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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Chlorogenic Acid in Coffee is powerful Immune modulator


Chlorogenic Acid in Coffee is powerful Immune modulator
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  ...  32  33  34  35  36  37   
 

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Dmitry
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 Posted: Mon May 7th, 2018 11:41

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Or one study is false to sell coffee

Yep! Like pay to the lab to produce a paper and later reference their 'work' while advertising a new supplement... cheap and highly effective :)



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MP resumed Sep'16: 6h*40mg Benicar + 48h*100mg mino | no meds | stress intolerance, fatigue, anxiety, brain fog, etc
Chris
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 Posted: Wed May 9th, 2018 03:09

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So maybe those who drink coffee are already trying to modulate inflammation with it.

That's definitely why I drink it in the morning.  On the odd morning when I feel good on waking, coffee has little attraction after the first mug.   On other days, I still want more after the first pot. 



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wrotek
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 Posted: Thu May 10th, 2018 08:17

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After first POT LOL how many pots ?



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Dmitry
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 Posted: Thu May 10th, 2018 15:49

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I tried 1 cup of coffee several months ago and it palliated my brain out of anxiety so nice that I've became immediately addicted. The cravings last for about 3..4 days after. I wait a bit more and tried another cup and it gave me just extra brain fog and nothing else, so effect was not sustainable.



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MP(as TP) Jun'16 for 1 month -> 2 months break -> followed by blood check(frozen): 25D 17.6ng/ml, 1.25D 21.1pg/ml
MP resumed Sep'16: 6h*40mg Benicar + 48h*100mg mino | no meds | stress intolerance, fatigue, anxiety, brain fog, etc
Chris
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 Posted: Fri May 11th, 2018 04:44

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Two pots is the limit, so far. 



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sarcoid diagnosed 1991, probably started 1983
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wrotek
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 Posted: Fri May 11th, 2018 13:19

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How much coffee goes into one pot?



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wrotek
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 Posted: Wed May 16th, 2018 12:36

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Interesting

https://www.ncbi.nlm.nih.gov/pubmed/24629340

A2B adenosine receptor induces protective antihelminth type 2 immune responses.

Patel N1, Wu W1, Mishra PK1, Chen F1, Millman A1, Csóka B2, Koscsó B2, Eltzschig HK3, Haskó G2, Gause WC4.
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Abstract
The type 2 immune response evoked by intestinal nematode parasites contributes to worm expulsion and tolerance to associated tissue damage. We investigated whether this host response is affected by blocking signaling by the putative endogenous danger signal adenosine, which can be released during inflammation and host cell damage. Specific blockade of the A2B adenosine receptor (A2BAR) inhibited worm elimination and the development of innate and adaptive components of the type 2 primary and memory response. Infected mice lacking A2BAR exhibited decreased M2 macrophage and eosinophil recruitment and reduced IL-4 and IL-13 cytokine production. Additionally, shortly after infection, upregulation of the alarmin IL-33, which drives type 2 immunity, and activation of innate lymphoid type 2 (ILC2) cells was inhibited, while exogenous IL-33 restored ILC2 cell activation and type 2 cytokine expression. Thus, adenosine acts as a danger-associated molecular pattern (DAMP) that initiates helminth-induced type 2 immune responses through A2BAR.
PMID: 24629340 DOI: 10.1016/j.chom.2014.02.001

Last edited on Wed May 16th, 2018 12:39 by wrotek



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Chris
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 Posted: Wed May 16th, 2018 19:12

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Pot = 40 oz or about 1.1 liters.



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wrotek
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 Posted: Thu May 17th, 2018 07:19

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Yeah but how many grams of coffee



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 Posted: Thu May 17th, 2018 21:08

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30-32 g / pot



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sarcoid diagnosed 1991, probably started 1983
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wrotek
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 Posted: Sat May 19th, 2018 06:14

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so it is like 4 coffees in those two pots.



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Chris
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 Posted: Sun May 20th, 2018 00:00

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Yes, about 4 /pot. About 1 pot/day. Still not enough to shut down IP for full 24 hours, just enough to give relief for about 12.



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sarcoid diagnosed 1991, probably started 1983
D25/1,25: Mar04 17/80, Sep04 12/50, Nov04 8/23, Jan05 9/39 May05 6/27; in phase3; fevers, muscle pain, tinnitus, depression, mental-fog, IBS, carpal-tunnel, fatigue, osteopenia, fall 2017 - osteoarthritis
jrfoutin
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 Posted: Sun May 20th, 2018 01:41

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Modulating immune response is a tricky business. Immunopathology seems a series of tough choices over time.

MPKB.org pages discuss avoiding known substances and environments that interfere or otherwise modulate immune function.

Popular, frequently ingested, or plain old happy habits supported by socially-acceptable addictions are tricky ground to dance along daily. I have read many personal posts identifying regular "palliation" mentioned for years and wondered what that really means. That almost innocent "palliation" necessity often persists alone while other options are not explored, and no attention is payed to dependency patterns. Seems odd.

Do we flip out the "palliation" card out as if the long term effects of our favorite items are innocent, have short term consequence only, and are absolutely necessary as the only way to manage immunopathology daily? Can we easily "palliate" with something else or skip a week or two on that palliation to try something else?

We might ask, also: "What options are available that won't hamper immune function or possibly cause other long-term harm if my goal really must be palliation once in a long time?"

Chart progress, read over years of posts. If you find yourself frequently "palliating" with just one favorite addictive thing and getting the same no-progress results, then maybe "palliating" is not the correct term.

Immunopathology is a tough daily choice process. Some days are better than others with zig-zag patterns for most getting well on the MP. Constant palliation with a favorite addiction might flag the exact point of hampering immune processes necessary for recovery.

Or maybe not. I don't have the exact science nailed down for palliation that doesn't hamper immune competency. But I'm also not yet convinced even after reading scores of scholarly articles that coffee is a simple, innocent and helpful palliation ideal for the MP (by pot or by cup).

Best to all--Janet



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 Posted: Mon May 21st, 2018 03:20

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Palliation is tricky, but I've made quite a bit of progress over 14 years, while drinking coffee.  Your mileage may vary, of course.



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D25/1,25: Mar04 17/80, Sep04 12/50, Nov04 8/23, Jan05 9/39 May05 6/27; in phase3; fevers, muscle pain, tinnitus, depression, mental-fog, IBS, carpal-tunnel, fatigue, osteopenia, fall 2017 - osteoarthritis
Dmitry
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 Posted: Mon May 21st, 2018 08:10

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Chris, what kinds of IP you are trying to palliate with coffee? Neuro herx? Fatigue herx?



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MP(as TP) Jun'16 for 1 month -> 2 months break -> followed by blood check(frozen): 25D 17.6ng/ml, 1.25D 21.1pg/ml
MP resumed Sep'16: 6h*40mg Benicar + 48h*100mg mino | no meds | stress intolerance, fatigue, anxiety, brain fog, etc
wrotek
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 Posted: Mon May 21st, 2018 08:15

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I am guessing in general, because type of herx depends on where bacteria reside.



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Dmitry
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 Posted: Mon May 21st, 2018 08:30

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Coffee also boosts adrenaline(fight flight response) which leads to vasoconstriction -> drop in immune cells infiltration:

https://www.ncbi.nlm.nih.gov/pubmed/6511102

The urine samples were specified with respect to the following parameters: sampling period, volume, urine status, density, creatinine, noradrenaline, and adrenaline. Adrenaline showed a significant correlation with coffee consumption, whereas noradrenaline did not.

Adrenaline shots are used as septic shock treatment:
https://www.ncbi.nlm.nih.gov/pubmed/2037723
https://www.ncbi.nlm.nih.gov/m/pubmed/2012297/

Last edited on Mon May 21st, 2018 08:44 by Dmitry



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MP(as TP) Jun'16 for 1 month -> 2 months break -> followed by blood check(frozen): 25D 17.6ng/ml, 1.25D 21.1pg/ml
MP resumed Sep'16: 6h*40mg Benicar + 48h*100mg mino | no meds | stress intolerance, fatigue, anxiety, brain fog, etc
wrotek
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 Posted: Mon May 21st, 2018 08:59

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It increases cortisol if You are exposed to stressor, higher. But not when you are resting apparently.

When You are resting, cortisol rises but not that high.

You think it is vasoconstriction that leads to lower immune cells infiltration ? I think it is cortisol that paralyzes immune cells.

Last edited on Mon May 21st, 2018 09:01 by wrotek



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Dmitry
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 Posted: Mon May 21st, 2018 09:06

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You think it is vasoconstriction that leads to lower immune cells infiltration ?


I read it over there: https://www.quora.com/Is-adrenaline-an-anti-inflammatory
hoping it is correct..



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MP(as TP) Jun'16 for 1 month -> 2 months break -> followed by blood check(frozen): 25D 17.6ng/ml, 1.25D 21.1pg/ml
MP resumed Sep'16: 6h*40mg Benicar + 48h*100mg mino | no meds | stress intolerance, fatigue, anxiety, brain fog, etc
wrotek
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 Posted: Mon May 21st, 2018 09:22

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Immune cell migrate actively, not only with the blood flow-passively. They roll, use endothelial cells, lymphatic fluid... It is quite complex. But their function for sure is dependent on amount of fluid in tissues, which carries oxygen which they use to produce reactive oxygen species to kill pathogens.

Last edited on Mon May 21st, 2018 09:32 by wrotek



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