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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Great news - they have found what causes ALS, and other motor-neuron diseases


Great news - they have found what causes ALS, and other motor-neuron diseases
 Moderated by: Prof Trevor Marshall
 

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Prof Trevor Marshall
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 Posted: Sun Aug 21st, 2011 21:32

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An excellent example of why current paradigms of medical research will not produce solutions for disease, even when the answer is staring them in the face, can be found in this BBC story:

http://www.bbc.co.uk/news/health-14591364

Here are the problems I see with the way disease research is conducted these days.

1. All research attempts to identify a single defective pathway, so that it can potentially be addressed with a (patentable) single drug

2. Discovery is focused on getting more research grants, not on providing immediate solutions. According to the non-profit which drives this funding:
"We've known for some time that the waste and recycling system in motor neurons is damaged, but this is the first time that there has been direct proof. This discovery provides researchers with an exciting new avenue to explore as they search for an effective treatment."
So where is the incentive for "out of the box" thinking when it is easier to get funding for your research by reinforcing the current way of thinking...

..Trevor..
 

Russ
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 Posted: Sun Aug 21st, 2011 23:28

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How would the MP address this issue with the cell recycling system?



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 Posted: Sun Aug 21st, 2011 23:51

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Russ, how have we done that?

1. By understanding that the cell cycle is very, very complex, and that reductionist approaches will never lead to a cure. You cannot reduce a hundred pathways down to one protein

2. By standing back and recognizing the way that the human microbiome inside phagocytic cells causes a cascade of thousands of dysfunctional cellular pathways, including those involved in the cell cycle.

3. By identifying a potential solution, and immediately making that knowledge generally accessible, so that it can be quickly tested. This has cut decades off the normal drug-delivery timetables



Where have we failed?

1. By telling the truth, especially since that truth is unpalatable to those looking for a simplistic, drug-based, answer, we are not attracting the funding which would be such a help in moving our discoveries to widespread implementation :)
 

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 Posted: Sun Aug 21st, 2011 23:55

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This is definitely good news as they are getting closer to identifying the cause of ALS with this study.  But they are still not focusing enough on the possible pathogenic causes ... like l-forms and such! 

If the protein recycling problem identified by these researchers is caused by the accumulated microbiota ... then the MP should fix the problem over time! 

I also agree with Dr Marshall that these researchers appear to be more interested in patenting another drug or getting funding ... than identifying WHAT is causing this protein recycling problem in the first place.  But that would mean there might be existing drugs and even treatments like the MP that could solve the problem!  :X



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 Posted: Mon Aug 22nd, 2011 05:27

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It's the same with hematology. All the research is done on mice & zebrafish. Do I look like a zebrafish? :X



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 Posted: Mon Aug 22nd, 2011 13:29

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I got an interesting reply from a doctor friend of mine that I thought I'd share on here:

Chris, interesting news -- I'd like to read the original article in the journal Nature but I don't subscribe.   As background information about protein degradation pathways you might like this piece describing the work that won a Nobel Prize in 2004.   http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2004/public.html     Although it does not discuss the UBQLN2 protein it does describe "ubiquitination machinery" and mentions some instances in which infection can influence protein degradation pathways.

Interesting that this Nobel Prize winning research DOES mention infection as a possible cause of the dysfunction of the protein pathways.



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 Posted: Mon Aug 22nd, 2011 14:37

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Dr. Marshall,

You are an absolutely wonderful teacher.  The science you have taught me has provided far more understanding of the world than I learned in college.

Information, by its very nature, yearns to be free.  IMHO.  What has been so beatifully explained here will only grow onwards.  And that is success.

Sherry



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findinganswers
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 Posted: Mon Aug 22nd, 2011 17:11

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I was listening to NPR the other day and I heard mentioned "The Patient Centered Outcomes Research Institute" (a lady from there was speaking - they were talking about cancer). I looked it up (http://pcori.org) and it appears the Marshall Protocol is compatible with their goals:

"The Patient-Centered Outcomes Research Institute (PCORI) is an independent organization created to help patients, clinicians, purchasers and policy makers make better informed health decisions. PCORI will commission research that is responsive to the values and interests of patients and will provide patients and their caregivers with reliable, evidence-based information for the health care choices they face.
 

PCORI is committed to transparency and a rigorous stakeholder-driven process that emphasizes patient engagement. PCORI will use a series of forums and formal public comment periods to increase awareness of its work and obtain public input and feedback prior to adoption of priorities, agendas, methodological standards, peer review processes or dissemination strategies"

Maybe if enough MPers provide feedback, ARF could get some funding or at least more exposure for the MP (which might then lead to funding) through them.

From their list of "Initial Topics for PCORI's Tier 1 Pilot Projects" (http://pcori.org/tier1topics.html):

"2. Developing, testing, and/or evaluating methods for bringing together patients, caregivers, clinicians and non-traditional partners in all stages of a multi-stakeholder research process, from the generation and prioritization of research questions to the conduct and analysis of a study to dissemination of study results.
3. Developing, testing, and/or evaluating novel processes for translating research findings into changes in health care practices"

They are asking for feedback on these topics and for suggestions for additional topics. From http://pcori.org/provideinput/tier1input.html:
"
All of the pilot projects will focus on methods and approaches appropriate to PCOR, including observational methodologies . . . qualitative methodologies . . ."

Is http://www.marshallprotocol.com an example of an "observational methodology," as they put it? It seems like Dr. Blaney is an example of number 2 above.



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 Posted: Tue Aug 23rd, 2011 00:15

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On a similar theme:

'As recently as the 1970s, America’s universities were heavily influenced, if not completely driven, by faculty ideas and concerns. Today, institutions of higher education are mainly controlled by administrators and staffers who make the rules and increasingly set the priorities of academic life....

'With regard to research, academics tend to take the view that ideas and discoveries should be broadly disseminated through peer-reviewed publications and presentations at professional meetings. Some professors, to be sure, are interested in the possibility of profiting from their discoveries. But most professors are more concerned with the process of discovery and the professional recognition that comes from developing new ideas in the laboratory, and they see any pecuniary gain to themselves as incidental to their main goals.

'University administrators, on the other hand, view faculty research mainly as a source of revenue for the institution. They are not particularly entranced by its intellectual merits, except when commissioning puff pieces for the alumni magazine. In recent years, through the introduction of technology transfer offices, administrators have taken charge of knowledge dissemination. To administrators, scientific discoveries are primarily sources of hundreds of millions of dollars in potential overhead fees and licensing fees.'

http://the-scientist.com/2011/08/01/faculty-fallout/



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Prof Trevor Marshall
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 Posted: Tue Aug 23rd, 2011 00:38

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I agree with Frenchie's post 100%, but note that the corruption of academic principles  is still not so bad Internationally, especially in Europe and China. And I think Russia too, although I haven't had a chance to take a first hand look there yet.

Findinganswers, PCORI is just one of many government initiatives which just cannot throw off the bonds of the past. If you look at their management boards, eg http://www.gao.gov/press/pcori_2011jan21.html , you find the establishment figures firmly entrenched. Do you see any names there who might actually be interested in advancing patient health as their first priority?

Having said that, the best way for these organizations to find out about our work (other than Google) is for our members to contact them, and suggest PCORI (etc) should be looking at what we have done, and where we are going. I am happy to spend time  with anybody who calls or emails me :) I would be appreciative if any of you could put aside some time to make some phone calls with follow-up emails :)

..Trevor..
 
 

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 Posted: Tue Aug 23rd, 2011 06:40

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Great news!  I phoned to ask if they're accepting input from outside the US and YES they are! :D

Last edited on Tue Aug 23rd, 2011 06:42 by SharonN



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 Posted: Tue Aug 23rd, 2011 06:42

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Would someone suggest wording for contacting this organization?

Thanks,

Sherry



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Prof Trevor Marshall
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 Posted: Tue Aug 23rd, 2011 06:58

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Wording is best if left to the individual, Sherry, no need to make it an essay. The shorter the better. Two paragraphs maximum, I think.

However I would suggest sending a PDF copy of each of the following two documents:

http://AutoimmunityResearch.org/transcripts/ICA2008_Transcript_TomPerez.pdf
and
http://autoimmunityresearch.org/preprints/Proal2010CellularMolecularImmunologyPreprint.pdf

to explain in scientific terms what we have done, by using collaborative "Patient Centered Outcomes" to confirm our theoretically-based discovery :)
 


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 Posted: Tue Aug 23rd, 2011 09:00

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Great links, Dr. Marshall - Thank you!
I've just sent them to my son who is studying bio-medical engineering in hope that he will start challenging his professors' thinking and research methodologies.



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 Posted: Tue Aug 23rd, 2011 11:55

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I submitted the form online, and also will send in two papers via U.S. mail tonight after work.

The deadline for input is September 2, 20110.

http://www.pcori.org

Sherry



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 Posted: Tue Aug 23rd, 2011 12:15

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Dr Marshall, do you know if anybody has tried any of the DNA sequencing work on ALS brain tissues to see if there are DNA fingerprints of pathogens in these destroyed motor neurons?  If they have and found nothing, how would that be explained?



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 Posted: Tue Aug 23rd, 2011 20:35

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I submitted my feedback as well last night on the website:
http://www.pcori.org
This seems to be just the beginning where they are taking feedback on the goals of the institute and such. When we will really need to let our voices be heard is when they begin doing the studies on the efficacy of different treatments / protocols (actually says the word "protocols" in the statute). I would think anyone who has had a diagnosed condition improve on the MP should let them hear about it. It appears they are going to be doing comparative analysis studies on the available treatments for specific conditions. So once those studies start, anyone with a diagnosed condition that has improved on the MP - let your voice be heard!



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Prof Trevor Marshall
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 Posted: Tue Aug 23rd, 2011 21:13

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Chris, autopsy tissues are not much good, as the pathogens disintegrate once the patient dies. Those videos we show of the infected cells have to be taken between 6 and 36  hours after being drawn (in the blood). After 36 hours all that are left are bits and pieces.

I haven't heard of anybody doing sequencing of fresh human brain tissue.
 

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 Posted: Sat Nov 19th, 2011 02:27

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if this protocol fails i will surely give the arf a piece of my brain. hopefully the hospital will comply.:X:)



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