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Whole-cell in-silico emulations
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2   
 

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Prof Trevor Marshall
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 Posted: Tue Apr 5th, 2011 20:07

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Yes, Teresa, it reaches peak concentration very quickly, in about an hour (same delay as in mice, incidentally)  and is extremely reliable - always kicks in when you need it...

..Trevor..
ps: to FDA-type folk reading this - Teresa is capable of understanding that the above is purely my opinion and experience, and not an advertisement or guarantee of performance :) :)
 

ChrisMavo
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 Posted: Tue Apr 5th, 2011 23:16

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Thanks for the very interesting link to that presentation Wrotek!  While much of it was a bit over my head, I understood enough to see how exciting the field of computational biology truly is and how closely it is related to Dr Marshall's work! 

At approximately the 44 minute mark he talks about how misfolded proteins cause various neurological diseases.  He did not list ALS there, but I know from reading other papers that the misfolding of a key protein is one of the things ALS researchers recently discovered.

So thanks again for posting this fascinating find! 



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wrotek
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 Posted: Wed Apr 6th, 2011 00:08

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ChrisMavo, i liked the whole presentation too, because it contains a lot of nice animations .I always liked science fiction movies, except it is not fiction anymore ;)

This fragment about folding protein was very interesting for me when he said that crystallographic structure of the protein matched completely computer simulation. That is how we know this computations are correct .

Last edited on Wed Apr 6th, 2011 00:12 by wrotek



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mvanwink5
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 Posted: Thu Apr 7th, 2011 09:54

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Wrotek, I appreciate your thoughts, but your comment is more strongly worded than warranted, IMO. The match is a nice indicator, but keep eyes peeled for deviations from real world.



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Prof Trevor Marshall
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 Posted: Thu Apr 7th, 2011 14:18

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Protein folding is profoundly affected in-vivo by enzymatic actions, any highly charged molecules drifting around affect the folding in non-deterministic as well as deterministic ways.

I have always been  critical of the Stanford folding group's work because they pay no attention to the effect of the in-vivo environment.
 

wirion
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 Posted: Tue Apr 19th, 2011 21:26

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Probably no news to Dr Marshall, but it's good to see that some people understand that protein folding can be a pretty subtle process. This page on Scientific American explains that it is crucial for some proteins not to be fully folded right after synthesis:
http://www.scientificamerican.com/article.cfm?id=flexible-proteins-web-extra
It also has a nice video at the end that shows a molecular walking apparatus where this delayed folding is important.



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titta
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 Posted: Wed Apr 20th, 2011 10:09

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Very impressing find!

Thank you for sharing.

Titta



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