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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Alzheimers Amyloid protein is an Antimicrobial Peptide


Alzheimers Amyloid protein is an Antimicrobial Peptide
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Prof Trevor Marshall
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 Posted: Sat Jan 21st, 2012 04:07

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I went to a conference at the Salk a couple of years ago. It focused on how the brain works - there were lots of videos of poor animals running around with wires into their brains. Ugggh. In any case, it turns out the brain responds most to waves, ergo, it probably communicates with waves, alternating current, not direct ON/OFF currents like Medicine currently thinks. Neurons are viewed as if they were something like Digital computers, but they are more like analog computers, with a complexity beyond anything we could devise to measure them, I think.

So the scientists can research as much as they like - they have a life's vocation ahead of them. It is most unlikely the brain will ever be decoded beyond the outer layers, those which fire and directly stimulate muscles. The cognition and memory layers are hidden deep below that superficial, but easily observed, functionality. And it is those layers which make us human.
 

Sallie Q
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 Posted: Sat Jan 21st, 2012 14:05

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Lottis, IMO the neuro epidemic has kicked in well and truly, which is why I no longer necessarily vote for age and experience in elections: age and experience make you truly dangerous if you are going nuts like many dictators have done

Trevor, the downside of my broadband is that (short of big house modifications) the gadget is less than 2m from my bed. Fortunate not to spend as much "down time" as many of the old hands here, but the penny dropped late that I really do not know if it is retarding my recovery.
I now switch of the transmitter thingy in the evening and switch it back on in the morning for phone calls. We did not replace the last Microwave oven either

Last edited on Sat Jan 21st, 2012 14:06 by Sallie Q



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Prof Trevor Marshall
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 Posted: Sat Jan 21st, 2012 14:16

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Sallie, I have seen nothing which would make me think that WiFi energy, or the leakage from a microwave oven, is going to retard healing.

A few members are especially sensitive to radiation, but that is a symptom, and would not retard healing, as far as I can see :)

Sallie Q
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 Posted: Sat Jan 21st, 2012 15:21

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Thankyou for passing on your knowledge of physics
I know my older son is hugely sensitive to radiation and perhaps does not talk about it much because can be regarded as a delusion :(
I know he is healthier and happier after moving from a flat near high voltage transmitter, which of course, is a different kettle than ovens and domestic communications.
Sallie Q

btw
Alzheimer's disease is forecast to affect nearly 75,000 New Zealanders by 2026http://www.stuff.co.nz/the-press/news/6296012/Kiwis-at-edge-of-brain-study

A blood test aimed at the early detection of Alzheimer's disease is being developed by researchers at the University of Otago.but does not say what they are looking out for, only " Plasma molecules would then be screened using biochemical and molecular techniques"
The team leader, Professor Cliff Abrahams, said treatments for the disease would probably be developed in the near future,
watch that space, any of you kiwis skilled in PR??

Last edited on Sat Jan 21st, 2012 15:46 by Sallie Q



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 Posted: Sun Jan 22nd, 2012 01:27

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Sallie Q wrote:
I know my older son is hugely sensitive to radiation and perhaps does not talk about it much because can be regarded as a delusion :(
I know he is healthier and happier after moving from a flat near high voltage transmitter, which of course, is a different kettle than ovens and domestic communications.

This page lists as symptoms of EM sensitivity a lot of th1 diseases:

http://emfsensitivity.com/

This is an article from last year about the conductivity of biofilms:

http://physicsworld.com/cws/article/news/46821

So it seems possible that th1 disease could make people sensitive to EM radiation.  I have noticed feeling rough myself after a couple of hours sitting next to a wifi transmitter although I don't know that I would be able to pick it out in a double blind study.

I know somebody who has what is almost certainly a th1 disease who is so electrosensitive that she moved from her flat in Paris to a farmhouse in a hamlet in the countryside outside Toulouse, I have tried to tell her to look for the underlying issue in her health but as yet to no avail.



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Prof Trevor Marshall
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 Posted: Sun Jan 22nd, 2012 07:00

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Yes, it is the underlying issues which need to be addressed. Generally there is an underlying Th1 inflammatory problem which has not yet been recognized.

Only after one's brain starts to really heal, is it possible to understand the profound nature of the delusions which a Th1 patient has to deal with. I look back on so many over my life.

There is no doubt that super-high frequency waves (upwards of 50GHz) have the potential to alter the way that biological molecules function. Not only do my in-silico emulations indicate atomic dynamics at those frequencies, but there have been numerous reports of problems with those ultra-high frequencies. Many molecules have resonances up above 50GHz.

Do any molecules have resonances at WiFi frequencies? Probably, but WiFi energy is low, and does not penetrate the skin very far. Additionally, they would need to be larger molecules, which are already subject to many other forces in-vivo, and have thus developed a resistance to damage.

..Trevor..
 

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 Posted: Sun Jan 22nd, 2012 14:43

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kudos for the interest in electrical functions.
Didn't Tesla have a "vision" of how his ac motor worked?
What a nut job a real "Einstein". :D

So also cell towers cannot hurt brain function ever?
Even if turned up to 11?

Last edited on Sun Jan 22nd, 2012 14:52 by jlunn247



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 Posted: Sun Jan 22nd, 2012 15:22

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NickBowler wrote:
Autophagy and the VDR:

http://www.cell.com/cell-host-microbe/abstract/S1931-3128%2809%2900283-2


Jees try breaking down Cathelicidin and understanding the connections between anti microbial cells as they mature.
hows that riddle go? "What walks in the morning on all 4 legs? in the afternoon ect.

bzzt there goes another synapse connection, hope it was in piano lessons. And not where i remember good stuff. I dont care if i remember some music.

Last edited on Sun Jan 22nd, 2012 15:34 by jlunn247



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Prof Trevor Marshall
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 Posted: Sun Jan 22nd, 2012 15:43

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jlunn247 wrote: So also cell towers cannot hurt brain function ever? Even if turned up to 11?
Well, when I was at High School I was a Ham Radio operator (VK5ZTM) using 'ultra-high frequencies' (576MHz) so I designed some "turned up to 11" transmitters for setting the distance records (one of which stands to this day LOL).

I was already very sick by then, and standing right in front of these large antenna arrays didn't seem to make me any worse... the shadows were already on my lung X-rays. Yes, there was some heat, and yes, you could strike a 40 Watt fluorescent tube from the energy, and hold it lighted in your hand.

So I am  hard to convince that RF energy is so causative of harm. All that I suffered from was from misfiring neurons, later in life :)

I was going to say that my brain went progressively wrong later in life, but who but a deranged lunatic would light a 40W bulb from RF in their hands and stand in an RF field to show it off :)

..trevor..
 

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 Posted: Sun Jan 22nd, 2012 20:41

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who but a deranged lunatic would light a 40W bulb from RF in their hands and stand in an RF field to show it off :)
You WERE a daredevil in your younger days!!  :D



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 Posted: Mon Jan 23rd, 2012 05:54

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looking in to photon output of diff elements.
Does that possibly affect internal vit d production?
vicious circle of mal absorption in diet as well?
And or also "In physics, absorption of electromagnetic radiation is the way by which the energy of a photon is taken up by matter, typically the electrons of an atom."
We dont all share the same body chemistry some bodies are cokes others are pepsis. Although we probably all taste the same.



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 Posted: Mon Jan 23rd, 2012 07:49

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http://www.reproduction-online.org/content/14/3/355.short
Darn ageing process are not sperm the shortest living human cells?
Thought it was about more than just a tanning booth experiment.
:)

Last edited on Mon Jan 23rd, 2012 08:31 by jlunn247



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 Posted: Thu Feb 2nd, 2012 12:03

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Hi,

This study is getting alot of attention today:

http://news.yahoo.com/mouse-study-suggests-alzheimers-spreads-brain-infection-190410018.html

THURSDAY, Feb. 2 (HealthDay News) -- Alzheimer's disease appears to spread through the brain, traveling from neuron to neuron in much the same way that an infection or cancer moves through the body, new research with mice suggests.

Scientists reported Thursday that their work indicates that abnormal tau protein -- already identified in the brains of those with Alzheimer's -- starts in one region of the brain and spreads along linked cellular circuits.

Identification of this tau pathway could influence the direction of future research and treatment of the mind-wasting disease, the study authors and other experts said.

"This opens up a whole new area of biology that has direct relevance for Alzheimer's disease. We now have a whole new set of targets that perhaps we can develop drugs for," said study lead author Karen Duff, a professor of pathology at Columbia University's Taub Institute for Research on Alzheimer's Disease and the Aging Brain...



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Prof Trevor Marshall
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 Posted: Thu Feb 2nd, 2012 12:22

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Rosie,
It sounds like another dead-end to me. Just like the prion diseases. Remember the prions that were supposed to be at the root of neuromuscular diseases?

It is very difficult to do experiments in animals and tissue culture, and to be able to extrapolate them to the clinic. I go to a lot of conferences, meet a lot of these researchers.

My assessment is that these researchers drew an incorrect conclusion from an inadequate model. It is up to them to show that their discovery can induce recovery in human beings. I don't give them a chance in Hades of being successful at that.

But then, here at the MP site, we have seen stuff these researchers could only dream of. Since they clearly haven't Googled, I guess dreaming is their best bet :) :)

Thanks for the link, though :) :)

..Trevor..
 

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 Posted: Thu Feb 23rd, 2012 09:21

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Toxins from diseased brain cells make diseases of the brain even worse

http://news.ku.dk/all_news/2012/2012.2/toxins_from_brain_cells/

"If the NADHP Oxidase does not work in the macrophages, patients become so ill that they die".

This is because if the macrophages do not remove foreign bodies, the immune system decides instead to encapsulate viruses, bacteria, fungus and parasites in special shells. These granulomata accumulate in the body until they kill the patient before the latter has reached the age of thirty. This disease is known as Chronic granulomatous disease.


"Things have to be in balance", says Associate Professor Vilhardt. "In neurodegenerative diseases such as Alzheimer's and dementia the level of free radicals in the brain is out of balance: it is too high"

Last edited on Thu Feb 23rd, 2012 09:22 by Bane

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 Posted: Thu Feb 23rd, 2012 15:12

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Still, there is a belief that free radicals are bad and antioxidants are sold... If not for free radicals, immune cells would not clean our bodies, kill pathogens.

Very nice article, beside h202 body also produces ozone... That was discovered relatively recently.

Last edited on Thu Feb 23rd, 2012 17:43 by wrotek



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wrotek
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 Posted: Fri Feb 24th, 2012 06:01

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Here is an interesting enzyme - indoleamine 2 3-dioxygenase, it supresses intracellular pathogens and produces ozone and hydrogen peroxide, to kill pathogens, from tryptophan  (could the lack of tryptophan caused by this process,from which serotonin is produced, result in a depression ? ) and from other indoleamines.

Some articles about it

http://www.ncbi.nlm.nih.gov/pubmed/1907934
http://bloodjournal.hematologylibrary.org/content/113/11/2394.full

Infections Early studies have demonstrated a role for IDO in the inhibition of viruses and intracellular pathogens, such as Toxoplasma gondii and Chlamydia psittaci.44,45 Moreover, the activity of IDO on the induction of a specific inhibitory environment during chronic infection has recently been revisited. In particular, IFN-dependent expression of IDO by different cell subsets, including DCs, is often seen during infections and represents an innate mechanism of pathogen elimination.46 Listeria monocytogenes infection of the mouse placenta, which leads to granulomatous disease, results in the induction of IDO, which, in turn, plays a role in counteracting the bacterial infection while maintaining a barrier to T cells to prevent fetal rejection.47 Similar observations were made with other granulomatous infections caused by Bartonella henselae and Mycobacterium tuberculosis, where IDO-expressing APCs prevent T cell–mediated granuloma destruction and subsequent pathogen dissemination.48 More recently, a critical role for IDO has been found in the generation of immunologic resistance to fungal infections, including candidiasis and aspergillosis. In this setting, DC expression of IDO, tryptophan catabolites, and Tregs all cooperate in regulating the fine balance between inflammation, which is required for protection, especially at the early pathogen encounter phase, and tolerance, which is necessary to down-modulate potentially overwhelming inflammatory responses.41,49


I have heard about this enzyme from Foreydoon Batmanghelidj ,MD, and his hydration protocol. He says that this pathway is suppressed, when there is dehydration in the body.




Last edited on Fri Feb 24th, 2012 06:15 by wrotek



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 Posted: Tue Mar 6th, 2012 10:02

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UCLA scientists pinpoint how vitamin D may help clear amyloid plaques found in Alzheimer's

http://www.eurekalert.org/pub_releases/2012-03/uoc--usp030612.php

A team of academic researchers has identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main component of plaques associated with Alzheimer's disease.

Published in the March 6 issue of the Journal of Alzheimer's Disease, the early findings show that vitamin D3 may activate key genes and cellular signaling networks to help stimulate the immune system to clear the amyloid-beta protein.


Previous laboratory work by the team demonstrated that specific types of immune cells in Alzheimer's patients may respond to therapy with vitamin D3 and curcumin, a chemical found in turmeric spice, by stimulating the innate immune system to clear amyloid beta. But the researchers didn't know how it worked.


"This new study helped clarify the key mechanisms involved, which will help us better understand the usefulness of vitamin D3 and curcumin as possible therapies for Alzheimer's disease," said study author Dr. Milan Fiala, a researcher at the David Geffen School of Medicine at UCLA and the Veterans Affairs Greater Los Angeles Healthcare System.


For the study, scientists drew blood samples from Alzheimer's patients and healthy controls and then isolated critical immune cells from the blood called macrophages, which are responsible for gobbling up amyloid beta and other waste products in the brain and body.


The team incubated the immune cells overnight with amyloid beta. An active form of vitamin D3 called 1a,25–dihydroxyvitamin D3, which is made in the body by enzymatic conversion in the liver and kidneys, was added to some of the cells to gauge the effect it had on amyloid beta absorption.


Previous work by the team, based on the function of Alzheimer's patients' macrophages, showed that there are at least two types of patients and macrophages: Type I macrophages are improved by addition of 1a,25–dihydroxyvitamin D3 and curcuminoids (a synthetic form of curcumin), while Type II macrophages are improved only by adding 1a,25–dihydroxyvitamin D3.


Researchers found that in both Type I and Type II macrophages, the added 1a,25–dihydroxyvitamin D3 played a key role in opening a specific chloride channel called "chloride channel 3 (CLC3)," which is important in supporting the uptake of amyloid beta through the process known as phagocytosis. Curcuminoids activated this chloride channel only in Type I macrophages.


The scientists also found that 1a,25–dihydroxyvitamin D3 strongly helped trigger the genetic transcription of the chloride channel and the receptor for 1a,25–dihydroxyvitamin D3 in Type II macrophages. Transcription is the first step leading to gene expression.


The mechanisms behind the effects of 1a,25–dihydroxyvitamin D3 on phagocytosis were complex and dependent on calcium and signaling by the "MAPK" pathway, which helps communicate a signal from the vitamin D3 receptor located on the surface of a cell to the DNA in the cell's nucleus.


The pivotal effect of 1a,25–dihydroxyvitamin D3 was shown in a collaboration between Dr. Patrick R. Griffin from the Scripps Research Institute and Dr. Mathew T. Mizwicki from UC Riverside. They utilized a technique based on mass spectrometry, which showed that 1a,25–dihydroxyvitamin D3 stabilized many more critical sites on the vitamin D receptor than did the curcuminoids.


"Our findings demonstrate that active forms of vitamin D3 may be an important regulator of immune activities of macrophages in helping to clear amyloid plaques by directly regulating the expression of genes, as well as the structural physical workings of the cells," said study author Mizwicki, who was an assistant research biochemist in the department of biochemistry at UC Riverside when the study was conducted.


According to the team, one of the next stages of research would be a clinical trial with vitamin D3 to assess the impact on Alzheimer's disease patients. Previous studies by other teams have shown that a low serum level of 25–hydroxyvitamin D3 may be associated with cognitive decline. It is too early to recommend a definitive dosage of vitamin D3 to help with Alzheimer's disease and brain health, the researchers said. They add that ongoing studies are showing that vitamin D3 may be beneficial in reducing the incidence of a growing number of human diseases.



Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention.

http://www.ncbi.nlm.nih.gov/pubmed/20153625


Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention.

http://www.ncbi.nlm.nih.gov/pubmed/18844852


Last edited on Tue Mar 6th, 2012 10:11 by Bane

Prof Trevor Marshall
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 Posted: Tue Mar 6th, 2012 10:32

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I have chatted casually with Pat Griffin several times, and I can't recall one time he has asked whether I might be able to suggest possible pitfalls in their use of in-vitro analysis of in-vivo disease activity. Usually all these guys want to talk about is the weather :) :)

Nor do any of them Google for ideas, or pick up the telephone to chat about their work. It is just mind-boggling the gap which has opened up between these scientific research groups at the very time they could be closely coordinating their activities...

Oh well. IMO this will delay the solution for Dementia and Alzheimers patients by a decade. First they will try them all on high-dose Vitamin-D supplements, and after a few years, even higher dose vitamin-D supplements. Only then will they begin to notice the bodies accumulating :X

I just hope they leave the autistic kids alone..

..Trevor..
 

Last edited on Tue Mar 6th, 2012 12:07 by Prof Trevor Marshall

wrotek
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 Posted: Tue Mar 6th, 2012 23:52

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So Curcumin does not work in VDR ? Or does it ?



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