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kathleen
Member in Phase 2/3
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Posted: Fri Nov 12th, 2004 02:08 |
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Now that it's dark early I can do most errands after dark. There still are some days that I have to go out in the afternoon though. When I go out into the daylight, I'm all covered except for the lower 1/2 of my face.
Is the miconazole cream really helpful in blocking light? Might it cause trouble, being antifungal? Is the prescription ketoconazole cream more effective? And of course, will it raise havoc with my complexion (least important)?
Thank you, Kathleen
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CFS '86, LTD '86 (50 yrs old)pacemaker - total heart block '99 fatigue, cognitive, sleep, digestion, dysautonomia, weakness, headache, tinnitus, IC, new anemia 9/9/04 D,25 44 - D,125 76 4/05 D,25 24 4/05 Ben 40mg/6hrs, Mod Ph 2
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Reenie
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Posted: Fri Nov 12th, 2004 02:24 |
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kathleen says, "Is the prescription ketoconazole cream more effective?"
Ketoconazole 2%, is the cream recommended. It is an antifungal, but can be used as "sunblock."
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Posted: Fri Nov 12th, 2004 02:25 |
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Kathleen,
The study we cited used Ketoconazole 2% cream to prevent production of 1,25-D in the skin. I don't know if miconazole OTC would be as effective. It's not quite the same and I think it's a lower strength.
Topical antifungals in such a small amount should not affect the liver. I believe that during the short time I used K-cream it improved my complexion.
Best,
Meg
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Posted: Fri Nov 12th, 2004 05:13 |
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Kathleen,
The 2% ketoconazole cream isn't used to block sun, but instead because it supresses the skin's independent manufacture of 1,25-D in response to irradiation. The study reporting this is:
Demonstration of UVB-induced synthesis of 1 alpha,25-dihydroxyvitamin D3 (calcitriol) in human skin by microdialysis.
Arch Dermatol Res. 2003 Apr;295(1):24-8. Epub 2003 Mar 11.
PMID: 12709817 [PubMed - indexed for MEDLINE]
"Topical treatment of skin with an ointment containing 2% ketoconazole immediately after irradiation suppressed UVB-induced intraepidermal calcitriol synthesis."
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kathleen
Member in Phase 2/3
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Posted: Fri Nov 12th, 2004 20:01 |
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So, is it a good idea to use the K cream when we have to go outside during the day?
Kathleen
____________________
CFS '86, LTD '86 (50 yrs old)pacemaker - total heart block '99 fatigue, cognitive, sleep, digestion, dysautonomia, weakness, headache, tinnitus, IC, new anemia 9/9/04 D,25 44 - D,125 76 4/05 D,25 24 4/05 Ben 40mg/6hrs, Mod Ph 2
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Posted: Sat Nov 13th, 2004 07:27 |
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Kathleen,
From what we have gathered via research and limited trial, Ketoconazole 2% cream is a way to reduce the 1,25-D produced in exposed skin when you must go out. It should be safe when used infrequently and on a small area such as the face and neck.
Best,
Meg
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