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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Chlorogenic Acid in Coffee is powerful Immune modulator


Chlorogenic Acid in Coffee is powerful Immune modulator
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  ...  33  34  35  36  37  38   
 

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jrfoutin
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 Posted: Mon May 21st, 2018 20:45

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Managing perceptions of immunopathology required for healing can get derailed with chronic dependence on favorite palliations. (Opioid receptor possibility may be involved.)

Terms to google research in scholarly articles [any one favorite palliation choice made daily for years without a break or change of palliation type that hits hormones is worth looking into... I found a lot for different compounds in coffee]:

nociceptive
relating to or denoting pain arising from the stimulation of nerve cells (often as distinct from that arising from damage or disease in the nerves themselves).

antinociceptive
the action or process of blocking the detection of a painful or injurious stimulus by sensory neurons. Compared with systemic narcotic analgesia, intraspinal narcotic antinociception has a longer duration.

Olmesartan acts on the super-hormone famiy receptor D, but full pathways within the super-hormone family group may have complexities and correlations worthy of avoiding palliation (especially when dependencies exist of never changing from one palliation to another over time on the MP).

Weaning from all palliations might offer the best perception clarity.

A regular consumption habit of any one palliation daily, especially in large quantities, might not stop all the good that olmesartan can do. But what progress might be made without palliation is not known without weaning.

Best to all--Janet

Last edited on Mon May 21st, 2018 20:59 by jrfoutin



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Chris
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 Posted: Mon May 21st, 2018 23:56

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Not sure how to distinguish neuro and fatigue.  Probably both, have neither the will nor the energy to get up & do things without coffee.



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wrotek
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 Posted: Wed May 23rd, 2018 15:10

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https://drive.google.com/open?id=1PUoLY4ey7JWZgo6WcSV0TyVDBC8Z34j3Adenosine acting on A 2a receptors suppresses IL-12 production by mature DCs leading to diminished
Th1- versus Th2-cell development


page 5 of this document.

Last edited on Wed May 23rd, 2018 15:10 by wrotek



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Dmitry
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 Posted: Wed May 23rd, 2018 15:23

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So basically coffee shifts from Th1 to Th2?



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wrotek
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 Posted: Wed May 23rd, 2018 15:24

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No. Caffeine blocks adenosine that is supposed to shift. Caffeine blocks all 4 adenosine receptors, nonspecifically

Last edited on Wed May 23rd, 2018 15:24 by wrotek



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Dmitry
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 Posted: Wed May 23rd, 2018 15:29

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Interesting...

Also
https://www.ncbi.nlm.nih.gov/pubmed/18625677

Adenosine is an immunosuppressive nucleoside, and adenosine A(2A) receptors inhibit T-cell activation. We investigated the role of A(2A) receptors in regulating T helper (Th)1- and Th2-cell development and effector function. A(2A)-receptor stimulation suppressed the development of T-cell receptor (TCR) -stimulated naive T cells into both Th1 and Th2 cells, as indicated by decreased IFN-gamma production by cells developed under Th1-skewing conditions ...
...
Using in vivo established Th1 and Th2 cells, we further demonstrate the nonselective nature of A(2A) receptor-mediated immunosuppressive effects
...



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wrotek
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 Posted: Wed May 23rd, 2018 16:22

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yes a2a is antiinflammatory, but other receptors can be proinflammatory. So adenosine system also facilitates inflammation to elliminate bacteria.

Last edited on Wed May 23rd, 2018 16:25 by wrotek



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jrfoutin
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 Posted: Wed May 23rd, 2018 19:20

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If we look at outcomes, it seems reasonable to consider that gateways and paths controlled by healthy homeostasis are susceptible to ingested compounds, especially complex compounds with highly atypical ranges for chlorogenic acid, like coffee, that are known to circumvent normal systems controls and homeostasis required for health.

Coffee (caffeinated or not) is a complex mess of compounds (read all posts above, starting with Dr Marshall's).

Coffee is also known to be addictive but caffeine doesn't seem to be the main culprit here, just a happy add-on booster pack that encourages us to think we are not being robbed of energy or well being.

Coffee also plays tricks on nerve signal perceptions (nociceptive/antinociceptive), so one might not really know what is going on with their own recovery or not. Those on the MP depend on accurate sensory neuron detection of painful or injurious stimulus to adjust olmesartan or even know if they are improving over time. With coffee on board at regularly ingested intervals or high amounts via dependencies, we might expect to have extreme difficulty accurately reporting 1-10 scale details.

With coffee on board, we can't trust our signals to accurately report improvement. (Never mind research accuracy that depends on 1-10 self-reporting scales in small cohorts.)

Even with our own personal notes/charts or offering our very expensive and elaborate EMF/RFR blocking devices to achieve a clearer wave environment to chart/note, it makes very little research-accuracy sense to toss in regular coffee consumption or to suggest it is an innocent "palliation."

We might also want to avoid the far too misleading label of "palliation" at all, especially with opiates, coffee, hormones or other Rx that control sensory nerve signals with Central processing complexity (not so simple or direct as intracellular signals, and absolutely involved in what we report on with 1-10 charting or choices we make to manage pain or severe symptoms).

But that is something I've thought about while reading the discussion on this thread. I could be wrong. Thank you all for your study and insights.

Best to all--Janet



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