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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Chlorogenic Acid in Coffee is powerful Immune modulator


Chlorogenic Acid in Coffee is powerful Immune modulator
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Ron
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 Posted: Thu Sep 21st, 2017 23:14

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As I recall this point was also addressed in the Vitamin D and MS Summit talk back in 2010. It led to an interesting Q&A session afterwards. "Magic" :-)

https://youtu.be/iO-f0cqnz-4?t=6m58s

https://youtu.be/iO-f0cqnz-4?t=29m54s

wrotek
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 Posted: Sat Apr 14th, 2018 13:20

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Regarding first movie, when 1.25-D binds to thyroid receptor, Dr Marshall said that it causes thyroiditis. Why ? Should not it cause thyroid insufficiency ? Why inflammation ?



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jrfoutin
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 Posted: Wed Apr 18th, 2018 23:50

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"Hashimoto's thyroiditis is the most common cause of hypothyroidism in the United States." (https://www.thyroid.org/thyroiditis/)

That seems to help support the idea that "hypo" (insufficiency) is the rational expectation per blocking thyroid hormones from activating receptor, as described in Dr Marshall's discussion in video https://youtu.be/iO-f0cqnz-4?t=6m58s about 14:45.



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wrotek
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 Posted: Thu Apr 19th, 2018 10:47

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I see it is about thyroid cells being infected to produce 1,25-D in excess, blood 1,25-d would not affect it and displace thyroid hormones ?



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wrotek
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 Posted: Sun Apr 22nd, 2018 13:31

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478213/#B31

Tea and coffee consumption in relation to vitamin D and calcium levels in Saudi adolescents

Methylxanthine, theophylline and caffeine were found to inhibit the conversion of 25 hydroxyvitamin D3, to 1,25 dihydroxyvitamin D3 in isolated renal tubules in vitamin D deficient chicks, which led to increased vitamin D circulating levels [22].

Circulating 25-hydroxyvitamin D levels were significantly elevated among girls consuming coffee 9–12 times per week, even after adjusting for age and BMI.

Last edited on Sun Apr 22nd, 2018 14:22 by wrotek



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Dmitry
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 Posted: Mon Apr 23rd, 2018 09:52

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Very nice find - shows that even a small amounts of immune inhibitors have a profound impact on our bodies!

Here is the picture of tea consumption vs D25 levels from the above study:



Tea has some anti NF-κB properties:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339285/



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wrotek
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 Posted: Mon Apr 23rd, 2018 15:52

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https://www.ncbi.nlm.nih.gov/pubmed/29678503

Caffeine inhibits STAT1 signaling and downregulates inflammatory pathways involved in autoimmunity.


TNF and PPARG were suppressed even with the lowest caffeine dose tested, which corresponds to the serum concentration of caffeine after administration of one cup of coffee

Last edited on Mon Apr 23rd, 2018 15:53 by wrotek



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jrfoutin
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 Posted: Mon Apr 23rd, 2018 16:52

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For a long time I was a tad annoyed that the terminology in studies carried a huge bias load in popular but errant perspectives of good/bad wanted/unwanted effect per "deficiency" and "immune suppressing," for example. Certainly, dumping more 25D into humans has produced plenty of human-based research over the last 15 years.

That misunderstanding process is currently buying a lot of studies with plenty of zeal per long-held standard consumption habits around the planet for feel-good indigestibles, too. For most of the same misconceptions per what is good and what is bad, Humans will be used in many of those studies because of absolute confidence in the value of pain and inflammation, so the fear that keeps new drug studies in murine models will be abandoned without question.

So maybe it is a good thing people are eager to believe coffee and tea are their buddies. There will be many humans available and willing to participate in those studies that are helping to define immune processes (circulating and cellular).

Maybe, when the flip side comprehension of the value and purpose of pain and inflammation and how that impacts longevity is understood better, then the objective study data can be rolled into metastudy analysis for better clarity.

Dunno. Just musing.



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 Posted: Fri Apr 27th, 2018 07:00

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Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells

Chlorogenic acid significantly inhibited not only NO production but also the expression of COX-2 and iNOS, without any cytotoxicity. Chlorogenic acid also attenuated pro-inflammatory cytokines (including IL-1β and TNF-α) and other inflammation-related markers such as IL-6 in a dose-dependent manner. Additionally, endotoxin-induced adhesion of macrophages and the expression level of ninjurin1 (Ninj1) were decreased by chlorogenic acid. Finally, chlorogenic acid inhibited the nuclear translocation of NF-κB.

Antibacterial activity and mechanism of action of chlorogenic acid

The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition

Last edited on Fri Apr 27th, 2018 10:15 by Dmitry



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wrotek
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 Posted: Fri Apr 27th, 2018 10:14

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I think this is quite interesting


The adenosine system modulates Toll-like receptor function: basic mechanisms, clinical correlates and translational opportunities

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052217/


Adenosine-receptor stimulation skews TLR4-mediated responses, inhibiting pro-inflammatory Th1-polarizing responses and enhancing Th2-polarizing and anti-inflammatory cytokine production. In general, adenosine inhibits LPS-induced pro-inflammatory/Th1-polarizing cytokines TNF [21,22] and IL-12p70 [23] but enhances production of IL-6 [21], a cytokine with Th2-polarizing and inflammation-resolving properties [24]

Last edited on Fri Apr 27th, 2018 10:18 by wrotek



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mvanwink5
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 Posted: Fri Apr 27th, 2018 11:51

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Isn't IL-6 (& IL-5?) needed for the expression of stem cells (and I think both are expressed by the VDR)? Sorry, it has been a while...

Last edited on Fri Apr 27th, 2018 11:52 by mvanwink5



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 Posted: Fri Apr 27th, 2018 12:30

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I thought TM had said Tea was fine some time ago ?



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 Posted: Fri Apr 27th, 2018 18:13

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Tea is to be brewed "very weak".



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 Posted: Sat Apr 28th, 2018 09:42

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More data on adenosine.

Selfish Immune System:

Immune response is energetically demanding process. Immune cells, upon activation, switch their metabolism to increased aerobic glycolysis to support rapid synthesis of macromolecules; this switch is associated with increased glucose consumption by immune cells. Increased aerobic glycolysis was originally described by Otto Warburg in cancer cells and it is now recognized as being common for proliferating cells (Vander Heiden 2009), for example during development (Tennessen 2011).

During the infection, activated immune system is allowed to behave selfishly. We have shown that activated immune cells, which must proliferate and differentiate into lamellocytes, produce adenosine that serves as a “selfish signal”. Extracellular adenosine (e-Ado) then suppresses the rest of the organism, leading to lower consumption of glucose by non-immune tissues and thus to a delay in development. This systemic metabolic switch is crucial for rapid production of lamellocytes and thus for effective immune response against the parasitoid egg. When we block adenosine transport from immune cells or when we block adenosine signaling, infected larva does not slow down the development, consumes the energy required by immune system and thus the resistance to parasitoid drastically drops. This represents a clear experimental evidence for a trade-off between development and immune response and a “selfish” behavior of immune system during stress. The selfishness of the immune system is crucial for effective immune response.

Caffeine and adenosine:

Caffeine causes most of its biological effects via antagonizing all types of adenosine receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons and glial cells of all brain areas. In consequence, caffeine, when acting as an AR antagonist, is doing the opposite of activation of adenosine receptors due to removal of endogenous adenosinergic tonus.



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wrotek
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 Posted: Sat Apr 28th, 2018 14:42

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I have read stories of ms patients on watercure2.org website before it was shut down. But i saved copy https://mega.nz/#!Sd5hQAJZ!Ju8CBQikSeh4CDT3jztXKyf2nRqjvg-WsRwr7IQM1SA The hydration protocol no alcohol and caffeine, resulted in disappearance of MS lesions in one case. It is like adenosine facilitates repair in CNS. angiogenesis etc... White blood cells recruitment.
It is important for regeneration

Thank you Dmitry this is very interesting article. Otto Warburg and adenosine correlation is very nice i think.Chronic insulin resistance, caused by chronic inflammation or by chronic mental activation, then leads to various pathologies such as diabetes, obesity, metabolic syndrome or chronic inflammatory diseases.

Last edited on Sun Apr 29th, 2018 12:44 by wrotek



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 Posted: Sat Apr 28th, 2018 18:15

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This is amazing effects of caffeine on brain blood flow https://youtu.be/DCJ34kZEgcM

30-40% drop



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 Posted: Mon May 7th, 2018 09:52

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Associations between coffee consumption and inflammatory markers in healthy persons: The ATTICA study:
https://www.ncbi.nlm.nih.gov/pubmed/15447891

Compared with coffee nondrinkers, men who consumed >200 mL coffee/d had 50% higher interleukin 6 (IL-6), 30% higher C-reactive protein (CRP), 12% higher serum amyloid-A (SAA), and 28% higher tumor necrosis factor alpha (TNF-alpha) concentrations and 3% higher white blood cell (WBC) counts (all: P < 0.05). Women who consumed >200 mL coffee/d had 54% higher IL-6, 38% higher CRP, 28% higher SAA, and 28% higher TNF-alpha concentrations and 4% higher WBC counts (all: P < 0.05) than did coffee nondrinkers.


Associations of coffee drinking with systemic immune and inflammatory markers:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490956/

Lower circulating levels of inflammatory markers among coffee drinkers may partially mediate previously observed associations of coffee with cancer and other chronic diseases.



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 Posted: Mon May 7th, 2018 12:14

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Second paper says it is antiinflammatory ?



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 Posted: Mon May 7th, 2018 12:21

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Yep, as it happens quite often one study contradicts another.

from the first paper:

The effect of coffee consumption on inflammation marker
concentrations was investigated in 3042 randomly selected men and women from the region of Attica in Greece.

So maybe those who drink coffee are already trying to modulate inflammation with it.

Also since caffeine is messing around the VDR - https://www.ncbi.nlm.nih.gov/pubmed/17223552 -
maybe it effects the levels of both anti and pro-inflammatory substances(like LL-37 and D1.25)

Last edited on Mon May 7th, 2018 12:37 by Dmitry



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 Posted: Mon May 7th, 2018 12:37

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Or one study is false to sell coffee



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