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Two Key Papers Published in Autoimmunity Reviews
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Prof Trevor Marshall
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 Posted: Sat Feb 21st, 2009 10:52

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Over the last several months, my colleagues and I have been frantically writing (and editing) (and revising) papers which we were invited to write after the successful presentations in Portugal.

Two papers have just been published on Elsevier's website:

Proal AD, Albert PJ, Marshall TG. Autoimmunity in the Era of the Metagenome. Autoimmunity Reviews, in press.
http://dx.doi.org/10.1016/j.autrev.2009.02.016

A full-text preprint is available from:
http://AutoimmunityResearch.org/transcripts/AR-Proal-Metagenome.pdf

and

Albert PJ, Proal AD, Marshall TG. Vitamin D: The alternative hypothesis. Autoimmunity Reviews, in press.
http://dx.doi.org/10.1016/j.autrev.2009.02.011

A full-text preprint is available from:
http://AutoimmunityResearch.org/transcripts/AR-Albert-VitD.pdf


There are still 3 papers "in press" at the Annals of the New York Academy of Sciences. They have been peer reviewed and accepted, but are awaiting publication in the special issue "Frontiers in Autoimmunity." There is also still a paper in gestation, which has not yet been submitted.

I am sure you will realize that these two papers embody the very latest elements of our scientific knowledge, and will make a huge difference to the way that the public (and your Doctors) view our work. My sincere thanks go to Amy, Paul, Joyce, Tom, Greg, Chris B, and all the others who have worked so hard to turn these papers into a reality. Without the indirect contributions of Joyful, Janet, and indeed all of our moderators and members, we could not have made this huge step forward. My thanks to you all

Sincerely
Trevor
 

Joyful
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 Posted: Sat Feb 21st, 2009 15:01

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Dr. Marshall,

After reading both of these new papers,
I have two words for you: Excellent work!

Congratulations & Thanks
to you and all the team. :cool:



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lpbryant
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 Posted: Sat Feb 21st, 2009 19:56

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I enjoyed reading these two articles.

And I do hope you are right that these articles will change "mainstream" doctor's opinions.   I just hope they read them!

I will look forward to the publication in "Frontiers in Autoimmunity."   Is this evalable to the lay-person or will we look for them on this site when they are ready?

Thanks again for everything,

Leah Bryant



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Deedee
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 Posted: Sat Feb 21st, 2009 20:01

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I am sharing this with everyone that I can. Thank you! Deedee



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kenc
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 Posted: Sun Feb 22nd, 2009 21:08

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These papers seem to be really well written. Good work! The picture just gets clearer and more complete with every release of another paper.

I have a question:

Beta-Defensin and cathelicidin antimicrobial peptides are described as broad-spectrum antibacterials in the paper "Vitamin D: the alternative hypothesis". Does this imply they have no effect on virus or fungi? Does the VDR transcribe any peptides that effect viruses and/or fungi?

Ken



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Prof Trevor Marshall
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 Posted: Sun Feb 22nd, 2009 21:30

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Does the VDR transcribe any peptides that effect viruses and/or fungi?

Yes. If you look through the Brahmachary paper you will find there are a number of the endogenous antimicrobials which target pathogens other than bacteria :)

Brahmachary, M., et al. 2006. Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes. BMC Bioinformatics. 7 Suppl
5: S8.

http://www.biomedcentral.com/1471-2105/7/S5/S8
 
 


Martin78
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 Posted: Mon Feb 23rd, 2009 02:01

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I have read both papers and they are (according my abilities and judgement) well written, and marks an important breakthrough for all of us!

Great work and credos to all the people involved in the work! And with the knowlegde of even 3 or 4 more papers on the way this is a great start on 2009.

(...Lets not forget that is is donations to the ARF that makes this possible...)

BR

Martin



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Ron
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 Posted: Mon Feb 23rd, 2009 03:26

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Yes. Great work indeed and I too enjoyed reading both papers.

It surprised me a bit to read below Fig. 1 that "The two metabolites have nearly identical affinities for the VDR".

It seemed so logical in the presentation by Prof. Dr. Paul Lips (slide 4) last November:

affinity to VDR            25-D: very low        1,25-D: very high
since the concentrations of both metabolites differ by a factor 1000.

But when you think about it, if they indeed are nearly identical molecules, I guess they must also have nearly identical affinities to the VDR.

Does that make sense?

Prof Trevor Marshall
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 Posted: Mon Feb 23rd, 2009 08:19

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The affinity is due to forces of attraction between adjacent atoms in the molecules. The shape is the only thing which is important, and the two nearly-identically shaped molecules have nearly-identical affinities.

The concentration differences arise because physicians are not measuring concentrations in the cytoplasm of the cell, but in the blood. Within the cell, there is very little difference in the concentrations; 1,25-D is about 2 nanomolar.
 

Ron
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 Posted: Mon Feb 23rd, 2009 11:49

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Now it makes sense again!

Thank you Dr. Marshall. :)

Dogster
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 Posted: Wed Feb 25th, 2009 11:22

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"Does the VDR transcribe any peptides that affect viruses and/or fungi?" -- Yes, see Bramachary et al ....

Is this (in part) why you have said that as the innate immunity improves, so will the adaptive immunity-- and why, when  a cfs patient asked you about Montoya's approach to the viral aspect  you basically said not to bother . .  .

(I think i am becoming living proof of this!!!!)



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Prof Trevor Marshall
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 Posted: Wed Feb 25th, 2009 12:39

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Dogster wrote: Is this (in part) why you have said that as the innate immunity improves, so will the adaptive immunity-- and why, when  a cfs patient asked you about Montoya's approach to the viral aspect  you basically said not to bother
Yes, we have seen the body manage to deal with every insult. Once the immune system is restored, the human genome can start doing its work again, without interference from the plethora of microbial genomes.
 
See Amy's new paper:
http://AutoimmunityResearch.org/transcripts/AR-Proal-Metagenome.pdf
 

Cynthia S
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 Posted: Wed Feb 25th, 2009 20:46

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Wow, that's great.  Did you say that a number of these recent articles are going to show up in a particular issue of a journal?  Maybe it would be a good idea to buy the issue and give it to my doctor.  It may be more effective given in that manor.  Cynthia



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Aunt Diana
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 Posted: Wed Feb 25th, 2009 21:16

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Good thinking, Cynthia!



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Prof Trevor Marshall
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 Posted: Thu Feb 26th, 2009 00:59

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There is a special forthcoming issue of the Annals titled "Frontiers in Autoimmunity." It doesn't show yet on the Annals' web page:

http://www.nyas.org/annals/forthcoming.asp
 

JENNYV
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 Posted: Tue Mar 31st, 2009 08:58

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The articles are just what I was looking for - a perspective on the media's push of vit D supplementation.  As an American concerned about health insurance's effect on the economy, I see the Vit D recommendations (and other public health misguided messages) as a health move that's going to rebound in excalating health care costs.  While I want the US to have universal health care, I don't see how the public or private industry can afford the costs of the chronically ill - more people ill, and in more severe levels.

I work in the public health field as a dietitian in a food assistance program for young families.  I've seen families where sickness tends to hit everybody. Over the 13 years I''ve worked, it seems like more people are sick and often multiple family members, and that severity levels are higher since a decade ago. 

I want to write to my government and share my observations and own health triumphs and my concerns about health insurance  and misdirected public health messages. Your articles will make the Vit D issues easy to explain.     Jenny        

 



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Cynthia S
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 Posted: Wed Jul 22nd, 2009 19:47

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Dr Trevor Marshall wrote: There is a special forthcoming issue of the Annals titled "Frontiers in Autoimmunity." It doesn't show yet on the Annals' web page:

http://www.nyas.org/annals/forthcoming.asp
 

Hi Dr Marshall.  Is this still in the works?  Hope I haven't missed it.  I looked over the last few months of offerings and didn't see it, so I'm guessing it is still in the works.  Cynthia



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jcwat101
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 Posted: Wed Jul 22nd, 2009 20:07

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It is supposed to be published sometime in the fall.

Joyce Waterhouse



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Cynthia S
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 Posted: Thu Jul 23rd, 2009 09:22

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OK, patience.  Thank you, Cynthia



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Bane
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 Posted: Fri Sep 18th, 2009 01:34

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jcwat101 wrote: It is supposed to be published sometime in the fall.

Joyce Waterhouse


Reversing Bacteria-induced Vitamin D Receptor Dysfunction Is Key to Autoimmune Disease:

http://www.ncbi.nlm.nih.gov/pubmed/19758226


Vitamin D metabolites as clinical markers in autoimmune and chronic disease:

http://www.ncbi.nlm.nih.gov/pubmed/19758177


Dysregulation of the vitamin D nuclear receptor may contribute to the higher prevalence of some autoimmune diseases in women:

http://www.ncbi.nlm.nih.gov/pubmed/19758159
 
 


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