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FDA investigating the safety of Benicar
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  ...  8  9  10  11  12  13  14  Next Page Last Page  
 

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Trudy.Heil_NP
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 Posted: Wed Feb 19th, 2014 07:08

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The MP is in the NY Times.....

http://well.blogs.nytimes.com/2014/02/07/think-like-a-doctor-stomach-bug-solved/?_php=true&_type=blogs&comments&_r=0#permid=11118976

http://well.blogs.nytimes.com/2014/02/07/think-like-a-doctor-stomach-bug-solved/?comments#permid=11137419

My comments were finally vetted and published.

I also added this comment:
"Good question, Sandy. Now you are asking the right questions! In fact , it is not a side effect of the other ARB or ACE drugs with or without HCTZ. Only Benicar/Olmesartan Medoxomil alone (no HCTZ) has this unique property to stimulate the immune system. It was discovered during the clinical drug trials back in the early 2000's. It is being re-targeted for this purpose. See Proal AD, Albert PJ, Blaney GP, Lindseth IA, Benediktsson C, Marshall TG: Immunostimulation in the Era of the Metagenome. Cell Mol Immunol. 2011 Jan 31

http://www.ncbi.nlm.nih.gov/pubmed/21278764
http://dx.doi.org/10.1038/cmi.2010.77

It is very exciting to see chronic inflammatory diseases begin to succumb to our immune system by stimulation and not suppression of this body system."

:cool:

Trudy

Last edited on Wed Feb 19th, 2014 07:20 by Trudy.Heil_NP



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MP June08(NoBreaks)Ph1June28-08 ModPh2Aug11-08 Ph2Sept25-08 Ph3Oct4-10 Benicar Only 2012|VitD1,25 6-08:72; VitD25:12-15 12.0 |FMS40+yrs CystAcne65 EBV66 ClsdHdInjry66 PCOS71 Hashmtos81 HSV2&6 81 TotlHyst86 Endmtrs PsorFeet95 Strep&ClamydPneumx3
scooker48
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 Posted: Wed Feb 19th, 2014 07:23

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Hooray Trudy!

Take a bow for a job well done.:)

Sherry



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GillyB
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 Posted: Wed Feb 19th, 2014 08:33

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Your comment was thoughtful, and your responses well measured. I wonder if anyone will be willing to take a further look?



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Trudy.Heil_NP
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 Posted: Wed Feb 19th, 2014 08:44

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We can only hope....;)

Trudy



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Limburg
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 Posted: Wed Feb 19th, 2014 10:54

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:dude:



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linda veerman
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 Posted: Fri Feb 21st, 2014 11:22

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Wow Trudy :cool::cool::cool:

love it and you,
linda a.k.a. the microbe terminator



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Bane
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 Posted: Tue Aug 5th, 2014 11:11

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cathys2007 wrote: Common Blood Pressure Drug Linked to Severe Gastrointestinal Problems

http://www.sciencedaily.com/releases/2012/06/120621130722.htm

ScienceDaily (June 21, 2012) — Mayo Clinic researchers have discovered an association between a commonly prescribed blood pressure drug, Olmesartan, and severe gastrointestinal issues such as nausea, vomiting, diarrhea, weight loss and electrolyte abnormalities -- symptoms common among those who have celiac disease. The findings are published online June 21 in the medical journal Mayo Clinic Proceedings.

Olmesartan, Other Antihypertensives, and Chronic Diarrhea Among Patients Undergoing Endoscopic Procedures: A Case-Control Study.http://www.ncbi.nlm.nih.gov/pubmed/25023670


RESULTS: We identified 2088 patients undergoing EGD and 12,428 patients undergoing colonoscopy meeting inclusion criteria. On multivariate analysis, there was no statistically significant association between olmesartan and diarrhea among those undergoing EGD (odds ratio, 1.99; 95% CI, 0.79-5.00) or colonoscopy (odds ratio, 0.63; 95% CI, 0.23-1.74). Review of pathology reports of the EGD and colonoscopy groups showed no association between the use of olmesartan and the histologic diagnosis of celiac disease (P=.61) or microscopic colitis (P=1.0), respectively

CONCLUSION: Our findings suggest that neither olmesartan nor other ARBs were associated with diarrhea among patients undergoing endoscopy. The spruelike enteropathy recently associated with olmesartan is likely a rare adverse effect and milder presentations are unlikely.

GillyB
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 Posted: Thu Aug 7th, 2014 13:44

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Nice work, Cathy and Bane. I'll send this off to the fine doctors at Flat Earth Hospital, who advised me that olmesartan was the cause of my diarrhea.



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Bane
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 Posted: Sun Aug 17th, 2014 11:28

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FDA Finds Olmesartan Does Not Cause Cardiovascular Events

http://www.fda.gov/drugs/drugsafety/ucm402323.htm
http://www.lgmpharma.com/blog/fda-finds-olmesartan-does-not-cause-cardiovascular-events/


"There was no viable evidence found to cause the FDA to deem Olmesartan unsafe, and earlier concerns from study investigators claiming there was an increased risk for heart attack in patients taking Olmesartan was nullified"

"Patients ages six and older may safely be prescribed Olmesartan, which is in a class of medications deemed angiotensin II receptor antagonists. While tablet form of Olmesartan is most common a liquid form can be made for children who have trouble swallowing the tablet"

Last edited on Sun Aug 17th, 2014 11:31 by Bane

Sallie Q
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 Posted: Sun Aug 17th, 2014 16:22

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Bane wrote:
Olmesartan, Other Antihypertensives, and Chronic Diarrhea Among Patients Undergoing Endoscopic Procedures: A Case-Control Study.http://www.ncbi.nlm.nih.gov/pubmed/25023670


.....
CONCLUSION: Our findings suggest that neither olmesartan nor other ARBs were associated with diarrhea among patients undergoing endoscopy. The spruelike enteropathy recently associated with olmesartan is likely a rare adverse effect ....



Seems to me that all the "adverse effects" which occasionally inspire doctors to stop prescribing Olmesartan, are the to-be-expected MP Immuno-Pathology (in various individual organs) which kicks in as immunity begins recovery.
:D



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GillyB
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 Posted: Tue Aug 19th, 2014 16:05

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That's what I believe, Sallie.  I tried to explain to the Flat Earth Hospital docs, but they weren't operating their brains in parachute mode, i.e. works better when open.



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Bane
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 Posted: Mon May 4th, 2015 16:16

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Lack of an Association between Angiotensin Receptor Blocker Based Therapy and Increased Risk of Cancer: Evidence from Large Observational Studies

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366349/

"Overall, ARB-based therapy was not associated with increased risk of cancer. However, its use may be related to decreased incidence of lung cancer; this finding should be considered carefully and confirmed with further studies"

Joyful
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 Posted: Mon May 4th, 2015 17:36

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its use may be related to decreased incidence of lung cancer
When they say its use may be related to decreased incidence of lung cancer, it would seem they are trying to differentiate between types of cancers, right?



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Sallie Q
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 Posted: Mon May 4th, 2015 21:45

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the subgroup analysis gives no statistic for eprosartan or olmesartan, I guess there exists at present no long term large population study for either in isolation, a pity :?

and of course I have a personal interest, as my skin cancer seems to be disappearing, my breast cancer has not returned
Also my Sjogren's has gone and so apparently I am now highly unlikely to meet with the associated lymphomas :)



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Trudy.Heil_NP
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 Posted: Mon May 4th, 2015 22:04

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:D:D:D:D:D

Trudy



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Bane
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 Posted: Wed Oct 21st, 2015 16:25

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Immunopathogenesis of olmesartan-associated enteropathy.

http://onlinelibrary.wiley.com/doi/10.1111/apt.13413/epdf

"Olmesartan-associated enteropathy shares many features with coeliac disease, including symptoms and immunopathogenic pathways, such as increased numbers of CD8+ cells and corresponding overexpression of IL15 by epithelial cells"


IP???

Prof Trevor Marshall
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 Posted: Wed Oct 21st, 2015 16:27

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Sure looks like it :) :)

Ron
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 Posted: Wed Oct 21st, 2015 20:01

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Wow, Olmesartan - IP. It really does say so. Nice find Bane! :cool:

Bane
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 Posted: Wed Oct 21st, 2015 21:01

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Gastrointestinal Disorder Associated with Olmesartan Mimics Autoimmune Enteropathy.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477936/

"Among seven olmesartan-treated patients who developed villous atrophy refractory to a gluten free diet, three had extra-intestinal autoimmune diseases, two had antibodies reacting with the 75 kilodalton antigen characteristic of AIE and one had serum anti-goblet cell antibodies"


"Before olmesartan discontinuation, remission was induced in all patients (7/7) by immunosuppressive drugs. After interruption of both olmesartan and immunosuppressive drugs in six patients, remission was maintained in 4 but anti-TNF-α therapy was needed in two"

"This case-series shows that olmesartan can induce intestinal damage mimicking AIE. OIE usually resolved after olmesartan interruption but immunosuppressive drugs may be necessary to achieve remission. Our data sustain the hypothesis that olmesartan interferes with intestinal immuno regulation in predisposed individuals"

Bane
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 Posted: Thu Oct 22nd, 2015 06:39

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Bane wrote:
Immunopathogenesis of olmesartan-associated enteropathy.

http://onlinelibrary.wiley.com/doi/10.1111/apt.13413/epdf

"Olmesartan-associated enteropathy shares many features with coeliac disease, including symptoms and immunopathogenic pathways, such as increased numbers of CD8+ cells and corresponding overexpression of IL15 by epithelial cells"


IP???


Olmesartan gets immune function rolling?

IL-15 Links TLR2/1-Induced Macrophage Differentiation to the Vitamin D-Dependent Antimicrobial Pathway

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678236/

" In this study, we found that TLR2/1-induced IL-15 was required for induction of CYP27b1, the VDR and the downstream antimicrobial peptide cathelicidin. Although both IL-15 and IL-4 triggered macrophage differentiation, only IL-15 was sufficient by itself to induce CYP27b1 and subsequent bioconversion of 25-hydroxyvitamin D3 (25D3) into bioactive 1,25D3, leading to VDR activation and induction of cathelicidin"


Vitamin D Is Required for IFN-γ–Mediated Antimicrobial Activity of Human Macrophages

http://pubmedcentralcanada.ca/pmcc/articles/PMC3269210/

"demonstrating that IL-15 is a critical cytokine for activating the antimicrobial program in human macrophages. Together, these data show that both the innate and the acquired immune responses converge on a common antimicrobial pathway by inducing IL-15, which is required for up-regulation of CYP27b1 and the subsequent induction of cathelicidin and DEFB4"


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