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Minocycline is an excellent Anti-inflammatory
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  4  5  Next Page Last Page  
 

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mvanwink5
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 Posted: Sat Apr 20th, 2013 08:33

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A dose of mino before a date?



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Joyful
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 Posted: Sat Apr 20th, 2013 19:34

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Gilly wrote:Do you trust these shoes? Or will you, after mino, recognize that they will kill your feet? Inquiring minds want to know.
LOLOLOLOLOL



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David_in_UK
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 Posted: Sun Apr 21st, 2013 04:05

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I find that minocycline does have quite a profound effect on my mental state and improves my mood. It's a much better antidepressant than antidepressants.



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GillyB
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 Posted: Mon Apr 22nd, 2013 12:51

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So, I'm asking for an opinion:

If I were to take minocycline for its anitdepressant effects only, would I be better off using a pulsed approach, or take it more regularly?  Should I start now before I'm off of these meds, or wait until I notice any uptick in IP?

I'm weaning off my HRT meds, and hopefully my AD meds eventually, and it would be nice to have something available to help if my neuro IP became too much.



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David_in_UK
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 Posted: Mon Apr 22nd, 2013 14:24

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GillyB wrote:
So, I'm asking for an opinion:

If I were to take minocycline for its anitdepressant effects only, would I be better off using a pulsed approach, or take it more regularly?  Should I start now before I'm off of these meds, or wait until I notice any uptick in IP?

I'm weaning off my HRT meds, and hopefully my AD meds eventually, and it would be nice to have something available to help if my neuro IP became too much.


I think regular rather than pulsed - within the MP guidelines up to 50mg every 12 hours is OK, which I find to be quite enough to have the desired effect.

I don't see why you shouldn't try it first without dropping your other meds - that would make sense to me.

Of course it might not work for everyone, but it definitely works for me.



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Bane
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 Posted: Thu Jun 27th, 2013 04:07

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Oral Minocycline in Treatment of Cutaneous Sarcoidosis

http://archderm.jamanetwork.com/article.aspx?articleid=1698603

"Of 27 patients, 6 (22%) had complete remission; 14 (52%) had partial remission; and 7 (26%) had no remission. Of the 2 severe ulcerative cases, 1 achieved a partial remission and 1 no remission. In total, 20 of 27 (74%) patients showed response to the treatment, and the proportion of those who responded was significantly greater than those who did not respond. There was no difference in the response of minocycline across age, race, or sex"

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Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death

http://tiny.cc/yf6bzw

"Mino induced autophagy by eliciting endoplasmic reticulum stress response and switched cell death from autophagy to apoptosis when autophagy was blocked"

Bane
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 Posted: Sat Jul 20th, 2013 04:20

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Minocycline targets NF-kcyB pathway through suppression of TGF-β1-TAK1-IkcyB kinase axis in ovarian cancer: in vitro and in vivo studies.

http://www.ncbi.nlm.nih.gov/pubmed/23858099

"Both acute and chronic administration of minocycline led to suppression of p65 phosphorylation and nuclear translocation accompanied by down-regulation of NF-κB activity and endogenous protein levels of its dependent gene products. Our results reveal the therapeutic potential of minocycline as an agent targeting the pro-oncogenic TGF-β-NF-κB pathway in ovarian cancer"

Kas
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 Posted: Mon Jul 22nd, 2013 13:09

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http://www.purdue.edu/newsroom/releases/2013/Q3/researcher-finds-way-to-convert-blood-cells-into-autoimmune-disease-treatment.html


What do you all make of the above article?



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Joyful
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 Posted: Mon Jul 22nd, 2013 15:30

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So they are teaching your own white blood cells to stop attacking whatever your body was targeting?

I guess that would be call immune suppression.

Here was an interesting part of their story:Kim discovered that naïve T-cells cultured in the presence of the hormone progesterone can be induced to become suppressive T-cells.

Haven't we read many times that progesterone is an immune suppressor of some sort. Not that we aren't modulating our immune system all the time, but personally I've gone to a lot of trouble and expense to go onto a protocol that stimulates my immune system (the MP!). :)



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leroybrown
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 Posted: Tue Jul 23rd, 2013 05:10

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This is just off the top of my head so I might be wrong, but I thought that the MP will slowly make your immune system less reactive (by eliminating pathogens), therefore your suppressor T cells should increase, and the cytotoxic ones decrease.

The article doesn't address eliminating pathogens.

Deb



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Bane
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 Posted: Wed Jul 27th, 2016 14:49

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Minocycline attenuates interferon-α-induced impairments in rat fear extinction

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928293/

Administering minocycline prevented IFN-α from impairing fear extinction. The immunohistochemical and biochemical results show that minocycline inhibited IFN-α-induced microglial activation and reduced IL-1β and TNF-α production.


Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879188/

When stressed mice were treated with minocycline, the observed gut microbiota changes included increase in relative abundance of Akkermansia spp. and Blautia spp., which are compatible with beneficial effects of attenuated inflammation and rebalance of gut microbiota, respectively, and the increment in Lachnospiracea abundance was consistent with microbiota changes of caspase-1 deficiency.

Prof Trevor Marshall
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 Posted: Wed Jul 27th, 2016 22:35

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Bane wrote: When stressed mice were treated with minocycline, the observed gut microbiota changes included increase in relative abundance of Akkermansia spp. and Blautia spp., which are compatible with beneficial effects of attenuated inflammation and rebalance of gut microbiota, respectively, and the increment in Lachnospiracea abundance was consistent with microbiota changes of caspase-1 deficiency.
 
And there you have 100% of the reason I moved away from antibiotic palliation in 2008. I decided it was best to let the body figure out what species it wanted to thin down without interference from ingested antibiotics.

That was a decade ago, and I didn't have this experimental data back then, but it was obvious (to me) how the drugs worked at the molecular level, and that they would cause the microbiome imbalance which has been documented in this study.



mvanwink5
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 Posted: Thu Jul 28th, 2016 00:04

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Antibiotics in food through treatment of animals is a problem. Plus the antibiotics distorts the animal's Microbiome, a double whammy.



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Cairo123
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 Posted: Fri Jul 29th, 2016 06:15

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The existence of antibiotics in meat fed to animals is one of many good reasons to avoid meat and other animal products that comes off of the feedlot sometimes referred to as CAFOs. Most if not virtually all meat and other animal products bought in the supermarket will have this problem. This can be avoided by buying direct from a farmer that does not administer anti-biotics and only feeds his livestock grass.



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mvanwink5
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 Posted: Fri Jul 29th, 2016 14:35

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For that reason I buy my cheese as 100% grass fed from:
http://simplycheese.net
I can't find it local so I have to order it.



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Grateful Survivor
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 Posted: Sat Aug 6th, 2016 03:23

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Mike I checked their website and the grass fed cheeses look great--but I can't figure out how large their "units" are--how many ounces, do you know?  I know they're gonna cost more than at the store, but I want to know how much more....
Tx, Grateful



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Cairo123
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 Posted: Sat Aug 6th, 2016 03:30

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Here is where I buy my organic grass fed cheese. They have confirmed that they do not fortify with A or D.

http://www.swisslandcheese.com/



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mvanwink5
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 Posted: Sat Aug 6th, 2016 17:05

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Grateful,
I have been using 'Simply Cheese' for a couple of years and just recently they have raised their prices markedly. No idea why, market I suppose.

I am trying to switch to their normal cheese in hopes it is the same as their 'grass fed'. I can't get grass fed anywhere locally. Locally even milk is unavailable as 'grass fed.

'Units'? I am unsure what that is referring to, perhaps their discount? Anyway they do have a discount for repeat business, If I recall correctly I think it is about 5%. A bit tricky to apply to your order though. If you have trouble and need assistance PM me.



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Lyme joints, EMF sensitive, MP start 8/10; 25D 5.6ng/ml 9/16; vegetarian; olmesartan only-240mg/d, coffee as needed, RF shielding required, My Progress: http://tinyurl.com/z2stwo8
Joyful
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 Posted: Sat Aug 6th, 2016 18:36

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If you work with a local health food store, you might be able to get them to order what you want at a better price?

Looks like there are stores in Massachusetts that carry one my favorite brands: http://rumianocheese.com/
 

Last edited on Sat Aug 6th, 2016 18:40 by Joyful



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 Posted: Wed Jun 6th, 2018 17:27

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Here is some new data on TLR2 which expression is reduced with mino(https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-5-15)

https://www.ncbi.nlm.nih.gov/pubmed/27695100
Borrelia burgdorferi is transmitted into the skin of the host where it encounters and interacts with two dendritic cell (DC) subsets; Langerhans cells (LCs) and dermal DCs (DDCs). These cells recognize pathogens via pattern recognition receptors, mature and migrate out of the skin into draining lymph nodes, where they orchestrate adaptive immune responses. In order to investigate the response of skin DCs during the early immunopathogenesis of Lyme borreliosis, we injected B. burgdorferi intradermally into full-thickness human skin and studied the migration of DCs out of the skin, the activation profile and phenotype of migrated cells. We found a significant increase in the migration of LCs and DDCs in response to B. burgdorferi. Notably, migration was prevented by blocking TLR2. DCs migrated from skin inoculated with higher numbers of spirochetes expressed significantly higher levels of CD83 and produced pro-inflammatory cytokines. No difference was observed in the expression of HLA-DR, CD86, CD38, or CCR7. To conclude, we have established an ex vivo human skin model to study DC-B. burgdorferi interactions. Using this model, we have demonstrated that B. burgdorferi-induced DC migration is mediated by TLR2. Our findings underscore the utility of this model as a valuable tool to study immunity to spirochetal infections.



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