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FDA investigating the safety of Benicar
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  ...  5  6  7  8  9  10  11  12  13  14  Next Page Last Page  
 

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Bane
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 Posted: Thu Jun 21st, 2012 14:14

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cathys2007 wrote: Common Blood Pressure Drug Linked to Severe Gastrointestinal Problems

http://www.sciencedaily.com/releases/2012/06/120621130722.htm

ScienceDaily (June 21, 2012) — Mayo Clinic researchers have discovered an association between a commonly prescribed blood pressure drug, Olmesartan, and severe gastrointestinal issues such as nausea, vomiting, diarrhea, weight loss and electrolyte abnormalities -- symptoms common among those who have celiac disease. The findings are published online June 21 in the medical journal Mayo Clinic Proceedings.

Severe Sprue-Like Enteropathy Associated With Olmesartan

http://www.youtube.com/watch?v=KjIWzIUN-eA

2:36 "and we also used steroids"

Last edited on Thu Jun 21st, 2012 14:18 by Bane

cathys2007
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 Posted: Thu Jun 21st, 2012 14:36

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glad you found that...nice catch Bane!



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MP 7/7/08 Dx Sarcoid-determined by lymph node, skin, stomach biopsies/neurosarcoid, FMS, IBS, Chronic Fatigue, brain fog, Primary Parahyperthyroidism, MTHFR, migraines, TMJ, Narcolepsy, Osteopenia, Gerd, Raynauds, Thoracic outlet, poss Lyme/D125=48(Mar07)
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 Posted: Thu Jun 21st, 2012 14:44

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Hi Cathy,

I read the link to the article.  I am sure that the patients  described were taking 20 or 40 mg of Olmesartan once a day and (through no fault of their own) getting the worst of possible results.  We are fortunate to know that the beneficial effects of Olmesartan come from keeping the concentration high enough, around the clock, instead of turning things on for a little while then off for the rest of the daily cycle.

All best,
Dody



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MP Feb'07 (no breaks)| Lyme '98, Arrhythmia-Tachy-Vertigo '06, Appendicitis-Colon-Resection '89, Bipolar '83, Meningitis '47 | my progress | last 25D= 9ng/mL Aug'16
Ron
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 Posted: Thu Jun 21st, 2012 23:04

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Thanks for finding this, Cathy and Bane! And thanks, Dr. Marshall, for posting the comments on YouTube.

Prof Trevor Marshall
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 Posted: Fri Jun 22nd, 2012 00:12

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Ron, I find is utterly amazing, and negligent, for this type of article to be published without a decent search for our prior art on either PubMed, YouTube or Google. Sadly, that is the state of Medicine I see as I travel around -- a very few bright sparks who have adapted to the 21st Century, while most remain firmly locked in the past :X
 

Russ
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 Posted: Fri Jun 22nd, 2012 03:12

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Always get worried when I see these articles about negative effects of Olmesartan.  I dread the day when I can walk into a store and buy a pack of smokes for $10 but Olmesartan has been taken off the market for my "protection".  Federal agencies have been such a big help so far with these diseases that an outcome like this seems par for the course. 

So was glad to hear the Mayo clinic doctor, at around the 2m 50s point in the video, say that this was a "very rare" association and that "the vast majority of patients on this medication should not change it at all".  He repeats this sentiment towards the end.

Also, at around 5m he admits that "we've described an association, not necessarily cause and effect".  Then goes on to say they need to figure out what the mechanism is and if this is confirmed elsewhere.  Hopefully they will see Dr. Marshall's comments and review his papers and presentations.

Prof Trevor Marshall
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 Posted: Fri Jun 22nd, 2012 03:23

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Russ, we have Pure Olmesartan in the wings, which, from the outset, is being properly described to the FDA. No need to lose any sleep just yet :) :)
 

Russ
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 Posted: Fri Jun 22nd, 2012 03:36

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Good to hear.  Dr. Marshall, do you think it's possible that researchers like these at the Mayo clinic do search the internet and find your work but don't consider it "mainstream" enough to cite?  That would be an even bigger offense in my opinion.

Prof Trevor Marshall
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 Posted: Fri Jun 22nd, 2012 03:41

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No, I don't think so, Russ. Relevant peer-reviewed papers should have been cited, if known to the author. Mainstream, by its very definition, is peer-reviewed papers.

You would be surprised how insular most researchers really are :)
 

Bane
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 Posted: Fri Jun 22nd, 2012 04:07

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Long-term use of angiotensin II receptor blockers and risk of cancer: A population-based cohort analysis.

http://www.ncbi.nlm.nih.gov/pubmed/22709730

"All ARBs significantly correlated with lower rates of cancer. Malignancies from the 7 most common sites were fewer in ARB users with the relative risk reduction of 28 to 49%. ARBs were associated with a decrease in incident cancer across subgroups including prior and concomitant exposure to angiotensin-converting enzyme inhibitors"

CONCLUSIONS:
In the cohort with indications for ARB treatment, exposure to ARBs was associated with lower risk of overall and site-specific cancers compared to nonusers. These findings reassure the safety of ARBs and support further investigations on ARBs and cancer prevention at the molecular level.

Russ
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 Posted: Fri Jun 22nd, 2012 04:07

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Fyi, just did a Google search on "olmesartan celiac" and another one on "olmesartan gastrointestinal".  The first MP related hit shows up on page 4 and page 8 of the results respectively.  In both cases it's the MPKB page on Managing Immunopathology which does not talk about those symptoms in relation to Olmesartan but as potential non-IP symptoms caused by gluten intolerane or NSAIDS.  Of course, the majority of results are for the recent report from the Mayo clinic, so if searching before they went public the MP related hits would have been higher.

On YouTube, "olmesartan celiac" returns 13 results of which 5 are MP related including the third result.  "olmesartan gastrointestinal" returns 13 results of which 1 is MP related and it is the second result.

HealthyAgain
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 Posted: Fri Jun 22nd, 2012 05:24

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Angiotensin II receptor blockers

In 2008, they were reported to have a remarkable negative association with Alzheimer's disease (AD). A retrospective analysis of five million patient records with the US Department of Veterans Affairs system found different types of commonly used antihypertensive medications had very different AD outcomes. Those patients taking angiotensin receptor blockers (ARBs) were 35—40% less likely to develop AD than those using other antihypertensives.[7][8]

[7],[8]http://en.wikipedia.org/wiki/Angiotensin_II_receptor_antagonist#cite_note-6

Taken from Wikipaedia

[8]



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16 months on MP, Lymes symptoms - with a sprinkling of Multiple Sclerosis - disappeared. No disabilities now.
****Off Benicar since Jan 2016****
I intend to see this through. No turning back. We are pioneers dammit!! Started Aug 2009
PatsyAnn
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 Posted: Fri Jun 22nd, 2012 18:19

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Hi - I've trusted Olmecip Q4 for over a year, then recovered enough to think I could take a break from the MP while my husband was recovering from a stroke and heart surgery. I became sick again. When recently returning to the MP (thank God!) I felt so comfortable - even with the fatigue it causes me - because I knew I was returning to the "Benicar Blockade" Dr. Marshall has described. With the "Blockade" in place, I can begin the antibiotics again. I'm relieved to hear that Olmesartan is still being proven safe (loved the catch Bane made on "steroids"). From a couple of the recent entries, I'm wondering: Is it possible to obtain Olmesartan here in the U.S.??
For Dr.Marshall: Thanks so much for saving my life! How can countless numbers of people you've helped ever thank you enough?! Whenever telling others about the MP, I also speak of your character - a man who could have made millions of dollars, yet instead chose to save millions of lives! You are amazing.



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Dixie
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 Posted: Sat Jun 23rd, 2012 07:00

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Dear Dr. Marshall,

Is there ANY means by which I can obtain Pure O living in the U.S?

Thank you for responding to my request.:)

Dixie (Deborah Cleaveland)



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 Posted: Sat Jun 23rd, 2012 09:24

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PatsyAnn, olmesartan is still under patent in the US as Benicar.  The patent does not expire for a few years yet.  So, if you can afford the ~6x higher price, or can cajole your insurance company into paying for it, most of us can't, then you just need to go to any pharmacy with a prescription and pay 3 or more dollars per pill.

Cynthia



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 Posted: Sat Jun 23rd, 2012 09:59

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Pure olmesartan is not available, as it hasn't been approved by the FDA for any purpose.  Dr Marshall is working on this.

Olmesartan Medoximil (Benicar, Olmecip, etc.) is the only approved and available form anywhere outside of research efforts.



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sarcoid diagnosed 1991, probably started 1983
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SanDiegoJoy
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 Posted: Sat Jun 23rd, 2012 10:38

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Patsy Ann: What most of us do who live in the US is order generic Olmesartan (usually called Olmecip) from a reputable Canadian pharmacy which requires a prescription. The cheapest one I've found is PlanetDrugsDirect.com, I order 180 tablets x 2 (for a total of 360 tablets which is about a 3 month supply) and the cost is $204. If you want to order 180 tablets it is $102. It takes about a week to process the order and 3 weeks to receive it, so that's why I order a 3 mos. supply at a time, and they will take refills so I try to get my doc to authorize 1 or 2 refills at the time they fax their prescription.

PlanetDrugs has been great to do business with and are very responsive. I've communicated with them via e-mail and on the phone several times. (They will follow up with a fax to you after you place your order reminding you that they need to get a prescription from your doc and your doc should reference your order # when they fax your Rx.)

Last edited on Sat Jun 23rd, 2012 10:39 by SanDiegoJoy



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PatsyAnn
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 Posted: Sat Jun 23rd, 2012 13:44

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Thanks so much for the response(s) to my Olmesartan question . . . and the details you gave, SDJoy, are very informative. I, too, have ordered the O from an international pharmacy - but this one sounds better! By the way, we previously lived in San Diego for many years - and our eldest daughter & family are there. We'll be there the week of the Fourth to celebrate our 35th Anniversary AND our first Grandaughter's 18th birthday! :)



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MP start July 2010 (no breaks) | Lupus, Rheumatoid Arthritis, Sjogren's Syndrome, suspected Sarcoidosis | exhaustion, severe joint pain, brain fog | Last 1,25D 42 11/2010
Bane
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 Posted: Thu Oct 11th, 2012 15:19

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How Does Inhibition of the Renin-Angiotensin System Affect the Prognosis of Advanced Gastric Cancer Patients Receiving Platinum-Based Chemotherapy?

http://content.karger.com/produktedb/produkte.asp?doi=337979

Conclusion: ACEI/ARB in combination with standard chemotherapy might improve survival in patients with AGC and hypertension. These results support further investigation into the anticancer effects of ACEL/ARB.

Bane
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 Posted: Fri Dec 21st, 2012 03:33

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Long-Term Use of Angiotensin Receptor Blockers and the Risk of Cancer

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050893

"This study provides additional evidence that the use of ARBs does not increase the risk of cancer overall or any of the four major cancer sites"


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