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Granulomatous Disease or Cancer??
 Moderated by: Prof Trevor Marshall
 

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DNStog
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Joined: Mon Aug 16th, 2004
Location: Sandy Springs, Georgia USA
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 Posted: Thu Dec 6th, 2007 21:27

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Below is a link to recent research on the need to use caution when diagnosing breast cancer in autoimmune/inflammatory disease patients.  After reading it over, I'm of the opinion that it might come in handy for Sarc and other inflammatory disease patients when trying to discuss granulomas versus malignant tumors with oncologist specialists. IMHO, it would back up our plea that we are often misdiagnosed--perhaps, because the medical community is so quick to err on the side of caution.

Any thoughts?  --Donna


Idiopathic granulomatous mastitis masquerading as carcinoma of the breast
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1949402



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Sarcoidosis systemic; Raynaud's, uveitis, sinus, wt. gain, Peradontal disease, GERD-hiatal hernia, breast ca 11/06, 25D7, Cinnamon, claritine, Milk Thistle, Rx glacier, 05/09 25D5, 125D7
LH1953
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 Posted: Fri Dec 7th, 2007 09:36

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Donna,  Thanks for the info.  VERY INTERESTING!  Here is a question, I am on the MP due to my Lyme diagnosis.  I am totally not familiar HOW any of the Sarc people got their diagnosis.  I fully understand that we all have this common TH1.  I for one have had a very noticeable change in small "growths" on my face that the dermatologist told me not to worry about.  Before the MP, they continued to grow at a steady pace.  Now, they definately are getting smaller.  I assume this is Sarc tissue?  I remember insisting that the one in the middle of my forehead be removed.  The Doc told me it would only grow back, which it did.  The 2 years on the MP, it does not exist any longer.

I am concerned as to WHAT to do about my pending needle biopsy of the mass in my breast.  This process is so difficult to decide what is real and what is "old" thinking in medicine.  I like so many of us here on the MP, for 15 years have never fit the medical "norm".

I am also a carrier of the alpha 1 antitrypsin deficiency.  Was tested due to a 1st cousin.  All so much to absorb!

Take Care,   Lori



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Lyme, MCS, IC, Asthma, Reflux, UC, Osteopenia, Hypothy, EBV, AMD. 1,25D-48, MP 8/05, ProAir inhaler,neb. Singulair, Probiotic, Diazepam, Fioricet, Zyrtec Ph3 7/06, NoIRs limited outings D25 7 12/13 Benicar Only 8/13
Reenie
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 Posted: Fri Dec 7th, 2007 15:37

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Hi Lori,

I don't claim to understand medical diagnoses or how they come up with so many different names but it always baffles me that there seems to be a different name for so many similar symptoms. 

I had a breast aspiration years ago which gave no answers other than the need for a breast biopsy to remove a lump.  It turned out to be a fatty tumor which grew shortly after having been hospitalized with secondary Addison's disease.  (adrenal failure due to steroid use)

Dr Cantwell looked at some rather large skin lesions on my shins which I thought might be a sarc-type symptom rather than psoriatic lesions after learning how similar our illnesses are and reading about erethyma nodosum, which is common in sarc patients. 

Well, to sum it up, it was psoriasis according to Dr Cantwell and I've also had my elbow tissue biopsied which returned a psoriatic diagnosis too. 

LH1953
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 Posted: Fri Dec 7th, 2007 15:48

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Diagnosing Cancer Accurately and Breast Cancer.
 
Meg was kind enough to send me these links in my progress report.  Very interesting reading.  Important tests that one needs to know so one can share with their doctor.



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Lyme, MCS, IC, Asthma, Reflux, UC, Osteopenia, Hypothy, EBV, AMD. 1,25D-48, MP 8/05, ProAir inhaler,neb. Singulair, Probiotic, Diazepam, Fioricet, Zyrtec Ph3 7/06, NoIRs limited outings D25 7 12/13 Benicar Only 8/13
LH1953
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 Posted: Sat Dec 8th, 2007 16:05

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A case of granulomatous mastitis mimicking breast cancer

Donna was kind enough to send me this article by PM.  I think this will help Doctors understand the need of what Dr. Marshall has been saying all along.  It has to do with the need for proper diagnosing for breast cancer by excisional biopsy vs. needle.  This is going to help support my need to my doctor, along with the MP papers.  Many Thanks to all!  

Take Care,   Lori



____________________
Lyme, MCS, IC, Asthma, Reflux, UC, Osteopenia, Hypothy, EBV, AMD. 1,25D-48, MP 8/05, ProAir inhaler,neb. Singulair, Probiotic, Diazepam, Fioricet, Zyrtec Ph3 7/06, NoIRs limited outings D25 7 12/13 Benicar Only 8/13
NickBowler
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 Posted: Wed Dec 3rd, 2008 08:12

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There have been a couple of articles published recently highlighting the relevance of the VDR in controlling cancer cell proliferation and in protecting the foetus from infection:

http://www.prohealth.com/fibromyalgia/library/showArticle.cfm?libid=14094&B1=EM111908F
http://www.nutraingredients-usa.com/Publications/Food-Beverage-Nutrition/NutraIngredients/Research/Vitamin-D-may-protect-against-placental-infection-Study/?c=TSqlTaJaZt4gSKYrBSHVsA%3D%3D

In both these studies calcitriol is named as the active substance, although the authors make the usual mistake of thinking that levels can be boosted by supplementing vitamin D.

Interestingly trophoblastic cells share some properties with cancer cells, for example they exhibit highly invasive properties:

http://www3.interscience.wiley.com/journal/109903722/abstract



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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
DNStog
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 Posted: Sat Feb 13th, 2010 15:53

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As am MP patient diagnosed several years ago with breast cancer and being interested in my cohorts who are facing the same possibility, I am sharing information I've gathered on Sarcoidosis, inflammatory diseases and their ability to often cause a misdiagnosis of cancer.  

Below is a link to Dr. Yale Rosen's, an Anatomical Patholgist in Bellemore NY, Atlas of Granulomatus Diseases. His work is beneficial to correctly decipher Sarcoidosis, etc. from various types of cancer. My oncologists, especially the one on a breast tumor review committee, love the complete print outs I gave them from this link:

http://granuloma.homestead.com/

Saroidosis of the breast:

http://www.ncbi.nlm.nih.gov/pubmed/16705947?

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12185341&ordinalpos

Idiopatic Granulomatos Mastitis mimics Inflammatory Breast Disease.

https://www.journals.elsevierhealth.com/periodicals/acs/article/S1072-7515(07)01399-3/abstract

Lobular Granulomatous Mastitis Mimicing Advance Breast Cancer:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687584/

http://www.cmaj.ca/cgi/content/full/176/13/1822

I'll post more as I become aware of them.

Wishing you all well, gently, of course!  Donna



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Sarcoidosis systemic; Raynaud's, uveitis, sinus, wt. gain, Peradontal disease, GERD-hiatal hernia, breast ca 11/06, 25D7, Cinnamon, claritine, Milk Thistle, Rx glacier, 05/09 25D5, 125D7
DNStog
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 Posted: Sat Feb 13th, 2010 19:11

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The radiographics report linked below appears to be fairly comprehensive on types of inflammatory breast responses from autoimmune and Th1 diseases.  


http://radiographics.rsna.org/content/25/2/411.full



____________________
Sarcoidosis systemic; Raynaud's, uveitis, sinus, wt. gain, Peradontal disease, GERD-hiatal hernia, breast ca 11/06, 25D7, Cinnamon, claritine, Milk Thistle, Rx glacier, 05/09 25D5, 125D7
DNStog
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 Posted: Fri Apr 30th, 2010 13:50

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Breast Calcifications...the basics.

http://breastcancer.about.com/od/mammograms/p/calcifications.htm

Core Biopsies and Stereotactic Biopsies of the breast are often accompanied by the use of Xylocaine to prevent discomfort during the procedure. Xylocaine is okay as long as it doesn't contain epinephrine. Below is a link on why epinephrine is contraindicated while on the MP.

http://www.marshallprotocol.com/forum32/4638.html



____________________
Sarcoidosis systemic; Raynaud's, uveitis, sinus, wt. gain, Peradontal disease, GERD-hiatal hernia, breast ca 11/06, 25D7, Cinnamon, claritine, Milk Thistle, Rx glacier, 05/09 25D5, 125D7

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