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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Chlorogenic Acid in Coffee is powerful Immune modulator


Chlorogenic Acid in Coffee is powerful Immune modulator
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  ...  31  32  33  34  35  36   
 

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Ron
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 Posted: Thu Sep 21st, 2017 22:14

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As I recall this point was also addressed in the Vitamin D and MS Summit talk back in 2010. It led to an interesting Q&A session afterwards. "Magic" :-)

https://youtu.be/iO-f0cqnz-4?t=6m58s

https://youtu.be/iO-f0cqnz-4?t=29m54s

wrotek
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 Posted: Sat Apr 14th, 2018 12:20

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Regarding first movie, when 1.25-D binds to thyroid receptor, Dr Marshall said that it causes thyroiditis. Why ? Should not it cause thyroid insufficiency ? Why inflammation ?



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jrfoutin
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 Posted: Wed Apr 18th, 2018 22:50

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"Hashimoto's thyroiditis is the most common cause of hypothyroidism in the United States." (https://www.thyroid.org/thyroiditis/)

That seems to help support the idea that "hypo" (insufficiency) is the rational expectation per blocking thyroid hormones from activating receptor, as described in Dr Marshall's discussion in video https://youtu.be/iO-f0cqnz-4?t=6m58s about 14:45.



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wrotek
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 Posted: Thu Apr 19th, 2018 09:47

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I see it is about thyroid cells being infected to produce 1,25-D in excess, blood 1,25-d would not affect it and displace thyroid hormones ?



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wrotek
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 Posted: Sun Apr 22nd, 2018 12:31

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478213/#B31

Tea and coffee consumption in relation to vitamin D and calcium levels in Saudi adolescents

Methylxanthine, theophylline and caffeine were found to inhibit the conversion of 25 hydroxyvitamin D3, to 1,25 dihydroxyvitamin D3 in isolated renal tubules in vitamin D deficient chicks, which led to increased vitamin D circulating levels [22].

Circulating 25-hydroxyvitamin D levels were significantly elevated among girls consuming coffee 9–12 times per week, even after adjusting for age and BMI.

Last edited on Sun Apr 22nd, 2018 13:22 by wrotek



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Dmitry
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 Posted: Mon Apr 23rd, 2018 08:52

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Very nice find - shows that even a small amounts of immune inhibitors have a profound impact on our bodies!

Here is the picture of tea consumption vs D25 levels from the above study:



Tea has some anti NF-κB properties:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339285/



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wrotek
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 Posted: Mon Apr 23rd, 2018 14:52

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https://www.ncbi.nlm.nih.gov/pubmed/29678503

Caffeine inhibits STAT1 signaling and downregulates inflammatory pathways involved in autoimmunity.


TNF and PPARG were suppressed even with the lowest caffeine dose tested, which corresponds to the serum concentration of caffeine after administration of one cup of coffee

Last edited on Mon Apr 23rd, 2018 14:53 by wrotek



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jrfoutin
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 Posted: Mon Apr 23rd, 2018 15:52

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For a long time I was a tad annoyed that the terminology in studies carried a huge bias load in popular but errant perspectives of good/bad wanted/unwanted effect per "deficiency" and "immune suppressing," for example. Certainly, dumping more 25D into humans has produced plenty of human-based research over the last 15 years.

That misunderstanding process is currently buying a lot of studies with plenty of zeal per long-held standard consumption habits around the planet for feel-good indigestibles, too. For most of the same misconceptions per what is good and what is bad, Humans will be used in many of those studies because of absolute confidence in the value of pain and inflammation, so the fear that keeps new drug studies in murine models will be abandoned without question.

So maybe it is a good thing people are eager to believe coffee and tea are their buddies. There will be many humans available and willing to participate in those studies that are helping to define immune processes (circulating and cellular).

Maybe, when the flip side comprehension of the value and purpose of pain and inflammation and how that impacts longevity is understood better, then the objective study data can be rolled into metastudy analysis for better clarity.

Dunno. Just musing.



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