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Aussie Barb
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| Joined: | Thu Jul 22nd, 2004 |
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Posted: Wed Apr 13th, 2005 05:54 |
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Infectious Etiology/Pathology of Sarcoidosis (click here)
More studies
Chlamydophila bacteria prevalent in Sarcoidosis patients
Detection of antibodies against Borrelia burgdorferi in patients with uveitis. Am J Ophthalmol. 1991 Jul 15;112(1):23-30. Isogai E, Isogai H, Kotake S, Yoshikawa K, Ichiishi A, Kosaka S, Sato N, Hayashi S, Oguma K, Ohno S. PMID: 1882917
[Borrelia burgdorferi may be the causal agent of sarcoidosis] PMID: 1582344 Zhonghua Nei Ke Za Zhi. 1992 Oct;30(10):631-3, 659.Note: 81% positive out of 33 patients with Sarc
[Spirochetes in the cheilits granulomatosa and sarcoidosis]
Zhonghua Yi Xue Za Zhi. 1993 Mar;73(3):142-4, 189-90.
PMID: 8391908
“Determination of antibody of Borrelia burgdorferi in the serum of patients with sarcoidosis and its significance” PZhonghua Nei Ke Za Zhi. 1994 Jan;33(1):15-7. MID: 8045180
“The diagnostic value of anti-BB-antibody estimation in acidosis” Zhonghua Jie He He Hu Xi Za Zhi. 1994 Jun;17(3):162-4, 190-1. PMID: 7834773 [PubMed - indexed for MEDLINE]
“Detection of Borrelia burgdorferi DNA in granulomatous tissues from patients with sarcoidosis using polymerase chain reaction in situ technique” Zhonghua Jie He He Hu Xi Za Zhi. 1996 Oct;19(5):279-81
Positive Lyme titers in a patient with active sarcoidosis.
Sarcoidosis Vasc Diffuse Lung Dis. 1997 Mar;14(1):86. No abstract available. Graber TA, Ejazuddin S. PMID: 9186996
"Seroprevalence of anti-Borrelia antibodies amoung patients with confirmed sarcoidosis in a region of Japan where Lyme borreliosis is endemic" Graefe's Arch Clin Exp Opthalmol (1998) 236:280-284 Ishihara, Ohno, Ono, Isogai, Kimura, Isogai, Aoki, Ishida, Suzuki, Kotake, Hiraga
Molecular Analysis of Sarcoidosis Tissues for Mycobacterium Species DNA Emerging and Infectious Diseases
Presence of Rickettsia helvetica in granulomatous tissue from patients with sarcoidosis. J Infect Dis. 2002 Apr 15;185(8):1128-38.
Mycobacterial DNA in recurrent sarcoidosis in the transplanted lung - a PCR-based study on four cases Virchows Archiv Apr 2000;436(4):365 - 369.
Identification of mycobacterial DNA in cutaneous lesions of sarcoidosis. J Cutan Pathol. 1999 Jul;26(6):271-8.
Identification of Mycobacterium avium complex in sarcoidosis.
J Clin Microbiol. 1996 September; 34(9): 2240–2245.
Pulmonary sarcoidosis: could mycoplasma-like organisms be a cause? Sarcoidosis Vasc Diffuse Lung Dis. 1996 Mar;13(1):38-42
Growth of acid fast L forms from the blood of patients with sarcoidosis. Thorax. 1996 May;51(5):530-3.
Histologic observations of variably acid-fast pleomorphic bacteria in systemic sarcoidosis: a report of 3 cases. Growth. 1982 Summer;46(2):113-25.
The nature and physical characteristics of a transmissible agent from human sarcoid tissue. Ann N Y Acad Sci. 1976;278:233-48.
Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis.
The presence of Propionibacterium spp. in the vitreous fluid of uveitis patients with sarcoidosis. Acta Ophthalmol Scand. 2005 Jun;83(3):364-9. PMID: 15948792
"Using a cDNA microarray to study cellular gene expression altered by Mycobacterium tuberculosis"
RT-PCR analysis of selected mRNA expression in response to M.tuberculosis H37Ra infection. (Note particularly bcl-2 in Fig1. This is used as a marker in the flow-cytometry assays for cancer - yet it is activated by intraphagocytic infection.)
"Multinucleate giant cells and the control of chemokine secretion in response to Mycobacterium tuberculosis."
Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis. (Links between viral and bacterial pathogens.)
Gene expression profiling analysis of Mycobacterium tuberculosis genesin response to salicylate. Department of Molecular Microbiology and Immunology Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
Role of infectious agents in systemic rheumatic diseases.
Clin Exp Rheumatol. 2008 Jan-Feb;26(1 Suppl 48):S27-32.
Considering an infectious etiology of sarcoidosis.
Clin. Dermatol. 2007 May-Jun;25(3):259-66.
Ezzie ME, Crouser ED.
Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University Medical Center, Columbus, OH 43210-1252, USA.
Sarcoidosis is a systemic granulomatous disease of unknown cause. An infectious etiology of sarcoidosis has long been suspected, but only recently has scientific evidence provided a strong link between infectious agents and sarcoidosis. Moreover, recent advances in our understanding of the relationships between sarcoidosis phenotype and host genetic factors may further illuminate the mechanisms linking infection and sarcoidosis. PMID: 17560303 [code]Last edited on Sun Aug 24th, 2008 21:07 by
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Barb: Dx Inflammatory Disease Endocrine Imbalance 2003| Depression| 24+ years not Dx| MP Aug04| ABC of MP| MP Search|
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Foundation Staff.
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Posted: Wed Apr 13th, 2005 16:58 |
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Bacterial evidence for chronic idiopathic diseases
Emerging Infectious Determinants of Chronic Diseases
Siobhán M. O'Connor, Christopher E. Taylor, and James M. Hughes Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †National Institutes of Health, Bethesda, Maryland, USA; and Emory University, Atlanta, Georgia, USA
Infectious agents and the etiology of chronic idiopathic diseases.
Curr Clin Top Infect Dis. 1998;18:180-200. Review.
Uncultivable Bacteria: Implications and recent trends towards identification
Bhattacharya, N Vijayalakshmi, *SC Parija
Diseases due to uncultivable bacteria could represent emerging infectious diseases. However, the growing importance of these pathogens remains ill understood and undefined. Non-culture based approaches, especially molecular genetic methods are evolving as the most important tool in our understanding of these enigmatic pathogens. This article attempts to discuss the scientific implications of the evolution of uncultivable bacteria, review the recent trends in identification, and highlight their relevance in clinical medicine.
Detection and Identification of Previously Unrecognized Microbial Pathogens.
David A. Relman
Stanford University, Stanford, California, USA, and Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
Does Blood of Healthy Subjects Contain Bacterial Ribosomal DNA?
Journal of Clinical Microbiology, May 2001 Simo Nikkari, Ian J. McLaughlin, Wanli Bi, Deborah E. Dodge, and David A. Relman
Department of Microbiology and Immunology and Department of Medicine, Stanford University School of Medicine, Stanford, California 94305; Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304; and Applied Biosystems, Foster City, California 94404
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Aussie Barb
Research Team
| Joined: | Thu Jul 22nd, 2004 |
| Location: | Australia |
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Posted: Wed Jun 15th, 2005 20:52 |
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(filelink)
Fibromyalgia
Latent intracellular macrophage colonies are an important causal factor in Sarcoidosis and Fibromyalgia (FMS) inflammation.
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Barb: Dx Inflammatory Disease Endocrine Imbalance 2003| Depression| 24+ years not Dx| MP Aug04| ABC of MP| MP Search|
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Aussie Barb
Research Team
| Joined: | Thu Jul 22nd, 2004 |
| Location: | Australia |
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Posted: Fri Jul 22nd, 2005 23:27 |
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(filelink)
Multiple sclerosis
Interesting new abstract about MS as an infection
Epidemiology and etiology of multiple sclerosis.
Phys Med Rehabil Clin N Am. 2005 May;16(2):327-49.
PMID: 15893675
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Barb: Dx Inflammatory Disease Endocrine Imbalance 2003| Depression| 24+ years not Dx| MP Aug04| ABC of MP| MP Search|
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| Joined: | Sat Jul 10th, 2004 |
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Posted: Wed Aug 10th, 2005 05:50 |
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Studies Citing Bacterial Causelink
Crohn's disease
Crohn's disease uveitis. Parasitization of vitreous leukocytes by mollicute-like organisms.
Am J Clin Pathol. 1989 Mar;91(3):259-64.
Johnson LA, Wirostko E, Wirostko WJ.
http://tinyurl.com/dh8th
"Uveitis is a symptom, and has many identified causes and associations at this point. Some cases are widely accepted to be due to bacteria or viruses. Other cases are associated with “autoimmune diseases” like Crohns disease and rheumatic arthritis. I suspect that these other cases are due to CWD bacteria. There are several interesting papers that explore this. The researchers found cell-wall deficient bacteria (sometimes called mollicute-like organisms) in the vitreous fluid of patients with sardoidosis, Crohn’s disease, ulcerative colitis, juvenile rheumatoid arthritis, etc."
See also Crohn's Disease Information
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Posted: Wed Sep 7th, 2005 23:11 |
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(filelink)
ALS (Lou Gehrig's Disease)
Cell Wall-Deficient (CWD) Bacterial Pathogens: Could Amylotrophic Lateral Sclerosis (ALS) Be Due to One?
Authors: Koch, Arthur L.
Source: Critical Reviews in Microbiology; Jul-Sep2003, Vol. 29 Issue 3, p215-221, 7p
Abstract: Recently, a number of diseases that had been thought previously to be caused by something other than an infectious agent are now known to be caused by bacteria. It now appears that it is not uncommon that bacteria, viruses, or fungi can cause diseases even when
these organisms have not been detected or cultured. The most recent, well-publicized case is that of stomach ulcers; these are largely due to Helicobacter pylori infections. Here, the possibility is explored that
amylotrophic lateral sclerosis (ALS) is caused by a cell wall-deficient microorganism.
Author Affiliations: 1Biology Department, Indiana University, Bloomington, IN 47405-6801, USA
ISSN: 1040-841X Accession Number: 11262074
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Foundation Staff
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Posted: Sat Dec 3rd, 2005 01:38 |
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Osteoarthritis
(filelink)
The Promise of a Tetracycline Antibiotic for Treating Osteoarthritis
Kenneth D. Brandt; Steven A. Mazzuca; Barry P. Katz; Kathleen A. Lane; Kenneth A. Buckwalter; David E. Yocum; Frederick Wolfe; Thomas J. Schnitzer; Larry W. Moreland; Susan Manzi; John D. Bradley; Leena Sharma; Chester V. Oddis; Steven T. Hugenberg; Louis W. Heck Arthritis & Rheumatism. 2005;52(7):2015-2025. ©2005 Wiley InterScience Posted 08/22/2005
Study Shows Effectiveness of Doxycycline in Slowing Disease Progression
A tetracycline antibiotic, doxycycline, has been successfully used to treat a wide-range of bacterial infections. In addition to its effects as an antibiotic, doxycycline has other actions as a drug and, in laboratory studies with animals and with human tissue, can inhibit the degradation of cartilage in a way that could be useful for the treatment of osteoarthritis
(OA). OA is a common form of arthritis associated with pain and disability related to the breakdown of cartilage, the tissue in the joint that absorbs shock and promotes smooth movement On the strength of preclinical evidence, a team of rheumatologists affiliated with six clinical research centers across the United States conducted the first long-term clinical trial to determine the benefits of doxycycline in the treatment of OA-particularly, OA of the knee. Their findings, featured in the July 2005 issue of Arthritis & Rheumatism, suggest that doxycycline may slow the progression of joint damage and point to the need for further research into the drug's effect on the signs and symptoms of this disease.
For the trial, the team recruited 431 overweight women between the ages of 45 and 64 with moderately advanced OA in one knee. The subjects were randomly assigned to receive either 100 milligrams of doxycycline or a placebo twice a day for 30 months. At baseline, the 2 treatment groups were roughly equal with respect to all demographic variables, body mass index, and types of drugs taken for pain, as well as for the x-ray severity of OA in the affected knee and the level of knee pain and functional impairment. OA progression was assessed by measuring joint space narrowing in the medial tibiofemoral compartment through X-rays obtained at baseline, 16 months and 30 months. Severity of joint pain was assessed every 6 months after a washout period of all nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics.
Seventy-one percent of the subjects completed the treatment protocol. Radiographs were obtained from 85 percent of all subjects at 30 months. After 16 months of treatment, the mean loss of joint space width in the diseased knee in the doxycycline group was 40 percent less than in the placebo group. After 30 months, it was 33 percent less. Yet, despite significantly slowing disease progression, doxycycline did not reduce the severity of joint pain. However, mean pain scores at baseline were low in both treatment groups, leaving only limited opportunity to demonstrate improvement in joint pain. On the other hand, the drug significantly reduced the frequency with which subjects reported increases in knee pain 20 percent or greater than the level of pain they had at their previous semi-annual visit.
Notably, doxycycline seemed to have no effect on joint space narrowing or pain in the relatively disease-free knee. In both knees in both treatment groups, the rate of joint space narrowing was more than twice as rapid in subjects who reported frequent increases in pain than in those with a stable pain score. "Joint pain may serve as an indicator of synovitis that leads to cartilage destruction," observes the study's leading author, Kenneth D. Brandt, M.D.
Throughout the trial, fewer than 5 percent of all subjects reported side effects. In general, doxycycline seemed to be well tolerated. Subjects in the active treatment group experienced the unexpected side benefits of fewer urinary tract and upper respiratory tract infections than their placebo counterparts.
In conclusion, in this study, doxcycyline showed benefits in slowing the rate of joint space narrowing in knees with established OA. Whether this drug has any value in the early treatment and symptomatic management of OA, however, will require further investigation. Last edited on Thu Jul 26th, 2007 05:16 by Foundation Staff
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jrfoutin
Research Team
| Joined: | Tue Aug 9th, 2005 |
| Location: | Oregon USA |
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Posted: Fri Mar 3rd, 2006 18:31 |
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filelink
Scleroderma
Bacterial Infection as the Cause of Scleroderma:
A Guide to Antibiotic Therapy
by Dr. Alan Cantwell MD, Pat Ganger
This easy-read article (with pictures) is intended as an Internet guide to considering this disease for antibiotic therapy, and a review of supporting literature. Dr Cantwell's illuminating microscopic work and understanding of CWD pathogens occupies the first half of the article. Pat Ganger completes the article as she describes her use of The Road Back therapy in the mid 1980's and how it saved her life (A 1995 Canadian study by Abu-Shakra and Lee showed 61% of systemic scleroderma patients died within 9 years).
Pat Ganger continues to take minocycline today, 23 years later. (MPer's might see this as a complementary, but limited antibiotic therapy by today's MP standards, but also, there was no MP in 1985.)
Dr. Cantwell reported finding pleomorphic bacteria in the skin of scleroderma patients over 20 years ago.
Member joanbpass: Scleroderma: Assessing my improvements
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Sarcoidosis 125D61, MP10/05 ModP2 12/05 Ph2 6/06 Ph3 10/06, NoIRs limited outings covered, 2/08 25D6.2, 10/08 25D6.9
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Aussie Barb
Research Team
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Posted: Mon Jun 19th, 2006 04:15 |
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Vitiligo [filelink]
The skin symptom Vitiligo may simply be another symptom of your disease. Some of us have had this depigmentation effect, too. We offer these citations for consideration.
http://tinyurl.com/5feur
Autoimmune aspects of depigmentation in vitiligo.
http://tinyurl.com/53jp7
Subcutaneous sarcoidosis associated with vitiligo, pernicious anaemia and autoimmune thyroiditis.
http://tinyurl.com/4v47d
Cutaneous manifestations of systemic diseases.
NALP1 in Vitiligo-Associated Multiple Autoimmune Disease
Conclusions DNA sequence variants in the NALP1 region are associated with the risk of several epidemiologically associated autoimmune and autoinflammatory diseases, implicating the innate immune system in the pathogenesis of these disorders. http://content.nejm.org/cgi/content/full/356/12/1216
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Barb: Dx Inflammatory Disease Endocrine Imbalance 2003| Depression| 24+ years not Dx| MP Aug04| ABC of MP| MP Search|
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