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Vitamin D discovery outpaces FDA decision making
 Moderated by: Prof Trevor Marshall Page:    1  2  3  4  5  6  Next Page Last Page  
 

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Prof Trevor Marshall
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 Posted: Tue Jan 15th, 2008 14:39

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Marshall TG: Vitamin D Discovery outpaces FDA decision making.
BioEssays Volume 30, Issue 2, Pages 173-182, February 2008
Online ISSN: 1521-1878 Print ISSN: 0265-9247
Copyright 2008 Wiley Periodicals, Inc., A Wiley Company
http://www3.interscience.wiley.com/cgi-bin/abstract/117885976/ABSTRACT


In accordance with the copyright assignment agreement I have put a free copy of the preprint of the Full Text on my personal website at
http://TrevorMarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf


Enjoy! :)
..Trevor..

scooker48
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 Posted: Tue Jan 15th, 2008 15:58

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Dr. Marshall,

Very impressive work and I hope and pray this will help "get the word out."

Sherry



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Prof Trevor Marshall
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 Posted: Tue Jan 15th, 2008 16:30

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Sherry,
The whole team deserves Kudos for this - Meg, Barb, Belinda, Joyce, Janet, PB, Vez, Lottie, Carole, and all the folk whose dedication allowed us to collect the data which led  us to this understanding :):):)
 

PaulT
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 Posted: Tue Jan 15th, 2008 16:38

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Trevor

Great work as far as my limited ability to think straight allows. (but it's getting better - to misquote Monty python)

One question - you mention gliding bacteria and persistent infections on prosthethic joints - do you think that MP will be able help someone with this issue? 

Cheers

Paul



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Prof Trevor Marshall
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 Posted: Tue Jan 15th, 2008 16:41

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Any persistent infection is a sign that the immune system has been unable to clear the pathogen. The MP is an easy, safe intervention to try in such situations. The D-metabolites tests will usually give a pretty good idea if there are likely to be Th1 pathogens present in any quantity.

Guss Wilkinson
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 Posted: Tue Jan 15th, 2008 16:42

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Cracking article - congratulations to whole team.

Physicians can't ignore this one.

Cheers

Guss



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laura1814
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 Posted: Tue Jan 15th, 2008 18:13

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Thanks for the wonderful article, and congrats to you and the whole team.

I found two typos. Do you want them?



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Prof Trevor Marshall
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 Posted: Tue Jan 15th, 2008 19:38

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Arrgh... Hopefully the typos were caught in the final phases of publishing :):) Let's wait until the printed journal comes out...

 

zeno_the_stoic
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 Posted: Tue Jan 15th, 2008 20:03

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My thanks to Dr. M and the research team for your good work and for being so open in your methods.

Copernican revolutions are a beautiful thing and I hope we are seeing one now, on the medical side as well as the research side :D

I guess we should tip our hats to Stallman and Torvalds too.

Very exciting times!



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Frans
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 Posted: Wed Jan 16th, 2008 04:58

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Trevor, I have a question.

In the paper, you state that the conversion of 7-dehydrocholesterol to pre-vitamin D is also observed in macrophages and intestinal cell lines.

I would think this means that (sun)light is not necessary at all to keep sufficient levels of vit. D ??

Sincerely, Frans

Last edited on Wed Jan 16th, 2008 05:04 by Frans



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Prof Trevor Marshall
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 Posted: Wed Jan 16th, 2008 05:00

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Frans,
Yes, please move to the top of the class :):)

I wonder how many other folk will notice that subtlety, and that Figure 1 talks about "energy" rather than solely "UVB"?
 

Frans
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 Posted: Wed Jan 16th, 2008 05:15

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You make me blush :D

I will be sure to mention this if and when I try to contact reporters who would like to publish this in their newspapers or medical magazines  :cool:

Sincerely, Frans



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Prof Trevor Marshall
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 Posted: Wed Jan 16th, 2008 05:23

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Frans,
Belinda is working on finishing a Press Release, which should be available at about the same time that the paper appears in PubMed (it hasn't propagated to their computer yet). Keep an eye open for her announcement :)
 

Frans
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 Posted: Wed Jan 16th, 2008 05:25

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Trevor,

I was thinking of producing something like that myself, so I will stay tuned for it.

Sincerely, Frans



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Frans
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 Posted: Wed Jan 16th, 2008 11:24

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Trevor, a follow up question.

Did these guys understand that they, in fact, have proven that humans do not need (sun)light at all?

Or to be specific, are they looking further to elucidate the probable enzyme that delivers the energy this mechanism needs?

Considering the steps from previtamin D to 1,25D are all also done by enzymes, another wouldn't come as a surprise?

Sincerely, Frans



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wrotek
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 Posted: Wed Jan 16th, 2008 12:56

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This will surely bring attention of other Vitamin D researchers and they will have problems to digest it, but it logically outlines the points that other researchers have simply troubles believing, but cannot argue with. This really must hurt when you are a studying something for years and u find out to be wrong in the end.



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Prof Trevor Marshall
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 Posted: Wed Jan 16th, 2008 14:50

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Frans,
Nobody has thought too much about the enzyme/energy issue in Homo sapiens. In nocturnal animals, of course, and in fish (etc) there has been exploration, but in man nobody has been asking questions. It seemed all so simple...

I was recently contacted by a 25-year veteran of a Nuclear power station, who claimed that there were many staff there suffering from Sarcoidosis. Since it is a rare disease, such a cluster would be highly unusual. But it got me thinking about radiation poisoning, and how low-level poisoning produces many symptoms like Th1 disease. I am sure that Vitamin D is not the only sterol which would be catalyzed by radiant energy, but I was certainly intrigued by this line of research too. Now I wonder who would want to fund a study of such workers??:)
 

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 Posted: Wed Jan 16th, 2008 16:04

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I dont think I understood that last post corectly?

Are you stating that those patients sarcoidosis was caused by radiation poisoning? Also, I thought Sarc was not rare at all? I also thought that sarc was caused by bacteria. If there are a cluster of people with sarc from radiation poisoning, wouldnt we have to rethink the causes of sarc? Please help me understand. I am having a hard time as of late..:X

Shandy

Prof Trevor Marshall
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 Posted: Wed Jan 16th, 2008 16:17

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Shandy,
There are about 134,000 people with Sarcoidosis in the USA, it is classified as a rare disease. About 2 in 10,000 suffer from it.

Frans asked about the step in which 7-dehydrocholesterol is changed to pre-Vitamin D. This requires energy, or an enzyme. Medicine currently believes that this can only occur when the body is exposed to UVB radiation, but we have proven this is not the case. Biologists know that some mammals create their own Vitamin D, through processes such as enzymatic conversion. I was suggesting that this could be the case for humans too. We have a lot of members who are not ingesting any vitamin D, and have been diligently avoiding UVB for several years, yet their bodies are functioning well.

I was further suggesting that the transition from 7-dehydrocholesterol to pre-Vitamin-D could very well be caused by the energy coming from low levels of nuclear, or similar, radiation. As an anecdote, I cited a single power station where such a 'Th1 epidemic' seems to have occurred, and I am also aware of at least one case in a nuclear submarine reactor officer. Just a suggestion at this point - an indication for us to watch the papers, and start to gather epidemiological data which might lead to better insight into the factors which cause the initial decline into Th1 disease. We have already identified pregnancy as one such factor.

I hope this helps:)

Frans
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 Posted: Thu Jan 17th, 2008 11:49

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Dr Trevor Marshall wrote: Frans,
Belinda is working on finishing a Press Release, which should be available at about the same time that the paper appears in PubMed (it hasn't propagated to their computer yet). Keep an eye open for her announcement :)
 


Trevor,

I completed the snippet I wanted to write to this reporter I have been in contact with, I had it almost ready...

Maybe Belinda can use some things

Here it goes:

Dear Sir, madam,

I would like to draw your attention to a research paper about vitamin D soon to be published in the magazine BioEssays. It is a paper by professor Trevor Marshall.

You can access the abstract here:
- http://www3.interscience.wiley.com/cgi-bin/abstract/117885976/ABSTRACT

You can access the preprint version here:
- http://TrevorMarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf

Marshall's paper comprises a molecularly derived model of vitamin D in relation to (with regards to) cancer and other chronic diseases linked to vitamin D.


You will be aware of the sugestion that vitamin D somehow protects against cancer, despite the critical comments of Professor Colin Cooper, of the Institute of Cancer Research en Dr Mark Metfield, of the Association for International Cancer Research, when confronted with a review paper of prof. Cedric Garland, who found a distinct correlation between several cancers and plasmalevels of vitamin 25 OHD.

Professor Colin Cooper, of the Institute of Cancer Research, commented that 'further research was necessary to provide definitive proof of the benefits of vitamin D.

He commented that the evidence was rather suggestive, but provided no definitive proof.

Furthermore he stated that prof. Garland failed to provide a MECHANISM to explain how exactly low levels of vitamin 25OHD are related to cancers.

Marshall's paper delivers a model explaining just such a mechanism !

Dr Mark Metfield, of the Association for International Cancer Research, agreed with Cooper that prof. Garland's research did not provide ANY PROOF about the benefits of vitamin D.

He further commented that he was conservative, in that there is clearly a correlation, but it is 'just a correlation'.

(see: http://news.bbc.co.uk/1/hi/health/4563336.stm)

 

Several highlights of Marshall's paper:

- reference 16: in this research they found tat several cell-lines have the capability to create pre-vitamin D from 7-dehydrocholesterol, which clearly implies that homo sapiens most probably does not need any (sun)light to create enough vitamin D, rendering the present definition of vitamin D deficiency totally outdated and useless;  considering the steps from pre-vitamin D to 1,25 dihydroxyvitamin D involve several enzymes, it is likely that the conversion from from 7-dehydrocholesterol to pre-vitamin D also involves an as yet undiscovered enzyme

- vitamin 25OHD is an ANTAgonist of the VDR, implying that high levels of 25OHD are immunosuppressive, rendering several key components of the innate immune system useless, amongst which are several beta defensins and antimicrobial peptides AMPs

- Marshall's delivers a schematic model that explains how and why levels of 25OHD get lower in disease; despite all this molecular knowledge, many sufferers of chronic disease are still being supplemented with vitamin D, rendering their already compromised immunesystems even more powerless, in effect acting as oil upon a fire

- the model also provides the clear insight that plasmalevels of vitamin 25OHD are not a constant, but are regulated by several enzymes and only measuring this level just does not cut mustard;  one should ALWAYS (also) measure the level of 1,25 dihydroxyvitamin D to make better assumptions about activity of the VDR

PS:  More background information:

Rickets is not caused, nor cured by vitamin D, see:
- PubmedID: 15976027: Rickets cuased by hypophosphatemia  (from 2005!)
- PubmedID: 17332234: actions of VDR on skeletal development INDIRECT

Osteoporosis linked to high levels of 1,25D dihydroxyvitamin D

Every paper looking into the benefits of 1,25 dihydroxyvitamin D in cancers states that high levels of 1,25D lead to BONE RESORPTION ! (see pubmed and try query: VDR CANCER)


Maybe it helps,

Sincerely, Frans



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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)

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