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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Chlorogenic Acid in Coffee is powerful Immune modulator


Chlorogenic Acid in Coffee is powerful Immune modulator
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Nick B.
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 Posted: Thu Mar 29th, 2012 13:13

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Wrotek - great find !!

>  The Solanaceae cause at least two known health problems. They contain cholinesterase inhibiting glycoalkaloids and steroids [6,34,35,36] including, among others, the drugs solanine in potato and eggplant, tomatine in tomato, nicotine in tobacco, and capsaicin in garden peppers. When these inhibitors accumulate in the body, alone or with other cholinesterase inhibitors such as caffeine or food impurities containing systemic cholinesterase inhibiting pesticides, the result may be a paralytic-like muscle spasm, aches, pains, tenderness, inflammation, and stiff body movements

Does this mean that we should add these foods, to the list of foods to be avoided !

:(



Nick B



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Limburg
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 Posted: Thu Mar 29th, 2012 14:04

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Sorry to interrupt in your thread, but if this is right, how to fit in bacteria as a cause of disease?
I mean, how can we tell the difference between bacteria and Solanaceae/caffeine/pesticides/etc.etc. as a cause of disease/symptoms?

I'm just a lay person in research items, but reading all this is rather confusing.

It could mean the MP is rather unnecessary and avoiding all the (pathogenic) substances is the way to heal.

Or the MP is the right way and will eliminate the above?

Or a combination of the two above is a better way to heal?

Anyway, you can see that I'm confused :shock:

I respect your searches and hope it contributes to the way we function as human beings and brings more solutions to healing.

Last edited on Thu Mar 29th, 2012 14:09 by Limburg



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wrotek
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 Posted: Thu Mar 29th, 2012 14:43

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Nick B. wrote:
Wrotek - great find !!
> The Solanaceae cause at least two known health problems. They contain cholinesterase inhibiting glycoalkaloids and steroids [6,34,35,36] including, among others, the drugs solanine in potato and eggplant, tomatine in tomato, nicotine in tobacco, and capsaicin in garden peppers. When these inhibitors accumulate in the body, alone or with other cholinesterase inhibitors such as caffeine or food impurities containing systemic cholinesterase inhibiting pesticides, the result may be a paralytic-like muscle spasm, aches, pains, tenderness, inflammation, and stiff body movements

Does this mean that we should add these foods, to the list of foods to be avoided !





Nick B




Lets not get too much excited, Dr Marshall needs to comment on that. I dont know how reliable these informations are.

Last edited on Thu Mar 29th, 2012 14:44 by wrotek



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keithw
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 Posted: Thu Mar 29th, 2012 15:07

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There is little doubt that nightshades are a major problem in society due to marketing and convenience and could be considered a poisonous substance when taken in large amounts.
The body can process them and extract food value but the toxins build up and are slow to be voided which is where I believe the problem lies, we eat far too many of them.

Bacteria are a different matter as are virus strains as they move in and breed which changes us and MP is about teaching the immune system to recognise them and kill them.

Oxygen is another matter, we don't get enough!
Life on this planet developed under an Oxygen content of about 30% but since the industrial revolution this has dropped to about 20% and if you live in a major city with a high pollution index the level may be as low as 10%!

Then there are the other additives which we consume, Coffee in point on this thread and this is the purpose of posting on forums, we spread information.

We advise on MP and help you understand the treatment but we sometimes have to look outside the square for reasons why some people seem to progress faster than others and at the moment we are having some success with advising people to eliminate or at least minimise the amount of nightshades in there diet.

At the moment we are short on info on this topic so I am starting a new topic called Nightshades and I will copy this post into it so the coffee people can have their thread back!

http://www.marshallprotocol.com/view_topic.php?id=14732&forum_id=39

:dude:



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Ron
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 Posted: Thu Mar 29th, 2012 20:28

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wrotek wrote: Do Nightshades contain Vitamin D 3 ?
http://noarthritis.com/research.htm

Osteoarthritis appears to be a result of long-term consumption and/or use of the Solanaceae which contain naturally the active metabolite, vitamin D3, which in excess causes crippling and early disability (as seen in livestock). Rigid omission of Solanaceae, with other minor diet adjustments, has resulted in positive to marked improvement in arthritis and general health.

Hi Wrotek, thanks for drawing attention to the nightshade plants, maybe awareness of possible problems and avoiding them could help some members relieve IP. However, I don't think the insights of Dr. Norman F. Childers are very accurate.

http://noarthritis.com/vitaminD3.htm

In our early work, arthritic cooperators were warned against excess intake of vitamin D3 (ten times more active than vitamin D) from consumption and use of nightshades- potato, tomato, eggplant, tobacco, and peppers of all kinds except black pepper (another plant family, Piperaceae). Later, it was found that a deficiency of vitamin D also could be a problem with osteoporosis and other health problems. So, monitoring of vitamin D intake is paramount to get about 400 to 500 IU per day from either 20 to 30 minutes of sun daily or from a multivitamin/mineral pill if confined or during a low-light winter period.
See also Prof. Marshall's comments in this thread:

http://www.marshallprotocol.com/forum11/13722.html

Best,
Ron

wrotek
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 Posted: Fri Mar 30th, 2012 02:59

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I see the subject was discussed at this level and the little compendium is already available. Thanks Ron .
The fact that 1.25-D degrades fastly is strong argument.

Hi Wrotek, thanks for drawing attention to the nightshade plants, maybe awareness of possible problems and avoiding them could help some members relieve IP.

Relieving IP ? Intersting idea, escpecially that not everybody seems to experience symptoms from nightshades.
Or maybe people dont realize symptoms until they quit.
Data indicate that solanecae toxins accumulate in fat.
It takes 6-7 weeks of nightshade abstinence to observe significant to moderate relief .

Last edited on Fri Mar 30th, 2012 03:40 by wrotek



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wrotek
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 Posted: Fri Apr 20th, 2012 03:02

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Since caffeine increases blood sugar levels(i am trying to find out how much)...
Caffeine Blocks Insulin
Gabe Mirkin, M.D.

http://www.drmirkin.com/diabetes/9897.html


It is amazing how increased blood sugar levels can be bad for health, which of course is very visible in diabetic patients.

Another interesting article
New Zealand woman’s Coca-Cola habit cited in death
http://lifestyle.inquirer.net/44197/new-zealand-womans-coca-cola-habit-cited-in-death

Last edited on Fri Apr 20th, 2012 03:12 by wrotek



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Kas
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 Posted: Fri Apr 20th, 2012 11:39

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http://www.independent.co.uk/life-style/health-and-families/researchers-report-surprising-news-about-coffee-and-diabetes-2188259.html


I am a pre diabetic. I allow myself about one cup of week coffee with some almond milk once a week or so, and I have never found that my sugar numbers were raised afterwards.

Seems there are such different opinions about coffee out there....



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wrotek
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 Posted: Sat Apr 21st, 2012 01:09

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Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test.

http://www.ncbi.nlm.nih.gov/pubmed/11478588

Abstract

We tested the hypothesis that caffeine ingestion results in an exaggerated response in blood glucose and (or) insulin during an oral glucose tolerance test (OGTT). Young, fit adult males (n = 18) underwent 2 OGTT. The subjects ingested caffeine (5 mg/kg) or placebo (double blind) and 1 h later ingested 75 g of dextrose. There were no differences between the fasted levels of serum insulin, C peptide, blood glucose, or lactate and there were no differences within or between trials in these measures prior to the OGTT. Following the OGTT, all of these parameters increased (P < or = 0.05) for the duration of the OGTT. Caffeine ingestion resulted in an increase (P < or = 0.05) in serum fatty acids, glycerol, and plasma epinephrine prior to the OGTT. During the OGTT, these parameters decreased to match those of the placebo trial. In the caffeine trial the serum insulin and C peptide concentrations were significantly greater (P < or = 0.001) than for placebo for the last 90 min of the OGTT and the area under the curve (AUC) for both measures were 60 and 37% greater (P < or = 0.001), respectively. This prolonged, increased elevation in insulin did not result in a lower blood glucose level; in fact, the AUC for blood glucose was 24% greater (P = 0.20) in the caffeine treatment group. The data support our hypothesis that caffeine ingestion results in a greater increase in insulin concentration during an OGTT. This, together with a trend towards a greater rather than a more modest response in blood glucose, suggests that caffeine ingestion may have resulted in insulin resistance.

PMID:
11478588
[PubMed - indexed for MEDLINE]



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wrotek
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 Posted: Sat Apr 21st, 2012 05:33

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And here some regarding decaffeinated coffee
The Effect of green, roasted and decaffeinated coffee on
serum glucose, insulin and serum lipid profile in diabetic rat models.

http://www.jofamericanscience.org/journals/am-sci/am0610/114_3760am0610_968_977.pdf

Conclusion :   The observed improvement in glucose ,insulin profile , triacylglycerol and HDL-C confirm the
potent biological action of green, roasted and decaffeinated coffee and suggest that chlorogenic acid (a component in
coffee ) might have an antagonistic effect on glucose transport.
Suggesting a novel function of coffee on lowering
the risk factors of diabetes and delaying the progress of diabetes complications as well. [



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wrotek
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 Posted: Fri Apr 27th, 2012 03:30

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Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles.

http://www.ncbi.nlm.nih.gov/pubmed/20180783

Caffeine and theophylline completely blocked insulin-stimulated glucose uptake in both soleus and epitrochlearis muscles at 10 mm.



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wrotek
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 Posted: Fri Apr 27th, 2012 15:34

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Decaffeinated coffee and glucose metabolism in young men.

http://www.ncbi.nlm.nih.gov/pubmed/19918017



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IngeD
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 Posted: Sat Apr 28th, 2012 00:50

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Kas wrote:
http://www.independent.co.uk/life-style/health-and-families/researchers-report-surprising-news-about-coffee-and-diabetes-2188259.html


I am a pre diabetic. I allow myself about one cup of week coffee with some almond milk once a week or so, and I have never found that my sugar numbers were raised afterwards.

Seems there are such different opinions about coffee out there....


Hi Kas. I can't imagine 1 cup a week could cause issues?



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wrotek
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 Posted: Sun May 6th, 2012 07:57

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Caffeine Impairs Glucose Metabolism in
Type 2 Diabetes


http://care.diabetesjournals.org/content/27/8/2047.full



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Santa Monica
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 Posted: Wed May 23rd, 2012 19:32

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OK, so as a non- coffee drinker, I have been hypnotized by the green coffee bean craze. One popular website says:


"Chlorogenic acid is a compound present in coffee which has been long known for its beneficial properties. It is an antioxidant, which means it destroys the free radicals formed in the body as a result of metabolism. These free radicals if left as they are, destroy cell membranes and contribute to symptoms of aging. By destroying these harmful free radicals, green coffee bean extract actually slows down the onset of aging.

The chlorogenic acids present in the extract also help alleviate high blood pressure levels and can be helpful in treating hypertension. By neutralizing free radicals and regenerating vitamin E, Green Coffee Bean Extract has been shown to inhibit lipid and LDL peroxidation, thereby promoting cardiovascular health.

Because this green bean has not been boiled, it lacks cafestol, which is a diterpene. Cafestol is associated with the negative effects of using coffee as a stimulant, and increases the levels of bad cholesterol or LDG.

"Green coffee bean extract has also been found to promote weight loss. This weight loss is due to the natural chemical compounds, caffeine and chlorogenic acid. The caffeine from the coffee releases fatty acids from stored body fat, while the chlorogenic acid assists the liver in processing the fatty acids more efficiently, which together contribute to weight loss. Also, the green coffee bean extract boosts metabolism by altering the way in which glucose is absorbed in the body. The caffeic acids act as a stimulant and boosts the energy levels as well.

Green Coffee Bean Extract promotes glucose regulation and balance by inhibiting the activity of glucose-6-phosphatase, an enzyme involved in the release of glucose from liver stores, thus slowing the release of glucose into the blood."

Ok, so the thing I'm looking at is: "Because this green bean has not been boiled, it lacks cafestol, which is a diterpene. Cafestol is associated with the negative effects of using coffee as a stimulant, and increases the levels of bad cholesterol or LDG."

Could it be that cafestol is the thing that we react to, and not chlorogenic acid? Cafestol is a known anti inflammatory. Could it be cafestol, and not chlorogenic acid, that inhibits wellness?



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Cynthia S
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 Posted: Thu May 24th, 2012 07:50

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Well, as far as the cooking (boiling) to produce Cafestol, remember that fresh apple skins are a known IP reducer, so that sort of puts a monkey wrench in your idea that cafestol is the active ingredient in coffee that is mildly immune suppressive.

These people put forth a great many effects of their green coffee bean extract.  I have to ask the question how they have so much technical info.  I would be willing to bet that a great deal of it is supposition from outward effects.  Certainly the loss of weight can be the reduction of inflammation, and the resulting loss of water that accompanies inflamed tissue.

Cynthia



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wrotek
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 Posted: Fri May 25th, 2012 02:57

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Sure, cafestol was discussed in this topic, and the cholesterol rising effect means that it has big effect on human body.



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Santa Monica
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 Posted: Fri May 25th, 2012 06:48

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Ah crud. was hoping for a miracle:(



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wrotek
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 Posted: Thu May 31st, 2012 14:15

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Adenosine Receptors and Wound Healing

http://goo.gl/nJsoS



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Sallie Q
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 Posted: Sat Jun 2nd, 2012 17:39

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bingo
the last explains why all the methtrexate that US doctors prescribed for my daughter did not prevent her from being certifiably crippled by RA
She is as badly addicted to coffee as I am :D



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