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Even Bacteria get lonely
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  4  Next Page Last Page  
 

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NickBowler
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 Posted: Mon Jun 21st, 2010 03:00

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quorom sensing in tumours:

http://www.nature.com/bjc/journal/v100/n12/full/6605071a.html

http://www.economist.com/node/15268859

'What they do know is that when they grow these cells in culture, they can push them toward either asymmetrical or symmetrical division by controlling the density of cells and the amount of oxygen available.'



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seanlane
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 Posted: Wed Jul 14th, 2010 07:53

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Of course....when I took Pamelor...a powerful Trycyclic anti-depressant that increases ephinephrine....I went manic and was hospitalized.



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Lyme positive Sept 2014
NickBowler
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 Posted: Wed Aug 18th, 2010 05:05

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'A mixture of just 10 nM of each amino acid is sufficient to disrupt biofilms'


http://pubs.acs.org/cen/news/88/i18/8818notw3.html




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Prof Trevor Marshall
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 Posted: Wed Aug 18th, 2010 06:40

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By living inside the cytoplasm of living cells, the microbiota ensures that their environment is very carefully controlled (by the host).

Diesel
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 Posted: Fri Oct 22nd, 2010 02:22

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TINKER, BACTERIA, EUKARYOTE, SPY

Bacteria and their hosts may reside in different kingdoms, but that doesn't stop them from intercepting each other's communications. Asher Mullard reports

http://www.nature.com/news/2009/090513/pdf/459159a.pdf

"Bacteria are conversing with us, and we're conversing with them," says Lyte. The question now is how to record more of the conversation — and work out what is being said. 

Regards,

Diesel



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inuk2600
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 Posted: Fri Oct 22nd, 2010 09:16

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One of the most universal and faithfully repeatable symptoms of CFS is post exertion malaise/fatigue. Most people with CFS would agree that you can replace the word exertion with any kind of stress in general. A flood of epinephrine always accompanies this exertion/stress. Could it be that this abnormal reaction (post exertion malaise) occurs somewhat directly from  a quorum-type response to epinephrine of certain intracellular bacteria species/combinations?


Last edited on Fri Oct 22nd, 2010 09:21 by inuk2600



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Prof Trevor Marshall
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 Posted: Fri Oct 22nd, 2010 10:15

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inuk2600 wrote: Could it be that this abnormal reaction (post exertion malaise) occurs somewhat directly from  a quorum-type response to epinephrine of certain intracellular bacteria species/combinations?
Most certainly :) This is indeed the best current explanation for why Th1 patients' bodies behave abnormally to epinephrine.
 

leroybrown
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 Posted: Fri Oct 22nd, 2010 15:52

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I feel much better after exercising, but breaking through the pre-exertion malaise is the big problem for me.

Deb



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I just know that something good is going to happen
And I don't know when - Kate Bush
Aplastic anemia Apr/10, PRCA Jan/09, Agranulocytosis 1991
25D = 25 1,25D = 58 Aug 18/09|25D<4.8 Mar/10|10.8 Nov/12
Sep '09 q8h Nov '09 q6h
Serena
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 Posted: Mon Oct 25th, 2010 06:28

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I am reading, for the first time in my life, about others who have a problem with epinephrine.  I am so grateful for this information.

I was unconscious at the dentist office - about 20 years ago - while having all of my old mercury fillings replaced with hypoallergenic material.  I was awakened by a sensation of my body having a massive earthquake.  It felt like my body was shaking violently while my heart raced out of control.  Although I was awake enough to realize all of this, I was not awake enough, at first, to open my eyes or to speak.  I was absolutely terrified.  I thought, "what is wrong with these people...can't they see that something is very wrong with me."  I thought this because they continued to work right along in my mouth as if nothing was amiss.  When I reached a point where I could open my eyes, my panic worsened as I looked down and realized that I was not moving, although the sensations of violent shaking from head to toe continued while my heart raced.  When I finally reached a point where I could speak and sit up, I shot up like an arrow, pushing these people back with my arm...almost knocking them to the floor.  Of course,  they were shocked that I would do such a thing.  I explained what I was feeling. The dentist called my neurologist and asked what was going on.  My neuologist asked what they had given me in the anaesthesia.  It was the epinephrine.  I had received a combination of carobaine, lidocaine, and epinephrine. 

I had a lot of auto antibodies to many of my own tissues.  My titer for anti-myelin antibodies was substantial and my neuro had previously diagnosed peripheral neuropathy, but he had never said anything about steering clear of epinephrine.  The point of this excerpt is this.  Tell your dentist, oral surgeon, peridontist, etc., to make a sign in big letters, "NO EPI" and place it on the inside front page of your file so everyone in the office will realize that you cannot have epi.  The last thing you need is to have a reaction like mine.  Of course, if you are ever taken to the ER in an unconscious state, you may get a shot of epinephrine, but, it is not necessary to use epinephrine at the dentist office... there are other substances that can be used.  

If this warning has been posted here or someplace else at this website, please forgive my intrusion and the use of your time to read this. 



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Joyful
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 Posted: Mon Oct 25th, 2010 06:50

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Your story is not a new one, but it is worth retelling so that others are made aware of this.

It is addressed in the MP Knowledge Base here:
   Working with a dentist



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minski2
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 Posted: Mon Oct 25th, 2010 07:45

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Hi Joyful......it may not be a new story,  but I have only run into one dentist that was aware of this and fortunately that was over 40 years ago.  I have moved often so I have had at least a dozen so called good dentists  I even had one dentist in Charlotte NC ignore my request not to use epi.....when I had a severe reaction he was as terrified as I was.  Should have sued!!!  We are so lucky to have this study site that affords us the opportunity to learn what is not common knowledge!!!!
  
Dian



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inuk2600
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 Posted: Tue Dec 21st, 2010 12:53

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Moderate Exercise Increases Expression for Sensory, Adrenergic,
and Immune Genes in Chronic Fatigue Syndrome Patients
But Not in Normal Subjects


http://www.co-cure.org/Light.pdf

The mRNA was sampled from leukocytes.
The differences between the CFS group and healthy controls are interesting, especially the adrenergic function gene expression following exercise, ie. epinephrine dump. ;)




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Marysue
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 Posted: Tue Dec 21st, 2010 14:52

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Are you kidding???? Don't we already know from research cited here (somewhere) that the bacteria feed on epinephrine? Is that just the injected epinephrine that the dentists use, or is it the stuff we produce in our bodies as well?
Yikes. That's another good reason to avoid exercise until we've killed off a substantial amount of the bacteria (not that I have a choice anyway, since even small amounts of exertion trigger too much immune activity).
Marysue



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eClaire
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 Posted: Tue Dec 21st, 2010 15:27

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Darn... whatever is killing me with this CFS definitely wants me to stay still.  Meanwhile, there are those running around telling me I need graded exercise.  Me?  I just want to do stuff.



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Sallie Q
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 Posted: Tue Dec 21st, 2010 19:11

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Happy Christmas Claire
don't just do something
curl up with a good book ;-)
and a hopeful New Year to everybody
Sallie



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Aunt Diana
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 Posted: Tue Dec 21st, 2010 23:58

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I have learned through trial and error over twenty years of Lyme and then 5 more years with Lyme + the MP....exercise will come back to BITE you every time. (At least it does come back and bite me...even the genlest form). Walking is about as far as I will go anymore and even then it is easy to overdo.
I know how frustrating this is since we all want to get back to what we were before we were ill, exerciise was so good for us. But, when one has neurological impairment, excercise will not rebuild muscle tone.
There are times one has no choice but to push oneself to get a necessary job done. I just came through such an ordeal when our shipping container with all or our world possessions arrived and we had a crew of 5 men who had two days to empty and sort and place furniture as well as possible. For two days, I had no choice but to muster all my strength and get the job done. (Frankly I was amazed at what I could get done....even the 5 stevadores were impressed with my energy).
That was 5 days ago and I am only now able to hobble around a bit...I have slept for the major part of the past 4 days and nights just recovering.)
Such is life...but it keeps getting better, slowly but surely.



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HeatherK
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 Posted: Wed Dec 22nd, 2010 03:58

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I too can still easily overdo it, in fact I just did... usually walking a few minutes a day is OK, but Saturday I went with my hubby  into the hill/field /woods across from us to cut some fir boughs and a christmas tree, Fun ! but the hill is steep, I was puffing in no time and did I ever pay up for that excursion, worst aches/pains in a year I think, especially hips and knees... 

we have medically proven reasons to be couch potatoes ? !!!  :D:D:D  



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CFS - crashed 5 yrs+ before diagnosis and starting MP Sept 2007. (Sept 07 25D=24pg/ml, 1,25D=47.5pg/ml)~~ Mar 2011,25D-6.4 ~~ Started Phase Two Mar 4/08. Off all ABX Oct 2011. In blackout home still, wearing NoIRs, celiac. 25D=4.8 June/11
leroybrown
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 Posted: Wed Dec 22nd, 2010 04:12

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I feel way better after I exercise (getting myself to DO it is the problem), but I can understand why people with certain diseases feel worse, especially in light of that study. Very interesting stuff.

Deb



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I just know that something good is going to happen
And I don't know when - Kate Bush
Aplastic anemia Apr/10, PRCA Jan/09, Agranulocytosis 1991
25D = 25 1,25D = 58 Aug 18/09|25D<4.8 Mar/10|10.8 Nov/12
Sep '09 q8h Nov '09 q6h
JanEE
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 Posted: Wed Dec 22nd, 2010 11:39

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Recently I thought I was doing fine by walking every other day or two, and it did make me feel better too.   I made it for about seven times in two and a half weeks or so, which is the longest I've been able to keep at it.  But once again I've had to stop.  There are so many of us that seem to react this way to exercise. 
 
I remember before beginning the MP I was taking lots of Aleve tablets trying to control the pain in my legs.  While it didn't totally do the job I sometimes wondered if underneath the masking of the pain I might be getting better and would slack off the Aleve slightly for a couple days.  I went through that many times, but always had to go back on all the pills.   Eventually though I discovered that I was able to take less of them, and finally, after a year or so, none.  So maybe it's sort of like that with the exercise.  We just have to keep trying every once in a while, and one day we'll find that we're able to keep at it longer and longer without crashing---and that will be the beginning of the good times.  That will be a day for rejoicing.



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 Posted: Wed Dec 22nd, 2010 23:42

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Jan,
I agree--and I do look forward to that day. ;):cool::D



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