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Tobi
Member
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Posted: Mon Jan 1st, 2007 23:56 |
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I'm having difficulty getting clear about the difference between "genuine" vitamin D deficiency and a high 25D/1,25D ratio resulting from Th1 disease.
I read "When patients are Vitamin D deficient, the parathyroid hormone increases and drives the renal 1-alpha-hydroxylase,so that 1,25(OH) vitamin D levels increase. Only in severe deficiency, when substrate is depleted, does 1,25 (OH) vitamin D become low. Partially treated vitamin D deficiency also results in marked elevations of 1,25(OH) vitamin D levels"
I understand that Th1 disease cases rapid conversion of 25D to the metabolite, 1,25D, so this could result in low 25D and high 1,25 D. But how are these people distinguished from those described above - with partially treated D deficiency,whose 25D is low, with high 1,25D? And what about those whose levels are both low? Of course this could be the mishandling of the sample, lab error, etc., but let us assume it is an accurate result. Does this indicate "true" vitamin D deficiency?
My question arises from recent test results after 10 months break from the MP and no avoidance of D foods or light.
My 25D is <18nmo/L (the lab's detection level)
1,25D is 50pmo/L
During my two years on the MP my D levels were checked monthly and both have been consistently low, despite using different labs, but never as low as this. My ionized calcium is also very low.
How do I know whether I have a "real" vitamin D deficiency, or whether this result indicated worsening Th1 disease?
I"m sure I"m missing or misunderstanding a basic concept - please put me right!
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CFS,Rickettsia Conoori-,HHV6,Ureaplasma(all 3 culture,PCR) 25D 16.4ng/ml,1.25D 26pg/ml.Ratio 1,3 Blood probably NOT frozen Benicar 9/18/04 Mino 100mg 10/18/04 Phase 2 01/26/05
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Dr Trevor Marshall
Foundation Staff
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Posted: Tue Jan 2nd, 2007 00:59 |
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Tobi,
There is no such thing as "Vitamin D Deficiency." The body makes all the vitamin D it needs. It is made from 7-dehydrocholesterol. UVB light is not necessary at any point in this process.
The concept of D-ratio is one I no longer use. After we made the breakthroughs (late in 2005) we were able to define exactly how the D metabolism works. The slide showing the complete metabolite control system is in my Bio21 and AAEM presentations on the "Science" DVD.
..Trevor..
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Tobi
Member
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Posted: Tue Jan 2nd, 2007 01:09 |
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Trevor,
Thank you. I need to keep reading I see. Is there no such thing then as Ricketts caused by D deficiency? Is there no danger to bones if D levels become very,very,very, low? Would D food and light avoidance still be recommended on the MP?
Tobi
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CFS,Rickettsia Conoori-,HHV6,Ureaplasma(all 3 culture,PCR) 25D 16.4ng/ml,1.25D 26pg/ml.Ratio 1,3 Blood probably NOT frozen Benicar 9/18/04 Mino 100mg 10/18/04 Phase 2 01/26/05
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Aussie Barb
Member in Phase 3
| Joined: | Thu Jul 22nd, 2004 |
| Location: | Australia |
| Posts: | 19553 |
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Posted: Tue Jan 2nd, 2007 01:42 |
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Tobi
from Dr Marshall's Perspective see Rickets is not cured by Vitamin D Nor is it caused by 'Vitamin D Deficiency'
Can my Vitamin 25-D go too low? and VITAMIN D Tutorial
Osteoporosis and Th1 illness
Risk factors, BMD testing and other information
What does my bone density test mean?
A Review - Vitamin D and Calcium in Sarcoidosis (7-5-03)
http://www.sarcinfo.com/calcium.htm
Don't I need to take a calcium supplement to prevent osteoporosis?
all best, Barb ...
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Barb: Dx Inflammatory Disease Endocrine Imbalance 2003| Depression| 24+ years not Dx| MP Aug04| ABC of MP| MP Search|
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Lantern
Guests visiting Phase 1/2/3
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Posted: Wed Jan 3rd, 2007 07:00 |
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Tobi wrote:
Is there no danger to bones if D levels become very,very,very, low?
At Trevor's patient meeting here in Adelaide he mentioned that Vitamin D is, in fact, osteoclastic (sorry if I've spelt it wrong). Osteoclastic = breaks down bones. Not only is Vit D not needed to build bones, but it is actually detrimental to bones.
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CFS IBS Malabsorption Hypothyroid Rickettsia. Ph1 Apr06, Mod.Ph2 Oct06, Ph2 Feb07, Ph3 Aug07. Endep T3/T4 Panadol. NoIRs, homebound in low lux. Apr07 1,25D=15.4, 25D=13.6
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