DISCUSSION > Public Questions and Discussion > Minocycline Resistance from Pre-Marshall treatments for Lyme?


Minocycline Resistance from Pre-Marshall treatments for Lyme?
 Moderated by: Dr Trevor Marshall  

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Eve
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 Posted: Sat Oct 15th, 2005 17:59

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In a recent article I read Dr. Marshall states that "if minocycline is used for a few months (for pulsing without implimenting protocol), there is a risk of clearing tissues of bacteria sensitve to mino allowing more resistant strains to take over those tissues." 

In 2003 I began minocycline.  Within days I had a severe mental reaction and my family took me off all ABX.  (I now am sure it was a lyme herx.)  In Summer of 2004 I began six months of minocycline (100mg 2xs daily).  I had no beginning herx but slowly over time felt better.  Unfortunately I moved to Carribbean in  early 2005 and went of minocycline...slowly got worse...now am back in deary, low vitamin D level New Jersey :-).  Question:  Will the Benicar/Mino First Phase be of use as I have, according to Marshall, probably "allowed more resistant strains to take over."  What do you recommend for those of us that have used minocycle already?  (In the past five years I have also done several six week courses of Doxy, one six week of ceftin and another of bioxin, and nine months of IV Zithromax.  My initial treatment for the lyme bite in 2000 was two weeks of amoxicyline :-( )  Thank  you

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 Posted: Sat Oct 15th, 2005 18:18

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Eve,

Dr. Marshall was talking about the use of minocycline on the MP where it is pulsed and taken at low doses with a Benicar blockade in place to effectively kill the bacteria.

Minocycline taken at 100mg twice daily has the palliative effect of inhibiting the ability of the immune system to 'see' the bacteria. Bacteria aren't killed so you don't have Herx reactions and you feel better. Meanwhile the bacteria continue to multiply assisted by exposure to sun and your symptoms progress.

None of the antibiotics you listed have killed your cell-dwelling bacteria as evidenced by the fact that you are still ill. The first phase of the MP (minocycline) should be effecive for you.

Best,

Meg

Eve
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 Posted: Sat Oct 15th, 2005 18:59

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Thanks for reply.  I must say I am not getting much support from my family.  They have many reservations and fear that my typically low blood pressure will tank and that I could cause my self or others harm by passing out while driving etc.  It's hard for me to attempt such aggressive treatment without the support of my family...so I procrastinate.  Thanks again

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 Posted: Sat Oct 15th, 2005 19:44

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Eve,

Please note my B/P in my signature line. I lead an active life without dizziness now that my inflamamtion has resolved. Please see:

My blood pressure is already low. Can I take Benicar?

I don't think I've heard the MP called "aggressve" before. Didn't you say you had nine weeks of IV Zithromax? Did your family support all your other antibiotic treatments?

The MP isn't for everyone. Please see:

How do I know if I have the 'right stuff' to be successful with the Marshall Protocol?

Whenever you're ready to begin the MP road to recovery, we will be here to support you.

Best,

Meg

Eve
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 Posted: Mon Oct 17th, 2005 00:46

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Hi Meg!

My family, mainly my number one advocate, my mom, is an amatuer but effective and sucessful health internet researcher.  She has three questions that I hesitate to ask.

Eve

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 Posted: Mon Oct 17th, 2005 01:18

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Eve,

If your questions are of a very personal nature, you may send me a private message. If they are just skeptical, please post them here.

Best,

Meg

jacque
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 Posted: Fri Oct 21st, 2005 14:08

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Meg,

Jacque was on 100mg mino 2 x per day previous to starting MP and had massive pain (described as "cell exploding") throughout her body. Since finding out about MP we assumed her pain was Herx due to no pain blockade.  What you say above contradicts this?

Matt



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Mino 25 mg every 2 days, Benicar 8 hrly, Rickettsia, CFS, et al. Phase 2 started 8-Nov-05.
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 Posted: Fri Oct 21st, 2005 15:35

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Matt,

For some people high doses of minocycline do seem to kill bacteria and cause a Herxheimer reaction. But, for most it exerts a palliative anti-inflammatory action when taken 100mg twice daily as recommended by rheumatologists. The American Rheumatology Association has approved minocycline has one of its Disease-modifying antirheumatic drugs (DMARDs) because of its "anti-inflammatory effects".

Best,

Meg

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 Posted: Fri Oct 21st, 2005 20:35

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Meg,

this explanation (your post directly above) has been VERY helpful to me , and I'm sure, others. I wondered why some on high dose antibiotics would feel worse, and some better, and some nothing. I had been assuming that it was because those who feel a little better are getting a palliative, anti-inflammatory effect. I was one of those who mainly felt nothing, certainly no herx, just a hair of anti-inflammatory effect (not enough to continue the abx).

Dog

Do you have the understanding why some get the microbe kill when on high dose and some don't??????????



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CFS lyme RSD: pain migraine| tylenol fioricet flexeril tramadol temazepam| acidoph guaif/cold| Q| Cut D/exp Feb05| NoIR Mar05| June05 Comm Beni Q8H| July05 mino| Jan06 PH2| Aug06 1,25D=29 25D=17|
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 Posted: Sat Oct 22nd, 2005 05:21

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Dog,

Those who Herx on high dose minocycline may do so because of the species of CWD bacteria infecting them or because of the location of the bacteria. I don't think this has been studied. It's not an uncommon inital effect of minocycline and causes some doctors to automatically order doxycycline because it has fewer 'side effects'.

Best,

Meg


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