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Dr Trevor Marshall
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The video of my presentation at Bio21 is now online at URLs

http://autoimmunityresearch.org/bio21.ram
and
http://autoimmunityresearch.org/bio21b.ram
and
http://autoimmunityresearch.org/bio21a.ram

You can download the whole 50 Megabytes of the presentation, which is worthwhile if you want to view it more than once, from the URLs
http://82.192.67.82/downloads/bio21.rm or
http://autoimmunityresearch.org/bio21.rm or
http://www.borelioza.tivi.pl/downloads/mp/bio21.rm

More details can be found in the flyer at URL http://autoimmunityresearch.org/Marshall_Bio21_flyer.pdf

: 20 page PDF transcript, aprox 5MB
(Suggested: PC users right click, choose "save target as" or "save file as" and open from saved location. Mac users Cmd+Click and choose "save to desktop," then open downloaded file.)

The scientific content is somewhat similar to the presentation I gave at AAEM in October, but several key slides have been added, and the emphasis has been changed to more basic science, in keeping with the University audience. This is essentially the same content as in the presentation I had given at Australian National University's John Curtin School of Medical Research on the previous day.

Note particularly the new slide at 10:45 into the presentation, explaining why antibodies are not what makes Th1 patients so sick.

The Foundation has produced a DVD containing the AAEM presentation, this Bio21 presentation, and my FDA 'Visiting Professor' presentation, and this DVD is being sent to people who request the AAEM presentation on our website.


(those of you who have recently been sent the AAEM talk will (eventually) be updated with the new DVD)

wrotek
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Wrotek's mirror

http://autoimmunityresearch.org/bio21.ram

Last edited on Thu Dec 7th, 2006 22:17 by Dr Trevor Marshall

Dr Trevor Marshall
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Thanks Wrotek :)

wrotek
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My pleasure :)

Jvancan
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Another mirror HTTP:
http://autoimmunityresearch.org/bio21b.ram
The full download link is at:
http://82.192.67.82/downloads/bio21.rm
MD5 checksum: 70554ef2d70135b520dd1a972b8af378 (size: 52,7 MB)


Free Realplayer software to play the video on Windows OS:
http://www.free-codecs.com/download/Real_Alternative.htm

Last edited on Fri Dec 8th, 2006 09:21 by Dr Trevor Marshall

Dr Trevor Marshall
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Thanks, Jeroen:)

wrotek
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Dr Marshall You have  shown that Olmesartan docks to MRSA genome. I am wondering if vitamin D has affinity to bacterial genome receptors ?

tickbite
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Great work Dr. M. Not to be critical, but you seem even more relaxed and confident in your presentations. Thanks so much for working so well. I also want to say that i'm really fascinated and intrigued watching the Q&A stuff at the ends of your presentations. Sometimes i'm flabbergasted at some of the questions you receive. I think watching you answering questions from physicians and scientists gives me more insight into the science. I come up against questions from others around me and sometimes find it difficult to answer in a clear and concise way. It would be really cool to get an "out takes" film of you answering questions.....

~Greg

MarkN
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I enjoyed this presentation, less details so I was able to understand it better than the AAEM. The Q&A at the end was very helpful.

shamutooth
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Trevor,what a compelling video.Is it OK to forward it to Kraft and let them know that they face potentially devestating consequences if/when the class action suits start flying? This video, I'm sure, would be a dream come true for any class action attorney.

Dr Trevor Marshall
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I think it is better to keep a low profile with Kraft right now. In any case, in about a month, the Australian Foundation will be writing about Kraft starting to put Vit D in Australian cheeses too.

wrotek
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Recently i have encountered movies in new real media file format called RMVB .

The  compression is very good (i don't see any significant loss of quality) and the files are much smaller. For example full length movie (when the same movie in divx format would have 700MB)  may have 500 MB or less, if it is cartoon it can have as low as 300MB (the lowest i saw were about 250MB ).

Since MP presentations are built basically from static slides , this RealMedia Variable Bitrate (RMVB) file format may be a very usefull tool for saving web space.

Last edited on Thu Dec 14th, 2006 00:23 by wrotek

Dr Trevor Marshall
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Wrotek, I have been using 2-pass, variable birate, encoding:)

wrotek
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Ah, ok. I am curious what RMVB is exactly then.

Julia
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I downloaded this, which took ages, and I didn't have time to watch it.  Now I can't find it!  Neither can 'search' - it brings it up in Temporary Internet Files, but when I try to open it, it just opens Real Player which says it can't find the clip.  The shortcut I put on the desktop can't find it either.  Any suggestions from all you computer buffs out there? :(

wrotek
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Julia i see two possibilities why this happened .

1) U downloaded ram extension file which is for streaming only

2) u clicked on rm file with Your left mouse button and chose "open", when u should click right mouse button on it and "save as".

tickbite
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Trevor, I really like the feedback loops you've made. Those help so much to understand. Anyway, I would like to know more about plasmids and how they interact pathogenically. I'm really having a tough time trying to figure out what they do and how they do it, etc. For me, when I try and think about the pea-soup theory the words 'unified theory' come up in my mind. 

I read something about Copper ion dumping in response to TB infection. Is this just a novel mechanism for targeted drug therapy? Does innate immunity and proper receptor functioning trump just about everything when we talk about curative therapy? 

Thanks, ~Greg

Julia
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Wrotek,

Trevor said:
You can download the whole 50 Megabytes of the presentation, which is worthwhile if you want to view it more than once, from the URLs http://82.192.67.82/downloads/bio21.rm or http://autoimmunityresearch.org/bio21.rm or http://www.borelioza.tivi.pl/downloads/mp/bio21.rmThe first two links didn't work for me, so I clicked on the third.  I left-clicked, but it didn't give me any options, just started downloading to 'temporary folder'.  It took about half an hour, so surely it must have put it somewhere, even if I didn't specify 'save as'?

wrotek
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I am intrested in plasmids too, particulary how they are shared with other bacteria species and if Borrelia "blebs" have something to do with plasmids.

How plasmids are beeing picked up by other bacteira ?

Julia, do it again with third link but this time click right mouse button on it and choose "save as". What U did is u saved files to temporary internet file folder where it was deleted after u used it.

Last edited on Thu Dec 14th, 2006 21:51 by wrotek

norman
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Hi,

So I just watched your video- very interesting as usual. If I understand correctly, are plasmids just part of a bacteria ( not actually living) but the body reacts to them as an infection, or are they in fact alive?

At the end of your seminar, the host seemed, well, a bit skeptical it seemed. Maybe it was shock- lol. Did you have any further conversations with him? What did he and others at the conference think?  It was a bit disheartening that he still mentioned your ideas as "radical" and that you might have a long road to hoe. Ah well maybe, as they say, nothing worthwhile in life comes easy,

Dr Trevor Marshall
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Norman,
Academics interact a little bit differently from the average "man-in-the-street." The welcome I got at University of Melbourne was warm, and my discussion with the attendees at the drinks-gathering after the presentation was exceptionally stimulating.

I took the context of the 'long road to hoe' (in the the closing remarks) as being with reference to Barry Marshall's Nobel Prize, and few would argue that we have some years still to go before acceptance of the MP to the level of Nobel.

tickbite
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Plasmids..........

Transposons..........

Also, I know this has nothing to do with this thread but this is interesting news:

Antibody Therapy Prevents Type 1 Diabetes In Mice

~Grego

norman
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Thanks for the info and the article. I guess I am not sure what to make of the article. The article seems to indicate a genetic problem, correct?

norman
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Ah, thanks for the reply Trevor. I guess I seemed to take it differently, as if he was saying " novel idea, but not for us" but I guess I interpreted those marks differently.

 I wish you the best of luck (obviously- lol). I have to tell you, it seems to me that I am seeing, what seems to me, to be more and more people with autoimmune disorders!  I have told quite a few people about your site, and hopefully my aunt will be starting this soon ( she's getting close to getting approval from doc I hope !)

Hopefully there will be another conference soon so I can meet more of the wonderful people I am talking to on here.

Take care!

Norman

tickbite
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Hey Norman,

The only reason why I would think that the antibodies worked "when the researchers transferred a certain subset of T-cells from anti-CD137-treated mice that expressed two other receptors known as CD4 and CD25 to other immune-deficient NOD mice, it prevented the onset of diabetes in the recipient mice" (S.D. http://www.sciencedaily.com/releases/2007/01/070108121653.htm)

is because "An antibody or immunoglobulin is a large Y-shaped protein used by the immune system to identify and neutralize foreign objects like bacteria and viruses. Each antibody recognizes a specific antigen unique to its target." (wiki http://en.wikipedia.org/wiki/Antibody)

Genetic predisposition? or infectious genetics? or CWD forms embedded within the phagocytes? IMO, normal base rate mutation is a blip compared to infectious mutation occuring in mankind these days.

I'm not for sure though, i'm still researching genetics and i'm an amatuer. Mutagens have been catching my eye recently.  



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