The Marshall Protocol Study Site Home

Search
   
Members

Calendar

Help

Home
Search by username
   Not logged in - Login | Register 


Every week brings more bad news for Vitamin D
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  ...  4  5  6  7  8  9  10  11  12  13  14  ...  Next Page Last Page  
 

New Topic

Reply

Print
AuthorPost
Bane
Member*
 

Joined: Sat Jan 26th, 2008
Location: Norway
Posts: 997
Status:  Offline
 Posted: Tue Aug 5th, 2014 11:20

Quote

Reply
Prenatal vitamin D3 supplementation suppresses LL-37 peptide expression in ex vivo activated neonatal macrophages but not their killing capacity.

http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9314541&fileId=S0007114514001512

Vitamin D
 has regulatory effects on innate immunity. In the present study, we aimed to assess the effect of prenatal vitamin D3 (vitD3) supplementation on neonatal innate immunity in a randomised, placebo-controlled trial by evaluating cathelicidin (LL-37) expression and the killing capacity of macrophages. Healthy pregnant women (n 129) attending a clinic in Dhaka were randomised to receive either a weekly oral dose of 0·875 mg vitD3 or placebo starting from 26 weeks of gestation up to delivery. Serum, plasma and monocyte-derived macrophages (MDM) were obtained from the cord blood. 25-Hydroxyvitamin D (25(OH)D) concentration was measured in serum. MDM were stimulated with or without Toll-like-receptor 4 ligand (TLR4L). Innateimmune function was assessed by measuring LL-37 peptide levels in the culture supernatant of MDM by ELISA, LL-37 transcript levels by quantitative PCR, and ex vivo bactericidal capacity of MDM. vitD3 supplementation did not increase LL-37 peptide levels in plasma or in the extracellular fluid of macrophages with or without TLR4L induction. However, stimulated intracellular LL-37 expression (ratio of stimulated:unstimulated MDM) was significantly reduced in the vitamin D group v. placebo (P= 0·02). Multivariate-adjusted analyses showed that intracellular LL-37 peptide concentration from stimulated MDM was inversely associated with 25(OH)D concentration in serum (P= 0·03). TLR4L stimulation increased the bactericidal capacity of MDM compared with the unstimulated ones (P= 0·01); however, there was no difference in killing capacity between the two groups. A weekly dose of 0·875 mg vitD3 to healthy pregnant women suppressed the intracellular LL-37 peptide stores of activated macrophages, but did not significantly affect the ex vivo bactericidal capacity of cord blood MDM.


----------------------

0·875 = 35000 IU

Last edited on Tue Aug 5th, 2014 12:33 by Bane

Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 16174
Status:  Offline
 Posted: Tue Aug 5th, 2014 14:04

Quote

Reply
Nice find :) I guess they are going to have to think it out again...

be-well
Member
 

Joined: Thu Dec 6th, 2007
Location: England, United Kingdom
Posts: 188
Status:  Offline
 Posted: Thu Sep 4th, 2014 18:41

Quote

Reply
http://www.momentummagazineonline.com/the-ebers-effect-unraveling-the-ms-and-vitamin-d-connection/#sthash.NoE0aKav.dpufDr.

The above reference focuses upon the work of a celebrated canadian Neurologist, often interviewed and consulted by popular media and clinical fellows worldwide regarding the relationship between Vitamin D and Multiple Sclerosis. His speciality is MS.  He continues to present a conflicting analysis of his own studies (and comparative data) 'over subsequent decades', in presenting the case for supplementation, while recommending Vitamin D with confidence to both 'deficient' and non 'deficient' groups.

 “For 3 million years humans were naked on the plains of Africa, and plenty of vitamin D was made in the skin from sunlight.” As humans migrated northward, they became deficient in vitamin D, which led to evolutionary changes toward lighter skin. “The frequency of MS increases with distance from the equator,” he continues, “suggesting that one risk factor may be vitamin D, which is only synthesized in the body when sunlight is of sufficient strength.” -

No trees, foliage, caves or moonlit nights I guess. And the big one, a gigantic error by nature itself for homo sapiens ?

I struggle to understand how someone who clearly works passionately and devotedly to his subject, studied 1000 MS patients taking no medications over a twenty year period, found no evidence of disparity in active metabolite dysregulation - yet did note the frequency of relapses in this patient group compared to those taking prescribed immunosuppressives. 

When I asked him to describe in brief correspondence, the Sarcoid metabolism in relation to Vitamin D synthesis, many of us here would be impressed with his response. So how hard can it be to note the correlation with other chronic diseases and this metabolic marker 'blip.



____________________
mcs,chronic fatigue,hiatus hernia,grains intolerance,tinnitus,photosensitivity.
25-D-3.3,-1,25D-70,Dec 2014.25-D-18, 1,25D,45.Sept 2019.
Markt9452
Support Team


Joined: Fri Oct 26th, 2007
Location: Ontario Canada
Posts: 1123
Status:  Online
 Posted: Fri Sep 5th, 2014 06:37

Quote

Reply
$15,000 prize to be used at the recipient's discretion
Complimentary registration for the latest American Academy of Neurology Annual Meeting
Reimbursement for attending the latest Annual Meeting
travel and two days' meals and lodging expenses
Recognition at the AAN Awards
Luncheon at the latest Annual Meeting

http://www.nationalmssociety.org/For-Professionals/Researchers/Society-Funding/Special-Awards-and-Prizes-(1)/Speical-Awards-and-Prizes

The Ebers group in Oxford is studying in detail the single gene that in previous studies has consistently been correlated with occurrences of multiple sclerosis using a large database of DNA from thousands of families with MS. They have recently published results showing evidence that it is a combination of genetic and environmental factors that can cause MS.

http://www.ox.ac.uk/international/oxford_around_the_globe/north_and_central_america_the_caribbean/canada_.html

Last edited on Fri Sep 5th, 2014 06:43 by Markt9452



____________________
MP Feb08 (no breaks) light sensitivity, fatigue, confusion, muscle twitching, memory loss, dyslexia, skin lesions, sore feet, electrical sensations, vertigo, tinnitus, 125D20 D25<10 2008.Olm.60mg/day. Iver(1/2 dose)q4days+22mg zinc pinc/day.
be-well
Member
 

Joined: Thu Dec 6th, 2007
Location: England, United Kingdom
Posts: 188
Status:  Offline
 Posted: Tue Sep 9th, 2014 14:24

Quote

Reply
"Dr. Ebers’ group discovered that people who have a genetic deficiency of an enzyme called 1,25-alpha-hydroxylase, which converts vitamin D to the active form, were more likely to develop MS." -

This source has to be one of the most frustrating for people around the world with chronic diseases and doctors like Dr Greg Blaney who over ten years ago discovered the two inflammatory markers 25d and 1,25 as a reliable guide of presence and severity of disease.

Ebers states that his findings remain effectively unsubstantiated yet he does not advise caution for anyone going for the higher doses. 





____________________
mcs,chronic fatigue,hiatus hernia,grains intolerance,tinnitus,photosensitivity.
25-D-3.3,-1,25D-70,Dec 2014.25-D-18, 1,25D,45.Sept 2019.
Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 16174
Status:  Offline
 Posted: Tue Sep 9th, 2014 15:51

Quote

Reply
Prof Ebbers was the chairman of the Glasgow 'Vitamin D and MS summit', and he wound up the conference giving us an earful of this "plains of Africa" nonsense.  I challenged him on two things:

1. How does he know that exactly 4000 Units was the daily daily dose received by early man (perhaps they wore fragmentary clothing?), and

2. How does he know that there have been no changes to the genes which determine how our bodies use Vitamin D since the plains of Africa.

He responded by saying "everybody knows you Americans are Evolution Deniers" and that was that...

Not a nice man at all, and I suspect too mean for his fellow Oxford Dons to discipline.

..Trevor..
 

be-well
Member
 

Joined: Thu Dec 6th, 2007
Location: England, United Kingdom
Posts: 188
Status:  Offline
 Posted: Wed Sep 10th, 2014 08:02

Quote

Reply
Yes indeed, not a friendly man at all. But he did mumble something about the possibility that your hypothesis is spot on Dr Marshall, but to a much smaller audience than Glasgow!

The reason I posted this is in the hope of empowering the counter arguments for this particular individual's 'findings' especially in view of the fact that Vitamin D3 may well soon be added to more food groups globally. And also, recently, some clinicians have been told to relax the necessity for the 1,25d blood sample to be frozen prior to analysis

Last edited on Wed Sep 10th, 2014 08:27 by be-well



____________________
mcs,chronic fatigue,hiatus hernia,grains intolerance,tinnitus,photosensitivity.
25-D-3.3,-1,25D-70,Dec 2014.25-D-18, 1,25D,45.Sept 2019.
Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 16174
Status:  Offline
 Posted: Wed Oct 1st, 2014 08:03

Quote

Reply
New study in The Lancet concluding that low levels of 25-D in the blood are not the cause of Diabetes-II:

http://www.thelancet.com/journals/landia/article/PIIS2213-8587%2814%2970184-6/abstract

An explanatory article is at : http://goo.gl/vEuFEo

seanlane
Member


Joined: Mon Oct 19th, 2009
Location: Memphis, Tennessee USA
Posts: 609
Status:  Offline
 Posted: Fri Oct 3rd, 2014 14:06

Quote

Reply
http://www.everydayhealth.com/news/gene-study-finds-no-proof-vitamin-d-guards-against-type-2-diabetes/?xid=aol_eh-news_20_20140929_&aolcat=HLT&icid=maing-grid7%7Cmain5%7Cdl13%7Csec3_lnk4%26pLid%3D540010



____________________
bipolar CFS neuropathy arrhythmia food sensitivities psoriasis MCS guillain-barre tinnitus 125D58 Ph1Jul/08 Ph2Oct/08 25D=17.8 Sept/08 25D=11.8 Jul/09 Ph3 Sept/09
Lyme positive Sept 2014
scooker48
Member*
 

Joined: Mon Jan 3rd, 2005
Location: Sunnyvale, California USA
Posts: 1738
Status:  Offline
 Posted: Tue Oct 14th, 2014 11:07

Quote

Reply
http://www.gainesville.com/article/20141014/COLUMNISTS/141019856/-1/news?Title=Vitamin-D-testing-needs-to-be-more-thorough

Oversimplified and probably not totally accurate.  But at least it is hinting at the truth...




____________________
D25, Total: 12 measured 11/3/15 Started MP=01/04/05 Diagnosis: Sarc 12/04; "cat scratch disease" or necrotizing graunulomas 10/88; Raynaud's (diagnosed 1980?)
Joyful
Foundation Staff


Joined: Fri Jun 8th, 2007
Location: USA
Posts: 15036
Status:  Offline
 Posted: Tue Oct 14th, 2014 20:12

Quote

Reply
Starts out strong but then misses it...
Your lab reveals a level of “1,25 D” of 60, and a “25 D” level of 20. Hopefully, the units are the same.
25D is in ng/ml
1,25D is in pg/ml (much, much smaller)

So all the following ratio making is off by a factor of 1000. :?

The reason why the 1,25D is so much less in the bloodstream is that it is made on an "as needed" basis in the cells.


Last edited on Tue Oct 14th, 2014 20:13 by Joyful



____________________
Video • Be Kind, We Are All Fragile • Forums
`•.¸♥¸.•´`•.¸♥¸.•´`•.¸♥¸.•´`•.¸♥¸.•´`•.¸♥¸.•´
PGA Terry
inactive member
 

Joined: Thu Mar 15th, 2007
Location: Florissant, Missouri USA
Posts: 296
Status:  Offline
 Posted: Sat Oct 18th, 2014 23:30

Quote

Reply
Dr Mercola interviews a doctor who does not advocate oral vitamin D. In fact she says she hasn't swallowed a vit. D supplement in 5 years!

She goes on to talk about the "science" backing her decision not to supplement but more astonishing is that Dr. Mercola seems to agree with her!

http://articles.mercola.com/sites/articles/archive/2014/10/19/cholesterol-sulfate.aspx



____________________
Ank spondylitis/RA - Ph1Aug07 Ph2Jan08 Ph3Mar09, Tylenol, Vits for malabsorption: cal-mag boron melatonin, vit b,c,e, multi-mineral, 4/09-125D=20, 7/13-25D= 4

Cynthia S
Foundation Staff


Joined: Wed Dec 24th, 2008
Location: N., Arizona USA
Posts: 4148
Status:  Offline
 Posted: Sun Oct 19th, 2014 06:28

Quote

Reply
Well, according to her, we must all have blood cells that are falling apart.  It is typical micromanaging of our chemistry that alternative doctors want to do.

After 50 years of being immersed in that kind of thinking, I still am amazed at what the body can do for itself if you just keep the microbiota  on the run.

Cynthia



____________________
MP start 10/08,break 1/16 - 9/16, Spondylitis'97,early Diverticulosis'98,early AMD'08,Calcium anomaly'95,TypeII Diabetes(?)'02,Degenerative hip disease'12, 25D=10.8 May'18 (preMP 125D/25D=47/43) https://marshallprotocol.com/forum30/13911-2.html
Sallie Q
Member*


Joined: Sun Jan 25th, 2009
Location: Away From Computer Until Sept, Australia
Posts: 5808
Status:  Offline
 Posted: Sun Oct 19th, 2014 14:43

Quote

Reply
Cynthia S wrote: Well, according to her, we must all have blood cells that are falling apart. .....

but only if we ingest processed foods and GE crops ;)



____________________
VideoMP'08-'11(now@3x20mgOLM)Dx Depressn'70,node&brCancer'90,BCC'05,Sjgren08|SxCFS,RA,stroke,ASD,reflx 25D=9ng/ml_Nov'17Info
Joyful
Foundation Staff


Joined: Fri Jun 8th, 2007
Location: USA
Posts: 15036
Status:  Offline
 Posted: Sun Oct 19th, 2014 14:46

Quote

Reply
I am increasingly suspicious of food eaten from restaurants.
Even when it's fresh and easy foods, I always feel a bit "off" afterwards.

Remember when we ate meals at home all the time--except when it was at Grandma's house?



____________________
Video • Be Kind, We Are All Fragile • Forums
`•.¸♥¸.•´`•.¸♥¸.•´`•.¸♥¸.•´`•.¸♥¸.•´`•.¸♥¸.•´
Sallie Q
Member*


Joined: Sun Jan 25th, 2009
Location: Away From Computer Until Sept, Australia
Posts: 5808
Status:  Offline
 Posted: Sun Oct 19th, 2014 15:02

Quote

Reply
come visit, Joyful
i'm blessed with a great reliable local
and know where to find a couple of safe eateries when 'commuting' across the state :cool:



____________________
VideoMP'08-'11(now@3x20mgOLM)Dx Depressn'70,node&brCancer'90,BCC'05,Sjgren08|SxCFS,RA,stroke,ASD,reflx 25D=9ng/ml_Nov'17Info
Joyful
Foundation Staff


Joined: Fri Jun 8th, 2007
Location: USA
Posts: 15036
Status:  Offline
 Posted: Sun Oct 19th, 2014 15:04

Quote

Reply
Thanks for the invite! :)



____________________
Video • Be Kind, We Are All Fragile • Forums
`•.¸♥¸.•´`•.¸♥¸.•´`•.¸♥¸.•´`•.¸♥¸.•´`•.¸♥¸.•´
Sallie Q
Member*


Joined: Sun Jan 25th, 2009
Location: Away From Computer Until Sept, Australia
Posts: 5808
Status:  Offline
 Posted: Sun Oct 19th, 2014 15:15

Quote

Reply
Mercola may be a bit too slow on the uptake re v.D
but there is hope
...already has come out on GMO
http://articles.mercola.com/sites/articles/archive/2014/10/14/regenerative-agriculture.aspx



____________________
VideoMP'08-'11(now@3x20mgOLM)Dx Depressn'70,node&brCancer'90,BCC'05,Sjgren08|SxCFS,RA,stroke,ASD,reflx 25D=9ng/ml_Nov'17Info
Cairo123
Support Team*


Joined: Sat Oct 13th, 2007
Location: Texas USA
Posts: 6452
Status:  Offline
 Posted: Sun Oct 19th, 2014 15:31

Quote

Reply
Mercola has been preaching against GMOs for a long time.



____________________
Sarcoidosis, Arthritis, Fallen Arch, Vascular Insufficiency, fatty liver,diverticulosis, 1,25D 16 (Oct08) | Ph1 Nov07, Ph2 Jan08, Ph3 May 09 Ben Only: Jun 10- Sep 10|Break Sep 10-Dec 10|Resume MP Dec 10|
Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 16174
Status:  Offline
 Posted: Wed Oct 29th, 2014 03:42

Quote

Reply
BMJ (the prestigious British Medical Journal) has published a Swedish study which found that the risk of dying was doubled for women who drank three or more glasses of milk a day, and no protection from fractures -- in fact an increase --  was observed:

http://www.bmj.com/content/349/bmj.g6015

After reciting that milk is rich in vitamin D, and hence good for you, the authors propose a hypothesis based on D-galactose as doing the harm. Clearly they have not Googled for "Vitamin D harmful", as the top hit there is this article:

http://www.medicalnewstoday.com/articles/260147.php

Sigh...

..Trevor..
 


 Current time is 21:14
Page:  First Page Previous Page  ...  4  5  6  7  8  9  10  11  12  13  14  ...  Next Page Last Page  



* We can help you understand chronic disease, but only your physician is licensed to give you medical care *

Powered by WowBB 1.7 - Entire site Copyright © 2004-2020 Autoimmunity Research Foundation, All Rights Reserved
Click here to view our PRIVACY POLICY
Page processed in 0.0470 seconds (68% database + 32% PHP). 18 queries executed.