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FDA investigating the safety of Benicar
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  ...  7  8  9  10  11  12  13  14  Next Page Last Page  
 

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Prof Trevor Marshall
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 Posted: Thu Jul 18th, 2013 10:15

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It is exposing sub-clinical existing problems. Early-stage disease which cannot yet be identified by symptoms or markers.

My research on "Predictive and Preventative Medicine" covers the topic of sub-clinical disease, how to tell if somebody is going to get ill, and prevent it before they really get sick.
 

Pamela H-F
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 Posted: Thu Jul 18th, 2013 14:40

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Thanks. That's what I thought. If it actually caused gut troubles I suppose we'd all be in quite a state.
Pam



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dietary changes-1/08,Noirs-4/08, phase 1-5/08 Sarcoidosis dx 1982 in Lymph, dx again 2007 in skin and lungs. Osteopenia, Anemia, low Adrenals, D25 <10 1-20-12.
Dogster
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 Posted: Thu Jul 18th, 2013 14:41

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Is that paper in the site somewhere?



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CFS lyme RSD: pain migraine| tylenol fioricet flexeril tramadol temazepam| acidoph guaif/cold| Q| Cut D/exp Feb05| NoIR Mar05| June05 Comm Beni Q8H| July05 mino| Jan06 PH2| Aug06 1,25D=29 25D=17|
Prof Trevor Marshall
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 Posted: Thu Jul 18th, 2013 14:44

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@dogster
Hmmm. There is a book chapter due to be released in September. That is the most comprehensive. There is also a series of conference abstracts. Not sure if I ever put any of those videos online, though. I will look into it.

stuckpac
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 Posted: Fri Jul 19th, 2013 07:58

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Talk about sub-clinical disease existing undiagnosed. I was seeing a patient in the ED the other day for another problem (heat exhaustion) and he gave as his Past Medical History "celiac sprue" and nothing else. Being on the MP and now having become alerted to the fact that rarely do we find one of these "autoimmune phenomena" existing completely alone, I began poking around to see if I could find anything else. Any psoriasis, lupus, RA, etc? Went through a whole list of them. Has your doctor thought you are ill in any other way? No, no and no. Then the mother speaks up from the other side of the room and say, "XXXX, why don't you tell the doctor about how you are absolutely so tired all the time and can sleep all day long and barely get out of bed sometimes"? The Ah-Ha moment..... :-)

Prof Trevor Marshall
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 Posted: Fri Jul 19th, 2013 08:31

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:)

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 Posted: Fri Jul 19th, 2013 16:40

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Whenever someone asks me if anything has improved while on the MP, I love to mention how many NEW symptoms I have developed as a result of the exposure of subclinical ailments.  Then I love to go on and tell them how, if it weren't for the MP, that subclinical thing would have popped up in a few months or years to knock me on my can.  One person told me I made her miserable, because now she has to wonder how many time bombs she's carrying.  I told her to find out - use the MP.



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MP start Jun'12, once again on an MP break | Degenerative Disc Disease, Osteoarthritis, Post-Lyme, depression/anxiety, GI. Most recent serum 25D: 6/15 -18
Carry on, and keep MP'ing
Bane
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 Posted: Fri Jan 31st, 2014 01:47

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Cardiac mortality in users of olmesartan, other angiotensin-receptor blockers and angiotensin-converting enzyme inhibitors.

http://www.ncbi.nlm.nih.gov/pubmed/24375940

"The results of this well-powered study do not raise concerns for the risk of SCD or death from all causes among olmesartan users in comparison with users of other ARBs or ACE inhibitors"

Trudy.Heil_NP
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 Posted: Fri Feb 7th, 2014 14:50

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An interesting blog in the NY Times by Dr. Lisa Sanders: Think Like a Doctor: Stomach Bug Solved!

http://well.blogs.nytimes.com/2014/02/07/think-like-a-doctor-stomach-bug-solved/

I answered the blog and directed them to the mpkb.org....

:shock::):D

Trudy



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MP June08(NoBreaks)Ph1June28-08 ModPh2Aug11-08 Ph2Sept25-08 Ph3Oct4-10 Benicar Only 2012|VitD1,25 6-08:72; VitD25:12-15 12.0 |FMS40+yrs CystAcne65 EBV66 ClsdHdInjry66 PCOS71 Hashmtos81 HSV2&6 81 TotlHyst86 Endmtrs PsorFeet95 Strep&ClamydPneumx3
Cairo123
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 Posted: Fri Feb 7th, 2014 17:00

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Hi Trudy,

I looked at the blog, but did not see your comments. Is there a delay involved in the posting of the comments?



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Sarcoidosis, Arthritis, Fallen Arch, Vascular Insufficiency, fatty liver,diverticulosis, 1,25D 16 (Oct08) | Ph1 Nov07, Ph2 Jan08, Ph3 May 09 Ben Only: Jun 10- Sep 10|Break Sep 10-Dec 10|Resume MP Dec 10|
Trudy.Heil_NP
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 Posted: Fri Feb 7th, 2014 17:07

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Yes, there is a delay.
Trudy



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MP June08(NoBreaks)Ph1June28-08 ModPh2Aug11-08 Ph2Sept25-08 Ph3Oct4-10 Benicar Only 2012|VitD1,25 6-08:72; VitD25:12-15 12.0 |FMS40+yrs CystAcne65 EBV66 ClsdHdInjry66 PCOS71 Hashmtos81 HSV2&6 81 TotlHyst86 Endmtrs PsorFeet95 Strep&ClamydPneumx3
Cairo123
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 Posted: Fri Feb 7th, 2014 17:19

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I am looking forward to reading what you said.



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Sarcoidosis, Arthritis, Fallen Arch, Vascular Insufficiency, fatty liver,diverticulosis, 1,25D 16 (Oct08) | Ph1 Nov07, Ph2 Jan08, Ph3 May 09 Ben Only: Jun 10- Sep 10|Break Sep 10-Dec 10|Resume MP Dec 10|
Limburg
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 Posted: Sat Feb 8th, 2014 00:29

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Well done Trudy, it's unbelievable to us Mp'ers.



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MP Jan.2009.Break from september 2017-december 2017. MS.1997. AIH 2004. Muscles, Joints, Skin, various symptoms. 25D=25.6(nmol/ml)september 2014.From april 2016; blood and protein in urine. Skinrashes, several allergies.
Grateful Survivor
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 Posted: Sun Feb 9th, 2014 04:47

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I haven't been able to see Trudy's comments yet either. 

My thought is that Benicar even at conventional dosage was provoking immunopathology--without the stabilizing effects of the steadier round-the-clock concentrations we are getting.  Blaming the agent that used properly could be curative.

Benicar at MP dosage is what, over the course of 6 years, transformed my borderline Crohns colon to a colon in which no inflammation could be seen.  Now I get diarrhea only from an occasional acute bug or, unfortunately several times this winter, when I have to use my abdominal muscles to lift a little too much weight, bothering the adhesions left from surgery in 1989 that removed my ascending colon to which multiple old abscesses were attached.  (Other than the need to restrict lifting, especially lifting with twisting, the resection was a complete success.)

Dody



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MP Feb'07 (no breaks)| Lyme '98, Arrhythmia-Tachy-Vertigo '06, Appendicitis-Colon-Resection '89, Bipolar '83, Meningitis '47 | my progress | last 25D= 9ng/mL Aug'16
Cairo123
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 Posted: Sun Feb 9th, 2014 10:57

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The same 4 comments that have been there all along are there with nothing from Trudy. I do not know what the delay time is. I wonder if her comments have been censored for not supporting the thesis of the article.

Last edited on Sun Feb 9th, 2014 11:20 by Cairo123



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Sarcoidosis, Arthritis, Fallen Arch, Vascular Insufficiency, fatty liver,diverticulosis, 1,25D 16 (Oct08) | Ph1 Nov07, Ph2 Jan08, Ph3 May 09 Ben Only: Jun 10- Sep 10|Break Sep 10-Dec 10|Resume MP Dec 10|
Prof Trevor Marshall
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 Posted: Sun Feb 9th, 2014 11:01

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It is very important to cite our peer-reviewed papers, rather than websites, when talking with TPTB (including your own Doctor).
 

Trudy.Heil_NP
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 Posted: Mon Feb 10th, 2014 11:16

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I'm attempting again....

"'Can you share with the rest of us why the mechanism of action of an angiotensin receptor antagonist results in such severe diarrhea?'

Glad you asked, Jen SJ. It is because of a characteristic of the drug Benicar that stimulates the innate immune system with each dose. See: http://mpkb.org/home/publications/marshall_theoretical_2006 for an explanation of why this happens."

Trudy

PS: If I need to quote some other scholarly paper, let me know. Let's see if this one gets through....



____________________
MP June08(NoBreaks)Ph1June28-08 ModPh2Aug11-08 Ph2Sept25-08 Ph3Oct4-10 Benicar Only 2012|VitD1,25 6-08:72; VitD25:12-15 12.0 |FMS40+yrs CystAcne65 EBV66 ClsdHdInjry66 PCOS71 Hashmtos81 HSV2&6 81 TotlHyst86 Endmtrs PsorFeet95 Strep&ClamydPneumx3
Prof Trevor Marshall
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 Posted: Mon Feb 10th, 2014 11:37

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Yes, I would use a scholarly paper such as this:

Proal AD, Albert PJ, Blaney GP, Lindseth IA, Benediktsson C, Marshall TG: Immunostimulation in the Era of the Metagenome. Cell Mol Immunol. 2011 Jan 31

http://www.ncbi.nlm.nih.gov/pubmed/21278764
http://dx.doi.org/10.1038/cmi.2010.77


leroybrown
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 Posted: Tue Feb 11th, 2014 07:49

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I don't see *any* comments. What am I missing?

The GI symptoms and relation to celiac disease sure sound familiar to me, but I had all that pre-benicar.



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I just know that something good is going to happen
And I don't know when - Kate Bush
Aplastic anemia Apr/10, PRCA Jan/09, Agranulocytosis 1991
25D = 25 1,25D = 58 Aug 18/09|25D<4.8 Mar/10|10.8 Nov/12
Sep '09 q8h Nov '09 q6h
leroybrown
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 Posted: Tue Feb 11th, 2014 07:53

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Nevermind - I enabled javascript and saw the comments link.



____________________
I just know that something good is going to happen
And I don't know when - Kate Bush
Aplastic anemia Apr/10, PRCA Jan/09, Agranulocytosis 1991
25D = 25 1,25D = 58 Aug 18/09|25D<4.8 Mar/10|10.8 Nov/12
Sep '09 q8h Nov '09 q6h

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