The Marshall Protocol Study Site Home

Search
   
Members

Calendar

Help

Home
Search by username
   Not logged in - Login | Register 


Vitamin D discovery outpaces FDA decision making
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  4  5  6  Next Page Last Page  
 

New Topic

Reply

Print
AuthorPost
Ival
inactive member


Joined: Mon Mar 14th, 2005
Location: Pensacola, Florida USA
Posts: 139
Status:  Offline
 Posted: Thu Jan 17th, 2008 20:50

Quote

Reply
Trevor ,

Am I correct in thinking this also explains how the antibiotic Rifampicin works in chronic Lyme. It modulates the VDR by way of the PXR causing an immunosuppressive affect. As long as they’re taking if they feel better but as soon as they stop they relapse.

I opened a bottle of wine and had a toast when I got through reading it just fascinating to see a disease process at the molecular level on paper congratulations

 Ival



____________________
MP 4/12/05/Benicar Q6h Ph1 4/26/05/ 25D13ngml 125D44pgml Ph2/6/1/05 Ph3/1/25/06 diag RA 2001 Male 47
Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 15727
Status:  Offline
 Posted: Thu Jan 17th, 2008 21:53

Quote

Reply
Ival,
It certainly is an interesting possibility, isn't it Ival :)

The effect would be different in chronic disease from what it is in TB.
 

Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 15727
Status:  Offline
 Posted: Fri Jan 18th, 2008 06:14

Quote

Reply
The paper is now catalogued in PubMed, PMID: 18200565

http://tinyurl.com/ypk53t


Russ
inactive member
 

Joined: Fri Mar 24th, 2006
Location: Hartford, Connecticut USA
Posts: 812
Status:  Offline
 Posted: Mon Jan 21st, 2008 02:40

Quote

Reply
Dr Trevor Marshall wrote: I wonder how many other folk will notice that subtlety, and that Figure 1 talks about "energy" rather than solely "UVB"? 

Does there have to be an external input of energy or does the body literally produce 1,25D all by itself?  I'm thinking of a theoretical situation where a human is exposed to absolutely zero light of any kind (UVB, IR, visible, electromagnetic, etc.).  Would you expect a human in this theoretical situation to still produce a sufficient amount of 1,25D?

Many congratulations on the paper.  I look forward to the day when your work is fully recognized for the amazing discovery that it is.



____________________
*** I recently moved to Connecticut so if anyone knows of MP docs in this state or nearby, please send me a PM. ***
Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 15727
Status:  Offline
 Posted: Mon Jan 21st, 2008 02:55

Quote

Reply
Russ,
As far as we can tell, the body can produce all the 1,25-D it needs by itself. It upregulates keratinocyte production of 1,25-D in the presence of the inflammatory cytokine TNF-alpha, for example, and I suspect there are other mechanisms as well.
 

Foundation Staff.
.


Joined: Sat Jul 10th, 2004
Location:  
Posts: 1137
Status:  Offline
 Posted: Mon Jan 21st, 2008 03:29

Quote

Reply
A press release about the BioEssays paper is available online at
ttp://www.prweb.com/releases/2008/1/prweb639651.htm

We have a discussion of media coverage of the paper at Our Press Release Today January 21.

Belinda

didierchretien
member


Joined: Fri Jan 4th, 2008
Location: Mont-Saint-Guibert, Belgium
Posts: 161
Status:  Offline
 Posted: Mon Jan 21st, 2008 08:15

Quote

Reply
Trevor,

When you talk about radiation, could it be that radio EM radiations like GSM, DCS, UMTS, BLUETOOTH, WIFI,...may fuel also these conversions?
I am asking this because I am working in a telecommunication company where everything is radio inside our building (LAN, phone, ...) since many years.

Even if it sounds crazy, the period when WIFI was introduced in our building and the more frequently usage of bluetooth devices correspond with an increase of my HypervitaminoseD symptoms. It is most probably a coincidence but...

Didier



____________________
Sarcoidosis 25D10(Jan08) 25D6.9ng(May08) 25D7.1ng(July08) BeniFeb08 to wean prednisone Ph1 Jun08 Ph2 Jul08 Ph3 Jan09 Out of Ben Nov13
Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 15727
Status:  Offline
 Posted: Mon Jan 21st, 2008 09:26

Quote

Reply
The lower frequency of these sources reduces their energy. Bluetooth is too low power to cause problems. Sources above 1 GHz and high power might be a possible problem. But I am talking about transmission tower power levels here, not WiFi wireless routers.

It is almost impossible to link symptoms with a cause. Just focus on recovery...
 

migsies
inactive member


Joined: Sat Mar 26th, 2005
Location: Gainesville, Florida USA
Posts: 101
Status:  Offline
 Posted: Wed Jan 30th, 2008 11:25

Quote

Reply
Reuters press release a couple of days ago:

"African immigrants with low levels of vitamin D are much more likely to be infected with tuberculosis"

"Their study of all 375 African immigrants treated at one Melbourne hospital showed that those who had low vitamin D levels were far more likely to have TB infections than those with adequate levels"

...so far, so good, and in clear agreement with Dr. Marshall's research.

But then they conclude with a serious lapse in critical thinking...

"Gibney's team said doctors might consider vitamin D supplements as a treatment for TB, or a way to prevent it.":X

(Not sure this is the right place for this post. Feel free to create a new thread if appropriate.):)



____________________
Sarcoidosis FM Lyme babesia 25D>7(Feb07) Ph1Aug05 Ph2Oct05 Ph3 Jun06 Valium Lyrica Ambien NoIRs limited outings covered Phase I 8/05, II 10/05, III 6/06.
Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 15727
Status:  Offline
 Posted: Wed Jan 30th, 2008 11:35

Quote

Reply
Yes, this is the correct place. And yes, you are correctly identifying their lapse in thinking. The article is at URL
http://www.reuters.com/article/healthNews/idUSN2846942520080128

Maybe this line of thought was suggested by a peer-reviewer, and accepted in order to get the paper published, or maybe they had it in the back of their minds all along. I guess we shall never know unless somebody contacts the study authors, and draws their attention to the correct interpretation, the interpretation which was formed in the 1985 study of TB (my citation 67)(Don't you find it incredible that the authors were not aware of this paper? All it takes is Google or PubMed to find it...).

Maybe some of our Aussie mates could do some helpful follow-up here
:):)

Folk who live in underdeveloped nations are very likely to be carrying a heavy load of Th1 pathogens. Quite apart from their difficulty avoiding contact with nasty pathogens, the West has been exporting our Vitamin D fortified powdered milk and infant formula to these nations since the 1950s:(
 

Grace
inactive member
 

Joined: Mon Sep 13th, 2004
Location: Australia
Posts: 396
Status:  Offline
 Posted: Wed Jan 30th, 2008 19:09

Quote

Reply
Gibney's contact info

http://www.journals.uchicago.edu/doi/abs/10.1086/525268



____________________
CFS, oct04 Ds=26/48, 4/07=7/24 MP PHI 2/05, PhII 6/05, PhIII 6/06, beni Q6H, Noirs rarely inside no nature light low watt, outside 40%10%, Hat, all covered, no gloves, paracetamol
Russ
inactive member
 

Joined: Fri Mar 24th, 2006
Location: Hartford, Connecticut USA
Posts: 812
Status:  Offline
 Posted: Sat Feb 2nd, 2008 22:56

Quote

Reply
Dr Trevor Marshall wrote: I wonder how many other folk will notice that subtlety, and that Figure 1 talks about "energy" rather than solely "UVB"? 

Since heat is energy (I think), is it possible that all forms of heat, and not just IR, can trigger the Vit D metabolism?  Many TH1 folk complain of symptoms when they get overheated, even in cases where there is no high-energy IR source involved.  For instance, if I go to sleep under too many covers and get real hot in the night, I will wake up feeling terrible.  This is true even when the heat in my apartment is turned off.  Is it possible that the overheating and the resultant heat energy is causing increased 1,25D or are symptoms like these more likely due to something else?



____________________
*** I recently moved to Connecticut so if anyone knows of MP docs in this state or nearby, please send me a PM. ***
Foundation Staff
.


Joined: Fri Jul 9th, 2004
Location:  
Posts: 17204
Status:  Offline
 Posted: Sun Feb 3rd, 2008 00:52

Quote

Reply
"Humans perceive infrared radiation as "heat radiation", which is one way of energy transport. This may be why many persons with Th1 disease feel very uncomfortable when they get overheated." ..Trevor.. See Incident Radiation Tutorial

Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 15727
Status:  Offline
 Posted: Sun Feb 3rd, 2008 01:03

Quote

Reply
An increase in body temperature can also increase the effect of antibiotics. Which might also make you feel less comfortable :)
 

Russ
inactive member
 

Joined: Fri Mar 24th, 2006
Location: Hartford, Connecticut USA
Posts: 812
Status:  Offline
 Posted: Mon Feb 4th, 2008 12:22

Quote

Reply
I guess I was wondering which explanation was more likely the cause of the symptoms, since in one case (IR) you'd want to try hard to avoid it and in the other (increased abx effectiveness) it wouldn't be such a bad thing. 



____________________
*** I recently moved to Connecticut so if anyone knows of MP docs in this state or nearby, please send me a PM. ***
Rico
Support Team
 

Joined: Tue May 30th, 2006
Location: Canada
Posts: 1354
Status:  Offline
 Posted: Mon Feb 4th, 2008 19:17

Quote

Reply
Vitamin D deficiency paper is stirring up some debate:

http://www.freerepublic.com/focus/f-news/1960227/posts
http://tinyurl.com/39cttp
http://tinyurl.com/2v2w35
http://brain.hastypastry.net/forums/showthread.php?p=208026
http://www.her2support.org/vbulletin/showthread.php?p=150942
http://stopsarcoidosis.clinicahealth.com/comments.pl?sid=08/01/12/167232

I imagine there will be letters to the editor in the next edition or two...



____________________
No diagnosis/some symptoms (more than I knew); wife with Sarc on MP; Olm 40mg q4-6h | 25D=22 (May 2014) | 25D=27 (Nov 2014)
Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 15727
Status:  Offline
 Posted: Mon Feb 4th, 2008 20:03

Quote

Reply
Thanks Rico, I hadn't had time to go looking myself.

You know, one of the reasons I had to publish that paper was to draw a line in the sand that I had decoded the riddle of chronic disease, and to describe the processes in a way that they would be able to subjected to peer review.

In many ways, by trying to marginalize our thought, these folk are helping us immensely, as they are showing how radical our breakthrough has been. It is not an evolutionary improvement in knowledge, it is truly a break away from commonly accepted pragma.

There have been letters to the editor at BioEssays, and I have responded to one of them. It is tough to respond to letters where the writer, although well meaning, does not comprehend the concept of the VDR or gene expression, or indeed, even include it their in analysis :(

I have also had letters from Biologists that congratulated me on saying what had to be said. They themselves can now be more outspoken in the future, by citing my work.
 

inge
Health Professional


Joined: Sun Sep 24th, 2006
Location: Oslo, Norway
Posts: 246
Status:  Offline
 Posted: Tue Feb 5th, 2008 02:25

Quote

Reply
Trevor,

I am thinking about writing a paper in a Norwegian medical journal on the vitamin d subject. In that regard, it would be helpful to have a reference to vitamin 25-D being an antagonist to the VDR. Do you have one at hand?

Inge

Last edited on Tue Feb 5th, 2008 02:25 by inge



____________________
CFS/ME, stopped olmesartan March 2014, feeling quite well, but not 100 %
Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 15727
Status:  Offline
 Posted: Tue Feb 5th, 2008 06:30

Quote

Reply
Oh dear, Inge. That is a like asking me to prove water is wet.  I just can't recall any single paper which shows that, as it is a pragma which forms the underpinning of all the drug discovery in Vitamin D analogs, and has been proven many, many times by individual drug discovery groups.

For example, this study:
http://www.ncbi.nlm.nih.gov/pubmed/10677578
and this one
http://www.ncbi.nlm.nih.gov/pubmed/11179729
are typical of those in drug discovery exploring compounds which activate the VDR. 'Everybody knows' that 25-D is not one of them :X

I proved it for myself in two ways. They can be seen in my Karolinska presentation, and my Harvard presentation.
For Karolinska I provided the 2D plots of the amino acid residue interactions for 1,25-D 25-D and Olmesartan, while for Harvard I showed diagrams of how the Rat and Human VDR were activated - which residues were important. This was based on my own work, and a review of many papers in the literature. But note that by Harvard I had started to use the more accurate molecular dynamics simulations, which showed that Olmesartan actually changed the shape of the VDR a little from that of 1,25-D, so the key residues are a little different for that drug. There was no change between the 25-D and 1,25-D dynamic and static simulations, however. My paper on receptor modeling gives all the background on how one performs the 2D simulations.
Marshall TG: VDR Nuclear Receptor Competence is the Key to Recovery from Chronic Inflammatory and Autoimmune Disease. Abstract presentation, Days of Molecular Medicine, Karolinska Institutet, Stockholm, May 2006.
Copy available from URL http://autoimmunityresearch.org/karolinska-handout.pdf
Marshall TG: Molecular Static and Dynamic Analyses Reveal Flaw in Murine Model used by US FDA to Detect Drug Carcinogenicity. Abstract presentation, Days of Molecular Medicine, Cambridge MA, May 22-24, 2007. doi:10.1038/npre.2007.52.1
Copy available from URL http://autoimmunityresearch.org/dmm2007/dmm2007-handout.pdf
Marshall TG: Molecular genomics offers new insight into the exact mechanism of action of common drugs - ARBs, Statins, and Corticosteroids. FDA CDER Visiting Professor presentation, FDA Biosciences Library, Accession QH447.M27 2006
Online Video available from URL http://autoimmunityresearch.org/fda-visiting-professor-7mar06.ram
Marshall TG, Lee RE, Marshall FE: Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b. Theor Biol Med Model. 2006 Jan 10;3(1):1. Available from URL http://www.tbiomed.com/content/3/1/1
I hope that helps.
 

Last edited on Tue Feb 5th, 2008 06:32 by Prof Trevor Marshall

inge
Health Professional


Joined: Sun Sep 24th, 2006
Location: Oslo, Norway
Posts: 246
Status:  Offline
 Posted: Tue Feb 5th, 2008 06:59

Quote

Reply
Thank you, that helps a lot!

Inge



____________________
CFS/ME, stopped olmesartan March 2014, feeling quite well, but not 100 %

 Current time is 21:51
Page:  First Page Previous Page  1  2  3  4  5  6  Next Page Last Page  



* We can help you understand chronic disease, but only your physician is licensed to give you medical care *

Powered by WowBB 1.7 - Entire site Copyright © 2004-2019 Autoimmunity Research Foundation, All Rights Reserved
Click here to view our PRIVACY POLICY
Page processed in 0.0417 seconds (65% database + 35% PHP). 19 queries executed.