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My AAEM 2006 presentation is on YouTube
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Prof Trevor Marshall
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 Posted: Sat Sep 29th, 2007 19:06

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Yesterday a journalist suggested we should have something up on YouTube so it could be easily incorporated into a blog.

It is in two 35-minute segments at URLs:
http://www.youtube.com/watch?v=RpocxjKJxag
http://www.youtube.com/watch?v=ZMn-zUTTHgw

A slightly higher resolution version is in 8 segments:
http://www.youtube.com/watch?v=-FzYARFQ9ZE
http://www.youtube.com/watch?v=7RVXgEOBASo
http://www.youtube.com/watch?v=ngfOyXdfDn4
http://www.youtube.com/watch?v=BmPHSI3YoSM
http://www.youtube.com/watch?v=j8Is2bFyx_0
http://www.youtube.com/watch?v=08TF7qPNs2A
http://www.youtube.com/watch?v=zpXIFJ3t-zU
http://www.youtube.com/watch?v=MdmrKCcvnzI

Please feel free to let your favorite journalist/blogger know about the new material.

remember that the written transcript PDF is at
http://www.autoimmunityresearch.org/transcripts/marshall_aaem_2006.pdf

..Trevor..

ps: An uninterrupted copy of the presentation is now available from Google video. The quality is not quite as good as YouTube, as Google insists on doing their own video processing, so I was not able to use the latest technological tricks to make the slides easy-to-read.
http://video.google.com/videoplay?docid=-2390315864442431912

The YouTube videos can also be embedded into a webpage or blog.
 

Last edited on Tue Dec 18th, 2007 11:16 by Prof Trevor Marshall

wrotek
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 Posted: Sat Sep 29th, 2007 21:19

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Dr Marshall you can put your presentation on video.google.com, no limits there.
I know youtube and google are connected, but if one will use google video uploader(no MB limits) or web uploader (only up to 150 MB i guess), there are no limits.

Last edited on Sat Sep 29th, 2007 21:31 by wrotek



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jcwat101
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 Posted: Sat Sep 29th, 2007 21:55

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That's great!
 
If you contact someone with the YouTube link you might also want to include the link to Amy and Paul's site:  http://www.bacteriality.com
 
Joyce



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wrotek
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 Posted: Sun Sep 30th, 2007 00:27

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I have been watching presentation again and wondering, is it possible for different bacterium to acquire borrelia plasmids and stimulate anti-borrelia antibodies when borrelia alone was eradicated ?
Won't new bacterium with borrelia plasmid genes, become partially a borrelia ?

Last edited on Sun Sep 30th, 2007 00:43 by wrotek



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Prof Trevor Marshall
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 Posted: Sun Sep 30th, 2007 01:25

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Wrotek,
The answer is yes, proteins transcribed from plasmids will follow the plasmids. But in addition, antibodies are not that specific. At the 2004 Autoimmunity conference, a group from Stanford gave a presentation where they showed hundreds of molecules, from tiny ones all the way to large proteins, which could bind to a single antibody.

Antibodies are useful in a diagnostic environment, but not precise. PCR is better, but still imprecise until we know all the bacterial genomes... Only full genome sequencing is reliable, and that is very hard to do in a metagenomic community.
 

mysevenkids
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 Posted: Sun Sep 30th, 2007 13:16

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hi joyce,

i have question, not sure if i am posting correctly yet, havent used the list very often.

if some one has a birth defect or condition from birth, how would it be possible to fix it with antibotics? it seems the problem is structure if somthing didnt form correctly, and say even if it is from bacteria cause from the start, once formed it makes since someone would have to go in and fix it.

 



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looking into MP treatmemnt my diagnosis:(fibromalysia)(plumonary hypertension)(copd non smoker)(artheritis)(false positive lupus))(chiari o)(rash on neck back and arms)(cysts in all internal organs)(wolf parkinson white)
Prof Trevor Marshall
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 Posted: Sun Sep 30th, 2007 13:57

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Depends what caused the birth defect.
It seems that Vitamin D metabolism abnormalities (resulting from Th1 disease) are associated with pre-eclampsia. The VDR is also associated with the transcription of many genes, including assocuiated with Down Syndrome, which it is hard to "go in and fix." However, infections passed from mother to child can be treated. There is much still lto learn.However, which condition specifically are you concerned about?
 

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 Posted: Sun Sep 30th, 2007 14:07

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mysevenkids wrote:
if some one has a birth defect or condition from birth, how would it be possible to fix it with antibotics? it seems the problem is structure if somthing didnt form correctly, and say even if it is from bacteria cause from the start, once formed it makes since someone would have to go in and fix it.

 


Hi, this is a rather interesting question and timed perfectly, since I am at the moment corresponding with some Cystic Fibrosis patients, who also want to understand how one would explain that a disease that is said to be caused by a hereditary mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, could be an inflammatory disease, caused by (amongst others, CWD) bacteria.

By the way, this gene is mentioned as one of the 27,091 genes probably (partially) transcribed by the VDR, see table 4.

Paper:
http://mend.endojournals.org/cgi/content/full/19/11/2685

Table 1: (916 confirmed VDR-related genes)
http://tinyurl.com/38rtu5

Table 4: (27,000 probable VDR-related genes)
http://tinyurl.com/2wzhmb

I am very interested in any insight/answer Joyce or Trevor could provide. I have my ideas, like infectious pea-soup, but am not sure enough about them.

Sincerely, Frans

Last edited on Sun Sep 30th, 2007 14:08 by Frans



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Prof Trevor Marshall
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 Posted: Sun Sep 30th, 2007 14:16

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Frans,
Tha bacteria evade the immune system by shutting down the VDR, shutting down production of most of the body's antimicrobial peptides. An unfortunate side effect of this is that the genes the VDR is supposed to assist transcription (transcription or transrepression) are also not transcribed properly by the shut-down VDR.

It is of course more complex than this. In particular, mutations can be point mutations or fold mutations. They can occur at the DNA or RNA stages. But the explanation above should be enough to carry the key concept. The bugs target the VDR, which then causes a cascade of problems.
 

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 Posted: Sun Sep 30th, 2007 14:27

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I understand, it leads one to wonder if hereditary genetic disease is even a valid name or concept



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Prof Trevor Marshall
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 Posted: Sun Sep 30th, 2007 14:33

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Indeed. You might also ponder this paper, describing one of the pathways through which nuclear radiation affects the body: http://tinyurl.com/2qgmwv
 
Of course, once the D metabolism has been perturbed, the Th1 pathogens are likely to have proliferated somewhat as a result...
 

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 Posted: Sun Sep 30th, 2007 14:46

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Hmm, this reminds me of gulf war syndrome, we finally have the series House MD here on tv, and last week they had an episode about gulf war syndrome...



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mysevenkids
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 Posted: Sun Sep 30th, 2007 17:03

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hi, i am actually referring to wolf parkinson white syndrome. i have that and have been thinking of fixing it and did just recently.


my symptoms were happening more frenquently.
my dr who had been hoping i would fix it, decided to order me a heart moitor for a month. i wore it all of july. two weeks after caling in my readings he caled to schedule surgery for ablation and i decided to do it. glad i did because i was on the freeway only 4 days before my procedure and i almost fainted while driving, i felt myself going in and out quickly and had to pull over.
.

i wouldnt be able to see how antibotics could fix a problem as this, or fast enough.

thanks,

joyce

 

 



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looking into MP treatmemnt my diagnosis:(fibromalysia)(plumonary hypertension)(copd non smoker)(artheritis)(false positive lupus))(chiari o)(rash on neck back and arms)(cysts in all internal organs)(wolf parkinson white)
Prof Trevor Marshall
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 Posted: Sun Sep 30th, 2007 17:17

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Joyce says
i wouldnt be able to see how antibiotics could fix a problem as this, or fast enough

Well, Joyce, we are not going to argue with your doctor's diagnosis, nor are we going to interfere with his care. Have you asked your doctor how long the 'fix' will keep you in remission? What is its failure rate versus time? Real hard statistics?
 

Prof Trevor Marshall
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 Posted: Mon Oct 1st, 2007 07:17

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An uninterrupted copy of the presentation is now available from Google video.
The quality is not quite as good as YouTube, as Google insists on doing their own video processing, so I was not able to use the latest technological tricks to make the slides easy-to-read.
http://video.google.com/videoplay?docid=-2390315864442431912

It can also be embedded into a webpage, and surprisingly, the slides on the smaller embedded version are a little bit clearer.

Don't forget that there is a PDF transcript, which includes clear copies of the slides, available at URL
http://www.autoimmunityresearch.org/transcripts/marshall_aaem_2006.pdf

Enjoy :)
 

paulalbert
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 Posted: Mon Oct 1st, 2007 10:03

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David Bradley embedded a link to Trevor's AAEM presentation:

http://www.sciencebase.com/science-blog/trevor-marshall-lecture/

Paul



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Prof Trevor Marshall
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 Posted: Mon Oct 1st, 2007 19:00

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And now FOX news has syndicated it
http://tinyurl.com/2xtmmm

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 Posted: Mon Oct 1st, 2007 23:21

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Dr. Marshall,

Recently, I met up with my older brother who has been plagued with HPV pappaloma virus on his vocal cords, a virus he has dealt with for over 10 years. He has tried a myriad of different treatments without success.  Although he had experienced some initial positive results following surgery a few years back the virus returned. Although, I have not seen this on the roster of treatable illnesses, my improved understanding of this science increases my curiosity as to the potential the MP would have on my brother’s condition.

Thanks so much,

Tom



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Prof Trevor Marshall
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 Posted: Sun Oct 14th, 2007 21:56

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Tom,
The innate immune system is the body's last line of defense against pathogens. When it is perverted, the body cannot clear the pathogens which evade adaptive immunity. Suggest your brother do the D-tests, with Quest Diagnostics, and let's look at the numbers...
 

tom
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 Posted: Tue Oct 16th, 2007 19:08

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Dr,

Thanks very much. I'll get back to you

Tom



____________________
CFS: (1989). Morgellons: (Jan 2010). Systemic mold infection: (2010). Valley fever- coccidioidomycosis (March 2012). Started MP: (Jan 2007) W/ Numerous breaks. Resume MP Feb 2014 with 3 1/4 years total. D tests (Feb 26 2014) D25 = 10.

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