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The Marshall Protocol Study Site > MEMBER DISCUSSION > Public Questions and Discussion > ARF and West China Hospital announces upcoming trial on ankylosing spondylitis


ARF and West China Hospital announces upcoming trial on ankylosing spondylitis
 Moderated by: Dr Trevor Marshall  

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paulalbert
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 Posted: Tue Jul 21st, 2009 16:34

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Hi All,

I'm very excited to share the latest press release by ARF announcing our collaboration with West China Hospital. Here is the full announcement:
http://www.eurekalert.org/pub_releases/2009-07/arf-sat072109.php

Coverage in other sources:
http://www.physorg.com/news167399813.html

Best,
Paul



____________________
Diag CFS 6.03 / sympt since 9.02 / exercise, food intol, sleep prob / 1,25D: 16, 4.06; 1,25D:27, 25D:26 7.04; 1,25D:43, 25D:6 6.05; 1,25D:17, 25D:8 8.05; / MP: 7.04 / Ph. 3 / Bacteriality
Rico
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 Posted: Tue Jul 21st, 2009 23:11

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Congratulations! This is truly exciting news!!


More coverage...

http://stateandlake.net/ado/2009/07/21/study-aims-to-induce-recovery-from-ankylosing-spondylitis/

http://sciencecodex.com/study_aims_to_induce_recovery_from_ankylosing_spondylitis

Last edited on Wed Jul 22nd, 2009 23:10 by Rico



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expate
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 Posted: Fri Aug 7th, 2009 16:16

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Exciting news. 

I have a dumb question (I know, what else is new?  ;)).  Looking at this quote from the press release, "The NIH Human Microbiome Project now estimates that approximately 90% of cells in the human body are bacterial or otherwise non-human in origin," it would seem like we really shouldn't want to kill all the bacteria in our bodies, that then we would only be left with 10% of what we are.  :shock:

While I need to lose a little weight, that seems excessive!  :P

Thoughts?

Odette



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Hypervitaminosis D 1,25D 52 pg/ml (3/08), 49 pg/ml (2/11), 25D 38 (3/08), 25D 34 (8/08), 25D 29 (10/08), 25D 14 (3/09), 25D 15: D3=15, D2<4 (6/09) 25D=9 (1/27/10), 25D=9, D3 9, D2<4 (2/20/11): all ng/ml, started Ph1 7/17/08, Ph2 11/4/08, Ph3 2/18/09
paulalbert
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 Posted: Fri Aug 7th, 2009 16:28

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Didn't you hear Trevor say that your body weight will be 20 pounds by the time you complete the MP??? :)

Actually, the explanation is that human cells tend to be much bigger and heavier than bacterial cells. A given human cell can contain 1,000+ intracellular bacteria cells.

Paul



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Diag CFS 6.03 / sympt since 9.02 / exercise, food intol, sleep prob / 1,25D: 16, 4.06; 1,25D:27, 25D:26 7.04; 1,25D:43, 25D:6 6.05; 1,25D:17, 25D:8 8.05; / MP: 7.04 / Ph. 3 / Bacteriality
expate
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 Posted: Fri Aug 7th, 2009 16:59

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I knew you brainiacs would have a reasonable answer!  ;)

Now, I'd be happy to shed 20 pounds.  I'd be the perfect weight to get back to ballet!!



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Hypervitaminosis D 1,25D 52 pg/ml (3/08), 49 pg/ml (2/11), 25D 38 (3/08), 25D 34 (8/08), 25D 29 (10/08), 25D 14 (3/09), 25D 15: D3=15, D2<4 (6/09) 25D=9 (1/27/10), 25D=9, D3 9, D2<4 (2/20/11): all ng/ml, started Ph1 7/17/08, Ph2 11/4/08, Ph3 2/18/09
terrylmcc
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 Posted: Fri Aug 7th, 2009 19:54

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Hi Paul, Or any other peoples that may have a comment on this matter.

While were on the subject. Regarding the90%, bacterial load. If the bacteria can transfer horizontally to the human genome. How does the MP process take out that bacterial DNA from the human DNA strand?
Is it even possible to rid that bacterial DNA from the human body?
Just thought i would ask the question, any comments or thoughts on this?
--Terry

If this question is in the wrong thread, feel free to move it. :)

Last edited on Fri Aug 7th, 2009 20:22 by terrylmcc



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paulalbert
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 Posted: Fri Aug 7th, 2009 20:43

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Terry,

It is my understanding that the immune system typically destroys these infected cells. That's why your white blood cell count declines as you do the MP and then rebounds later on - at least that's what happened to me anyway.

Paul



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jcwat101
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 Posted: Sun Aug 9th, 2009 01:31

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I would keep in mind that a lot of the bacteria they are talking about in these articles are in the gut lumen and not in contact with a lot of human cells.  In fact, the Human Biome project does not even contemplate the large amounts of bacteria we believe are inside our cells and tissues (they are thinking of those on the skin, in the gut and in the stomach, esophagus, ear canal, mouth, vagina, bladder etc...).

I would think it would be hard to get rid of bacterial DNA that has been transferred to human cells except through killing the human cells (some of this occurs when we kill bacteria -- apoptosis, or programmed cell death occurs). 

I would think that a lot of the cells would be replaced in time with healthy cells from uninfected stem cells.  I think I've read that most of the body regenerates in something like 7 or 10 years.  Perhaps there could be some DNA repair that would remove a bacterial gene -- maybe someone else knows.

I do know the body can repair at least some mutations.

Joyce Waterhouse

 



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Sallie Q
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 Posted: Sun Aug 9th, 2009 08:15

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jcwat101 wrote: I would think that a lot of the cells would be replaced in time with healthy cells from uninfected stem cells.  I think I've read that most of the body regenerates in something like 7 or 10 years. 
My understanding also Joyce, although a Science drop-out I remembered 7 years.

I assume therefore that MPers continually on Benicar for 7 years may accomplish a total clean-up :shock:



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y
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 Posted: Thu Dec 29th, 2011 16:27

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Paul, or anyone else who knows about this study,

Has it concluded? What, insights/results came out of it?

Do you have any details on how the study was conducted? For example, what medicines were used?  How were the patients chosen and how did they report? What things were measured?

Thanks ...




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Dr Trevor Marshall
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 Posted: Fri Dec 30th, 2011 01:15

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Y,
It hasn't started. WCH 'discovered' the new TNF-alpha inhibitor being made in China, and want to trial that instead, as the drug company salesmen promise cure of the disease, something we were too professional to promise.

There were other problems too. They relate to the issues you mention - the concurrent use of other meds, etc. We are maintaining contact with WCH, but there is no interest in the MP at this point.

The cohort I put together here at the MP site will continue to provide the data we need to push our efforts forward. The pushback we have experienced in the past about it not being 'controlled', being 'self-reported' etc, mostly disappeared during 2011. You will note there was wide acceptance of the data Titta and I presented in Singapore :) The case series and histories were also deemed acceptable to the publishers of our latest paper, part of the Nature Publishing Group :) So things are still moving forward at a nice pace...
 
At this point, anybody who will not accept the veracity of our published paper(s) and the presentations to leading International conferences is never going to be fully satisfied :)
 

y
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 Posted: Sat Dec 31st, 2011 13:38

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Ah, I see. Oh well; it would have been interesting if they had done it. Thanks for letting me know.



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MP Benicar only Sep'10; lyme '06, cfs '89, hashimoto's '03; fatigue/weakness, brain hijinks, joint/muscle pain; 125D 77 (8/10), 25D 6.1 (08/13)

 Current time is 17:38



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