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"All autoimmune diseases have the same mechanism"
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2   
 

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mvanwink5
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 Posted: Thu Jul 4th, 2013 04:23

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Oh my, so is it possible Salmonella prolongs its GI flora impact by a rapid intracellular invasion and significant modification of intracellular microbiota? Is that right thinking?

I now remember the news article about Salmonella porcine proliferation triggered by slaughter house cortisol release. Article release in 2011, that sounds about right. I am not sure I connected it to Salmonella proliferation caused by quorum triggering via stress hormones. I do now.

The pin ball machine has lit up.



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Lyme joints, EMF sensitive, MP start 8/10; 25D 5.6ng/ml 9/16; vegetarian; olmesartan only-240mg/d, coffee as needed, RF shielding required, My Progress: http://tinyurl.com/z2stwo8
Prof Trevor Marshall
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 Posted: Thu Jul 4th, 2013 05:17

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Yup...

mvanwink5
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 Posted: Sun Jul 7th, 2013 05:23

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Dr. Marshall,
Dr Trevor Marshall wrote:
Well, isn't Salmonella one of the persistent intraphagocytic pathogens? It seems to be, at least in pigs...
mvanwink5 wrote: so is it possible Salmonella prolongs its GI flora impact by a rapid intracellular invasion and significant modification of intracellular microbiota? Is that right thinking?
Answer:Yup...
I can only infer that without olmesartan supported VDR activation, there is no hope against Salmonella intracellular efficacy in humans, especially since Salmonella can persist in pigs where the VDR is not the key to intracellular AMP innate immune protection.

This being the case, that there are pathogens such as Salmonella with such a broad intracellular innate immunity, It would seem that olmesartan is essential for humans, even healthy humans. Dr. Marshall, have you reached the same conclusion?

If so, that would be an important position to take on health maintenance and disease prevention.

One more question, would one expect that with a healthy person who is taking olmesartan dosed at 40 mg q4h plus serum 25D levels below suppressive levels, that is exposed to Salmonella, that the long term impact on gut flora spectrum would be avoided? One could then raise serum 25D levels and see what that does. Wouldn't that be a definitive research test?
Best regards
Mike

Last edited on Sun Jul 7th, 2013 05:30 by mvanwink5



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Prof Trevor Marshall
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 Posted: Sun Jul 7th, 2013 06:26

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Mike,
Most people die because of "diseases of the aging." These diseases are chronic, and result from the microbiome those folk have accumulated during their lifetime. There are many steps which need to be made to reduce that accumulation. Olmesartan is certainly an intervention which could be used after failed attempts at reducing the accumulation.

You will note that I am getting very involved in "Predictive and Preventative Medicine" which focuses on this very issue. Stopping people getting ill in the first place. We have many decades of work ahead of us, I think.

..Trevor..

mvanwink5
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 Posted: Sun Jul 7th, 2013 06:44

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However, it is a test that doesn't take a decade, would be repeatable, and supports the model. Plus it would be relatively inexpensive. It might not be 100% persuasive but would cast serious doubt on the D3 in, goodness and health out pragma. (I have friends that would say it is not daylight outside at high noon.)

It might also be important just to see what protection is gained for our cohort from continued olmesartan use once they have reached their target symptom reduction levels.

Just some thoughts...

Thanks,
Mike



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Lyme joints, EMF sensitive, MP start 8/10; 25D 5.6ng/ml 9/16; vegetarian; olmesartan only-240mg/d, coffee as needed, RF shielding required, My Progress: http://tinyurl.com/z2stwo8
mvanwink5
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 Posted: Mon Jul 8th, 2013 00:52

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lncRNA - organizers of genes

How some unusual RNA molecules home in on targets


The findings suggests a unique role for a class of RNAs, called lncRNAs, which Guttman and his colleagues at the Broad Institute of MIT and Harvard first characterized in 2009. Until then, these lncRNAs -- short for long, noncoding RNAs and pronounced "link RNAs" -- had been largely overlooked because they lie in between the genes that code for proteins. Guttman and others have since shown that lncRNAs scaffold, or bring together and organize, key proteins involved in the packaging of genetic information to regulate gene expression -- controlling cell fate in some stem cells, for example.
In the new work, the researchers found that lncRNAs can easily locate and bind to nearby genes. Then, with the help of proteins that reorganize genetic material, the molecules can pull in additional related genes and move to new sites, building up a "compartment" where many genes can be regulated all at once.
"You can now think about these lncRNAs as a way to bring together genes that are needed for common function into a single physical region and then regulate them as a set, rather than individually," Guttman says. "They are not just scaffolds of proteins but actual organizers of genes."


Functional organization, then, seems to be critical for cell behavior. It would not be a stretch to suspect intracellular innate immunity to also depend on such organizing lncRNA molecules. It also would suggest another pathway for immune disruption by diabolic bacteria invasion tools.

Last edited on Mon Jul 8th, 2013 00:57 by mvanwink5



____________________
Lyme joints, EMF sensitive, MP start 8/10; 25D 5.6ng/ml 9/16; vegetarian; olmesartan only-240mg/d, coffee as needed, RF shielding required, My Progress: http://tinyurl.com/z2stwo8
Prof Trevor Marshall
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 Posted: Mon Jul 8th, 2013 05:55

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mvanwink5 wrote: It might also be important just to see what protection is gained for our cohort from continued olmesartan use once they have reached their target symptom reduction levels.
Mike, this is the wrong way of thinking about health. IMO Health has nothing to do with symptoms, but with body functioning. My symptoms (largely) disappeared years ago, yet my body (and especially my mind) continues to incrementally function better, year by year. It is important to be able to quantify health. That is one use for Prof Poletaev's natural autoantibody testing. It is not quantifying disease, but a sensitive indicator that homeostasis is getting along just fine :)

As for molecular complexity, that has been known for some time. For example, look at at this 2007 paper: ncbi.nlm.nih.gov/pubmed/17368181

The recent work of Eva Nogale's lab has also underlined transcriptional complexity. Download the video from her paper at

http://www.nature.com/nature/journal/v495/n7442/full/nature11991.html

video: http://www.nature.com/nature/journal/v495/n7442/fig_tab/nature11991_SV1.html

for a real eye-opener...

stuckpac
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 Posted: Mon Jul 8th, 2013 09:50

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So what are we to make of this ARB-produced sprue-like enteropathy?

http://www.empr.com/fda-olmesartan-linked-to-intestinal-disorder/article/301689/?DCMP=EMC-MPR_WeeklyNewsbrief&CPN=eliqcard&spMailingID=6500088&spUserID=NDExODQ4MDI2NTUS1&spJobID=77570037&spReportId=Nzc1NzAwMzcS1

Prof Trevor Marshall
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 Posted: Mon Jul 8th, 2013 11:05

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"sprue-like enteropathy"

Why are we surprised that Olmesartan has properties which the FDA was not expecting? Old-fashioned thinking is what led Mayo to identify this one result of immunopathology, and no others. Sheer incompetence is what led FDA to myopia on this one aspect of Olmesartan's actions.

Any competent researcher would have used a Google search to locate our papers on Olmesartan's actions in the GI tract, such as "Immunostimulation in the era of the Metagenome," but competence seems severely lacking in most medical research these days...

The FDA also has inches of paperwork on file from us over the last seven years detailing Olmesartan's immune activity, and, to this date, their reaction has been disbelief. Not disbelief as in "tell us more," but disbelief as in "please go away: :)

..Trevor..

stuckpac
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 Posted: Mon Jul 8th, 2013 11:15

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I was thinking in a similar vein. Since celiac sprue is in the realm of "autoimmune" diseases, none of US are surprised with that type of reaction to olmasartan. Next they'll spend several million tax dollars and grant money that could be well-spent elsewhere trying to figure out why this would happen with an ARB. And the drug company will now need to spend millions fighting lawsuits because of this "unexpected adverse outcome, etc."

Even though I work in medicine, I am so distant from this whole phenomena and it still bothers me. I can't imagine how much it must bother you to have spent so much of your life and career on this and have people ignore your investigations.

All I can say is thanks for the help that you have given so many of us on the MP and..... Hang in there!

lorenzo von matterhorn
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 Posted: Tue Feb 16th, 2016 22:10

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Some more news on immune stimulating therapies.

"Revolutionary" Cancer Therapy Yields Extraordinary Results In Human Trials

http://www.iflscience.com/health-and-medicine/revolutionary-cancer-therapy-yields-unprecedented-results

I'm guessing some of this is what we call IP?

It’s important to note, however, that some patients experienced severe side-effects, including neurological problems and decreases in blood pressure, which the researchers are now working towards reducing.



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Sallie Q
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 Posted: Sun Feb 21st, 2016 23:50

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so they will come smack up against the usual immune restoration dilemma...
how to ameliorate the IP without helping microbes to stealthily suppress VDR functions :?



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minski2
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 Posted: Thu Mar 3rd, 2016 17:09

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Dr. Marshall..... just read "Timeline for MP" and saw that you were diagnosed with Pulmonary Hypertension at the beginning of your health problems. I have just been given the same diagnosis,but I disagree with the Drs. stated cause. I have never had high blood pressure and delayed starting the MP because BP was on the low side. As you know the MP has been very good to me and I credit it with getting me this far...83 in April. I had an ECHO because for several years I have been complaining that I felt I needed oxygen, but the tests would not confirm that. I went ahead and bought an oxygen concentrator and not amazing to me I no longer have tetany and can do a full body stretch without going into a full body spasm! So that is a good thing but how can I convince these Drs. not only do I not have low blood pressure, but I take 6 arbs a day!!! I have ascertained that these symptoms come and go with my use of antibiotics and until recently I was completely off and just started back with Benicar and Roxithromycin. This is also the pattern with my Lyme and what ever other bugs(Brucella) I have. I have had lung problems (4 spontaneous pneumothorax) years ago,but that was resolved by attaching lung to pleura and after exploratory surgery deemed lung in perfect condition. I guess what I am asking is how can I convince these guys that it's bacteria!!!!!

Thanks for listening.....Dian (minski)



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Prof Trevor Marshall
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 Posted: Thu Mar 3rd, 2016 17:15

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Dian, I am not a physician, so to me it sounds like there could be microwave radiation entering your environment. Ask for a Sniffer, and let's discuss the readings it gives you.

minski2
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 Posted: Thu Mar 3rd, 2016 18:48

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Dr. Marshall,

I know you are not an MD but considerably more intelligent than the people I have access to. I already have my order in for the sniffer. Just this morning I had an AT&T installer here to change from Time Warner and he informed me that my WiFi has not been disconnected as Time Warner assured me! He disconnected it!!!!!! So I unknowingly have had it for the last 8 months or more when I requested the removal. I long for the good old days!!!!!!!!!!!!!

Dian



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y
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 Posted: Tue Mar 8th, 2016 04:10

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That's frustrating, Dian. Those things won't happen once you have a sniffer. It's grrrrrrrrrreat.



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minski2
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 Posted: Tue Mar 8th, 2016 13:37

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Y, thanks for the encouragement! It's getting harder and harder to stay positive!
Dian



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Sallie Q
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 Posted: Sat Sep 15th, 2018 05:34

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Prof Trevor Marshall wrote: Dian, I am not a physician, so to me it sounds like there could be microwave radiation entering your environment. Ask for a Sniffer, and let's discuss the readings it gives you.


and here is Prof. Marshall's practical solution:- Building a DIY Faraday Cage



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