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Vitamin D discovery outpaces FDA decision making
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  4  5  6  Next Page Last Page  
 

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Prof Trevor Marshall
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 Posted: Sat Feb 23rd, 2008 00:29

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If you are interested in the conflicts of interest swirling around the Vit D advocates, then you will enjoy reading this article from the Canadian Broadcasting Commission:

"The Vitamin D Debate"
http://www.cbc.ca/news/viewpoint/vp_strauss/20080213.html
 

Rico
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 Posted: Sat Feb 23rd, 2008 05:57

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Ah, so that's why they want us all to ingest more Vitamin D. Now it all adds up! $$$$$
I'm glad to see that we, the population, are served by such well-meaning scientists.



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 Posted: Sat Feb 23rd, 2008 11:14

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Oh man, if it weren't such an important issue, I would be rolling on the floor laughing my tushy off...

It surely gives those of us trying to get through to people some ammunition.

Our beloved Vieth's wife made 30.000 times 20 dollars, equalling 600.000 dollars from this paper in two days, but he still says he has no conflicting interests...

Wow, did I make the wrong career choice...

Frans



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laura1814
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 Posted: Sun Feb 24th, 2008 23:05

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Great article! Thanks for sharing it!



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joedegs
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 Posted: Tue May 6th, 2008 07:37

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Dr. Marshall,

Just found this article online...don't know if you have seen it or not but it talks about Vit D causing several bladder conditions. Just thought you might be interested in it.

http://jcem.endojournals.org/cgi/content/full/90/2/962

Joe



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inge
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 Posted: Tue Jul 22nd, 2008 03:10

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I haven't checked things thoroughly, but to me it seems that during the winter months there is no vitamin D production at all in individuals living in countries situated at latitudes far from the equator (PMID: 2839537). Knowing that the skin has the ability to produce vitamin D it seems that it has this ability for a reason. I get the impression from the MP site that you really can't get vitamin D so low that you will experience adverse health effects. But why does the skin then only have the abiltity to produce vitamin d (as it appears from the study I linked to) from sunlight? Is anyone aware of findings showing that a minimum of vitamin D can be produced without sunlight? After all, a minimum of vitamin D production appears to be necessary for optimal health, knowing how many genes are transcribed by the VDR.

Last edited on Tue Jul 22nd, 2008 03:14 by inge



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kenc
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 Posted: Tue Jul 22nd, 2008 03:57

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inge,

Have you considered the possibility that the purpose of the skin producing vitamin D in the presence of sunlight is to activate the innate immune system to repair the damage to the skin caused by sunlight?

kenc



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Prof Trevor Marshall
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 Posted: Tue Jul 22nd, 2008 05:39

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Inge, that study is based on a model which was absolutely incorrect. Their early in-vitro work was not thorough, yet a generation of researchers did not question it.

The model was based on an in-vitro experiment which showed that skin keratinocytes expressed Vitamin D when exposed to high intensity UV light of a few key wavelengths. Recently, another study found that monocytes and other cell lines also generated D metabolites when exposed to UV radiation. So what is the reason for that? Those cells, unlike keratinocytes, are never exposed to such radiation. It is now clear that an incorrect and insufficient conclusion was drawn from the initial Vit D stidies of UV on keratinocytes.

Every pragma about sunlight on the skin producing Vitamin D or 25-D is probably incorrect, IMO, as there was a study a few years ago which showed that, especially in the presence of the inflammatory cytokine TNF-alpha, the keratinocytes produced 1,25-D directly, and did not stop at 25-D. This is what the model in my recent paper suggests.
http://www.ncbi.nlm.nih.gov/pubmed/15225839

The human body, just like the bodies of the nocturnal mice and rats in which we test all our medicines :):) does not need to be exposed to sunlight in order for its D metabolism to function correctly, and deliver activated 1,25-D to its VDR to enable transcription. Full stop. Holick, Vieth, and the others, were just incorrect.

You might like to read these recent articles by Stephen Strauss of the CBC. The first deals directly with misreading epidemiological studies so that they prove what you expect them to prove:
http://www.cbc.ca/technology/story/2008/07/07/strauss-vitamind.html
and
http://www.cbc.ca/news/viewpoint/vp_strauss/20080213.html

Vitamin D is not a nutrient. A nutrient would have a first-order mass-action model for its metabolism. AFAIK, only Cannell has been reckless enough to claim that it does. Figure 1 of my Bioessay makes it quite clear that we are dealing at least with a 6th order metabolism, probably even higher.
 

Last edited on Tue Jul 22nd, 2008 05:54 by Prof Trevor Marshall

inge
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 Posted: Fri Jul 25th, 2008 16:10

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Dr Trevor Marshall wrote: The model was based on an in-vitro experiment which showed that skin keratinocytes expressed Vitamin D when exposed to high intensity UV light of a few key wavelengths. Recently, another study found that monocytes and other cell lines also generated D metabolites when exposed to UV radiation. So what is the reason for that? Those cells, unlike keratinocytes, are never exposed to such radiation. It is now clear that an incorrect and insufficient conclusion was drawn from the initial Vit D stidies of UV on keratinocytes.



I hope that you can clarify the above a bit:

- why does it matter that monocytes and other cell lines also generated D metabolites? There are no enzymes needed for the 7-DHC to previtamin D conversion are there? So as long as 7-DHC is present in these cells, when they are exposed to radiation vitamin d will be generated (however unnatural radiation may be for them).

- From the abstract of the study you mentioned (http://www.ncbi.nlm.nih.gov/pubmed/15225839) it does not seem that TNF-alpha singlehandedly induced production of vitamin D metabolites (i.e. all cells were exposed to radiation as well) , or does the full text reveal other findings?)



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Prof Trevor Marshall
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 Posted: Fri Jul 25th, 2008 17:55

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Inge,
There is a pathway from 7-dehydrocholesterol to pre-vitamin-D which does not involve radiation, but which involves enzymatic, or some other energy (eg body heat) to cleave the benzene ring. It is likely that the reason macrophages and other cell lines react to UVB is that the UVB synthesis is incidental to the normal and usual way that pre-Vitamin-D is synthesised (eg enzymatic).

Other mammalian species, even invertebrates such as the Lamprey, have an active VDR metabolism in the absence of UVB radiation. You need to be thinking of the corollary, the alternate hypothesis, and not the pragma that you have been taught in medical school. That pragma doesn't fit the data:) If high intensity UVB was absolutely necessary for the Vitamin-D metabolism to function, then your countrymen would be sick and weakly by comparison with those in Africa:)

The importance of the TNF-alpha study was to demonstrate that 25-D is not necessarily the result of irradiation of keratinocytes, that the cells are acting under other influences as well, going straight to 1,25-D metabolite.  Again, this is in violation of the pragma in your textbooks:) We are dealing with the complex, multi-factorial feedback metabolism of my Figure 1, not the simple reactions we would expect from a nutrient.
 
 

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 Posted: Sat Aug 16th, 2008 05:04

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Hi,

A recent Belgian epidemiological study on Low-level 21-month microwave exposure on rats shows that there is an increased mortality of the exposed rats with respect to non-exposed rats. They also noticed a loss of some cognitive functions after a few monthes of exposure.

It may due to a weakening of the immune system, favouring the genesis of decay processes wich may result in life-threatening disorders including cardiovascular and pulmonary diseases, cancer or premature aging.

http://home.scarlet.be/~tsf94646/001/documents/Thesis%20Dirk%20Adang%20-%20Synthese.pdf

This would be a good opportunity for our CWD bacteria...

Didier



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Prof Trevor Marshall
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 Posted: Sat Aug 16th, 2008 05:21

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Didier,
The answer almost certainly lies in the VDR / Vitamin D axis )that they didn't even bother to measure). Note that in my Figure 1 I note that 7-dehydrocholesterol is changed to Vitamin D by the addition of ENERGY (I have UVB only as an example). There is also strong evidence for enzymatic catalysis.

Monocytes differentiate from hematopoetic stem cells, at least in part based on 1,25-D levels. This study found monocytes to be the most profoundly affected cell type.

I once took a quick look at the Atomic Radiation poisoning after Chernobyl, and certainly the chronic deaths of children there look awfully like an upset innate immune system. What the effect of any Th1 pathogens might be is not clear, as these folk seem to succumb to acute disease pretty readily, probably before the chronic pathogens become a significant factor.
 

Pat McKinzie
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 Posted: Sun Aug 17th, 2008 05:46

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Dear Dr Marshall,
My wife Pat started pn the MP 4 month ago, after years of sickness and declining helth, despite all efforts by her physicians. The protocoll, as harsh as it is to follow, is the first treatment which gave her hope for recovery and I am immensely gratefull to you for that.
She is doing very well in my opinion (she is almost ready for phase 3) but I do have a big concern with the low vitamin D level which are required.
I am not, by far, a medical expert, but have found many publications stating that low level of vitamin D lead to a cerain death, especially by elevating the heart failure's risks.
As far as I have understood the MP, the low vitamin D level is required to prevent the system from producing 25D & 1.25 D.
How long does this process generally last ? Is there a time when it is possible to go back to "normal" vitamin D levels ?
I would be gratefull if you could give me some hints on this topic, as I did not want to discuss it with her without knowing enough, in order to not stress her even more than she  already is.
Many thanks.
Gérald lechault
(Switzerland)



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Prof Trevor Marshall
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 Posted: Sun Aug 17th, 2008 06:10

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Gérald,
Next month I will be co-Chairman of a special session on "VDR, Vitamin D, and Autoimmune Disease" at the 6th International Congress on Autoimmunity. I, and my colleagues, will be presenting our data and science to that august gathering of expert researchers:
http://www.marshallprotocol.com/forum39/12376.html

Last year I published a paper which explained why the addition of Vitamin D to the food chain is responsible for the current epidemics of chronic disease. I opined that the mistake of calling Vitamin D a nutrient, which it is most certainly not, will go down in history as the biggest mistake Medicine has ever made:
http://TrevorMarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf

Vitamin D is not a nutrient. The reason that people are recovering their lives on the MP is because it is based on 21st century science, and not on 20th century mistakes:) Vitamin D is a seco-steroid transcriptional activator, the body produces all that it needs.

Anyway, there is a lot of detailed material here, and at the other sites on this topic. I trust it will set your mind at ease. For example:
http://mp-lifestyles.org/forum1/46.html
 

Pat McKinzie
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 Posted: Sun Aug 17th, 2008 07:38

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Dear Dr Marschall,

Many, many thanks for such a prompt reply.
I will read through this material and, hopefully, understand it. Ha !

Gérald



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eClaire
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 Posted: Sun Aug 17th, 2008 12:05

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Gerald,

You might also want to read (an easier read) Amy's "The Truth About Vitamin D: Fourteen Reasons Why Misunderstanding Endures." 

http://bacteriality.com/2007/09/15/vitamind/

Claire



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inge
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 Posted: Mon Aug 18th, 2008 13:26

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How can massive amounts of vitamin D supplementation lead to hypercalcemia if all other vitamin D forms than vitamin D 1,25 inactivate the VDR?  



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Prof Trevor Marshall
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 Posted: Mon Aug 18th, 2008 13:56

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Inge,
Pse look at my Bioessay figure 1.

Note that the VDR transcribes the Calcium Sensing Receptor, CASR. The function of CASR is to regulate the levels of calcium:
http://en.wikipedia.org/wiki/Calcium-sensing_receptor

So, if you knock out the VDR you take away the ability of the CASR to regulate calcium, as you reduce the expression of CASR.

Of course, the complete detail is a lot more complex than this, as there are many other pathways involved in the regulation of such a critical body function as calcium homeostasis.
 

Russ
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 Posted: Tue Aug 19th, 2008 08:28

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I have often wondered why for millions of years primitive man ate no dairy foods and yet did not suffer from calcium deficiency and yet today people risk deficiency if they do not keep calcium intake at the 1000-1500mg RDA which is surely much more calcium than primitive man got on his hunter-gatherer diet.  Is this the answer, that widespread TH1 disease which has shut down VDR function has messed up calcium homeostasis? 

Some of the advocates of a "paleolithic" diet claim that it was the addition of grains and the move to a high carb diet that has caused the need for more calcium and they claim that on a paleo-diet, which forbids dairy foods, one does not need to supplement calcium because the need for it drops.  Since my understanding is that too much calcium can be as bad as too little, I've wondered how much calcium one should aim for if they are eating paleo/low-carb and I guess if one is taking a VDR agonist as we are that might factor in to the amount needed as well.



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 Posted: Tue Aug 19th, 2008 09:16

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yet today people risk deficiency if they do not keep calcium intake at the 1000-1500mg RDA which is surely much more calcium than primitive man got on his hunter-gatherer diet.
A real hunter/gatherer ate a lot of small beasties whole, bones and all, just like other animals.  Lots of calcium there!  Same for small birds eggs. Our forebears were not so fastidious as we! :cool:



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