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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Alzheimers Amyloid protein is an Antimicrobial Peptide


Alzheimers Amyloid protein is an Antimicrobial Peptide
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  4  5  6  7  8  Next Page Last Page  
 

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wrotek
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 Posted: Fri Nov 11th, 2011 00:22

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I remember Dr Marshall discussed cigarette microbiome and human lung diseases - COPD, asthma .

I wonder, if mouth microbiome can contribute to these diseases.

Can mictobiota, or antigens, be inhaled from the mouth to the lungs ? And perpetuate inflammation ?



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mvanwink5
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 Posted: Fri Nov 11th, 2011 04:29

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Wrotek,
Any method that reduces bug colonies that does not involve immune suppressive chemicals is positive in my book and these ideas being suggested here sound good to me and I plan to incorporate them.

I want to point out something though. In the power plant where I worked for 30 years as an engineer, we had cooling water pipes carrying 115 F to 120 F water. It may be hard to imagine, but bacteria would form slime colonies on the inside of these pipes and eat right though the metal. So, we used biocides and a host of chemicals to try to control them. Even with the harshest chemicals and most potent industrial antibiotics, these slime colonies could not be eliminated. Eventually we had to start a project to replace the pipes.

I related the above industrial experience to give a reference point for what we are up against. The one thing we do have that the steel pipes did not and that is the innate immune system with its hundreds of different antimicrobial peptides.

Best regards,
Mike



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wrotek
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 Posted: Fri Nov 11th, 2011 05:14

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Mvanwink5, have You tried ozone for pipes ?
It is used to clean air conditioning in cars.

You can even build an ozone machine Yourself, and close it while being turned on, with air conditioning turned on as well, inside the car and it does the job.

:) Little trick, if You don't want to pay for this in Auto-service.



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mvanwink5
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 Posted: Fri Nov 11th, 2011 05:25

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Wrotek,
I don't know what the engineers are doing now for their cooling water treatment as I retired a bit ago. They have snake oil like sales people that consult and make money from chemical sales, just like doctors have drug sales people that visit. I know that ozone has become more popular for pool water treatment. I do like your suggestion for the car. For making an ozonator, do you perhaps have a link you favor?

Best regards,
Mike



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wrotek
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 Posted: Fri Nov 11th, 2011 05:36

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I dont have a link, but there is plenty ozonators available on the internet to buy.

You just need one that makes ozone from air, not from pure oxygen source.

My friend is electronic hobbyist so he can make his own ozonator.

Last edited on Fri Nov 11th, 2011 05:38 by wrotek



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jlunn247
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 Posted: Tue Nov 22nd, 2011 21:42

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wrotek wrote:
I remember Dr Marshall discussed cigarette microbiome and human lung diseases - COPD, asthma .

I wonder, if mouth microbiome can contribute to these diseases.

Can mictobiota, or antigens, be inhaled from the mouth to the lungs ? And perpetuate inflammation ?


My chest says yes, after having bad tooth pulled. From the lining of the mouth they can go to The upper gi as well.

Here ibuprofen helps Alzheimer knock out mice and humans
http://neuro.cjb.net/content/20/15/5709.full

It doesnt explain much but i prefer ibuprofeb over Tylenol. Palliation?

Last edited on Tue Nov 22nd, 2011 22:17 by jlunn247



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 Posted: Wed Nov 23rd, 2011 10:59

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NSAIDs actually inhibit immune tolerance/suppression. Prostanoids are highly immuno-suppressive, in particular PGE2, which is also associated with pain perception, fever and tissue healing. NSAIDs inhibit the cyclo-oxygenases and in this manner limit the conversion of arachidonic acid into PGE2. Thus, NSAIDs can alleviate pain and fever but can also lead to further joint destruction, for example. On the other hand, they are associated with a lower of rate of alzheimers and a strikingly reduced rate of cancers, particularly the COX2 inhibitors. The smoker/celebrex user lung cancer rates are super low compared to non-COX inhibitor users.

The angiotensin receptors increase the expression of COX-2. I suspect this is one of the pathways that the ARBs work on, amongst others, which lead to a reduction in cancers and neurodegenerative disease.

Last edited on Wed Nov 23rd, 2011 12:13 by Phillyguy

wrotek
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 Posted: Thu Nov 24th, 2011 11:24

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Do You think some people get darker teeth from minocycline, because they have bacteria in their mouth, that minocycline attacks ?

Some kind of reaction ?

Last edited on Thu Nov 24th, 2011 12:51 by wrotek



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Prof Trevor Marshall
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 Posted: Thu Nov 24th, 2011 11:39

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wrotek wrote: Do You think some people get darker teeth from minocycline, because they have bacteria in the mouth, that minocycline attacks ?
Could be, but remember that minocycline has profound biochemical effects on the human body, including its actions as a PXR receptor agonist. So one of these more direct actions might be in play, who knows?
 

wrotek
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 Posted: Thu Nov 24th, 2011 12:42

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Dr William D. Nordquist directed me to this website for my answers...

http://lifeguardyourhealth.com/

Many interesting materials, including videos, about mouth microbiome.

For example Helicobacter Pylori, beside spirochetes.
http://www.youtube.com/watch?v=IOalajsPBX8&feature=channel_video_title


It is a long website :) Just starting to read.

He also said he has written two books on the subject

The Stealth Killer: Is Oral Spirochetosis the Missing Link in the Dental and Heart Disease Labyrinth?

The Silent Saboteurs: Unmasking Our Own Oral Spirochetes as the Key to Saving Trillions in Health Care Costs


Dr Marshall, but many drugs target PXR, right ? Do they also make teeth darker ?

Last edited on Thu Nov 24th, 2011 13:03 by wrotek



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 Posted: Thu Nov 24th, 2011 15:45

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Excellent find wrotek.  It looks like folks are more and more finding a relationship between pathogens and chronic inflamatory disease.  I wonder when the tipping point will be reached to where the common therapy becomes immunostimulation versus immuno suppression.  I particularly noted the segment near the bottom connecting depression to an increase in inflamatory cytokines.   



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wrotek
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 Posted: Sat Nov 26th, 2011 00:10

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Yes depression, and generally feeling bad from cytokines really interests me.

Because if one has wide body inflammation it is like having source of their pain spread throughout the whole body.


I wonder, if cytokines can act stimulatory on sympathetic nervous system. Can they make you focus and alert and not sleepy ?



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seanc
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 Posted: Fri Dec 2nd, 2011 21:30

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Here is a recipe for making your own dental bleach as prescribed by Dr. Clark.
Recommended after tooth extractions to kill clostridium:

http://livingnetwork.co.za/drclarknetwork/recipes/dental-bleach-lugols-iodine/


She also suggests adding oregano oil to baking soda for toothpaste.






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Prof Trevor Marshall
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 Posted: Sat Dec 3rd, 2011 02:35

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Sean, I don't agree with the need for any mouthwash more potent that the Hydrogen Peroxide-Baking Soda combination. Cetylpyridinium Chloride 0.07% is a less aggressive, but acceptable substitute (eg Crest 'Pro-Health' mouthwash).

I would actively discourage members from following the formulation suggested in the Dr Clark link (above) :)
 

seanc
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 Posted: Sun Dec 4th, 2011 21:26

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I understand.  I was actually trying to nudge folks away from using clorox.  

Last edited on Sun Dec 4th, 2011 21:29 by seanc



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 Posted: Fri Dec 16th, 2011 11:10

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The Alzheimer's disease-associated beta-amyloid protein is an antimicrobial peptide with a redox mechanism of action

by Soscia, Stephanie J., Ph.D., BOSTON UNIVERSITY, 2011, 151 pages; 3463283

The ?-amyloid protein (A?) is believed to be a key factor underlying Alzheimer's disease (AD) pathology. The physiochemical and cytotoxic activity of A? has been the subject of intense study for over 25 years. However, few studies have addressed the normal role of A? in cell biology. At present A? is most often characterized as an accidental pathological product of catabolism with no normal function. Here, for the first time, we provide strong evidence that A? normally functions as an antimicrobial peptide (AMP) of the innate immune system. A? has potent antimicrobial activity equivalent to, and in some cases greater than, that of the archetypical human AMP LL-37. Furthermore, AD brain homogenates show increased A?-mediated AMP activity compared to age-matched controls.

A?/copper complexes that catalytically generate reactive oxygen species (ROS) cause lipid peroxidation in vivo . To date, A?-mediated ROS generation has been considered a pathological and likely accidental consequence of the peptide's metal binding. However, the second part of this study suggests ROS generated by A?/Cu may serve to increase the peptide's antimicrobial action. A? causes lipid peroxidation in microbial cells and induces a protective response in Staphylococcus aureus that is a marker for oxidative stress. Furthermore, catalase deficient S. aureus mutants are more sensitive to A? compared to wild type bacteria. These findings raise the possibility that while A? redox activity is cytotoxic, this action may normally be directed against pathogens and play a protective role. Selecting for redox active AMPs may be a novel strategy for enhancing the efficacy of these agents in therapeutic settings.

The final part of this study aims to analyze the toxicity profiles of soluble, covalently cross-linked A? protein species (CAPS). CAPS, particularly dimeric forms, are emerging as key pathological agents in AD pathology and appear to have increased redox activity. Methods for generating and purifying synthetic CAPS were developed. The synthetic CAPS were then used to study A?-mediated membrane disruption. The data suggest membrane permeabilization by CAPS is strongly modulated by the composition of the lipid bilayer and the peptide's access to metals. Future research will determine if redox-mediated oligomerization increases AMP activity.

--------------------------------------------------------------

Note:  ARBs block the expression of beta amyloid in mice.  The ATII receptor probably has a role in innate immunity.

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 Posted: Fri Dec 16th, 2011 12:33

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Phillyguy wrote: Note:  ARBs block the expression of beta amyloid in mice.  The ATII receptor probably has a role in innate immunity.

Wouldn't that be a bad thing, if beta amyloid is an anti-microbial peptide and part of the innate immune system?



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 Posted: Fri Dec 16th, 2011 12:41

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Russ,

if -- if -- if - and mice.

Too many variables to answer your question definitively :) In addition, Mice may well have totally different transcription of the Amyloid-beta genes. We just don't know.

It is good to see this type of research being done, however :) Gives me a nice warm feeling in this Holiday season...
 
 
 
(Thanks Phillyguy :) )

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 Posted: Fri Jan 20th, 2012 02:36

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Autophagy and the VDR:

http://www.cell.com/cell-host-microbe/abstract/S1931-3128%2809%2900283-2



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 Posted: Sat Jan 21st, 2012 02:45

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This 10 minutes TED talk is from 2008, but gives us more good arguments why the world must try the MP

Biochemist Gregory Petsko makes a convincing argument that, in the next 50 years, we'll see an epidemic of neurological diseases, such as Alzheimer's, as the world population ages. His solution: more research into the brain and its functions.

http://www.ted.com/talks/gregory_petsko_on_the_coming_neurological_epidemic.html



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