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Even Bacteria get lonely
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  4   
 

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inuk2600
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Joined: Sun Oct 11th, 2009
Location: Manitoba Canada
Posts: 17
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 Posted: Wed Jan 5th, 2011 07:10

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QseC Mediates Salmonella enterica Serovar Typhimurium Virulence In Vitro and In Vivo

http://iai.asm.org/cgi/content/full/78/3/914


"QseC plays a role in invasion of epithelial cells and intramacrophage survival."




____________________
CFS symptoms | 25D9(Mar09) | 25D14(Jun09) | 25D6 (Sept11) Ph1Apr09 | Ph2Aug09 | Ph3Jun10 | drop back to Ph1Nov10 | Olmesartan only q6h since early 2011
inuk2600
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Joined: Sun Oct 11th, 2009
Location: Manitoba Canada
Posts: 17
Status:  Offline
 Posted: Wed Jan 5th, 2011 07:25

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I haven't read the full text yet, but this looks interesting...

Targeting QseC Signaling and Virulence for Antibiotic Development


http://www.sciencemag.org/content/321/5892/1078.abstract

"Using a high-throughput screen, we identified a small molecule, LED209, that inhibits the binding of signals to QseC, preventing its autophosphorylation and consequently inhibiting QseC-mediated activation of virulence gene expression."





____________________
CFS symptoms | 25D9(Mar09) | 25D14(Jun09) | 25D6 (Sept11) Ph1Apr09 | Ph2Aug09 | Ph3Jun10 | drop back to Ph1Nov10 | Olmesartan only q6h since early 2011

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