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Our New Press Release about the BioEssays Paper
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Prof Trevor Marshall
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Joined: Fri Jul 9th, 2004
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 Posted: Mon Jan 21st, 2008 01:09

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Belinda has disseminated a Press release today, about our BioEssays paper. Please make sure the health editor for your local newspaper understands the importance of this work, as the Vitamin D lobby has been putting out its own PR, IMO intended to point out how much more qualified their experts are (LOL).

Our release is at:
http://www.prweb.com/releases/2008/1/prweb639651.htm

The PDF of the Press Release is at URL:
http://AutoimmunityResearch.org/presskits/Bioessays_Feb08_Marshall_release.pdf

Sample PR from the Vitamin D lobby is at
http://www.contracostatimes.com/ci_8026837?source=rss

--------------------------------------------
New Research Challenges Concept of Vitamin D Deficiency
 
Media Contact: Belinda Fenter, 1-817-732-7336
 
January 21, 2008 Thousand Oaks, CA
 
Low blood levels of vitamin D have long been associated with disease, and the assumption has been made that vitamin D supplements may protect against disease. In the light of new knowledge that hundreds of genes are dependent on vitamin D, this assumption needs to be reconsidered.
 
In a report published in the current issue of the journal BioEssays(1), Trevor Marshall, Ph.D., professor at Australia’s Murdoch University School of Biological Medicine and Biotechnology, explains  how increased vitamin D intake affects much more than just nutrition or bone health. The paper explains how the Vitamin D Nuclear Receptor (VDR) acts in the repression or transcription of hundreds of genes, including genes associated with diseases ranging from cancers to multiple sclerosis.
 
"The VDR is at the heart of innate immunity, being responsible for expression of most of the antimicrobial peptides, which are the body’s ultimate response to infection," Marshall said. "Molecular biology is now forcing us to re-think the idea that a low measured value of vitamin D means we simply must add more to our diet. Supplemental vitamin D has been used for decades, and yet the epidemics of chronic disease, such as heart disease and obesity, are just getting worse."
 
"Our disease model has shown us why low levels of vitamin D are observed in association with major and chronic illness," Marshall added. "Vitamin D is a secosteroid hormone, and the body regulates the production of all it needs. In fact, the use of supplements can be harmful, because they suppress the immune system so that the body cannot fight disease and infection effectively."
 
Marshall's research has demonstrated how ingested vitamin D can actually block VDR activation, the opposite effect to that of Sunshine. Instead of a positive effect on gene expression, Marshall reported that his own work, as well as the work of others, shows that quite nominal doses of ingested vitamin D can suppress the proper operation of the immune system. It is a different metabolite, a secosteroid hormone called 1,25-dihydroxyvitamin D, which activates the VDR to regulate the expression of the genes. Under conditions that exist in infection or inflammation, the body automatically regulates its production of all the vitamin D metabolites, including 25-hydroxyvitamin D, the metabolite which is usually measured to indicate vitamin D status.
 
Vitamin D deficiency, long interpreted as a cause of disease, is more likely the result of the disease process, and increasing intake of vitamin D often makes the disease worse. "Dysregulation of vitamin D has been observed in many chronic diseases, including many thought to be autoimmune," said J.C. Waterhouse, Ph.D., lead author of a book chapter on vitamin D and chronic disease (2). "We have found that vitamin D supplementation, even at levels many consider desirable, interferes with recovery in these patients."
 
"We need to discard the notion that vitamin D affects a disease state in a simple way," Marshall said. "Vitamin D affects the expression of over 1,000 genes, so we should not expect a simplistic cause and effect between vitamin D supplementation and disease. The comprehensive studies are just not showing that supplementary vitamin D makes people healthier."
 
Trevor Marshall is currently executive director of Autoimmunity Research, Inc., a 501(c)(3) non-profit organization chartered in California. Its mission is to conduct scientific research into the cause and cure of disease, and to educate physicians and the public on science related to disease. More information can be obtained from http://AutoimmunityResearch.org
 
 
Citations:
 
1.            Marshall TG. Vitamin D discovery outpaces FDA decision making. Bioessays. 2008 Jan 15;30(2):173-182 [Epub ahead of print] Online ISSN: 1521-1878 Print ISSN: 0265-9247 PMID: 18200565
Available from publisher's website at URL
http://www3.interscience.wiley.com/cgi-bin/abstract/117885976/ABSTRACT
Available from PubMed at URL
http://www.ncbi.nlm.nih.gov/pubmed/18200565
 
2.            Waterhouse JC, Marshall TG, Fenter B, Mangin M, Blaney G, Vitamin D Metabolism in Chronic Disease. In Vitamin D: New Research, Nova Science Publishers, NY, 2006.  ISBN: 1-60021-000-7
 
 
Additional Resources for Journalists:
 
1.            A pre-print full-text of Prof. Marshall's paper is available from the author's website at URL
http://TrevorMarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf
 
2.            American Academy of Dermatology fact sheet: “Myths and Realities of Vitamin D and Sun Exposure,” at URL http://www.aad.org/media/background/news/skincancer_2004_05_03_myths.html
 
3.           "Rickets .. is not due to vitamin D deficiency but is caused by not having enough calcium in the diet." U.S. Dept of Agriculture, Agricultural Research Service, Available from URL http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=169216
 
                                                                 -------------------------------------


jcwat101
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 Posted: Mon Jan 21st, 2008 09:12

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It should be very interesting to see the response!!

Joyce Waterhouse



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tickbite
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 Posted: Mon Jan 21st, 2008 11:09

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I sent it to the Tulsa World.........



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GeorgeinRollaMO
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 Posted: Mon Jan 21st, 2008 14:29

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I sent it to the local newspaper, and to Dr. Peter H. Gott, M.D., the retired doc that is now a syndicated medical writer.

His Vicks VaporRub cure for toenail fungus worked for me.  I figured if he can spread that treatment, he should be able to understand the MP.  :D

He graduated from Tulane Un School of Medicine in my hometown, New Orleans.

Wishing all wellness!!!  :)

Dark Vader...aka, George



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sujay
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 Posted: Tue Jan 22nd, 2008 06:55

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I see I've dropped my small musings into the pond when the water is already roiling. Congratulations to Trevor and the team! I continue to be amazed by the patience, persistence and dedication that characterizes this effort to spread the word about Th1 illness and the effective treatment program that has been developed to address it.

Thank you, too, Trevor, for the good health so many of us now enjoy because of your efforts! We never dreamed life could be this good!

Sujay

Prof Trevor Marshall
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 Posted: Tue Jan 22nd, 2008 14:38

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Thank you for your kind words, Sujay, and for all your help:):)
 

terrylmcc
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 Posted: Tue Jan 22nd, 2008 19:41

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Iv'e sent the link to FOX News, WDIV, and WXYX Detrot market.
Will see if any of them air it. And will update here if I see it aired.
Good work Dr Marshall, and Joyce. Fondly -Terry



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Prof Trevor Marshall
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 Posted: Wed Jan 23rd, 2008 06:06

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Thanks, Terry.
This is the best way to make sure that Journals and Newspapers take our releases seriously - they need to get the news value pointed out to them.
 

Jimbbb
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 Posted: Wed Jan 23rd, 2008 11:59

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I just Googled "New Research Challenges Concept of Vitamin D Deficiency"

(be sure to click the link, which uses quotes to be accurate about the pages returned)

and got 61 unique hits for the Press Release from various newswires,  blogs and other pages (kind of mind-boggling that there are that many such websites -- but none of those (yet) were the well know ones or popular newspaper sites either -- might take a day or two for google to scan thru everything).

One amusing aspect is how your article can be nestled next to Advertisements touting:

Finally 5,000 IU and 50,000 IU caps Sunshine vitamin at reduced prices

But to be fair a lot of webpage ads are dynamically displayed based on keyword content of the articles.  Members should visit some of these sites -- especially ones that allow you to leave comments or ratings.  I saw one comment that, although slightly incoherent, was definitely on The More D The Better camp.

That one should be countered with some good arguments.

Congrats Trevor and the whole AutoImmunity Gang!
 
 

Last edited on Wed Jan 23rd, 2008 12:02 by Prof Trevor Marshall



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Reenie
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 Posted: Wed Jan 23rd, 2008 14:29

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I just contacted our local newspaper, The Arizona Republic and faxed them the press release (their instructions for contact) and followed up with an email for tips on a story.  :cool:

Markt9452
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 Posted: Wed Jan 23rd, 2008 18:26

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Micheal Claydon, Andrew Johnson, Sandra Kleinfeld, Cathie James and Diane Rotteau from the Canadian Broadcasting Corporation have been informed about this through the contact information on the Canadian Independant Producers Website at

http://www.cbc.ca/independentproducers/

 

Last edited on Wed Jan 23rd, 2008 18:27 by Markt9452



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Prof Trevor Marshall
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 Posted: Fri Jan 25th, 2008 10:39

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Belinda has just posted an updated version of our release, for the European market, on AlphaGalileo. You can see the release at
http://www.alphagalileo.org/index.cfm?fuseaction=readrelease&releaseid=526621

If you live in Europe, please help your local news journalists to notice this item :)

..Trevor..

ps: Thanks also to Amy:)
 

Prof Trevor Marshall
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 Posted: Sat Jan 26th, 2008 00:57

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ScienceDaily has picked up the AlphaGalileo version of the news release

"Vitamin D Deficiency May Be Symptom Of Disease: Supplements May Make It Worse"
http://www.sciencedaily.com/releases/2008/01/080125223302.htm

..Trevor..

Joyful
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 Posted: Sat Jan 26th, 2008 01:28

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Hoorah!

Now the truth has hit the mainstream.

Good going to the whole team!

:):):)



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schesche
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 Posted: Sat Jan 26th, 2008 06:57

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hi--
good news--but if i may say ..it doesn´t come across easily understandable that the others are wrong and Dr Marshall is right--people reading papers need headlines all the way through the article..
you need to raise the volume-or people won´t hear you
good luck Chris



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tickbite
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 Posted: Sun Jan 27th, 2008 10:13

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Dr Trevor Marshall wrote: ScienceDaily has picked up the AlphaGalileo version of the news release

"Vitamin D Deficiency May Be Symptom Of Disease: Supplements May Make It Worse"
http://www.sciencedaily.com/releases/2008/01/080125223302.htm

..Trevor..

Nice. Good one. That should slap a few faces (figuratively:)



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Bella
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 Posted: Mon Jan 28th, 2008 00:43

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I sent the PR to the Shreveport Times to the reporter that did the story on antibiotics and MS. Shreveport Times Article  I mentioned the article in the email to hopefully get her attention.

Jeannine

Last edited on Mon Jan 28th, 2008 00:44 by Bella



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jillian
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 Posted: Mon Jan 28th, 2008 01:11

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Trevor,

Does it also make any sense to do a grass roots campaign and mail copies to docs in general (other than the ones we've all targeted that we know)? If yes, might there be reprints available to buy in bulk?

Looking forward to see the ripple rise to a tidal wave. Hope it happens sooner than later! Feels like it's been a long time coming.

Jillian



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Prof Trevor Marshall
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 Posted: Mon Jan 28th, 2008 02:02

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I think that individual Docs generally don't have any interest in material which doesn't come to them via drug companies, or their patients. I doubt that any 'grass roots' campaign would be worthwhile.

However, there are a number of non-profits whose work is impacted by what we have done, and it would be good if 'grass roots' could start calling the attention of those organizations to the press release and the paper.
 

Phil Schoner
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 Posted: Tue Jan 29th, 2008 08:25

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I wrote a comment to the contra coastal times which Trevor offered as an example of the D lobby's activities to push D.  I simply asked why all the research focused on 25 D and largly ignored the active hormone 1,25 D.

I have also been trying to contact Edge, a cutting edge publication of leading thinkers and scientists to recommend Trevor as a contributor to their website.  Hopefully I will hear from them soon so this important vitamin D message can be disseminated here.

Phil



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Phil Schoner, MP Support Spouse, no symptoms, 1,25D 74 5/08, 25D 16 12/08, 25D 16 7/09, 25D 15 2/10, ph1 11/08, ph2 12/08, ph3 7/09, started discontinuance of Benicar 12/28/11. NoIR's, sunscreen Went off MP 1/11/2012

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