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The Chinese pharmaceutical manufacturing industry
 Moderated by: Prof Trevor Marshall
 

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Prof Trevor Marshall
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Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
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 Posted: Thu Jun 3rd, 2010 03:32

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One of the things our collaboration with West China Hospital has forced upon us is the need to more fully understand the Chinese manufacturing industry, and its aspirations.

Last year at the Dalian (cancer) conference I heard a presentation on behalf of the Govt Health Minister, with slides showing how China wants to be shipping half the world's pharmaceuticals within the next 10 years.

I am making a quick visit to the CPhI conference in Shanghai to try and grasp the magnitude and methodology of their efforts. This is by far the largest conference I have ever attended, larger than even COMDEX in Las Vegas, at its peak a decade ago...

Here is a booth which put things in perspective for me, this was near the entrance....



Yes, that is 15,000 tons of Paracetamol (Panadol, Tylenol) which this one company ships every year.. It seems to be their only product :)

But to put that into perspective -- here is one of only a few companies which was publicly advertising its prices. in this case, bulk (unpackaged) Doxycycline is $42 per kilo (let's see, 1000 grams at 150mg per dose -- heck, that's over 6000 doses... for $42)
 



Pity they weren't advertising their Azithromycin price :)

I have taken videos of some of the machinery in action. First we have some super-size glass flask and equipment you would be familiar with from high School. But these are really big....

http://www.vimeo.com/12261552

Finally, here are two capsule filling machines, filling 11,000 and 90,000 capsules per hour respectively...

http://www.vimeo.com/12261195

One of those machines could make West China Hospital a year's supply of 25mg mino capsules pretty fast. Let's see ... hmmm.... instantly in fact...

One final image before I try to get some sleep... This was taken in the Magnetic Levitation train from the Airport to the conference center. That green digital speed indicator at the top of the photo is saying 430 kM/H (238 miles per hour). The most amazing thing was how we left the cars  speeding down the freeway as if they were standing still.. or going backwards...


ChrisMavo
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 Posted: Thu Jun 3rd, 2010 13:41

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Fascinating videos Dr Marshall!  I wish we could take advantage of some of those bulk prices on the drugs!

And the picture of the speed indicator on the mag-lev train is also amazing!  Wow 238 MPH!! ... and we think antiquated BART here in the Bay Area is pretty fast???   We need to undertake more projects like that here in the USA.

As always, thank you very much for sharing your experiences so generously when you are at these conferences.  I, like many on the MP, cannot get out of the house very much and these videos help to make life a bit more bearable!

Chris

Last edited on Thu Jun 3rd, 2010 13:41 by ChrisMavo



____________________
PLS/ALS, speech difficulty, dizziness, leg weakness, overly emotional, Ph1Aug2609,11/2012 25D-12, 11/11: 25D-10, 04/11: 25D-11, 07/10: 25D-13, 05/10: 25D-15, 11/09: 25D-20, 9/09: 25D-27, 7/09: 25D-38, 1,25D-46, Mod Ph2Oct09, 100mg Mino
Prof Trevor Marshall
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 Posted: Fri Jun 4th, 2010 01:09

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Today was spent at the "China Summit on sartan drugs," organized by eChinaChem. I gave a short (10 minute) presentation with some pretty in-silico pictures :) And the human-mouse-VDR movie :)

Sorry, Chris, no photo today. I will try and get the official group photo so I can put it online :)

Joyful
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 Posted: Fri Jun 4th, 2010 01:14

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Dr. Marshall,
The opportunities seem exceptional.

I hope that your audience was paying attention!

:)



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Prof Trevor Marshall
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 Posted: Fri Jun 4th, 2010 04:18

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OK - you shamed me into it -- here are a couple of minutes of video I shot at the local market this evening, while I was buying some bread.

http://vimeo.com/12292094
 
YouTube is blocked here in China, and I can only get to Vimeo :X :)

titta
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 Posted: Fri Jun 4th, 2010 10:29

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The human-mouse-VDR movie?

Is this just a new name for an 'old' filmed lecture ?
Or indeed  a new video?

I would like to get the link to it.

Titta



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 Posted: Fri Jun 4th, 2010 11:16

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Well, I'm all for anything that cuts the evil Medco out of it.



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Prof Trevor Marshall
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 Posted: Fri Jun 4th, 2010 12:08

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Titta,
The "human-mouse-VDR movie is a 1 minute molecular dynamics emulation which I show in many of my presentations. For example, it is in Ljubljana at the 4:48 minute mark.
 
SM,
Medco used to be part of Merck, and many senior Medco employees kept their 401K and stock in Merck when Merck was split into Medco, which focuses on insurance, and Merck, focusing on manufacture. Five years ago, Medco contacted me to find out why I wasn't using the Merck product, Losartan (Cozaar) in the MP. They pushed me to change from Olmesartan to Losartan. I am sure that these ex-Merck employees honestly feel Merck's Losartan is just as good as Sankyo's Olmesartan, so I would ascribe their behavior towards the MP as being motivated by greed, rather than malice. And, of, course , they were totally incapable of understanding the science behind either of the drugs...
 
According to the data I got at the Sartan Summit yesterday, total shipments of Losartan in the USA during 2009 were about 26 tons, equal to the 26 tons of Olmesartan (those are only metric tonnes, precisely 26,000,000 grams).
 

ChrisMavo
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 Posted: Fri Jun 4th, 2010 13:01

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Dr Marshall,  When I tried to view your latest video from China I get a message from Vimeo saying that I do not have permission to view this private video.   I am subscribed to your videos on Vimeo. 

Any ideas why this is happening? 



____________________
PLS/ALS, speech difficulty, dizziness, leg weakness, overly emotional, Ph1Aug2609,11/2012 25D-12, 11/11: 25D-10, 04/11: 25D-11, 07/10: 25D-13, 05/10: 25D-15, 11/09: 25D-20, 9/09: 25D-27, 7/09: 25D-38, 1,25D-46, Mod Ph2Oct09, 100mg Mino
Prof Trevor Marshall
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 Posted: Fri Jun 4th, 2010 14:53

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Chris,
I had the permissions messed up.
Try again now -- I have fixed that problem...

http://www.vimeo.com/12292094


ChrisMavo
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 Posted: Fri Jun 4th, 2010 15:04

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Just watched it Trevor!  Very good!  I especially enjoyed the meat vendors whom I assume, were poking fun of your "Western-stomach", and your good-natured laughing with them, in the last segment.   I have had THAT experience MANY times in my travels around Europe!  In fact when visiting my Greek relatives they always expected that I could eat as much as three men ... but of course they always tried to get my svelte wife to eat just as much... so maybe it is just Greek to do that!  :D

Thanks for posting these videos ... I really enjoy them! 



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PLS/ALS, speech difficulty, dizziness, leg weakness, overly emotional, Ph1Aug2609,11/2012 25D-12, 11/11: 25D-10, 04/11: 25D-11, 07/10: 25D-13, 05/10: 25D-15, 11/09: 25D-20, 9/09: 25D-27, 7/09: 25D-38, 1,25D-46, Mod Ph2Oct09, 100mg Mino
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 Posted: Sat Jun 5th, 2010 00:06

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Doctor Marshall,

Maybe you could just casually slip a tonne or two in your pocket when nobody's looking...



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SCORPIAN
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 Posted: Tue Jun 8th, 2010 15:20

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Those compact pharmaceutical machines are cool, clever Chinese, I wonder how much they go for...



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