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Workshop on Chlamydial Infection 2009
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  4  Next Page Last Page  
 

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Prof Trevor Marshall
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 Posted: Sat Apr 25th, 2009 15:11

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Isn't there some way you can make videos available to those of us with frustratingly slow connections?
I did not encode the video you downloaded from Vimeo. It was encoded by Vimeo's software for playing in Adobe's Flash player, which integrates itself with your browser when you click on the link. I have no idea what Real Player did when capturing it, I do not use that software. Nor did I choose the parameters which Vimeo uses for HD.

The version I encoded to send to Vimeo will play in VLC, if you have a sufficiently fast computer, which means at least a recent Pentium 4, preferably a Core-2 Duo CPU. Some Atom CPUs, in low-cost netbooks, are fast enough to run VLC and Adobe Flash.
 
DVDs are not really an option, either, It takes a huge effort for Liz to mail out DVDs, and we periodically even have problems with people whose equipment is having trouble viewing them. In the last two days over one hundred people have viewed the Prague videos, and over 1000 have viewed the China keynote since December. Distribution via Vimeo seems effective. I am sorry if it is creating headaches for you :X
 
 

Prof Trevor Marshall
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 Posted: Sat Apr 25th, 2009 15:15

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I could not see the value of ever eating foods naturally high in Vitamin D in moderation--that is, after I am well
Claire,
As long as the 25-D in the bloodstream dose not exceed the level at which it starts to affect the cells (<12ng/ml is certainly safe), healthy people can eat foods with Vitamin D without any real trouble. But you are correct, there is really no reason to eat foods high in Vitamin D, there are always alternatives.
 

Julia
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 Posted: Sat Apr 25th, 2009 15:26

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I have Pentium 4, but my phone line is only capable of around 300-400 Kbps due to my position in relation to the telephone exchange :X

Prof Trevor Marshall
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 Posted: Sat Apr 25th, 2009 17:19

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To help Julia, and the others who need a download, I have created a compact version of the videos, suitable for download. These will play using either the Mac or PC version of VLC

The MP presentation is 138 MB, and can be downloaded from
(right-click on this link to download, don't just click it or it will try to play)
http://MarshallProtocol.com/flash/Prague-MP.mp4

The main presentation is 176MB and can be downloaded from
(right-click on this link to download, don't just click it or it will try to play)
http://MarshallProtocol.com/flash/Prague-Science.mp4

:)
 
 

Last edited on Sat Apr 25th, 2009 19:05 by Prof Trevor Marshall

JohnMcC
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 Posted: Sun Apr 26th, 2009 09:45

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Hello Dr Marshall,
I really enjoyed the presentations and while much of the material is becoming familiar, some of the more in depth stuff is a challenge to get my head around...hopefully as I get my mind back..:cool:

I did have a question regarding part of the conversation and the usage of Clindy and Zith - with the unique challenges presented by both of these drugs to MP patients did I understand a potential shift in use, perhaps in a way to allow for more controlled IP - or did I misunderstand.

Thanks
John



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Prof Trevor Marshall
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 Posted: Sun Apr 26th, 2009 10:08

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John,
You will also detect a subtle shift in emphasis if you look carefully at the new Phase One guidance which is now online:

http://AutoimmunityResearch.org/phase1.pdf

As we move towards mainstream, and as West China Hospital gets up and running, I have had the chance to look back over the last seven years and take stock of what we observed from the vantage point of our better understanding of the science :):) The protocol guidance is necessarily going to have to change so that physicians do not feel so overwhelmed when they encounter problems :):)
 

eClaire
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 Posted: Sun Apr 26th, 2009 11:04

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Not to mention those of us who start the protocol (speaking from the experience of someone who ran into trouble under the previous Phase One guidelines)!!! 

I think the new Phase 1 is great and I am glad to have been a part of this study.  The new recommendations would have been extremely helpful to me when I started the MP back then (with 20/20 hindsight of course), and I am so incredibly glad they are in place for people who are beginning the protocol now. 

So...great job; the new document will benefit everyone.

Claire



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JohnMcC
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 Posted: Sun Apr 26th, 2009 11:09

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Thanks Dr Marshall,
It is always good policy to review & improve...I really take my hat off to the early adopters, with the steps forward that you have made - it makes it easier for the next gen adopters.

I did breeze through the new Phase I - I need to re-read (and pay attention) and look forward to the new  II & III docs.:cool:

I also wonder (rhetorical) what will become of the process once you have 10's of thousands and more MPer's and more research data....the story continues....can there be another quantum leap in process, changes in IP, time lines....The base is complete and solid for AI disease and it's treatment - where does the research continue from here?

I need to get some more clindy....I'm thinking too much...:cool:

Regards
John



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Karl B
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 Posted: Sun Apr 26th, 2009 20:34

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I just read the paper submitted by Amy:

http://AutoimmunityResearch.org/transcripts/AR-Proal-Metagenome.pdf

where she states that lactobacillus and bifidobacteria affects the ACE gene, that in turn is "associated" with sarcoidosis.

I my case I got the first signs that I can remember of sarcoidosis when I was 20 years old. Around 10 years ago at age 36, the symptoms got worse. Eye and lung affection started to cause problems.

Roughly at the same time I had started to eat both foodstuffs with probiotic flora and regularly also probiotic pills containing lactobacillus and sometimes bifidobacteria.
My stomach reacted positively to the probiotics.

Can it be that my sarc condition got worse because of the probiotics?

Last edited on Sun Apr 26th, 2009 20:38 by Karl B



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Prof Trevor Marshall
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 Posted: Sun Apr 26th, 2009 21:09

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Karl,
It is probable that your sarcoidosis started much earlier than you exhibited symptoms, but who knows? We are all at a learning-stage right now :)
 

Prof Trevor Marshall
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 Posted: Tue Apr 28th, 2009 08:33

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Just a reminder that Ron is coordinating the work to get a transcript completed. If you can help, please PM him directly.
 

Ron
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 Posted: Tue Apr 28th, 2009 14:25

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Almost finished transcribing the second presentation.

If someone is willing to start with the first (science) presentation then please go ahead. It's a huge job so working on it with several persons would be best.

Consider it a good way to get up to date with the latest cutting edge MP science! :)

Ron

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 Posted: Tue Apr 28th, 2009 16:11

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Good work Ron!

I really want to help out... just one good night of insomnia... and ...who knows how much I can get through. :cool:



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Joyful
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 Posted: Tue Apr 28th, 2009 22:27

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  Ok... 10% done.
At 5min,10seconds... how to spell "staph-or-eous"?

Edit: never mind... Google is now my spell-checker...

  50% done....

Last edited on Wed Apr 29th, 2009 04:29 by Joyful



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Knochen
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 Posted: Wed Apr 29th, 2009 05:35

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Dr. Marshall,

I have watched the new videos a couple of times and have really enjoyed them.  Great work.  I'm also seeing some changes in the recommendations on the forums based on these presentations.  Obviously, reinstating a competent VDR and innate immune system is the key, and that requires Benicar.  But you also make a brief comment at about 4 minutes in the MP presentation that needs some clarification.

"We have to use sub-inhibitory, that's very low doses, of bacteriostatic antibiotics in order to address the biofilms..."

What this is saying to me is that, although the MP is not an antibiotic therapy per se, they are still a critical component in the overall treatment plan.  Is this correct, or can benicar alone do the job right from day 1?  If benicar alone, how long might it take in the case of someone who has significant, long standing illness?  Does benicar alone sufficiently address well established biofilms?

Or are you saying that there must be an initial assault on the biofilms using antibiotics to clear the way for the reactivated innate immune system to do its work effectively? Stage 5 would be obvious for benicar alone, but what about earlier? 

My concern is that I've been seeing posted recommendations that benicar alone can do the job, and that is a big change in the way things have been presented before.  I wanted to be sure that people weren't engaged in "selective listening" to the presentation, hoping to find an easy way to "do the MP", while really not adressing all the issues.  If you could give us your thoughts, it would be very much appreciated.  Thanks.




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Prof Trevor Marshall
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 Posted: Wed Apr 29th, 2009 07:04

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What this is saying to me is that, although the MP is not an antibiotic therapy per se, they are still a critical component in the overall treatment plan.  Is this correct, or can benicar alone do the job right from day 1?

It depends on how ill a patient is to begin with, and the exact nature of their metagenome. Healthy people can take any quantity of Benicar and antibiotics, and never experience any immunopathology.

A few people get very severe immunopathology from day one of taking Benicar. They will not need antibiotics until their immunopathology fades, and their immune system needs help to identify and target any remaining pathogens.

However, some who are ill can start Benicar get palliation, no significant initial immunopathology, and need antibiotics to start the killing process.

At some point everybody will reach stage 5 of the disease process:

http://autoimmunityresearch.org/VDR-Time-Benicar.pdf
http://autoimmunityresearch.org/stage5.pdf

when their immune system is doing the job well enough by itself. Benicar primarily provides organ protection and palliation from this point to recovery.

Eventually everybody recovers to the point where the antibiotics have no effect any more, you can take them like candy. Those  who were healthy to start with are at this point from day one. Those who were very ill will take years of immunopathology to get to this point. It all depends on how sick the patient was, and the nature of their metagenome (some species are easier for the body to target than others).
 
I hope this helps :) You might like to review our new Phase 1 guidance document:

http://AutoimmunityResearch.org/phase1.pdf
 
 

ChristineL
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 Posted: Wed Apr 29th, 2009 08:58

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Dr. Marshall,

Is there ever a circumstance where a patient would only take Benicar and never need to add the antibiotics.  For example, a spouse of someone with TH1?

Thanks!



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Prof Trevor Marshall
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 Posted: Wed Apr 29th, 2009 09:10

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It is always a good idea to add some antibiotics from time to time, just to make sure they have no effect, and that the immune system is doing the job well enough :)
 

paulalbert
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 Posted: Thu Apr 30th, 2009 06:37

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Here are the transcripts (you can click on and see the vimeo video at these links also) . The second one needs further transcription, I think:
http://mpkb.mp-dev.com/doku.php/home:publications:marshall_chlamydia1_2009
http://mpkb.mp-dev.com/doku.php/home:publications:marshall_chlamydia2_2009

Both could be proofread.

By the way, substances like olmesartan are not capitalized. Brand names like Benicar are. Clindamycin and azithromycin are both substance names.

Paul

EDIT: credit for transcription goes to Joyful and Ron



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Prof Trevor Marshall
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 Posted: Thu Apr 30th, 2009 07:15

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Thanks Paul, I am proof-reading them now
 


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