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The Common Cold is really Immunopathology?
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  4  5   
 

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CousinTC
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Joined: Fri Nov 5th, 2010
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 Posted: Thu Jun 23rd, 2011 14:56

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I have an Idea Garv, why don't you open a Paleo Diet thread in the Lifestyles forum.  Then who ever wants to see it can and those that don't, don't have to visit there. 

Just an Idea, Taryn



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MP Start Sept'10 | Borreliosis/Lyme, Bartonella, Erlicilosis, Mycoplasma, OA, FM, CFS, Hypothyroid | migrating joint pain, fatigue, low body temp, |Start 25D=29 Last 25D=6 ng/mL Mar'18
Prof Trevor Marshall
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 Posted: Sat Dec 7th, 2013 09:56

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Bump, for Nyima's questions :)

Sallie Q
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 Posted: Sat Dec 7th, 2013 11:25

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Nyima asked
My question is whether someone who expresses robust symptoms to an infection is necessarily healthier than someone who does not?

My personal experience is that I almost never express symptoms to cold/flu type infections, such as running nose, sore throat, headaches, I just feel fatigue, dizziness and muscular aches. After 2.5 years on the MP I seem to respond to exposure to a virus by feeling off colour for a few days and then coming out of it - no symptoms.

I have a colleague who expresses very robust symptoms every time she has a viral infection, and other younger colleagues seem unaffected.

So does a healthier immune system 'see off' viruses before there is a need for symptoms, or is a lack of symptoms a sign that the immune system is not responding properly? Or maybe both are true, with someone who expresses symptoms somewhere in the middle?




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Nyima
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 Posted: Sat Dec 7th, 2013 23:37

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Thanks for bumping this thread into view for me Dr Marshall:)

This paper reviews causes of cold/flu symptoms (Science Direct and pdf links for access):

http://www.sciencedirect.com/science/article/pii/S147330990570270X

http://download.thelancet.com/flatcontentassets/H1N1-flu/pathogenesis/pathogenesis-4.pdf

The early symptoms were headache, sneezing, chilliness, and malaise, which developed quickly and also declined rapidly after 1–2 days, whereas the later symptoms—malaise, nasal discharge, nasal obstruction, and cough—developed slowly over several days and were still present 1 week after challenge.
and

The systemic symptoms of fever, headache, malaise, myalgia, and anorexia are related to the effects of cytokines released from immune cells and these responses develop rapidly in the first days of infection when the virus is detected by the immune system. The local symptoms of nasal congestion and rhinorrhoea are dependent on the generation of inflammatory mediators such as prostaglandins and bradykinin. The inflammatory mediator response may have a slower onset and longer duration than the cytokine response, which may explain the time course of local symptoms such as congestion and rhinorrhoea.
Looks like I do 'early onset' symptoms only. 

I have mostly always only done the early symptoms.  Pre-MP I would have them for weeks; since being on the MP the duration has become much shorter, and I can come across a cold, generally have a few days of feeling 'off colour' and then I'm ok again. Would it really be an indication of a healthier immune system for me to suffer florid symptoms for a week or so:?





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MP start Dec 10 (2 mo. break Jan-Mar '11) | Multinodular thyroid | frequent illness| fatigue | brain-fog | gluten intolerance (poss coeliac), eczema with dairy products | 25D (ng/ml): 4(14 Apr 11), 5.3(26 Apr 13), 4(Jan 14), 5.5(July 14)
Joyful
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 Posted: Sun Dec 8th, 2013 21:03

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I sure hope not Nyima. :(



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