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Links between Renal system and the VDR
 Moderated by: Prof Trevor Marshall
 

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Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 16047
Status:  Offline
 Posted: Mon Dec 1st, 2008 15:01

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A paper was published last year which described how the innate immune system seemed to be key to kidney damage:

http://www.nature.com/ki/journal/v73/n1/pdf/5002658a.pdf

Just this month, and next, there are a number of papers which show that the VDR is at the heart of kidney protection, and explain why Olmesartan is so effective at preventing Kidney Damage.

Here is a sampling:

http://www.nature.com/ki/journal/v74/n12/full/ki2008452a.html
(note that they transfected a Human VDR into the mice)

http://www.ncbi.nlm.nih.gov/pubmed/19008907
 

Lottis
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Joined: Sat Jan 20th, 2007
Location: Sweden
Posts: 688
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 Posted: Tue Dec 2nd, 2008 06:21

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Quote from the chinese in Illinois:
In sum, the main purpose of this Tg study was to address the relationship among calcium, PTH and 1,25(OH)2D3 in renin regulation, and together the data unequivocally confirm that 1,25(OH)2D3 negatively regulates renin gene expression in vivo through a VDR-dependent, and calcium- and PTH-independent mechanism.

All the three links are very promising for the future of the MP study.:)

The connection between PTH, calcium and 1,25 D has had a strong traditional explanation, were 1,25 D not has had any important purpose of action, not being a causative agent but more like a result. These studies are leading the medicine into new arenas, and it will approach the question "what is blocking the VDR ?".
It feels like Christmas is coming! :dude:

/Lottis in Iceland

Last edited on Tue Dec 2nd, 2008 06:22 by Lottis



____________________
HTN,LVH,CHF,arrhythmia,variant angina,IBS?,fibromyalgia?salivarystones,gallstones,CPAP,|15feb-07 init. 1,25D 37,5,|25-D 7,8(15/2-07)| Ph1 30/5-08|Olmesartan alone|NoIR's|covered up|disabled|

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