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Cosmos Magazine - Can you catch a Heart Attack?
 Moderated by: Prof Trevor Marshall
 

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Prof Trevor Marshall
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 Posted: Wed Dec 2nd, 2009 01:17

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UPDATE: The article is now online at:

http://www.cosmosmagazine.com/features/print/3477/can-you-catch-a-heart-attack

..Trevor..

------------------------------------------ Previous discussion ------------------------------------

The latest issue of (Australian) Cosmos Magazine, Dec 2009/Jan 2010, has an feature written by Becky McCall "Can you catch a Heart Attack" which quotes me a couple of times.

Becky interviewed me while I was in China, in June, via a Skype hook-up to my laptop, as nothing else seemed to get through :)

Any chance somebody could email me a scan of the article? I would love to know how it came out.

http://www.cosmosmagazine.com/issues/2009/30/

..Trevor..
ps: Oh - and discussion on the topic is welcome too. This journal just won an award as "best Oz science magazine" and it is great they are featuring talk about a microbiota causing chronic illness :)
 
pps: could somebody volunteer to send me a copy by postal mail, too? :)
 

Last edited on Wed Jul 14th, 2010 00:38 by Prof Trevor Marshall

Freddie Ash
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 Posted: Wed Dec 2nd, 2009 04:56

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HI ALL

This is Fred in WV.  In the Chicago Conference Lida Mattman's prestation she told a story about her husband having a heart attack. After she got the fluid from her husband and did a check on it to find the bactiera in it.  So she gave us a warning at the Chicago prestation to "DO NOT GO SEE SOME FRIENDs THAT HAD A HEART ATTACK BECAUSE IT WAS CATCHING."

So I tell some people that heart disease and heart attacks are contagous because it is caused by bactiera.

Remember, we are all in this together and I am pulling for us.

Your friend in Sarcoidosis

Freddie



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Freddie: dx-sarc 2/82 lymph; skin, eyes, joints, esophagus, intestines, spleen, heart,lungs-25D-7; 125-D43
Prof Trevor Marshall
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 Posted: Sun Dec 6th, 2009 16:46

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Aussie Barb just emailed me to say that her local bookshop has received the magazine, and she has bought me a copy :) Thanks Barb :)
 

ChrisMavo
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 Posted: Sun Dec 6th, 2009 23:11

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That is great!  Is there anyway we can get a copy here in the States?  I have contacted the magazine publisher about getting a copy... but have not received any response as of yet. 




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ChrisMavo
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 Posted: Sun Dec 20th, 2009 22:31

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I just got a reply back from Cosmos magazine and they tell me I can purchase a single issue of the magazine.  Can somebody who has read the article "Can You Catch a Heart Attack" tell me if it is good?  I don't want to spend the $ for the mag and postage if the article is not that good.

I appreciate any feedback on this!

Thanks,
Chris Mavo
San Francisco



____________________
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Prof Trevor Marshall
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 Posted: Mon Dec 21st, 2009 04:01

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It contains nothing new. Its value is in being a glossy article in a prestigious magazine which list our work alongside that of other international leaders, in a fair and objective manner.

Chris, if you need a copy of the text, I will send you one via email
 

Lottis
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 Posted: Wed Jul 14th, 2010 00:25

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This was published in Archives of Pathology & Laboratory Medicine, July 2010.

Stephen M. Lagana, Anil V. Parwani, Larry C. Nichols (2010) Cardiac Sarcoidosis: A Pathology-Focused Review. Archives of Pathology & Laboratory Medicine: Vol. 134, No. 7, pp. 1039-1046.
http://www.archivesofpathology.org/doi/full/10.1043/2009-0274-RA.1


Heffner 19 recently made the bold assertion that, by reason of logic, sarcoid must be caused by a foreign particle that is too small for us to discern with our current technologies or a nanoparticle. A cause indiscernible with currently available technology cannot be refuted but, by the same token, cannot be proven either.

The infectious agents most often cited as possible etiologies include mycobacteria, propionbacteria, Borrelia burgdorferi, Rickettsia helvetica, and human herpes virus 8.20
It has also been proposed that bacterial antigens that remain following successful immune clearance of infection are the most likely cause.

A recent study used proteomic techniques to search for a bacterial antigen in sarcoid tissues without an a priori hypothesis about what they expected to find. They discovered the mycobacterial antigen Mycobacterium tuberculosis catalase–peroxidase protein in slightly more than half of their samples.21

Nanobacteria have also been hypothesized as an etiologic cause of sarcoidosis.22
In 2007 a small study demonstrated a dramatic response when antifungal therapy was added in sarcoid patients whose disease was resistant to standard corticosteroid therapy alone.23

Other groups have demonstrated a beneficial effect of tetracycline-type antibiotics in sarcoidosis, although a possibility that the authors suggest is that this could be primarily derived from the antiinflammatory properties of such drugs.24



____________________
HTN,LVH,CHF,arrhythmia,variant angina,IBS?,fibromyalgia?salivarystones,gallstones,CPAP,|15feb-07 init. 1,25D 37,5,|25-D 7,8(15/2-07)| Ph1 30/5-08|Olmesartan alone|NoIR's|covered up|disabled|
Prof Trevor Marshall
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 Posted: Wed Jul 14th, 2010 00:36

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The COSMOS article is now online at:

http://www.cosmosmagazine.com/features/print/3477/can-you-catch-a-heart-attack
 

Rico
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 Posted: Wed Jul 14th, 2010 03:27

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It's becoming obvious that some new publications are dangling with the idea of infection as a possible cause of Sarcoidosis. A step forward, albeit slow. It's sad to see that none of them are giving you any credit, Trevor.



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Cynthia S
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 Posted: Wed Jul 14th, 2010 11:31

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Lottis wrote: This was published in Archives of Pathology & Laboratory Medicine, July 2010.

Stephen M. Lagana, Anil V. Parwani, Larry C. Nichols (2010) Cardiac Sarcoidosis: A Pathology-Focused Review. Archives of Pathology & Laboratory Medicine: Vol. 134, No. 7, pp. 1039-1046.
http://www.archivesofpathology.org/doi/full/10.1043/2009-0274-RA.1


...

In 2007 a small study demonstrated a dramatic response when antifungal therapy was added in sarcoid patients whose disease was resistant to standard corticosteroid therapy alone.23

...


Isn't it the position of the MP that antifungals are immune suppressants?
http://mpkb.org/home/othertreatments/antifungals
So I guess the corticosteroid is more effective w/antifungals because they are doubling up on the suppression.

Cynthia



____________________
MP start 10/08,break 1/16 - 9/16, Spondylitis'97,early Diverticulosis'98,early AMD'08,Calcium anomaly'95,TypeII Diabetes(?)'02,Degenerative hip disease'12, 25D=10.8 May'18 (preMP 125D/25D=47/43) https://marshallprotocol.com/forum30/13911-2.html
jlunn247
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 Posted: Tue Aug 3rd, 2010 05:52

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Rico wrote: It's becoming obvious that some new publications are dangling with the idea of infection as a possible cause of Sarcoidosis. A step forward, albeit slow. It's sad to see that none of them are giving you any credit, Trevor.
 
no credit it doesn'tmatter we will all be dancing on there graves.



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Living in the land of the lost. JUST OLMECIP 5 x a day.Sarcoidosis Dx.
Bone disintegration,lungs,joint/muscle/stomach pain, diarrhea,incontinence. Weakness on my left side sweats,fatigue,neuropathy,headaches,mood swings,cognitive diss.
Phillyguy
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 Posted: Tue Aug 3rd, 2010 07:34

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Cynthia Schnitz wrote: Lottis wrote: This was published in Archives of Pathology & Laboratory Medicine, July 2010.

Stephen M. Lagana, Anil V. Parwani, Larry C. Nichols (2010) Cardiac Sarcoidosis: A Pathology-Focused Review. Archives of Pathology & Laboratory Medicine: Vol. 134, No. 7, pp. 1039-1046.
http://www.archivesofpathology.org/doi/full/10.1043/2009-0274-RA.1


...

In 2007 a small study demonstrated a dramatic response when antifungal therapy was added in sarcoid patients whose disease was resistant to standard corticosteroid therapy alone.23

...


Isn't it the position of the MP that antifungals are immune suppressants?
http://mpkb.org/home/othertreatments/antifungals
So I guess the corticosteroid is more effective w/antifungals because they are doubling up on the suppression.

Cynthia

 

Similar to bacteria, an effective TH1 response is required to combat fungal infections so the question is do some species of fungus comprise the TH1 microbiota.

Intersestingly, the primary pseudomas quorum sensing molecule is a potent PPARg antagonist.  PPARg expresses the Dectin-1 receptors, which are the primary receptors associated with the recognition of B-1,3 Glucan, and they also express one of the primary anti-fungal metabolites.  These receptors are expressed on macrophages, dendritic cells, neutrophils and lymphocytes.

Invasive fungal infections are not uncommon in sarcies, nor are yeast infections in TH1 patients.  Whether or not they are the primary driver of disease in some patients or a piggy back infection is less important than the fact that once established, they are hard to eliminate.  Functioning PPARg is probably required to rid the body of fungus.

I recall one in vitro study that indicated olmesartan seems to have very little effect on PPARg, while telmisartan is a potent PPARg agonist.

1,25D is a potent PPARg antagonist.

I think this is another example of Dr. Marshall's point about 1,25 knocking out other receptors and the impact it has on innate immunity.  Olmesartan's affinity for PPARg appears to be much lower than 1,25D.  By lowering 1,25D and using olmesartan as a VDR agonist proxy, you get VDR functioning and PPARg functioning....or death to bacteria and fungus.

I know that Sedona credits knocking out her nasty fungal infection with the use of oregano oil.  Oregano oil contains carvacrol (over 50% of the phenolic content), which is a potent PPARg agonist and is also cidal to some fungal species and static to most species of bacteria. A paper just came out that indicates carvacrol is strongly cidal against propionobacteria, one of the species found in granulomas....I'm not suggesting consideration of its use, just throwing out a possible explanation of its action.

Final point: The participants in that studay almost certainly didn't restrict D consumption or 1,25D levels so its not surprising that fungus crept into the picture due to impaired PPARg functioning.

Last edited on Tue Aug 3rd, 2010 08:04 by Phillyguy

Lottis
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 Posted: Sun Aug 29th, 2010 02:20

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The European Society of Cardiology has its annual meeting in Stockholm the next coming week end.
http://www.escardio.org/congresses/esc-2010/Pages/welcome.aspx

The abstracts are interesting to read, especially the part about diastolic dysfunction.
There is an indication that inflammation could be causing Diastolic Heart Failure.

http://spo.escardio.org/abstract-book/presentation.aspx?id=82691
Conclusions:
Through downregulation of SERCA2 gene, inflammatory cytokines may cause cardiac diastolic dysfunction by decreasing diastolic calcium re-uptake. Our study offered the evidence to apply novel therapies for DHF patients aim at limiting the inflammatory reactions.

Last edited on Sun Aug 29th, 2010 02:21 by Lottis



____________________
HTN,LVH,CHF,arrhythmia,variant angina,IBS?,fibromyalgia?salivarystones,gallstones,CPAP,|15feb-07 init. 1,25D 37,5,|25-D 7,8(15/2-07)| Ph1 30/5-08|Olmesartan alone|NoIR's|covered up|disabled|
Prof Trevor Marshall
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 Posted: Sun Aug 29th, 2010 02:33

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Reuters has an interesting report from that conference:

"To some extent, cardiology is a victim of its own success, since treatment advances mean the field has contributed a hefty seven years to the 10 years increase in average life spans in recent years, as against just 2.4 months for oncology, he said"


I am not sure Oncologists would agree with 2.4 months. It would be interesting to know where he got that figure from :)

http://www.reuters.com/article/idUSTRE67R0TI20100828
 

Lottis
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 Posted: Sun Aug 29th, 2010 02:54

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And here is another one on how neurohormones and inflammation markers IL-6 and TNF-alfa is used to diagnose pregnant women.
http://spo.escardio.org/abstract-book/presentation.aspx?id=83521

Conclusions:
Normal pregnancy did not change in plasma concentrations of HF biomarkers. Increased levels of plasma neurohormones (BNP, ANP or NOR) and IL-6 cytokine were associated with HF in pregnant women with heart disease. Accordingly, this biomarkers assess provide useful tools for diagnosis of HF during pregnancy.



____________________
HTN,LVH,CHF,arrhythmia,variant angina,IBS?,fibromyalgia?salivarystones,gallstones,CPAP,|15feb-07 init. 1,25D 37,5,|25-D 7,8(15/2-07)| Ph1 30/5-08|Olmesartan alone|NoIR's|covered up|disabled|
Lottis
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 Posted: Sun Aug 29th, 2010 03:03

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Today in swedish media, they report from the upcoming conference that one study will present doubts about omega 3.
The study question the use of omega 3 in preventing heart disease.
It is a big deal!

Edit
Here is the list of pressreleases

http://www.escardio.org/about/press/press-releases/esc10-stockholm/Pages/welcome.aspx

Last edited on Sun Aug 29th, 2010 03:21 by Lottis



____________________
HTN,LVH,CHF,arrhythmia,variant angina,IBS?,fibromyalgia?salivarystones,gallstones,CPAP,|15feb-07 init. 1,25D 37,5,|25-D 7,8(15/2-07)| Ph1 30/5-08|Olmesartan alone|NoIR's|covered up|disabled|

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